-
1
-
-
33748114134
-
One hundred two consecutive hepatobiliary resections for perihilar cholangiocarcinoma with zero mortality
-
Sano T, Shimada K, Sakamoto Y, Yamamoto J, Yamasaki S and Kosuge T: One hundred two consecutive hepatobiliary resections for perihilar cholangiocarcinoma with zero mortality. Ann Surg244: 240-247, 2006.
-
(2006)
Ann Surg
, vol.244
, pp. 240-247
-
-
Sano, T.1
Shimada, K.2
Sakamoto, Y.3
Yamamoto, J.4
Yamasaki, S.5
Kosuge, T.6
-
2
-
-
34247600489
-
Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion
-
Leelawat K, Leelawat S, Narong S and Hongeng S: Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion. World J Gastroenterol 13: 1561-1568, 2007.
-
(2007)
World J Gastroenterol
, vol.13
, pp. 1561-1568
-
-
Leelawat, K.1
Leelawat, S.2
Narong, S.3
Hongeng, S.4
-
4
-
-
0034604067
-
Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer
-
Yuan ZQ, Sun M, Feldman RI, et al: Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer. Oncogene19: 2324-2330, 2000.
-
(2000)
Oncogene
, vol.19
, pp. 2324-2330
-
-
Yuan, Z.Q.1
Sun, M.2
Feldman, R.I.3
-
5
-
-
0032539664
-
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
-
Burnett PE, Barrow RK, Cohen NA, Snyder SH and SabatiniDM: RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc Natl Acad Sci USA 95: 1432-1437, 1998.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 1432-1437
-
-
Burnett, P.E.1
Barrow, R.K.2
Cohen, N.A.3
Snyder, S.H.4
Sabatini, D.M.5
-
6
-
-
0142071830
-
Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1
-
Beugnet A, Wang X and Proud CG: Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1. J Biol Chem 278: 40717-40722, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 40717-40722
-
-
Beugnet, A.1
Wang, X.2
Proud, C.G.3
-
7
-
-
0016713286
-
Rapamycin (AY-22, 989), a new antifungal antibiotic. II. Fermentation, isolation and characterization
-
Sehgal SN, Baker H and Vézina C: Rapamycin (AY-22, 989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J Antibiot (Tokyo) 28: 727-732, 1975.
-
(1975)
J Antibiot (Tokyo)
, vol.28
, pp. 727-732
-
-
Sehgal, S.N.1
Baker, H.2
Vézina, C.3
-
8
-
-
41349119602
-
Antitumor activity of rapamycin and octreotide as single agents or in combination in neuroendocrine tumors
-
Moreno A, Akcakanat A, Munsell MF, Soni A, Yao JC and Meric-Bernstam F: Antitumor activity of rapamycin and octreotide as single agents or in combination in neuroendocrine tumors. Endocr Relat Cancer 15: 257-266, 2008.
-
(2008)
Endocr Relat Cancer
, vol.15
, pp. 257-266
-
-
Moreno, A.1
Akcakanat, A.2
Munsell, M.F.3
Soni, A.4
Yao, J.C.5
Meric-Bernstam, F.6
-
9
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: A double blind, randomised, placebo-controlled phase III trial
-
Motzer RJ, Escudier B, Oudard S, et al: Efficacy of everolimus in advanced renal cell carcinoma: a double blind, randomised, placebo-controlled phase III trial. Lancet 372: 449-456, 2008.
-
(2008)
Lancet
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
-
10
-
-
33847314632
-
Monitoring antitumor efficacy of rapamycin in Kaposi sarcoma
-
Di Paolo S, Teutonico A, Ranieri E, Gesualdo L and Schena PF: Monitoring antitumor efficacy of rapamycin in Kaposi sarcoma. IS J Kidney Dis 49: 462-470, 2007.
-
(2007)
IS J Kidney Dis
, vol.49
, pp. 462-470
-
-
Di Paolo, S.1
Teutonico, A.2
Ranieri, E.3
Gesualdo, L.4
Schena, P.F.5
-
11
-
-
1942487890
-
Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function
-
Oshiro N, Yoshino K, Hidayat S, et al: Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. Genes Cells 9: 359-366, 2004.
-
(2004)
Genes Cells
, vol.9
, pp. 359-366
-
-
Oshiro, N.1
Yoshino, K.2
Hidayat, S.3
-
12
-
-
77955743591
-
Pilot study: Rapamycin in advanced hepatocellular carcinoma
-
Schöniger-Hekele M and Müller C: Pilot study: rapamycin in advanced hepatocellular carcinoma. Aliment Pharmacol Ther32: 763-768, 2010.
-
(2010)
Aliment Pharmacol Ther
, vol.32
, pp. 763-768
-
-
Schöniger-Hekele, M.1
Müller, C.2
-
13
-
-
64949150004
-
Rapamycin inhibits growth of cholangiocarcinoma cells
-
Okada T, Sawada T and Kubota K: Rapamycin inhibits growth of cholangiocarcinoma cells. Hepatogastroenterology 56: 6-10, 2009.
-
(2009)
Hepatogastroenterology
, vol.56
, pp. 6-10
-
-
Okada, T.1
Sawada, T.2
Kubota, K.3
-
14
-
-
77950541904
-
Everolimus (RAD001) in the treatment of advanced renal cell carcinoma: A review
-
Agarwala SS and Case S: Everolimus (RAD001) in the treatment of advanced renal cell carcinoma: a review. Oncologist 15: 236-245, 2010.
-
(2010)
Oncologist
, vol.15
, pp. 236-245
-
-
Agarwala, S.S.1
Case, S.2
-
15
-
-
33751010766
-
Establishment and characterization of a cholangiocarcinoma cell line (RMCCA-1) from a Thai patient
-
Rattanasinganchan P, Leelawat K, Treepongkaruna SA, et al: Establishment and characterization of a cholangiocarcinoma cell line (RMCCA-1) from a Thai patient. World J Gastroenterol 12: 6500-6506, 2006.
-
(2006)
World J Gastroenterol
, vol.12
, pp. 6500-6506
-
-
Rattanasinganchan, P.1
Leelawat, K.2
Treepongkaruna, S.A.3
-
16
-
-
70449900928
-
TOR complex 2: A signaling pathway of its own
-
Cybulski N and Hall MN: TOR complex 2: a signaling pathway of its own. Trends Biochem Sci 34: 620-627, 2009.
-
(2009)
Trends Biochem Sci
, vol.34
, pp. 620-627
-
-
Cybulski, N.1
Hall, M.N.2
-
17
-
-
0036674617
-
Live or let die: The cell's response to p53
-
Vousden KH and Lu X: Live or let die: the cell's response to p53. Nat Rev Cancer 2: 594-604, 2002.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
18
-
-
1342347885
-
An introduction to the molecular mechanisms of apoptosis
-
Delhalle S, Duvoix A, Schnekenburger M, Morceau F, Dicato M and Diederich M: An introduction to the molecular mechanisms of apoptosis. Ann N Y Acad Sci 1010: 1-8. 2003.
-
(2003)
Ann N Y Acad Sci
, vol.1010
, pp. 1-8
-
-
Delhalle, S.1
Duvoix, A.2
Schnekenburger, M.3
Morceau, F.4
Dicato, M.5
Diederich, M.6
-
19
-
-
23044442713
-
Proliferation and invasion: Plasticity in tumor cells
-
Gao CF, Xie Q, Su YL, et al: Proliferation and invasion: plasticity in tumor cells. Proc Natl Acad Sci USA 102: 10528-10533, 2005.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 10528-10533
-
-
Gao, C.F.1
Xie, Q.2
Su, Y.L.3
-
20
-
-
0029885707
-
Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity
-
Pei D and Weiss SJ: Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity. J Biol Chem 271: 9135-9140, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 9135-9140
-
-
Pei, D.1
Weiss, S.J.2
-
21
-
-
0031025218
-
Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules
-
Ohuchi E, Imai K, Fujii Y, Sato H, Seiki M and Okada Y: Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules. J Biol Chem 272: 2446-2451, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 2446-2451
-
-
Ohuchi, E.1
Imai, K.2
Fujii, Y.3
Sato, H.4
Seiki, M.5
Okada, Y.6
-
22
-
-
0034614939
-
Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5
-
Koshikawa N, Giannelli G, Cirulli V, Miyazaki K and QuarantaV: Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5. J Cell Biol 148: 615-624, 2000.
-
(2000)
J Cell Biol
, vol.148
, pp. 615-624
-
-
Koshikawa, N.1
Giannelli, G.2
Cirulli, V.3
Miyazaki, K.4
Quaranta, V.5
-
23
-
-
34547130295
-
RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model
-
Mabuchi S, Altomare DA, Cheung M, et al: RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model. Clin Cancer Res 13: 4261-4270, 2007.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4261-4270
-
-
Mabuchi, S.1
Altomare, D.A.2
Cheung, M.3
-
24
-
-
84892956103
-
The mTOR inhibitors rapamycin and RAD001 are active in experimental models of ALL and are antagonized by interleukin-7
-
Brown VI, Fang, JJ, Barr R, Alcorn K, Kim J and Grupp SA: The mTOR inhibitors rapamycin and RAD001 are active in experimental models of ALL and are antagonized by interleukin-7. Blood100: 761a, 2002.
-
(2002)
Blood
, vol.100
-
-
Brown, V.I.1
Fang, J.J.2
Barr, R.3
Alcorn, K.4
Kim, J.5
Grupp, S.A.6
-
25
-
-
84857789861
-
Aberrant activation of the mTOR pathway and anti-tumour effect of everolimus on oesophageal squamous cell carcinoma
-
Hirashima K, Baba Y, Watanabe M, et al: Aberrant activation of the mTOR pathway and anti-tumour effect of everolimus on oesophageal squamous cell carcinoma. Br J Cancer 106: 876-882, 2012.
-
(2012)
Br J Cancer
, vol.106
, pp. 876-882
-
-
Hirashima, K.1
Baba, Y.2
Watanabe, M.3
-
26
-
-
84856034758
-
Synergistic anti-tumor effects of RAD001 with MEK inhibitors in neuroendocrine tumors: A potential mechanism of therapeutic limitation of mTOR inhibitor
-
Ida S, Miki Y, Ono K, et al: Synergistic anti-tumor effects of RAD001 with MEK inhibitors in neuroendocrine tumors: a potential mechanism of therapeutic limitation of mTOR inhibitor. Mol Cell Endocrinol 350: 99-106, 2012.
-
(2012)
Mol Cell Endocrinol
, vol.350
, pp. 99-106
-
-
Ida, S.1
Miki, Y.2
Ono, K.3
-
27
-
-
61349171307
-
Inhibition of PI3K increases oxaliplatin sensitivity in cholangiocarcinoma cells
-
Leelawat K, Narong S, Udomchaiprasertkul W, Leelawat S and Tungpradubkul S: Inhibition of PI3K increases oxaliplatin sensitivity in cholangiocarcinoma cells. Cancer Cell Int 9: 3, 2009.
-
(2009)
Cancer Cell Int
, vol.9
, pp. 3
-
-
Leelawat, K.1
Narong, S.2
Udomchaiprasertkul, W.3
Leelawat, S.4
Tungpradubkul, S.5
-
28
-
-
72749102942
-
Mammalian target of rapamycin inhibitors rapamycin and RAD001 (everolimus) induce anti-proliferative effects in GH-secreting pituitary tumor cells in vitro
-
Gorshtein A, Rubinfeld H, Kendler E, et al: Mammalian target of rapamycin inhibitors rapamycin and RAD001 (everolimus) induce anti-proliferative effects in GH-secreting pituitary tumor cells in vitro. Endocr Relat Cancer 16: 1017-1027, 2009.
-
(2009)
Endocr Relat Cancer
, vol.16
, pp. 1017-1027
-
-
Gorshtein, A.1
Rubinfeld, H.2
Kendler, E.3
-
29
-
-
0018307730
-
Multiple phosphorylation of ribosomal protein S6 during transition of quiescent 3T3 cells into early G1, and cellular compartmentalization of the phosphate donor
-
Thomas G, Siegmann M and Gordon J: Multiple phosphorylation of ribosomal protein S6 during transition of quiescent 3T3 cells into early G1, and cellular compartmentalization of the phosphate donor. Proc Natl Acad Sci USA 76: 3952-3956, 1979.
-
(1979)
Proc Natl Acad Sci USA
, vol.76
, pp. 3952-3956
-
-
Thomas, G.1
Siegmann, M.2
Gordon, J.3
-
30
-
-
84856404470
-
Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6-and 8-production
-
Fitzgerald JP, Nayak B, Shanmugasundaram K, et al: Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6-and 8-production. PLoS One 7: e30712, 2012.
-
(2012)
PLoS One
, vol.7
-
-
Fitzgerald, J.P.1
Nayak, B.2
Shanmugasundaram, K.3
-
31
-
-
0036849099
-
Survival signaling goes BAD
-
Bergmann A: Survival signaling goes BAD. Dev Cell 3: 607-608, 2002.
-
(2002)
Dev Cell
, vol.3
, pp. 607-608
-
-
Bergmann, A.1
-
32
-
-
0040056864
-
p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis
-
Schürmann A, Mooney AF, Sanders LC, et al: p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol 20: 453-461, 2000.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 453-461
-
-
Schürmann, A.1
Mooney, A.F.2
Sanders, L.C.3
-
33
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cellintrinsic death machinery
-
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, et al: Akt phosphorylation of BAD couples survival signals to the cellintrinsic death machinery. Cell 91: 231-241, 1997.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
Masters, S.4
Fu, H.5
Gotoh, Y.6
-
34
-
-
0033635235
-
14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation
-
Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB, et al: 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell 6: 41-51, 2000.
-
(2000)
Mol Cell
, vol.6
, pp. 41-51
-
-
Datta, S.R.1
Katsov, A.2
Hu, L.3
Petros, A.4
Fesik, S.W.5
Yaffe, M.B.6
-
35
-
-
0034786019
-
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX-and BAK-mediated mitochondrial apoptosis
-
Cheng EH, Wei MC, Weiler S, et al: BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX-and BAK-mediated mitochondrial apoptosis. Mol Cell 8: 705-711, 2001.
-
(2001)
Mol Cell
, vol.8
, pp. 705-711
-
-
Cheng, E.H.1
Wei, M.C.2
Weiler, S.3
-
36
-
-
19944432123
-
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
-
Chen L, Willis SN, Wei A, et al: Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 17: 393-403, 2005.
-
(2005)
Mol Cell
, vol.17
, pp. 393-403
-
-
Chen, L.1
Willis, S.N.2
Wei, A.3
|