Molecular dynamics simulations show how the FMRP Ile304Asn mutation destabilizes the KH2 domain structure and affects its function

Journal of Biomolecular Structure and Dynamics

Volumn 32, Issue 3, 2014, Pages 337-350

  Di Marino, Daniele ^a,b,c   Achsel, Tilmann ^a,b   Lacoux, Caroline ^a,b   Falconi, Mattia ^b,d   Bagni, Claudia ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS   (Italy)

Author keywords

FMRP; KH domain; molecular dynamics simulation; protein nucleic acid docking

Indexed keywords

FRAGILE X MENTAL RETARDATION PROTEIN; P21 ACTIVATED KINASE 1;

ALPHA HELIX; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; HYDROPHOBICITY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN UNFOLDING; RNA BINDING; STRUCTURE ANALYSIS;

BINDING SITES; FRAGILE X MENTAL RETARDATION PROTEIN; FRAGILE X SYNDROME; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN UNFOLDING;

EID: 84892988933     PISSN: 07391102     EISSN: 15380254     Source Type: Journal    
DOI: 10.1080/07391102.2013.768552     Document Type: Article

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