ADP/ATP mitochondrial carrier MD simulations to shed light on the structural-dynamical events that, after an additional mutation, restore the function in a pathological single mutant

Journal of Structural Biology

Volumn 172, Issue 3, 2010, Pages 225-232

  Di Marino, Daniele ^a,b   Oteri, Francesco ^a,b   Morozzo della Rocca, Blasco ^a   Chillemi, Giovanni ^c   Falconi, Mattia ^a,b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b CIBB   (Italy)

^c CASPUR   (Italy)

Author keywords

Essential dynamics; Membrane proteins; Molecular dynamics; Nucleotide carrier; Salt bridges

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALANINE; CARRIER PROTEIN; METHIONINE; MITOCHONDRIAL PROTEIN; MUTANT PROTEIN; PROLINE; VALINE;

ARTICLE; GENE MUTATION; LIPID BILAYER; MOLECULAR DYNAMICS; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; RIGIDITY; SIMULATION; WILD TYPE;

ANIMALS; CATTLE; MEMBRANE PROTEINS; MITOCHONDRIAL ADP, ATP TRANSLOCASES; MOLECULAR DYNAMICS SIMULATION; MUTATION; PRINCIPAL COMPONENT ANALYSIS; PROTEIN STRUCTURE, SECONDARY;

BOVINAE;

EID: 77958198869     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2010.07.015     Document Type: Article

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