Potentiated adrenomedullin-induced vasorelaxation during hypoxia in organ cultured porcine coronary arteries

Journal of Cardiovascular Pharmacology

Volumn 63, Issue 1, 2014, Pages 58-67

  Hasbak, Philip ^a,b   Sheykhzade, Majid ^c   Schifter, Søren ^d   Edvinsson, Lars ^a  

^a GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^b Rigshospitalet   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Adrenomedullin; Amylin; Calcitonin like receptor; CGRP; CGRP receptors; Hypoxia; Porcine coronary arteries

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ADRENOMEDULLIN; ALPHA CALCITONIN GENE RELATED PEPTIDE; BETA ACTIN; CALCITONIN LIKE RECEPTOR; ENDOTHELIN 1; RECEPTOR ACTIVITY MODIFYING PROTEIN 1; RECEPTOR ACTIVITY MODIFYING PROTEIN 2; UNCLASSIFIED DRUG; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE-RELATED PEPTIDE (8-37); CALCITONIN RECEPTOR LIKE RECEPTOR; MESSENGER RNA; PEPTIDE FRAGMENT; RECEPTOR ACTIVITY MODIFYING PROTEIN; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY DILATATION; DRUG POTENTIATION; GENE EXPRESSION; HYPEROXIA; HYPOXIA; MUSCLE RELAXATION; NONHUMAN; ORGAN CULTURE; OXYGEN SUPPLY; OXYGEN TENSION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SWINE; ANIMAL; ANOXIA; BIOSYNTHESIS; CORONARY BLOOD VESSEL; DRUG EFFECTS; GENETICS; HEART MUSCLE; METABOLISM; MUSCLE CONTRACTION; ORGAN CULTURE TECHNIQUE; PATHOPHYSIOLOGY; PIG; VASODILATATION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ADRENOMEDULLIN; ANIMALS; ANOXIA; CALCITONIN GENE-RELATED PEPTIDE; CALCITONIN RECEPTOR-LIKE PROTEIN; CORONARY VESSELS; MUSCLE CONTRACTION; MYOCARDIUM; ORGAN CULTURE TECHNIQUES; PEPTIDE FRAGMENTS; RECEPTOR ACTIVITY-MODIFYING PROTEINS; RNA, MESSENGER; SWINE; VASODILATION; VASODILATOR AGENTS;

EID: 84892935420     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0000000000000025     Document Type: Article

References (42)

1. McLatchie LM, Fraser NJ, Main MJ, et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 1998;393:333-339
2. Hasbak P, Sams A, Schifter S, et al. CGRP receptors mediating CGRP-, adrenomedullin- And amylin-induced relaxation in porcine coronary arteries. Characterization with "Compound 1" (WO98/11128), a non-peptide antagonist. Br J Pharmacol. 2001;133:1405-1413
3. Poyner DR, Sexton PM, Marshall I, et al. International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev. 2002;54:233-246
4. Hasbak P, Opgaard OS, Eskesen K, et al. Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist. J Pharmacol Exp Ther. 2003;304: 326-333
5. Hinson JP, Kapas S, Smith DM. Adrenomedullin, a multifunctional regulatory peptide. Endocr Rev. 2000;21:138-167
6. Hay DL, Howitt SG, Conner AC, et al. CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: A comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS. Br J Pharmacol. 2003;140:477-486
7. Hasbak P, Eskesen K, Schifter S, et al. Increased alphaCGRP potency and CGRP-receptor antagonist affinity in isolated hypoxic porcine intramyocardial arteries. Br J Pharmacol. 2005;145:646-655
8. Mannan MM, Springall DR, Enard C, et al. Decreased endotheliumdependent pulmonary vasodilator effect of calcitonin gene-related peptide in hypoxic rats contrasts with increased binding sites. Eur Respir J. 1995;8:2029-2037
9. McBride JT, Springall DR, Winter RJ, et al. Quantitative immunocytochemistry shows calcitonin gene-related peptide-like immunoreactivity in lung neuroendocrine cells is increased by chronic hypoxia in the rat. Am J Respir Cell Mol Biol. 1990;3:587-593
10. Montuenga LM, Springall DR, Gaer J, et al. CGRP-immunoreactive endocrine cell proliferation in normal and hypoxic rat lung studied by immunocytochemical detection of incorporation of 5'-bromodeoxyuridine. Cell Tissue Res. 1992;268:9-15
11. Frayon S, Cueille C, Gnidehou S, et al. Dexamethasone increases RAMP1 and CRLR mRNA expressions in human vascular smooth muscle cells. Biochem Biophys Res Commun. 2000;270:1063-1067
12. Qing X, Svaren J, Keith IM. mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung. Am J Physiol Lung Cell Mol Physiol. 2001;280:L547-L554
13. Cueille C, Pidoux E, de Vernejoul MC, et al. Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure. Biochem Biophys Res Commun. 2002;294:340-346
14. Cueille C, Birot O, Bigard X, et al. Post-Transcriptional regulation of CRLR expression during hypoxia. Biochem Biophys Res Commun. 2005;326:23-29
15. Mulvany MJ, Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res. 1977;41:19-26
16. Winer BJ. Statistical Principles in Experimental Design. 2nd ed. New York, NY: McGraw-Hill; 1971
17. Jenkinson DH. How we describe competitive antagonists: Three questions of usage. Trends Pharmacol Sci. 1991;12:53-54
18. Jenkinson DH, Barnard EA, Hoyer D, et al. International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. IX. Recommendations on terms and symbols in quantitative pharmacology. Pharmacol Rev. 1995;47:255-266
19. Sheykhzade M, Nyborg NC. Characterization of calcitonin gene-related peptide (CGRP) receptors in intramural coronary arteries from male and female Sprague Dawley rats. Br J Pharmacol. 1998;123:1464-1470
20. Buhlmann N, Leuthauser K, Muff R, et al. A receptor activity modifying protein (RAMP)2-dependent adrenomedullin receptor is a calcitonin gene-related peptide receptor when coexpressed with human RAMP1. Endocrinology. 1999;140:2883-2890
21. Ladoux A, Frelin C. Coordinated up-regulation by hypoxia of adrenomedullin and one of its putative receptors (RDC-1) in cells of the rat blood-brain barrier. J Biol Chem. 2000;275:39914-39919
22. Cormier-Regard S, Nguyen SV, Claycomb WC. Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes. J Biol Chem. 1998;273: 17787-17792
23. Dschietzig T, Richter C, Asswad L, et al. Hypoxic induction of receptor activity-modifying protein 2 alters regulation of pulmonary endothelin-1 by adrenomedullin: Induction under normoxia versus inhibition under hypoxia. J Pharmacol Exp Ther. 2007;321:409-419
24. Lanner F, Lee KL, Ortega GC, et al. Hypoxia-induced arterial differentiation requires adrenomedullin and notch signaling. Stem Cells Dev. 2013;22:1360-1369
25. Makino I, Honda K, Makino Y, et al. Phenotypic changes of adrenomedullin receptor components, RAMP2, and CRLR mRNA expression in cultured rat vascular smooth muscle cells. Biochem Biophys Res Commun. 001;288:515-520
26. Nagata D, Hirata Y, Suzuki E, et al. Hypoxia-induced adrenomedullin production in the kidney. Kidney Int. 1999;55:1259-1267
27. Nakayama M, Takahashi K, Murakami O, et al. Induction of adrenomedullin by hypoxia in cultured human coronary artery endothelial cells. Peptides. 1999;20:769-772
28. Ogita T, Hashimoto E, Yamasaki M, et al. Hypoxic induction of adrenomedullin in cultured human umbilical vein endothelial cells. J Hypertens. 2001;19(3 Pt 2):603-608
29. Udono T, Takahashi K, Nakayama M, et al. Induction of adrenomedullin by hypoxia in cultured retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2001;42:1080-1086
30. Kitamuro T, Takahashi K, Nakayama M, et al. Induction of adrenomedullin during hypoxia in cultured human glioblastoma cells. J Neurochem. 2000;75:1826-1833
31. Zhao L, Brown LA, Owji AA, et al. Adrenomedullin activity in chronically hypoxic rat lungs. Am J Physiol. 1996;271(Pt 2):H622-H629
32. Kitamuro T, Takahashi K, Totsune K, et al. Differential expression of adrenomedullin and its receptor component, receptor activity modifying protein (RAMP) 2 during hypoxia in cultured human neuroblastoma cells. Peptides. 2001;22:1795-1801
33. Hay DL, Poyner DR, Quirion R. International Union of Pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptor. Pharmacol Rev. 2008;60:143-145
34. Alexander SP, Mathie A, Peters JA. Guide to receptors and channels (GRAC), 5th edition. Br J Pharmacol. 2011;164(suppl 1):S1-S324
35. Hong Y, Hay DL, Quirion R, et al. The pharmacology of adrenomedullin 2/intermedin. Br J Pharmacol. 2012;166:110-120
36. Wisskirchen FM, Gray DW, Marshall I. Receptors mediating CGRPinduced relaxation in the rat isolated thoracic aorta and porcine isolated coronary artery differentiated by h(alpha) CGRP(8-37). Br J Pharmacol. 1999;128:283-292
37. Alm R, Edvinsson L, Malmsjo M. Organ culture: A new model for vascular endothelium dysfunction. BMC Cardiovasc Disord. 2002;2:8
38. Chang AE, Detar R. Oxygen and vascular smooth muscle contraction revisited. Am J Physiol. 1980;238:H716-H728
39. Eltzschig HK, Carmeliet P. Hypoxia and inflammation. N Engl J Med. 2011;364:656-665
40. Eltzschig HK, Macmanus CF, Colgan SP. Neutrophils as sources of extracellular nucleotides: Functional consequences at the vascular interface. Trends Cardiovasc Med. 2008;18:103-107
41. Faigle M, Seessle J, Zug S, et al. ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia. PLoS One. 2008;3:e2801
42. Eckle T, Hartmann K, Bonney S, et al. Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med. 2012;18:774-782