The LKB1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Nakada, Yuji ^a   Stewart, Thomas G ^b   Peña, Christopher G ^a   Zhang, Song ^c   Zhao, Ni ^b   Bardeesy, Nabeel ^d   Sharpless, Norman E ^b   Wong, Kwok Kin ^e   Hayes, D Neil ^b   Castrillon, Diego H ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; MESSENGER RNA; MONOCLONAL ANTIBODY; PROTEIN KINASE LKB1; TUMOR SUPPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CORRELATIONAL STUDY; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC MARKER; HUMAN; HUMAN CELL; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; IMMUNOHISTOCHEMISTRY; LKB1 GENE; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; NONHUMAN; PHENOTYPE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REPRODUCIBILITY; RNA ANALYSIS; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION; TUMOR SUPPRESSOR GENE; UTERINE CERVIX CANCER;

ANIMALS; BIOLOGICAL MARKERS; GENES, TUMOR SUPPRESSOR; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; PROTEIN-SERINE-THREONINE KINASES;

EID: 84884551275     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073449     Document Type: Article

References (27)

1. Wingo SN, Gallardo TD, Akbay EA, Liang MC, Contreras CM, et al. (2009) Somatic LKB1 mutations promote cervical cancer progression. PLoS One 4: e5137.
2. Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, et al. (2007) LKB1 modulates lung cancer differentiation and metastasis. Nature 448: 807-810.
3. Shah U, Sharpless NE, Hayes DN, (2008) LKB1 and lung cancer: more than the usual suspects. Cancer Res 68: 3562-3565.
4. Guldberg P, Thor Straten P, Ahrenkiel V, Seremet T, Kirkin AF, et al. (1999) Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma. Oncogene 18: 1777-1780.
5. Liu W, Monahan KB, Pfefferle AD, Shimamura T, Sorrentino J, et al. (2012) LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma. Cancer Cell 21: 751-764.
6. Shackelford DB, Shaw RJ, (2009) The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer 9: 563-575.
7. Alexander A, Walker CL, (2011) The role of LKB1 and AMPK in cellular responses to stress and damage. FEBS Lett 585: 952-957.
8. Laplante M, Sabatini DM, (2012) mTOR signaling in growth control and disease. Cell 149: 274-293.
9. Vaahtomeri K, Makela TP, (2011) Molecular mechanisms of tumor suppression by LKB1. FEBS Lett 585: 944-951.
10. Contreras CM, Akbay EA, Gallardo TD, Haynie JM, Sharma S, et al. (2010) Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy. Dis Model Mech 3: 181-193.
11. Contreras CM, Gurumurthy S, Haynie JM, Shirley LJ, Akbay EA, et al. (2008) Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas. Cancer Res 68: 759-766.
12. Carretero J, Shimamura T, Rikova K, Jackson AL, Wilkerson MD, et al. (2010) Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. Cancer Cell 17: 547-559.
13. Chen Z, Cheng K, Walton Z, Wang Y, Ebi H, et al. (2012) A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature 483: 613-617.
14. Shackelford DB, Vasquez DS, Corbeil J, Wu S, Leblanc M, et al. (2009) mTOR and HIF-1{alpha}-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. Proc Natl Acad Sci U S A.
15. Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, et al. (1998) A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 391: 184-187.
16. Alessi DR, Sakamoto K, Bayascas JR, (2006) Lkb1-dependent signaling pathways. Annu Rev Biochem 75: 137-163.
17. Nony P, Gaude H, Rossel M, Fournier L, Rouault JP, et al. (2003) Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37. Oncogene 22: 9165-9175.
18. Liu S, Miao Y, Fan C, Liu Y, Yu J, et al. (2012) Clinicopathologic Correlations of Liver Kinase B1, E-Cadherin, and N-Cadherin Expression in Non-Small Cell Lung Cancer. Appl Immunohistochem Mol Morphol.
19. Kline ER, Muller S, Pan L, Tighiouart M, Chen ZG, et al. (2011) Localization-specific LKB1 loss in head and neck squamous cell carcinoma metastasis. Head Neck 33: 1501-1512.
20. Amin RM, Hiroshima K, Iyoda A, Hoshi K, Honma K, et al. (2008) LKB1 protein expression in neuroendocrine tumors of the lung. Pathol Int 58: 84-88.
21. Ma Y, Zhang G, Fu X, Xia O, Zhan C, et al. (2010) Wnt signaling may be activated in a subset of Peutz-Jeghers syndrome polyps closely correlating to LKB1 expression. Oncol Rep 23: 1569-1576.
22. Conde E, Suarez-Gauthier A, Garcia-Garcia E, Lopez-Rios F, Lopez-Encuentra A, et al. (2007) Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas. Hum Pathol 38: 1351-1360.
23. Wilkerson MD, Yin X, Hoadley KA, Liu Y, Hayward MC, et al. (2010) Lung squamous cell carcinoma mRNA expression subtypes are reproducible, clinically important, and correspond to normal cell types. Clin Cancer Res 16: 4864-4875.
24. Wilkerson MD, Yin X, Walter V, Zhao N, Cabanski CR, et al. (2012) Differential pathogenesis of lung adenocarcinoma subtypes involving sequence mutations, copy number, chromosomal instability, and methylation. PLoS One 7: e36530.
25. Zhao N, Ang MK, Yin XY, Patel MR, Fritchie K, et al. (2012) Different cellular p16(INK4a) localisation may signal different survival outcomes in head and neck cancer. Br J Cancer 107: 482-490.
26. Hezel AF, Bardeesy N, (2008) LKB1; linking cell structure and tumor suppression. Oncogene 27: 6908-6919.
27. Fichorova RN, Rheinwald JG, Anderson DJ, (1997) Generation of papillomavirus-immortalized cell lines from normal human ectocervical, endocervical, and vaginal epithelium that maintain expression of tissue-specific differentiation proteins. Biol Reprod 57: 847-855.