Lack of metabolic activation and predominant formation of an excreted metabolite of nontoxic platynecine-type pyrrolizidine alkaloids

Chemical Research in Toxicology

Volumn 27, Issue 1, 2014, Pages 7-16

  Ruan, Jianqing ^a,b   Liao, Cangsong ^b,c   Ye, Yang ^b,c   Lin, Ge ^a,b  

^a Prince of Wales Hospital   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID; CYTOCHROME P450; CYTOCHROME P450 3A4; ESTER; PLATYPHYLLINE; PYRROLIZIDINE ALKALOID; FUSED HETEROCYCLIC RINGS; PLATYNECINE;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; DRUG EXCRETION; DRUG METABOLISM; GLUTATHIONE METABOLISM; HUMAN; HUMAN TISSUE; LIVER METABOLISM; LIVER MICROSOME; MACROMOLECULE; METABOLIC ACTIVATION; METABOLIC RATE; NONHUMAN; OXIDATIVE DEHYDROGENATION; RAT; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; TANDEM MASS SPECTROMETRY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; HETEROCYCLIC COMPOUNDS, 2-RING; HUMANS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PYRROLIZIDINE ALKALOIDS; RATS; TANDEM MASS SPECTROMETRY;

EID: 84892867576     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx4004159     Document Type: Article

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