Effect of structural modification on the gastrointestinal stability and hepatic metabolism of α-aminoxy peptides

Amino Acids

Volumn 43, Issue 5, 2012, Pages 2073-2085

  Ma, Bin ^a   Yin, Chun ^a   Yang, Dan ^b   Lin, Ge ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Aminoxy peptide; Cytochrome P450 enzyme; Gastrointestinal stability; Hepatic metabolism; Structural modification

Indexed keywords

ALPHA AMINOXY PEPTIDE 1; ALPHA AMINOXY PEPTIDE 2; ALPHA AMINOXY PEPTIDE 3; ALPHA AMINOXY PEPTIDE 4; ALPHA AMINOXY PEPTIDE 5; CHLORIDE CHANNEL; CYTOCHROME P450 3A4; DRUG METABOLITE; PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG OXIDATION; DRUG STABILITY; DRUG STRUCTURE; GASTROINTESTINAL STABILITY; GASTROINTESTINAL TRACT FUNCTION; IN VITRO STUDY; INTESTINE FLUID; LIVER METABOLISM; LIVER MICROSOME; LIVER PARENCHYMA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN MODIFICATION; RAT; SIMULATION; STOMACH JUICE;

ANIMALS; BIOMIMETIC MATERIALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; GASTRIC JUICE; GASTROINTESTINAL AGENTS; IONOPHORES; LIVER; MALE; MICROSOMES, LIVER; PEPTIDES; PROTEIN STABILITY; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 84868152929     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-012-1291-1     Document Type: Article

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