Leptin and leptin-related gene polymorphisms, obesity, and influenza A/H1N1 vaccine-induced immune responses in older individuals

Vaccine

Volumn 32, Issue 7, 2014, Pages 881-887

  Ovsyannikova, Inna G ^a   White, Sarah J ^a,b   Larrabee, Beth R ^a   Grill, Diane E ^a   Jacobson, Robert M ^a   Poland, Gregory A ^a  

^a MAYO CLINIC   (United States)

^b ARKANSAS TECH UNIVERSITY   (United States)

Author keywords

A H1N1 virus; Adipocyte; BMI; Immune response; Immunosenescence; Influenza vaccine; Leptin; Obese; SNPs

Indexed keywords

C REACTIVE PROTEIN; GRANZYME B; HEMAGGLUTINATION INHIBITING ANTIBODY; INFLUENZA VACCINE; LEPTIN; LEPTIN RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN TYROSINE PHOSPHATASE 1B; STAT3 PROTEIN; T LYMPHOCYTE RECEPTOR;

ADULT; AGED; ARTICLE; B LYMPHOCYTE; BODY MASS; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE CONTROL; GENETIC VARIABILITY; HETEROZYGOSITY; HUMAN; IMMUNE RESPONSE; INFLUENZA A (H1N1); MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OBESITY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

A/H1N1 VIRUS; ADIPOCYTE; BMI; IMMUNE RESPONSE; IMMUNOSENESCENCE; INFLUENZA VACCINE; LEPTIN; OBESE; SNPS;

ADAPTIVE IMMUNITY; AGED; ANTIBODIES, VIRAL; B-LYMPHOCYTES; BODY MASS INDEX; FEMALE; GRANZYMES; HEMAGGLUTINATION INHIBITION TESTS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA VACCINES; INFLUENZA, HUMAN; LEPTIN; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84892860782     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2013.12.009     Document Type: Article

References (52)

1. Prevention control of influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010. MMWR Recomm Rep 2010, 59(RR-8):1-62.
2. Nichol K.L., Nordin J.D., Nelson D.B., Mullooly J.P., Hak E. Effectiveness of influenza vaccine in the community-dwelling elderly. N Engl J Med 2007, 357(14):1373-1381.
3. Bader M.S. Immunization for the elderly. Am J Med Sci 2007, 334(6):481-486.
4. Bernstein E., Kaye D., Abrutyn E., Gross P., Dorfman M., Murasko D.M. Immune response to influenza vaccination in a large healthy elderly population. Vaccine 1999, 17:82-94.
5. Gardner E.M., Gonzalez E.W., Nogusa S., Murasko D.M. Age-related changes in the immune response to influenza vaccination in a racially diverse, healthy elderly population. Vaccine 2006, 24(10):1609-1614.
6. Allman D., Miller J.P. B cell development and receptor diversity during aging. Curr Opin Immunol 2005, 17(5):463-467.
7. Katz J.M., Plowden J., Renshaw-Hoelscher M., Lu X., Tumpey T.M., Sambhara S. Immunity to influenza: the challenges of protecting an aging population. Immunol Res 2004, 29(1-3):113-124.
8. Franceschi C., Bonafe M., Valensin S., Olivieri F., De Luca M., Ottaviani E., et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000, 908:244-254.
9. Ongradi J., Kovesdi V. Factors that may impact on immunosenescence: an appraisal. Immun Ageing 2010, 7:7.
10. Martin-Romero C., Santos-Alvarez J., Goberna R., Sanchez-Margalet V. Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol 2000, 199(1):15-24.
11. Sanchez-Margalet V., Martin-Romero C., Santos-Alvarez J., Goberna R., Najib S., Gonzalez-Yanes C. Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action. Clin Exp Immunol 2003, 133(1):11-19.
12. Santos-Alvarez J., Goberna R., Sanchez-Margalet V. Human leptin stimulates proliferation and activation of human circulating monocytes. Cell Immunol 1999, 194(1):6-11.
13. Papathanassoglou E., El-Haschimi K., Li X.C., Matarese G., Strom T., Mantzoros C. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J Immunol 2006, 176(12):7745-7752.
14. Sanchez-Margalet V., Martin-Romero C. Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway. Cell Immunol 2001, 211(1):30-36.
15. Fernandez-Riejos P., Najib S., Santos-Alvarez J., Martin-Romero C., Perez-Perez A., Gonzalez-Yanes C., et al. Role of leptin in the activation of immune cells. Mediat Inflamm 2010, 2010:568343.
16. Gabriely I., Ma X.H., Yang X.M., Rossetti L., Barzilai N. Leptin resistance during aging is independent of fat mass. Diabetes 2002, 51(4):1016-1021.
17. Sheridan P.A., Paich H.A., Handy J., Karlsson E.A., Hudgens M.G., Sammon A.B., et al. Obesity is associated with impaired immune response to influenza vaccination in humans. Int J Obesity 2012, 36(August (8)):1072-1077.
18. Louie J.K., Acosta M., Samuel M.C., Schechter R., Vugia D.J., Harriman K., et al. A novel risk factor for a novel virus: obesity and 2009 pandemic influenza A (H1N1). Clin Infect Dis 2011, 52(3):301-312.
19. Morgan O.W., Bramley A., Fowlkes A., Freedman D.S., Taylor T.H., Gargiullo P., et al. Morbid obesity as a risk factor for hospitalization and death due to 2009 pandemic influenza A(H1N1) disease. PLoS ONE 2010, 5(3):e9694.
20. Karlsson E.A., Sheridan P.A., Beck M.A. Diet-induced obesity impairs the T cell memory response to influenza virus infection. J Immunol 2010, 184(6):3127-3133.
21. Kim Y.H., Kim J.K., Kim D.J., Nam J.H., Shim S.M., Choi Y.K., et al. Diet-induced obesity dramatically reduces the efficacy of a 2009 pandemic H1N1 vaccine in a mouse model. J Infect Dis 2012, 205(January (2)):244-251.
22. Prevention and control of influenza with vaccines: interim recommendations of the Advisory Committee on Immunization Practices (ACIP), 2013. MMWR Morbid Mortal Wkly Rep 2013, 62(May (18)):356.
23. Yang L., Chan K.P., Lee R.S., Chan W.M., Lai H.K., Thach T.Q., et al. Obesity and influenza associated mortality: evidence from an elderly cohort in Hong Kong. Prev Med 2013, 56(February (2)):118-123.
24. Kim C.O., Nam C.M., Lee D.C., Chang J., Lee J.W. Is abdominal obesity associated with the 2009 influenza A (H1N1) pandemic in Korean school-aged childrenα. Influenza Other Respir Viruses 2012, 6(September (5)):313-317.
25. Azziz-Baumgartner E., Cabrera A.M., Chang L., Calli R., Kusznierz G., Baez C., et al. Mortality, severe acute respiratory infection, and influenza-like illness associated with influenza A(H1N1)pdm09 in Argentina, 2009. PLOS ONE 2012, 7(10):e47540.
26. Targonski P.V., Jacobson R.M., Poland G.A. Immunosenescence: role and measurement in influenza vaccine response among the elderly. Vaccine 2007, 25(16):3066-3069.
27. Lambert N.D., Ovsyannikova I.G., Pankratz V.S., Jacobson R.M., Poland G.A. Understanding the immune response to seasonal influenza vaccination in older adults: a systems biology approach. Expert Rev Vaccines 2012, 11(8):985-994.
28. Salk H.M., Haralambieva I.H., Ovsyannikova I.G., Goergen K.M., Poland G.A. Granzyme B ELISPOT assay to measure influenza-specific cellular immunity. J Immunol Methods 2013, 398-399:44-50.
29. World Health Organisation WHO Global Influenza Surveillance Network: Manual for the Laboratory Diagnosis and Virological Surveillance of Influenza 2011.
30. Rizza S.R., Tangalos E.G., McClees M.D., Strausbauch M.A., Targonski P.V., McKean D.J., et al. Nelfinavir monotherapy increases naive T-cell numbers in HIV-negative healthy young adults. Front Biosci 2008, 13:1605-1609.
31. Ovsyannikova I.G., Dhiman N., Haralambieva I.H., Vierkant R.A., O'Byrne M.M., Jacobson R.M., et al. Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes. Hum Genet 2010, 127:207-221.
32. Talbot H.K., Coleman L.A., Crimin K., Zhu Y., Rock M.T., Meece J., et al. Association between obesity and vulnerability and serologic response to influenza vaccination in older adults. Vaccine 2012, 30(June (26)):3937-3943.
33. Weber D.J., Rutala W.A., Samsa G.P., Santimaw J.E., Lemon S.M. Obesity as a predictor of poor antibody response to hepatitis B plasma vaccine. JAMA 1985, 254:3187-3189.
34. Eliakim A., Schwindt C., Zaldivar F., Casali P., Cooper D.M. Reduced tetanus antibody titers in overweight children. Autoimmunity 2006, 39(2):137-141.
35. Scarpace P.J., Zhang Y. Leptin resistance: a prediposing factor for diet-induced obesity. Am J Physiol Regul Integr Comp Physiol 2009, 296(3):R493-R500.
36. Zhang Y., Scarpace P.J. The role of leptin in leptin resistance and obesity. Physiol Behav 2006, 88(3):249-256.
37. Smith A.G., Sheridan P.A., Tseng R.J., Sheridan J.F., Beck M.A. Selective impairment in dendritic cell function and altered antigen-specific CD8+T-cell responses in diet-induced obese mice infected with influenza virus. Immunology 2009, 126(2):268-279.
38. Lonnqvist F., Nordfors L., Jansson M., Thorne A., Schalling M., Arner P. Leptin secretion from adipose tissue in women. Relationship to plasma levels and gene expression. J Clin Invest 1997, 99(May (10)):2398-2404.
39. Lam Q.L., Wang S., Ko O.K., Kincade P.W., Lu L. Leptin signaling maintains B-cell homeostasis via induction of Bcl-2 and Cyclin D1. Proc Nat Acad Sci U S A 2010, 107(August (31)):13812-13817.
40. Yager E.J., Ahmed M., Lanzer K., Randall T.D., Woodland D.L., Blackman M.A. Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J Exp Med 2008, 205(3):711-723.
41. Chen J., Li J., Lim F.C., Wu Q., Douek D.C., Scott D.K., et al. Maintenance of naive CD8T cells in nonagenarians by leptin, IGFBP3 and T3. Mech Ageing Dev 2010, 131(January (1)):29-37.
42. Poland G.A., Ovsyannikova I.G., Jacobson R.M. Immunogenetics of seasonal influenza vaccine response. Vaccine 2008, 26S:D35-D40.
43. Matarese G., Moschos S., Mantzoros C.S. Leptin in immunology. J Immunol 2005, 174(March (6)):3137-3142.
44. Sharma N.K., Langberg K.A., Mondal A.K., Das S.K. Phospholipid biosynthesis genes and susceptibility to obesity: analysis of expression and polymorphisms. PLOS ONE 2013, 8(5):e65303.
45. Magliano D.C., Bargut T.C., de Carvalho S.N., Aguila M.B., Mandarim-de-Lacerda C.A., Souza-Mello V. Peroxisome proliferator-activated receptors-alpha and gamma are targets to treat offspring from maternal diet-induced obesity in mice. PLOS ONE 2013, 8(5):e64258.
46. Huang J.T., Welch J.S., Ricote M., Binder C.J., Willson T.M., Kelly C., et al. Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase. Nature 1999, 400(July (6742)):378-382.
47. Kochanek K.D., Kirmeyer S.E., Martin J.A., Strobino D.M., Guyer B. Annual summary of vital statistics: 2009. Pediatrics 2012, 129:338-348.
48. Wauman J., Tavernier J. Leptin receptor signaling: pathways to leptin resistance. Front Biosci 2011, 16:2771-2793.
49. Meshkani R., Taghikhani M., Al-Kateb H., Larijani B., Khatami S., Sidiropoulos G.K., et al. Polymorphisms within the protein tyrosine phosphatase 1B (PTPN1) gene promoter: functional characterization and association with type 2 diabetes and related metabolic traits. Clin Chem 2007, 53(September (9)):1585-1592.
50. Gallicchio L., Chang H.H., Christo D.K., Thuita L., Huang H.Y., Strickland P., et al. Single nucleotide polymorphisms in obesity-related genes and all-cause and cause-specific mortality: a prospective cohort study. BMC Med Genet 2009, 10:103.
51. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996, 334(5):292-295.
52. Maffei M., Halaas J., Ravussin E., Pratley R.E., Lee G.H., Zhang Y., et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995, 1(November (11)):1155-1161.