Design, synthesis and ex-vivo release studies of colon-specific polyphosphazene-anticancer drug conjugates

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 3, 2014, Pages 1104-1114

  Sharma, Rajiv ^a,b   Rawal, Ravindra K ^a,c   Malhotra, Manav ^a   Sharma, A K ^d   Bhardwaj, T R ^a  

^a ISF College of Pharmacy   (India)

^b UTTARAKHAND TECHNICAL UNIVERSITY   (India)

^c UNIVERSITY OF GEORGIA   (United States)

^d Asmara College of Health Sciences   (Eritrea)

Author keywords

Azoreductase; Colon specific; Gemcitabine; Methotrexate; Polyphosphazene

Indexed keywords

ANTINEOPLASTIC AGENT; BALSALAZIDE; BUTANOL; IPSALAZINE; MESALAZINE; METHOTREXATE; OLSALAZINE; POLYMER; POLYPHOSPHAZENE; POLYPHOSPHAZENE ANTICANCER DRUG CONJUGATE; POLYPHOSPHAZENE GEMCITABINE CONJUGATE; POLYPHOSPHAZENE METHOTREXATE CONJUGATE; SALAZOSULFAPYRIDINE; UNCLASSIFIED DRUG;

ACIDITY; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CECUM; COLON; COLORECTAL CANCER; CONTROLLED STUDY; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG FORMULATION; DRUG RELEASE; DRUG SPECIFICITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; EX VIVO STUDY; HUMAN; HUMAN CELL; NONHUMAN; RAT;

RATTUS;

AZOREDUCTASE; COLON-SPECIFIC; GEMCITABINE; METHOTREXATE; POLYPHOSPHAZENE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; COLON; COLORECTAL NEOPLASMS; DEOXYCYTIDINE; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG DESIGN; HT29 CELLS; HUMANS; METHOTREXATE; ORGANOPHOSPHORUS COMPOUNDS; POLYMERS; RATS;

EID: 84892812241     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.12.037     Document Type: Article

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