Injectable poly(organophosphazene)-camptothecin conjugate hydrogels: Synthesis, characterization, and antitumor activities

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 81, Issue 3, 2012, Pages 582-590

  Cho, Jung Kyo ^a,b   Chun, Changju ^d   Kuh, Hyo Jeong ^c   Song, Soo Chang ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c The Catholic University of Korea   (South Korea)

^d Chonnam National University   (South Korea)

Author keywords

Antitumor activity; Poly(organophosphazene); Polymer drug conjugate; Stability of camptothecin; Thermosensitive hydrogel

Indexed keywords

CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; CARBOXYLIC ACID; GLYCINE DERIVATIVE; POLY(ORGANOPHOSPHAZENE) CAMPTOTHECIN CONJUGATE; POLYMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DEGRADATION; DRUG EFFICACY; DRUG FORMULATION; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; FEMALE; HEAT SENSITIVITY; HUMAN; HUMAN CELL; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; INJECTION; MOUSE; NONHUMAN; PHASE TRANSITION; PHYSICAL CHEMISTRY; ROOM TEMPERATURE; SUSTAINED DRUG RELEASE; TUMOR XENOGRAFT; VISCOSITY;

ANIMALS; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CELL LINE, TUMOR; COLONIC NEOPLASMS; DRUG STABILITY; DRUG STORAGE; FEMALE; GLYCINE; HUMANS; HYDROGELS; INJECTIONS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASMS; ORGANOPHOSPHORUS COMPOUNDS; PHASE TRANSITION; POLYMERS; TEMPERATURE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84863774652     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2012.04.008     Document Type: Article

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