Design, synthesis and ex vivo evaluation of colon-specific azo based prodrugs of anticancer agents

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 19, 2013, Pages 5332-5338

  Sharma, Rajiv ^a,b   Rawal, Ravindra K ^a,c   Gaba, Tripti ^a   Singla, Nishu ^a   Malhotra, Manav ^a   Matharoo, Sahil ^a   Bhardwaj, T R ^a  

^a ISF COLLEGE OF PHARMACY   (India)

^b UTTARAKHAND TECHNICAL UNIVERSITY   (India)

^c UNIVERSITY OF GEORGIA   (United States)

Author keywords

Azoreductase; Colon specific; Gemcitabine; Methotrexate; Oxaliplatin; Prodrug

Indexed keywords

AZO REDUCTASE; GEMCITABINE; METHOTREXATE; OXALIPLATIN; PRODRUG;

ARTICLE; COLON; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; EX VIVO STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; RAT;

CITRUS MACROPHYLLA; RATTUS;

AZOREDUCTASE; COLON-SPECIFIC; GEMCITABINE; METHOTREXATE; OXALIPLATIN; PRODRUG;

ANIMALS; ANTINEOPLASTIC AGENTS; AZO COMPOUNDS; CELL LINE, TUMOR; COLON; COLONIC NEOPLASMS; DRUG DESIGN; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; FECES; HUMANS; INHIBITORY CONCENTRATION 50; MESALAMINE; PRODRUGS; RATS;

EID: 84883489176     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.07.059     Document Type: Article

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