Metronidazole prodrugs: Synthesis, physicochemical properties, stability, and ex vivo release studies

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4142-4150

  Mura, Carla ^a   Valenti, Donatella ^a   Floris, Costantino ^a   Sanna, Roberta ^a   De Luca, Maria Antonietta ^a   Fadda, Anna Maria ^a   Loy, Giuseppe ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Chitosan; Colon specific delivery; Enzymatic hydrolysis; Metronidazole; Prodrug

Indexed keywords

CHITOSAN; GLUCOSAMINE; GLUTARIC ACID; METRONIDAZOLE; PRODRUG; SUCCINIC ACID;

ACIDITY; ALKALINITY; ANIMAL EXPERIMENT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; COLON FLORA; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG STABILITY; DRUG SYNTHESIS; EX VIVO STUDY; HYDROLYSIS; INFRARED SPECTROSCOPY; MALE; NONHUMAN; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SOLID STATE; STOMACH CONTENT;

ANIMALS; ANTI-INFECTIVE AGENTS; COLON; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METRONIDAZOLE; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 80052946259     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.06.016     Document Type: Article

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