Poly[di(carboxylatophenoxy)phosphazene] (PCPP) is a potent immunoadjuvant for an influenza vaccine

Vaccine

Volumn 16, Issue 1, 1998, Pages 92-98

  Payne, Lendon G ^a   Jenkins, Sharon A ^a   Woods, Angela L ^a   Grund, Eric M ^a   Geribo, Walter E ^a   Loebelenz, Jean R ^a   Andrianov, Alexander K ^a   Roberts, Bryan E ^a  

^a Virus Research Institute Inc Cambridge   (United States)

Author keywords

Adjuvant; Influenza; Polyphosphazene

Indexed keywords

IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOLOGICAL ADJUVANT; INFLUENZA VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNIZATION; IMMUNOGENICITY; INFLUENZA; NONHUMAN; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, VIRAL; FEMALE; INFLUENZA VACCINES; MICE; MICE, INBRED BALB C; MOLECULAR WEIGHT; ORGANOPHOSPHORUS COMPOUNDS; ORTHOMYXOVIRIDAE; POLYMERS; VIRION;

EID: 0031986533     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(97)00149-7     Document Type: Article

References (16)

1. Centers for isease Control and Prevention. Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP). Issue number 5 Morbidity and Mortality Weekly. 45(5):1996;1-19.
2. Barker W.H., Mullooly J.D. Influenza vaccination of elderly persons; reduction in pneumonia and influenza hospitalization and deaths. J. Am. Med. Assoc. 244:1980;2547-2549.
3. Brandriss M.W., Betts R.F., Mathur U., Douglas R.G. Response of elderly subjects to monovalent A/USSR/77 (H1N1) and trivalent A/USSR/77 (H1N1)-A/Texas/77 (H3N2)-B/Hong Kong/72 vaccines. Am. Rev. Resp. Dis. 124:1981;681-684.
4. Petrov R., Mustafaev M., Norimov A. Physico-chemical criteria for the construction of artificial immunomodulators and immunogens on the basis of polyelectrolyte complexes. Sov. Med. Rev., Sect. D Immunol. 4:1992;1-113.
5. Allcock H.R., Kwon S. An ionically cross-linkable polyphosphazene: Poly[bis(carboxylatophenoxy)phosphazene] and its hydrogels and membranes. Macromolecules. 22:1989;75-79.
6. Payne, L.G., Jenkins, S.A., Andrianov, A.K. and Roberts, B.E. Water-soluble phosphazene polymers for parenteral and mucosal vaccine delivery. In Vaccine Design, ed. M.F. Powell and M.J. Neuman, Plenum Press, New York, 1995, pp. 473-493.
7. Andrianov A.K., LeGolvan M.P. Characterization of poly[di(carboxylatophenoxy)-phosphazene] by an aqueous gel permeation chromatography. J. Appl. Polymer Sci. 60:1996;2289-2295.
8. Freund J. The effect of paraffin oil and mycobacteria on antibody formation and sensitization. Am. J. Clin. Pathol. 21:1951;645-656.
9. Holt L.B. Quantitative studies in diphtheria prophylaxis: the primary response. Brit. J. Exp. Pathol. 30:1949;289-297.
10. Feery B.J., Evered M.G., Morrison E.I. Different protection rates in various groups of volunteers given subunit influenza virus vaccine in 1976. J. Infect. Dis. 139:1979;237-241.
11. Lu Y., Salvato M., Pauza D., Li J., Sodroski J., Manson K., Wyand M., Letvin N., Vogel F., Schultz A., Jenkins S., Touzjian N., Chutkowski C., Kushner N., LeFaile M., Payne L.G., Roberts B. Utility of SHIV for testing HIV1 vaccine candidates in macaques. J. AIDS Human Retrovirol. 12:1996;99-106.
12. Payne, L.G., Van Nest, G., Barchfeld, G.L., Siber, G.R., Gupta, R.K. and Jenkins, S.A. The utility of PCPP as a parenteral adjuvant for diverse antigens. In Modulation of the immune response to vaccine antigens, ed. L. Haaheim, International Association of Biological Standardization, 1997.
13. Burton, G.F., Kapasi, Z.F., Szakal, A.K. and Tew, J.G. The generation and maintenance of antibody and B cell memory: The role of retained antigen and follicular dendritic cells. In Strategies in Vaccine Design, ed. G.L. Ada, R.G. Landis Co., Austin, Texas, 1994, pp. 35-49.
14. Setia U., Serventi I., Lorenz P. Factors affecting the use of influenza vaccine in institutionalized elderly. J. Am. Geriat. Soc. 33:1985;856-858.
15. Ben-Yehuda A., Ehlieter D., Hu A.R., Wexler M.E. Recombinant vaccinia virus expressing PR/8 influenza hemagglutinin gene overcomes the impaired immune response and increased susceptibility of old mice to influenza infection. J. Infect. Dis. 168:1993;52-57.
16. Danenberg H.D., Ben-Yehuda A., Zakay-Rones Z., Friedman G. Dehydroepiandrosterone (DHEA) treatment reverses the impaired immune response of old mice to influenza vaccination and protects from influenza infection. Vaccine. 13:1995;1445-1448.