Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome

DNA Repair

Volumn 14, Issue 1, 2014, Pages 27-38

  Quinet, Annabel ^a,b   Vessoni, Alexandre T ^a   Rocha, Clarissa R R ^a   Gottifredi, Vanesa ^c   Biard, Denis ^d   Sarasin, Alain ^b   Menck, Carlos F M ^a   Stary, Anne ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Gustave Roussy Comprehensive Cancer Institute   (France)

^c FUNDACIÓN INSTITUTO LELOIR   (Argentina)

^d INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

Author keywords

H2AX; Cell cycle progression; DNA strand breaks; NER; Replication fork; TLS DNA polymerase ; UV damage bypass

Indexed keywords

ATR PROTEIN; CAFFEINE; CHECKPOINT KINASE 1; DNA DIRECTED DNA POLYMERASE ETA; HISTONE H2AX; SINGLE STRANDED DNA; SMALL INTERFERING RNA;

ARTICLE; CELL CYCLE S PHASE; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; DNA SYNTHESIS; DOUBLE STRANDED DNA BREAK; EXCISION REPAIR; G2 PHASE CELL CYCLE CHECKPOINT; GENE SILENCING; GENOTYPE; HISTONE PHOSPHORYLATION; HUMAN; HUMAN CELL; HUMAN GENOME; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; SIGNAL TRANSDUCTION; SINGLE STRANDED DNA BREAK; ULTRAVIOLET C RADIATION;

CELL CYCLE PROGRESSION; DNA STRAND BREAKS; NER; REPLICATION FORK; TLS DNA POLYMERASE Η; UV DAMAGE BYPASS; ΓH2AX;

CAFFEINE; CELL CYCLE CHECKPOINTS; CELL LINE; DNA BREAKS, DOUBLE-STRANDED; DNA BREAKS, SINGLE-STRANDED; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA, SINGLE-STRANDED; DNA-BINDING PROTEINS; DNA-DIRECTED DNA POLYMERASE; DOSE-RESPONSE RELATIONSHIP, RADIATION; G2 PHASE; GENOME, HUMAN; HISTONES; HUMANS; PHOSPHORYLATION; S PHASE; ULTRAVIOLET RAYS;

EID: 84892808982     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2013.12.005     Document Type: Article

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