-
1
-
-
67650289584
-
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
-
S.J. Scales, F.J. de Sauvage, Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol. Sci. 30, 303-312 (2009)
-
(2009)
Trends Pharmacol. Sci.
, vol.30
, pp. 303-312
-
-
Scales, S.J.1
De Sauvage, F.J.2
-
2
-
-
80052869447
-
Hedgehog signaling: Networking to nurture a promalignant tumor microenvironment
-
L.G. Harris, R.S. Samant, L.A. Shevde, Hedgehog signaling: Networking to nurture a promalignant tumor microenvironment. Mol. Cancer Res. 9, 1165-1174 (2011)
-
(2011)
Mol. Cancer Res.
, vol.9
, pp. 1165-1174
-
-
Harris, L.G.1
Samant, R.S.2
Shevde, L.A.3
-
3
-
-
84861536500
-
Hedgehog secretion and signal transduction in vertebrates
-
K.E. Ryan, C. Chiang, Hedgehog secretion and signal transduction in vertebrates. J. Biol. Chem. 287, 17905-17913 (2012)
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 17905-17913
-
-
Ryan, K.E.1
Chiang, C.2
-
4
-
-
57049089995
-
Hedgehog signaling in development and cancer
-
J. Jiang, C.C. Hui, Hedgehog signaling in development and cancer. Dev. Cell 15, 801-812 (2008)
-
(2008)
Dev. Cell
, vol.15
, pp. 801-812
-
-
Jiang, J.1
Hui, C.C.2
-
5
-
-
84856314865
-
Hedgehog signalling in gut development, physiology and cancer
-
J.L. Merchant, Hedgehog signalling in gut development, physiology and cancer. J. Physiol. 590, 421-432 (2012)
-
(2012)
J. Physiol.
, vol.590
, pp. 421-432
-
-
Merchant, J.L.1
-
6
-
-
0034461606
-
Sonic hedgehog promotes G (1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors
-
A.M. Kenney, D.H. Rowitch, Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors. Mol. Cell. Biol. 20, 9055-9067 (2000)
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 9055-9067
-
-
Kenney, A.M.1
Rowitch, D.H.2
-
7
-
-
33751337806
-
Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: It's inhibition leads to growth suppression and apoptosis
-
X. Chen,A.Horiuchi, N. Kikuchi, R. Osada, J.Yoshida, T. Shiozawa, I. Konishi, Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: It's inhibition leads to growth suppression and apoptosis. Cancer Sci. 98, 68-76 (2007)
-
(2007)
Cancer Sci.
, vol.98
, pp. 68-76
-
-
Chen, X.1
Horiuchi, A.2
Kikuchi, N.3
Osada, R.4
Yoshida, J.5
Shiozawa, T.6
Konishi, I.7
-
8
-
-
0030955557
-
Basal cell carcinomas in mice overexpressing sonic hedgehog
-
A.E. Oro, K.M. Higgins, Z. Hu, J.M. Bonifas, E.H. Epstein Jr., M.P. Scott, Basal cell carcinomas in mice overexpressing sonic hedgehog. Science 276, 817-821 (1997)
-
(1997)
Science
, vol.276
, pp. 817-821
-
-
Oro, A.E.1
Higgins, K.M.2
Hu, Z.3
Bonifas, J.M.4
Epstein Jr., E.H.5
Scott, M.P.6
-
9
-
-
14044266303
-
Hedgehog signaling and congenital malformations
-
E. Nieuwenhuis, C.C. Hui, Hedgehog signaling and congenital malformations. Clin. Genet. 67, 193-208 (2005)
-
(2005)
Clin. Genet.
, vol.67
, pp. 193-208
-
-
Nieuwenhuis, E.1
Hui, C.C.2
-
10
-
-
6044243650
-
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
-
S.S. Karhadkar, G.S. Bova, N. Abdallah, S. Dhara, D. Gardner, A. Maitra, J.T. Isaacs, D.M. Berman, P.A. Beachy, Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 431, 707- 712 (2004)
-
(2004)
Nature
, vol.431
, pp. 707-712
-
-
Karhadkar, S.S.1
Bova, G.S.2
Abdallah, N.3
Dhara, S.4
Gardner, D.5
Maitra, A.6
Isaacs, J.T.7
Berman, D.M.8
Beachy, P.A.9
-
11
-
-
58949100355
-
Aberrant activation of hedgehog signaling pathway in ovarian cancers: Effect on prognosis, cell invasion and differentiation
-
X. Liao, M.K. Siu, C.W. Au, E.S. Wong, H.Y. Chan, P.P. Ip, H.Y. Ngan, A.N. Cheung, Aberrant activation of hedgehog signaling pathway in ovarian cancers: Effect on prognosis, cell invasion and differentiation. Carcinogenesis 30, 131-140 (2009)
-
(2009)
Carcinogenesis
, vol.30
, pp. 131-140
-
-
Liao, X.1
Siu, M.K.2
Au, C.W.3
Wong, E.S.4
Chan, H.Y.5
Ip, P.P.6
Ngan, H.Y.7
Cheung, A.N.8
-
12
-
-
68149124175
-
Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer
-
F.G. Xu, Q.Y. Ma, Z. Wang, Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer. Cancer Lett. 283, 119-124 (2009)
-
(2009)
Cancer Lett.
, vol.283
, pp. 119-124
-
-
Xu, F.G.1
Ma, Q.Y.2
Wang, Z.3
-
13
-
-
33745745896
-
Hedgehog signal activation in gastric pit cell and in diffuse-type gastric cancer
-
M. Fukaya, N. Isohata, H. Ohta, K. Aoyagi, T. Ochiya, N. Saeki, K. Yanagihara, Y. Nakanishi, H. Taniguchi, H. Sakamoto, T. Shimoda, Y. Nimura, T. Yoshida, H. Sasaki, Hedgehog signal activation in gastric pit cell and in diffuse-type gastric cancer. Gastroenterology 131, 14-29 (2006)
-
(2006)
Gastroenterology
, vol.131
, pp. 14-29
-
-
Fukaya, M.1
Isohata, N.2
Ohta, H.3
Aoyagi, K.4
Ochiya, T.5
Saeki, N.6
Yanagihara, K.7
Nakanishi, Y.8
Taniguchi, H.9
Sakamoto, H.10
Shimoda, T.11
Nimura, Y.12
Yoshida, T.13
Sasaki, H.14
-
14
-
-
75149149098
-
Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells
-
C. Xiao, S.A. Ogle, M.A. Schumacher, M.A. Orr-Asman, M.L. Miller, N. Lertkowit, A. Varro, F. Hollande, Y. Zavros, Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells. Gastroenterology 138(550-561), e551-e558 (2010)
-
(2010)
Gastroenterology
, vol.138
, Issue.550-561
-
-
Xiao, C.1
Ogle, S.A.2
Schumacher, M.A.3
Orr-Asman, M.A.4
Miller, M.L.5
Lertkowit, N.6
Varro, A.7
Hollande, F.8
Zavros, Y.9
-
15
-
-
81155126047
-
Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt,EMT, andMMP-9 pathway in gastric cancer
-
Y.A. Yoo,M.H. Kang, H.J. Lee, B.H. Kim, J.K. Park, H.K. Kim, J.S. Kim, S.C. Oh, Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt,EMT, andMMP-9 pathway in gastric cancer. Cancer Res. 71, 7061-7070 (2011)
-
(2011)
Cancer Res.
, vol.71
, pp. 7061-7070
-
-
YooM.H. Kang, Y.A.1
Lee, H.J.2
Kim, B.H.3
Park, J.K.4
Kim, H.K.5
Kim, J.S.6
Oh, S.C.7
-
16
-
-
75149191890
-
Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog
-
M. Waghray, Y. Zavros, M. Saqui-Salces, M. El-Zaatari, C.B. Alamelumangapuram, A. Todisco, K.A. Eaton, J.L. Merchant, Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog. Gastroenterology 138(562-572), e561-e562 (2010)
-
(2010)
Gastroenterology
, vol.138
, Issue.562-572
-
-
Waghray, M.1
Zavros, Y.2
Saqui-Salces, M.3
El-Zaatari, M.4
Alamelumangapuram, C.B.5
Todisco, A.6
Eaton, K.A.7
Merchant, J.L.8
-
17
-
-
16844362860
-
Evidence that loss of sonic hedgehog is an indicator of Helicobater pylori-induced atrophic gastritis progressing to gastric cancer
-
A. Shiotani, H. Iishi, N. Uedo, S. Ishiguro, M. Tatsuta, Y. Nakae, M. Kumamoto, J.L. Merchant, Evidence that loss of sonic hedgehog is an indicator of Helicobater pylori-induced atrophic gastritis progressing to gastric cancer. Am. J. Gastroenterol. 100, 581-587 (2005)
-
(2005)
Am. J. Gastroenterol.
, vol.100
, pp. 581-587
-
-
Shiotani, A.1
Iishi, H.2
Uedo, N.3
Ishiguro, S.4
Tatsuta, M.5
Nakae, Y.6
Kumamoto, M.7
Merchant, J.L.8
-
18
-
-
0028841677
-
A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog
-
T.M. Hall, J.A. Porter, P.A. Beachy, D.J. Leahy, A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog. Nature 378, 212-216 (1995)
-
(1995)
Nature
, vol.378
, pp. 212-216
-
-
Hall, T.M.1
Porter, J.A.2
Beachy, P.A.3
Leahy, D.J.4
-
19
-
-
0030029527
-
Vectors for expression and secretion of FLAG epitope-tagged proteins in mammalian cells
-
R.G. Chubet, B.L. Brizzard, Vectors for expression and secretion of FLAG epitope-tagged proteins in mammalian cells. Biotechniques 20, 136-141 (1996)
-
(1996)
Biotechniques
, vol.20
, pp. 136-141
-
-
Chubet, R.G.1
Brizzard, B.L.2
-
20
-
-
58149236657
-
Cytotoxicity and antibacterial activity of Lindera strychnifolia essential oils and extracts
-
R. Yan, Y. Yang, Y. Zeng, G. Zou, Cytotoxicity and antibacterial activity of Lindera strychnifolia essential oils and extracts. J. Ethnopharmacol. 121, 451-455 (2009)
-
(2009)
J. Ethnopharmacol.
, vol.121
, pp. 451-455
-
-
Yan, R.1
Yang, Y.2
Zeng, Y.3
Zou, G.4
-
21
-
-
34347218991
-
In vitro scratch assay: A convenient and inexpensive method for analysis of cell migration in vitro
-
C.C. Liang, A.Y. Park, J.L. Guan, In vitro scratch assay: A convenient and inexpensive method for analysis of cell migration in vitro. Nat. Protoc. 2, 329-333 (2007)
-
(2007)
Nat. Protoc.
, vol.2
, pp. 329-333
-
-
Liang, C.C.1
Park, A.Y.2
Guan, J.L.3
-
22
-
-
20744453511
-
Cdc42 and Ras cooperate to mediate cellular transformation by intersectin-L
-
J.B. Wang, W.J. Wu, R.A. Cerione, Cdc42 and Ras cooperate to mediate cellular transformation by intersectin-L. J. Biol. Chem. 280, 22883-22891 (2005)
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 22883-22891
-
-
Wang, J.B.1
Wu, W.J.2
Cerione, R.A.3
-
23
-
-
84865151166
-
Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: Role of stem cell factor/c-kit pathway
-
H. Elmasri, E. Ghelfi, C.W. Yu, S. Traphagen,M. Cernadas, H. Cao, G.P. Shi, J. Plutzky, M. Sahin, G. Hotamisligil, S. Cataltepe, Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: Role of stem cell factor/c-kit pathway. Angiogenesis 15, 457-468 (2012)
-
(2012)
Angiogenesis
, vol.15
, pp. 457-468
-
-
Elmasri, H.1
Ghelfi, E.2
Yu, C.W.3
Traphagen, S.4
Cernadas, M.5
Cao, H.6
Shi, G.P.7
Plutzky, J.8
Sahin, M.9
Hotamisligil, G.10
Cataltepe, S.11
-
24
-
-
54249119561
-
JNK signaling in apoptosis
-
D.N. Dhanasekaran, E.P. Reddy, JNK signaling in apoptosis. Oncogene 27, 6245-6251 (2008)
-
(2008)
Oncogene
, vol.27
, pp. 6245-6251
-
-
Dhanasekaran, D.N.1
Reddy, E.P.2
-
25
-
-
33745807565
-
Gadd45a and Gadd45b protect hematopoietic cells from UV-induced apoptosis via distinct signaling pathways, including p38 activation and JNK inhibition
-
M. Gupta, S.K. Gupta, B. Hoffman, D.A. Liebermann, Gadd45a and Gadd45b protect hematopoietic cells from UV-induced apoptosis via distinct signaling pathways, including p38 activation and JNK inhibition. J. Biol. Chem. 281, 17552-17558 (2006)
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 17552-17558
-
-
Gupta, M.1
Gupta, S.K.2
Hoffman, B.3
Liebermann, D.A.4
-
26
-
-
33845693412
-
Diverse physiological functions for dual-specificity MAP kinase phosphatases
-
R.J. Dickinson, S.M. Keyse, Diverse physiological functions for dual-specificity MAP kinase phosphatases. J. Cell Sci. 119, 4607- 4615 (2006)
-
(2006)
J. Cell Sci.
, vol.119
, pp. 4607-4615
-
-
Dickinson, R.J.1
Keyse, S.M.2
-
27
-
-
21444439970
-
Phosphorylation of c-Fos by members of the p38MAPK family. Role in the AP-1 response to UV light
-
T. Tanos, M.J. Marinissen, F.C. Leskow, D. Hochbaum, H. Martinetto, J.S. Gutkind, O.A. Coso, Phosphorylation of c-Fos by members of the p38MAPK family. Role in the AP-1 response to UV light. J. Biol. Chem. 280, 18842-18852 (2005)
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 18842-18852
-
-
Tanos, T.1
Marinissen, M.J.2
Leskow, F.C.3
Hochbaum, D.4
Martinetto, H.5
Gutkind, J.S.6
Coso, O.A.7
-
28
-
-
0027065034
-
Human gastric carcinogenesis: A multistep and multifactorial process-first
-
American Cancer Society Award Lecture on Cancer Epidemiology and Prevention
-
P. Correa, Human gastric carcinogenesis: A multistep and multifactorial process-First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res. 52, 6735-6740 (1992)
-
(1992)
Cancer Res.
, vol.52
, pp. 6735-6740
-
-
Correa, P.1
-
29
-
-
33646137574
-
Increased expression of sonic hedgehog and altered methylation of its promoter region in gastric cancer and its related lesions
-
L.H. Wang, Y.L. Choi, X.Y. Hua, Y.K. Shin, Y.J. Song, S.J. Youn, H.Y. Yun, S.M. Park, W.J. Kim, H.J. Kim, J.S. Choi, S.H. Kim, Increased expression of sonic hedgehog and altered methylation of its promoter region in gastric cancer and its related lesions. Mod. Pathol. 19, 675-683 (2006)
-
(2006)
Mod. Pathol.
, vol.19
, pp. 675-683
-
-
Wang, L.H.1
Choi, Y.L.2
Hua, X.Y.3
Shin, Y.K.4
Song, Y.J.5
Youn, S.J.6
Yun, H.Y.7
Park, S.M.8
Kim, W.J.9
Kim, H.J.10
Choi, J.S.11
Kim, S.H.12
-
30
-
-
0035902115
-
Proliferation, cell cycle and apoptosis in cancer
-
G.I. Evan, K.H. Vousden, Proliferation, cell cycle and apoptosis in cancer. Nature 411, 342-348 (2001)
-
(2001)
Nature
, vol.411
, pp. 342-348
-
-
Evan, G.I.1
Vousden, K.H.2
-
31
-
-
0030971097
-
Mammalian GADD34, an apoptosis- and DNA damage-inducible gene
-
M.C. Hollander, Q. Zhan, I. Bae, A.J. Fornace Jr., Mammalian GADD34, an apoptosis- and DNA damage-inducible gene. J. Biol. Chem. 272, 13731-13737 (1997)
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 13731-13737
-
-
Hollander, M.C.1
Zhan, Q.2
Bae, I.3
Fornace Jr., A.J.4
-
32
-
-
79955822124
-
Mechanisms of the apoptosis induced by CD176 antibody in human leukemic cells
-
B. Yi, M. Zhang, R. Schwartz-Albiez, Y. Cao, Mechanisms of the apoptosis induced by CD176 antibody in human leukemic cells. Int. J. Oncol. 38, 1565-1573 (2011)
-
(2011)
Int. J. Oncol.
, vol.38
, pp. 1565-1573
-
-
Yi, B.1
Zhang, M.2
Schwartz-Albiez, R.3
Cao, Y.4
-
33
-
-
77955499212
-
Gadd45b mediates Fasinduced apoptosis by enhancing the interaction between p38 and retinoblastoma tumor suppressor
-
H.J. Cho, S.M. Park, E.M. Hwang, K.E. Baek, I.K. Kim, I.K. Nam, M.J. Im, S.H. Park, S. Bae, J.Y. Park, J. Yoo, Gadd45b mediates Fasinduced apoptosis by enhancing the interaction between p38 and retinoblastoma tumor suppressor. J. Biol. Chem. 285, 25500-25505 (2010)
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 25500-25505
-
-
Cho, H.J.1
Park, S.M.2
Hwang, E.M.3
Baek, K.E.4
Kim, I.K.5
Nam, I.K.6
Im, M.J.7
Park, S.H.8
Bae, S.9
Park, J.Y.10
Yoo, J.11
-
34
-
-
0037126303
-
Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage
-
J. Seoane, H.V. Le, J. Massague, Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 419, 729-734 (2002)
-
(2002)
Nature
, vol.419
, pp. 729-734
-
-
Seoane, J.1
Le, H.V.2
Massague, J.3
-
35
-
-
62749139614
-
HIV-1 TAR miRNA protects against apoptosis by altering cellular gene expression
-
Z. Klase, R. Winograd, J. Davis, L. Carpio, R. Hildreth, M. Heydarian, S. Fu, T. McCaffrey, E. Meiri, M. Ayash-Rashkovsky, S. Gilad, Z. Bentwich, F. Kashanchi, HIV-1 TAR miRNA protects against apoptosis by altering cellular gene expression. Retrovirology 6, 18 (2009)
-
(2009)
Retrovirology
, vol.6
, pp. 18
-
-
Klase, Z.1
Winograd, R.2
Davis, J.3
Carpio, L.4
Hildreth, R.5
Heydarian, M.6
Fu, S.7
McCaffrey, T.8
Meiri, E.9
Ayash-Rashkovsky, M.10
Gilad, S.11
Bentwich, Z.12
Kashanchi, F.13
-
36
-
-
0034856386
-
IL-1 receptor antagonist prevents apoptosis and caspase- 3 activation after spinal cord injury
-
O. Nesic, G.Y. Xu, D. McAdoo, K.W. High, C. Hulsebosch, R. Perez-Pol, IL-1 receptor antagonist prevents apoptosis and caspase- 3 activation after spinal cord injury. J. Neurotrauma 18, 947-956 (2001)
-
(2001)
J. Neurotrauma
, vol.18
, pp. 947-956
-
-
Nesic, O.1
Xu, G.Y.2
McAdoo, D.3
High, K.W.4
Hulsebosch, C.5
Perez-Pol, R.6
-
37
-
-
0037162507
-
Mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK
-
D. Sarkar, Z.Z. Su, I.V. Lebedeva, M. Sauane, R.V. Gopalkrishnan, K. Valerie, P. Dent, P.B. Fisher, mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. Proc. Natl. Acad. Sci. U. S. A. 99, 10054-10059 (2002)
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 10054-10059
-
-
Sarkar, D.1
Su, Z.Z.2
Lebedeva, I.V.3
Sauane, M.4
Gopalkrishnan, R.V.5
Valerie, K.6
Dent, P.7
Fisher, P.B.8
-
38
-
-
78651491544
-
Developmental changes in expression of genes involved in regulation of apoptosis in the bovine preimplantation embryo
-
J.M. Fear, P.J. Hansen, Developmental changes in expression of genes involved in regulation of apoptosis in the bovine preimplantation embryo. Biol. Reprod. 84, 43-51 (2011)
-
(2011)
Biol. Reprod.
, vol.84
, pp. 43-51
-
-
Fear, J.M.1
Hansen, P.J.2
-
39
-
-
34248583886
-
MAP kinase signalling pathways in cancer
-
A.S. Dhillon, S. Hagan, O. Rath, W. Kolch, MAP kinase signalling pathways in cancer. Oncogene 26, 3279-3290 (2007)
-
(2007)
Oncogene
, vol.26
, pp. 3279-3290
-
-
Dhillon, A.S.1
Hagan, S.2
Rath, O.3
Kolch, W.4
|