Probenecid protects against transient focal cerebral ischemic injury by inhibiting HMGB1 release and attenuating AQP4 expression in mice

Neurochemical Research

Volumn 39, Issue 1, 2014, Pages 216-224

  Xiong, Xiao Xing ^a   Gu, Li Juan ^b   Shen, Jian ^a   Kang, Xian Hui ^a   Zheng, Yue Ying ^a   Yue, Si Biao ^c   Zhu, Sheng Mei ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b HANGZHOU NORMAL UNIVERSITY   (China)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

AQP4; Focal cerebral ischemia; HMGB1; Pannexin 1; Probenecid

Indexed keywords

AQUAPORIN 4 ANTIBODY; HIGH MOBILITY GROUP B1 PROTEIN; P 8761; PROBENECID; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; ATTENUATION; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN WATER; CELL ACTIVATION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; UPREGULATION; WATER CONTENT; WESTERN BLOTTING;

MUS;

ANIMALS; AQUAPORIN 4; ASTROCYTES; BRAIN EDEMA; BRAIN INJURIES; CEREBRAL INFARCTION; DOWN-REGULATION; HMGB1 PROTEIN; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MICE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; PROBENECID;

EID: 84892681276     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-013-1212-z     Document Type: Article

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