CtIP is required for DNA damage-dependent induction of P21

Cell Cycle

Volumn 13, Issue 1, 2014, Pages 90-95

  Liu, Bo ^a   Cong, Rixin ^a   Peng, Bin ^a   Zhu, Bingtao ^a   Dou, Gelin ^a   Ai, Haiyan ^a   Zhang, Xiaodong ^b   Wang, Zhenghe ^c   Xu, Xingzhi ^a  

^a CAPITAL NORMAL UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA damage; DNA endonuclease CtIP; P21

Indexed keywords

CAMPTOTHECIN; CTBP INTERACTING PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DEOXYRIBONUCLEASE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HCT116; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA DAMAGE; HUMAN; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION;

DNA DAMAGE; DNA ENDONUCLEASE CTIP; P21;

CARRIER PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MCF-7 CELLS; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC;

EID: 84892616700     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.26810     Document Type: Article

References (29)

1. You Z, Bailis JM. DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints. Trends Cell Biol 2010; 20: 402-9; PMID:20444606; http://dx.doi.org/10.1016/j.tcb.2010.04.002
2. Quennet V, Beucher A, Barton O, Takeda S, Löbrich M. CtIP and MRN promote non-homologous endjoining of etoposide-induced DNA double-strand breaks in G1. Nucleic Acids Res 2011; 39: 2144-52; PMID:21087997; http://dx.doi.org/10. 1093/nar/gkq1175
3. You Z, Shi LZ, Zhu Q, Wu P, Zhang YW, Basilio A, Tonnu N, Verma IM, Berns MW, Hunter T. CtIP links DNA double-strand break sensing to resection. Mol Cell 2009; 36: 954-69; PMID:20064462; http://dx.doi.org/10.1016/j.molcel.2009.12.002
4. Schaeper U, Subramanian T, Lim L, Boyd JM, Chinnadurai G. Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif. J Biol Chem 1998; 273: 8549-52; PMID:9535825; http://dx.doi.org/10. 1074/jbc.273.15.8549 (Pubitemid 28176126)
5. Furuta S, Wang JM, Wei S, Jeng YM, Jiang X, Gu B, Chen PL, Lee EY, Lee WH. Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature. Cancer Cell 2006; 10: 13-24; PMID:16843262; http://dx.doi.org/10.1016/j.ccr.2006.05.022
6. Liu F, Lee WH. CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression. Mol Cell Biol 2006; 26:3124-34; PMID:16581787; http://dx.doi.org/10.1128/MCB.26.8.3124-3134.2006
7. Moiola C, De Luca P, Cotignola J, Gardner K, Vazquez E, De Siervi A. Dynamic coregulatory complex containing BRCA1, E2F1 and CtIP controls ATM transcription. Cell Physiol Biochem 2012; 30: 596-608; PMID:22832221; http://dx.doi.org/10.1159/000341441
8. Abbas T, Dutta A. p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer 2009; 9:400-14; PMID:19440234; http://dx.doi.org/10. 1038/nrc2657
9. Smits VA, Klompmaker R, Vallenius T, Rijksen G, Mäkela TP, Medema RH. p21 inhibits Thr161 phosphorylation of Cdc2 to enforce the G2 DNA damage checkpoint. J Biol Chem 2000; 275: 30638-43; PMID:10913154; http://dx.doi.org/ 10.1074/jbc.M005437200
10. Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A. Cyclin-binding motifs are essential for the function of p21CIP1. Mol Cell Biol 1996; 16: 4673-82; PMID:8756624 (Pubitemid 26272120)
11. Yagi A, Hasegawa Y, Xiao H, Haneda M, Kojima E, Nishikimi A, Hasegawa T, Shimokata K, Isobe K. GADD34 induces p53 phosphorylation and p21/WAF1 transcription. J Cell Biochem 2003; 90:1242-9; PMID:14635196; http://dx.doi.org/10.1002/jcb.10711 (Pubitemid 37485058)
12. Soria G, Podhajcer O, Prives C, Gottifredi V. P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation. Oncogene 2006; 25: 2829-38; PMID:16407842; http://dx.doi.org/10.1038/sj.onc.1209315 (Pubitemid 43739233)
13. Rodriguez R, Meuth M. Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress. Mol Biol Cell 2006; 17: 402-12; PMID:16280359; http://dx.doi.org/10.1091/mbc.E05-07-0594 (Pubitemid 43049492)
14. el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell 1993; 75: 817-25; PMID:8242752; http://dx.doi.org/10.1016/ 0092-8674(93)90500-P (Pubitemid 23346378)
15. Tu Y, Wu W, Wu T, Cao Z, Wilkins R, Toh BH, Cooper ME, Chai Z. Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways. J Biol Chem 2007; 282: 11722-31; PMID:17317670; http://dx.doi.org/10.1074/jbc.M609623200 (Pubitemid 47100724)
16. Khoronenkova SV, Dianova II, Ternette N, Kessler BM, Parsons JL, Dianov GL. ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. Mol Cell 2012; 45:801-13; PMID:22361354; http://dx.doi.org/10. 1016/j.molcel.2012.01.021
17. Somasundaram K, MacLachlan TK, Burns TF, Sgagias M, Cowan KH, Weber BL, el-Deiry WS. BRCA1 signals ARF-dependent stabilization and coactivation of p53. Oncogene 1999; 18:6605-14; PMID:10597265; http://dx.doi.org/10.1038/sj.onc. 1203284
18. Somasundaram K, Zhang H, Zeng YX, Houvras Y, Peng Y, Zhang H, Wu GS, Licht JD, Weber BL, El-Deiry WS. Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDKinhibitor p21WAF1/CiP1. Nature 1997; 389: 187-90; PMID:9296497; http://dx.doi.org/10.1038/38291 (Pubitemid 27400601)
19. Chai YL, Cui J, Shao N, Shyam E, Reddy P, Rao VN. The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter. Oncogene 1999; 18:263-8; PMID:9926942; http://dx.doi.org/10.1038/sj.onc.1202323 (Pubitemid 29060601)
20. Gartel AL, Tyner AL. Transcriptional regulation of the p21((WAF1/CIP1)) gene. Exp Cell Res 1999; 246: 280-9; PMID:9925742; http://dx.doi.org/10.1006/ excr.1998.4319 (Pubitemid 29393989)
21. Sharma N, Timmers C, Trikha P, Saavedra HI, Obery A, Leone G. Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 is essential for G1/S progression and cellular transformation. J Biol Chem 2006; 281: 36124-31; PMID:17008321; http://dx.doi.org/10.1074/jbc.M604152200 (Pubitemid 46041346)
22. Brenner C, Deplus R, Didelot C, Loriot A, Viré E, De Smet C, Gutierrez A, Danovi D, Bernard D, Boon T, et al. Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J 2005; 24: 336-46; PMID:15616584; http://dx.doi.org/10.1038/sj.emboj.7600509 (Pubitemid 40216138)
23. Jung P, Menssen A, Mayr D, Hermeking H. AP4 encodes a c-MYC-inducible repressor of p21. Proc Natl Acad Sci U S A 2008; 105: 15046-51; PMID:18818310; http://dx.doi.org/10.1073/pnas.0801773105
24. Wang H, Shao Z, Shi LZ, Hwang PY, Truong LN, Berns MW, Chen DJ, Wu X. CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks. J Biol Chem 2012; 287: 21471-80; PMID:22544744; http://dx.doi.org/10.1074/jbc.M112.355354
25. Yun MH, Hiom K. CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle. Nature 2009; 459:460-3; PMID:19357644; http://dx.doi.org/10.1038/nature07955
26. Meloni AR, Smith EJ, Nevins Jr. A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor. Proc Natl Acad Sci U S A 1999; 96: 9574-9; PMID:10449734; http://dx.doi.org/10.1073/ pnas.96.17.9574 (Pubitemid 29398772)
27. Wu M, Soler DR, Abba MC, Nunez MI, Baer R, Hatzis C, Llombart-Cussac A, Llombart-Bosch A, Aldaz CM. CtIP silencing as a novel mechanism of tamoxifen resistance in breast cancer. Mol Cancer Res 2007; 5: 1285-95; PMID:18171986; http://dx.doi.org/10.1158/1541-7786.MCR-07-0126
28. Abukhdeir AM, Vitolo MI, Argani P, De Marzo AM, Karakas B, Konishi H, Gustin JP, Lauring J, Garay JP, Pendleton C, et al. Tamoxifen-stimulated growth of breast cancer due to p21 loss. Proc Natl Acad Sci U S A 2008; 105: 288-93; PMID:18162533; http://dx.doi.org/10.1073/pnas.0710887105
29. Lv S, Bu W, Jiao H, Liu B, Zhu L, Zhao H, Liao J, Li J, Xu X. LSD1 is required for chromosome segregation during mitosis. Eur J Cell Biol 2010; 89:557-63; PMID:20189264; http://dx.doi.org/10.1016/j.ejcb.2010.01.004