메뉴 건너뛰기




Volumn 306, Issue 2, 2014, Pages

Megalin in acute kidney injury: Foe and friend

Author keywords

Acute kidney injury; Biomarkers; Cisplatin; Megalin; Nephrotoxins

Indexed keywords

APROTININ; ARISTOLOCHIC ACID; BIOLOGICAL MARKER; CADMIUM; CISPLATIN; CYTOKINE; GENTAMICIN; HEMOGLOBIN; KANAMYCIN; MEGALIN; MESSENGER RNA; METALLOTHIONEIN; MYOGLOBIN; NEOMYCIN; NETILMICIN; POLYMYXIN B; STREPTOMYCIN; TOBRAMYCIN; TRICHOSANTHIN;

EID: 84892608157     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00378.2013     Document Type: Review
Times cited : (50)

References (97)
  • 1
    • 0027179402 scopus 로고
    • Location of gp330/alpha 2-m receptor-associated protein (alpha 2-MRAP) and its binding sites in kidney: Distribution of endogenous alpha 2-MRAP is modified by tissue processing
    • Abbate M, Bachinsky D, Zheng G, Stamenkovic I, McLaughlin M, Niles JL, McCluskey RT, Brown D. Location of gp330/alpha 2-m receptor-associated protein (alpha 2-MRAP) and its binding sites in kidney: distribution of endogenous alpha 2-MRAP is modified by tissue processing. Eur J Cell Biol 61: 139-149, 1993.
    • (1993) Eur J Cell Biol , vol.61 , pp. 139-149
    • Abbate, M.1    Bachinsky, D.2    Zheng, G.3    Stamenkovic, I.4    McLaughlin, M.5    Niles, J.L.6    McCluskey, R.T.7    Brown, D.8
  • 2
    • 33750611276 scopus 로고    scopus 로고
    • The case for survivin as a regulator of microtubule dynamics and cell-death decisions
    • Altieri DC. The case for survivin as a regulator of microtubule dynamics and cell-death decisions. Curr Opin Cell Biol 18: 609-615, 2006.
    • (2006) Curr Opin Cell Biol , vol.18 , pp. 609-615
    • Altieri, D.C.1
  • 3
    • 0033454637 scopus 로고    scopus 로고
    • Pathophysiology and functional significance of apical membrane disruption during ischemia
    • Ashworth SL, Molitoris BA. Pathophysiology and functional significance of apical membrane disruption during ischemia. Curr Opin Nephrol Hypertens 8: 449-458, 1999.
    • (1999) Curr Opin Nephrol Hypertens , vol.8 , pp. 449-458
    • Ashworth, S.L.1    Molitoris, B.A.2
  • 5
    • 77954613885 scopus 로고    scopus 로고
    • Immunoglobulin light chains activate tubular epithelial cells through redox signaling
    • Basnayake K, Ying WZ, Wang PX, Sanders PW. Immunoglobulin light chains activate tubular epithelial cells through redox signaling. J Am Soc Nephrol 21: 1165-1173, 2010.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 1165-1173
    • Basnayake, K.1    Ying, W.Z.2    Wang, P.X.3    Sanders, P.W.4
  • 8
    • 3142676579 scopus 로고    scopus 로고
    • Megalin, cubilin and immunoglobulin light chains: Receptor-mediated uptake of light chains in kidney proximal tubule
    • edited by Aucouturier P. Dordrecht, The Netherlands: Kluwer Academic
    • Birn H, Leboulleux M, Moestrup SK, Aucouturier P, Christensen EI. Megalin, cubilin and immunoglobulin light chains: receptor-mediated uptake of light chains in kidney proximal tubule. In: Monoclonal Gam-mapathies and the Kidney, edited by Aucouturier P. Dordrecht, The Netherlands: Kluwer Academic, p. page typefirst37/pagex-/xpage typelast48/page, 2003.
    • (2003) Monoclonal Gam-mapathies and The Kidney
    • Birn, H.1    Leboulleux, M.2    Moestrup, S.K.3    Aucouturier, P.4    Christensen, E.I.5
  • 9
    • 0033968875 scopus 로고    scopus 로고
    • Receptor-associated protein is important for normal processing of megalin in kidney proximal tubules
    • Birn H, Vorum H, Verroust PJ, Moestrup SK, Christensen EI. Receptor-associated protein is important for normal processing of megalin in kidney proximal tubules. J Am Soc Nephrol 11: 191-202, 2000.
    • (2000) J Am Soc Nephrol , vol.11 , pp. 191-202
    • Birn, H.1    Vorum, H.2    Verroust, P.J.3    Moestrup, S.K.4    Christensen, E.I.5
  • 10
    • 0028988551 scopus 로고
    • 39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein
    • Bu G, Geuze HJ, Strous GJ, Schwartz AL. 39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein. EMBO J 14: 2269-2280, 1995.
    • (1995) EMBO J , vol.14 , pp. 2269-2280
    • Bu, G.1    Geuze, H.J.2    Strous, G.J.3    Schwartz, A.L.4
  • 11
    • 0029786288 scopus 로고    scopus 로고
    • Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein
    • Bu G, Rennke S. Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein. J Biol Chem 271: 22218-22224, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 22218-22224
    • Bu, G.1    Rennke, S.2
  • 13
    • 0022523463 scopus 로고
    • Ultrastructural localization by monoclonal antibodies of brush border antigens expressed by glomeruli. I. Renal distribution
    • Chatelet F, Brianti E, Ronco P, Roland J, Verroust P. Ultrastructural localization by monoclonal antibodies of brush border antigens expressed by glomeruli. I. Renal distribution. Am J Pathol 122: 500-511, 1986.
    • (1986) Am J Pathol , vol.122 , pp. 500-511
    • Chatelet, F.1    Brianti, E.2    Ronco, P.3    Roland, J.4    Verroust, P.5
  • 14
    • 84888985504 scopus 로고    scopus 로고
    • Survivin mediates renal proximal tubule recovery from AKI
    • doi:10.1681/ ASN.2013010076
    • Chen J, Chen JK, Conway EM, Harris RC. Survivin mediates renal proximal tubule recovery from AKI. J Am Soc Nephrol; doi:10.1681/ ASN.2013010076.
    • J Am Soc Nephrol
    • Chen, J.1    Chen, J.K.2    Conway, E.M.3    Harris, R.C.4
  • 16
    • 84984766757 scopus 로고    scopus 로고
    • Megalin and cubilin: Multifunctional endocytic receptors
    • Christensen EI, Birn H. Megalin and cubilin: multifunctional endocytic receptors. Nat Rev Mol Cell Biol 3: 256-266, 2002.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 256-266
    • Christensen, E.I.1    Birn, H.2
  • 18
  • 19
    • 0026722478 scopus 로고
    • Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein
    • Christensen EI, Gliemann J, Moestrup SK. Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein. J Histochem Cytochem 40: 1481-1490, 1992.
    • (1992) J Histochem Cytochem , vol.40 , pp. 1481-1490
    • Christensen, E.I.1    Gliemann, J.2    Moestrup, S.K.3
  • 21
    • 34548839643 scopus 로고    scopus 로고
    • Role of megalin and cubilin in renal physiology and pathophysiology
    • Christensen EI, Nielsen R. Role of megalin and cubilin in renal physiology and pathophysiology. Rev Physiol Biochem Pharmacol 158: 1-22, 2007.
    • (2007) Rev Physiol Biochem Pharmacol , vol.158 , pp. 1-22
    • Christensen, E.I.1    Nielsen, R.2
  • 24
    • 70349567495 scopus 로고    scopus 로고
    • Receptor-mediated endocytosis in renal proximal tubule
    • Christensen EI, Verroust PJ, Nielsen R. Receptor-mediated endocytosis in renal proximal tubule. PflUgers Arch 458: 1039-1048, 2009.
    • (2009) PflUgers Arch , vol.458 , pp. 1039-1048
    • Christensen, E.I.1    Verroust, P.J.2    Nielsen, R.3
  • 25
    • 0032828613 scopus 로고    scopus 로고
    • Essential role of megalin in renal proximal tubule for vitamin homeostasis
    • Christensen EI, Willnow TE. Essential role of megalin in renal proximal tubule for vitamin homeostasis. J Am Soc Nephrol 10: 2224-2236, 1999.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 2224-2236
    • Christensen, E.I.1    Willnow, T.E.2
  • 27
    • 30344447982 scopus 로고    scopus 로고
    • Kinetics and characterization of initially regenerating proximal tubules in S3 segment in response to various degrees of acute tubular injury
    • Fujigaki Y, Goto T, Sakakima M, Fukasawa H, Miyaji T, Yamamoto T, Hishida A. Kinetics and characterization of initially regenerating proximal tubules in S3 segment in response to various degrees of acute tubular injury. Nephrol Dial Transplant 21: 41-50, 2006.
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 41-50
    • Fujigaki, Y.1    Goto, T.2    Sakakima, M.3    Fukasawa, H.4    Miyaji, T.5    Yamamoto, T.6    Hishida, A.7
  • 30
    • 0036083551 scopus 로고    scopus 로고
    • Clusterin protects renal tubular epithelial cells from gentamicin-mediated cytotoxicity
    • Girton RA, Sundin DP, Rosenberg ME. Clusterin protects renal tubular epithelial cells from gentamicin-mediated cytotoxicity. Am J Physiol Renal Physiol 282: F703-F709, 2002.
    • (2002) Am J Physiol Renal Physiol , vol.282
    • Girton, R.A.1    Sundin, D.P.2    Rosenberg, M.E.3
  • 31
    • 79551489395 scopus 로고    scopus 로고
    • Acute kidney injury: Lessons from experimental models
    • Heyman SN, Rosenberger C, Rosen S. Acute kidney injury: lessons from experimental models. Contrib Nephrol 169: 286-296, 2011.
    • (2011) Contrib Nephrol , vol.169 , pp. 286-296
    • Heyman, S.N.1    Rosenberger, C.2    Rosen, S.3
  • 32
    • 12744272449 scopus 로고    scopus 로고
    • The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake
    • Hvidberg V, Jacobsen C, Strong RK, Cowland JB, Moestrup SK, Borregaard N. The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. FEBS Lett 579: 773-777, 2005.
    • (2005) FEBS Lett , vol.579 , pp. 773-777
    • Hvidberg, V.1    Jacobsen, C.2    Strong, R.K.3    Cowland, J.B.4    Moestrup, S.K.5    Borregaard, N.6
  • 33
    • 84859755474 scopus 로고    scopus 로고
    • Kim-1/Tim-1 and immune cells: Shifting sands
    • Ichimura T, Brooks CR, Bonventre JV. Kim-1/Tim-1 and immune cells: shifting sands. Kidney Int 81: 809-811, 2012.
    • (2012) Kidney Int , vol.81 , pp. 809-811
    • Ichimura, T.1    Brooks, C.R.2    Bonventre, J.V.3
  • 36
    • 0031068365 scopus 로고    scopus 로고
    • Effect of TGF-fj1 and TNF-a on the plasminogen system of rat proximal tubular epithelial cells
    • Kanalas JJ, Hopfer U. Effect of TGF-fj1 and TNF-a on the plasminogen system of rat proximal tubular epithelial cells. J Am Soc Nephrol 8: 184-192, 1997.
    • (1997) J Am Soc Nephrol , vol.8 , pp. 184-192
    • Kanalas, J.J.1    Hopfer, U.2
  • 39
    • 38949146336 scopus 로고    scopus 로고
    • Protective role of the inhibitor of apoptosis protein, survivin, in toxin-induced acute renal failure
    • Kindt N, Menzebach A, Van de Wouwer M, Betz I, De VA, Conway EM. Protective role of the inhibitor of apoptosis protein, survivin, in toxin-induced acute renal failure. FASEB J 22: 510-521, 2008.
    • (2008) FASEB J , vol.22 , pp. 510-521
    • Kindt, N.1    Menzebach, A.2    Van de Wouwer, M.3    Betz, I.4    De, V.A.5    Conway, E.M.6
  • 41
    • 0028016427 scopus 로고
    • Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1)
    • Korenberg JR, Argraves KM, Chen XN, Tran H, Strickland DK, Argraves WS. Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1). Genomics 22: 88-93, 1994.
    • (1994) Genomics , vol.22 , pp. 88-93
    • Korenberg, J.R.1    Argraves, K.M.2    Chen, X.N.3    Tran, H.4    Strickland, D.K.5    Argraves, W.S.6
  • 48
    • 49949114134 scopus 로고    scopus 로고
    • Silencing megalin and cubilin genes inhibits myeloma light chain endocytosis and ameliorates toxicity in human renal proximal tubule epithelial cells
    • Li M, Balamuthusamy S, Simon EE, Batuman V. Silencing megalin and cubilin genes inhibits myeloma light chain endocytosis and ameliorates toxicity in human renal proximal tubule epithelial cells. Am J Physiol Renal Physiol 295: F82-F90, 2008.
    • (2008) Am J Physiol Renal Physiol , vol.295
    • Li, M.1    Balamuthusamy, S.2    Simon, E.E.3    Batuman, V.4
  • 49
    • 55749097669 scopus 로고    scopus 로고
    • The COOH terminus of megalin regulates gene expression in opossum kidney proximal tubule cells
    • Li Y, Cong R, Biemesderfer D. The COOH terminus of megalin regulates gene expression in opossum kidney proximal tubule cells. Am J Physiol Cell Physiol 295: C529-C537, 2008.
    • (2008) Am J Physiol Cell Physiol , vol.295
    • Li, Y.1    Cong, R.2    Biemesderfer, D.3
  • 51
    • 79952753553 scopus 로고    scopus 로고
    • Renal liver-type fatty acid binding protein (L-FABP) attenuates acute kidney injury in aristolochic acid nephrotoxicity
    • Matsui K, Kamijo-Ikemorif A, Sugaya T, Yasuda T, Kimura K. Renal liver-type fatty acid binding protein (L-FABP) attenuates acute kidney injury in aristolochic acid nephrotoxicity. Am J Pathol 178: 1021-1032, 2011.
    • (2011) Am J Pathol , vol.178 , pp. 1021-1032
    • Matsui, K.1    Kamijo-Ikemorif, A.2    Sugaya, T.3    Yasuda, T.4    Kimura, K.5
  • 53
    • 0141678253 scopus 로고    scopus 로고
    • Identification of neutrophil gelatinase-associated lipoca-lin as a novel early urinary biomarker for ischemic renal injury
    • Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, Yang J, Barasch J, Devarajan P. Identification of neutrophil gelatinase-associated lipoca-lin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14: 2534-2543, 2003.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 2534-2543
    • Mishra, J.1    Ma, Q.2    Prada, A.3    Mitsnefes, M.4    Zahedi, K.5    Yang, J.6    Barasch, J.7    Devarajan, P.8
  • 57
    • 77955776508 scopus 로고    scopus 로고
    • Molecular-targeted approaches to reduce renal accumulation of nephrotoxic drugs
    • Nagai J, Takano M. Molecular-targeted approaches to reduce renal accumulation of nephrotoxic drugs. Expert Opin Drug Metab Toxicol 6: 1125-1138, 2010.
    • (2010) Expert Opin Drug Metab Toxicol , vol.6 , pp. 1125-1138
    • Nagai, J.1    Takano, M.2
  • 59
    • 44449094660 scopus 로고    scopus 로고
    • Renal L-type fatty acid-binding protein mediates the bezafibrate reduction of cisplatin-induced acute kidney injury
    • Negishi K, Noiri E, Maeda R, Portilla D, Sugaya T, Fujita T. Renal L-type fatty acid-binding protein mediates the bezafibrate reduction of cisplatin-induced acute kidney injury. Kidney lnt 73: 1374-1384, 2008.
    • (2008) Kidney Lnt , vol.73 , pp. 1374-1384
    • Negishi, K.1    Noiri, E.2    Maeda, R.3    Portilla, D.4    Sugaya, T.5    Fujita, T.6
  • 61
    • 84861748499 scopus 로고    scopus 로고
    • Role of megalin and the soluble form of its ligand RAP in Cd-metallothionein endocytosis and Cd-metallothion-ein-induced nephrotoxicity in vivo
    • Onodera A, Tani M, Michigami T, Yamagata M, Min KS, Tanaka K, Nakanishi T, Kimura T, Itoh N. Role of megalin and the soluble form of its ligand RAP in Cd-metallothionein endocytosis and Cd-metallothion-ein-induced nephrotoxicity in vivo. Toxicol Lett 212: 91-96, 2012.
    • (2012) Toxicol Lett , vol.212 , pp. 91-96
    • Onodera, A.1    Tani, M.2    Michigami, T.3    Yamagata, M.4    Min, K.S.5    Tanaka, K.6    Nakanishi, T.7    Kimura, T.8    Itoh, N.9
  • 65
    • 0023755521 scopus 로고
    • Hemoglobin-and myoglobin-induced acute renal failure in rats: Role of iron in nephrotoxicity
    • Paller MS. Hemoglobin-and myoglobin-induced acute renal failure in rats: role of iron in nephrotoxicity. Am J Physiol Renal Fluid Electrolyte Physiol 255: F539-F544, 1988.
    • (1988) Am J Physiol Renal Fluid Electrolyte Physiol , vol.255
    • Paller, M.S.1
  • 66
    • 4444226979 scopus 로고    scopus 로고
    • Identification and proteomic profiling of exosomes in human urine
    • Pisitkun T, Shen RF, Knepper MA. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci USA 101: 13368-13373, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13368-13373
    • Pisitkun, T.1    Shen, R.F.2    Knepper, M.A.3
  • 70
    • 1642283590 scopus 로고    scopus 로고
    • Gentamicin traffics retrograde through the secretory pathway and is released in the cytosol via the endoplasmic reticulum
    • Sandoval RM, Molitoris BA. Gentamicin traffics retrograde through the secretory pathway and is released in the cytosol via the endoplasmic reticulum. Am J Physiol Renal Physiol 286: F617-F624, 2004.
    • (2004) Am J Physiol Renal Physiol , vol.286
    • Sandoval, R.M.1    Molitoris, B.A.2
  • 71
    • 0019959284 scopus 로고
    • Identification of the aminoglycoside binding site in rat renal brush border membranes
    • Sastrasinh M, Knauss TC, Weinberg JM, Humes HD. Identification of the aminoglycoside binding site in rat renal brush border membranes. J Pharmacol Exp Ther 222: 350-358, 1982.
    • (1982) J Pharmacol Exp Ther , vol.222 , pp. 350-358
    • Sastrasinh, M.1    Knauss, T.C.2    Weinberg, J.M.3    Humes, H.D.4
  • 74
    • 84862495615 scopus 로고    scopus 로고
    • Acute endotoxemia in mice induces downregulation of megalin and cubilin in the kidney
    • Schreiber A, Theilig F, Schweda F, Hocherl K. Acute endotoxemia in mice induces downregulation of megalin and cubilin in the kidney. Kidney lnt 82: 53-59, 2012.
    • (2012) Kidney Lnt , vol.82 , pp. 53-59
    • Schreiber, A.1    Theilig, F.2    Schweda, F.3    Hocherl, K.4
  • 75
    • 84880706062 scopus 로고    scopus 로고
    • Receptor-associated protein blocks internalization and cytotoxicity of myeloma light chain in cultured human proximal tubular cells
    • Sengul S, Erturk S, Khan AM, Batuman V. Receptor-associated protein blocks internalization and cytotoxicity of myeloma light chain in cultured human proximal tubular cells. PLos One 8: e70276, 2013.
    • (2013) PLos One , vol.8
    • Sengul, S.1    Erturk, S.2    Khan, A.M.3    Batuman, V.4
  • 76
    • 79953175649 scopus 로고    scopus 로고
    • Pathophysiology of ischemic acute kidney injury
    • Sharfuddin AA, Molitoris BA. Pathophysiology of ischemic acute kidney injury. Nat Rev Nephrol 7: 189-200, 2011.
    • (2011) Nat Rev Nephrol , vol.7 , pp. 189-200
    • Sharfuddin, A.A.1    Molitoris, B.A.2
  • 77
    • 0033936194 scopus 로고    scopus 로고
    • Cell biology and molecular mechanisms of injury in ischemic acute renal failure
    • Sheridan AM, Bonventre JV. Cell biology and molecular mechanisms of injury in ischemic acute renal failure. Curr Opin Nephrol Hypertens 9: 427-434, 2000.
    • (2000) Curr Opin Nephrol Hypertens , vol.9 , pp. 427-434
    • Sheridan, A.M.1    Bonventre, J.V.2
  • 80
    • 0031691367 scopus 로고    scopus 로고
    • Mechanisms of cellular injury in ischemic acute renal failure
    • Sutton TA, Molitoris BA. Mechanisms of cellular injury in ischemic acute renal failure. Semin Nephrol 18: 490-497, 1998.
    • (1998) Semin Nephrol , vol.18 , pp. 490-497
    • Sutton, T.A.1    Molitoris, B.A.2
  • 81
    • 0036406956 scopus 로고    scopus 로고
    • Cisplatin-induced inhibition of receptor-mediated endocytosis of protein in the kidney
    • Takano M, Nakanishi N, Kitahara Y, Sasaki Y, Murakami T, Nagai J. Cisplatin-induced inhibition of receptor-mediated endocytosis of protein in the kidney. Kidney lnt 62: 1707-1717, 2002.
    • (2002) Kidney Lnt , vol.62 , pp. 1707-1717
    • Takano, M.1    Nakanishi, N.2    Kitahara, Y.3    Sasaki, Y.4    Murakami, T.5    Nagai, J.6
  • 84
    • 81155152351 scopus 로고    scopus 로고
    • Exosomes and the kidney: Prospects for diagnosis and therapy of renal diseases
    • van Balkom BW, Pisitkun T, Verhaar MC, Knepper MA. Exosomes and the kidney: prospects for diagnosis and therapy of renal diseases. Kidney lnt 80: 1138-1145, 2011.
    • (2011) Kidney Lnt , vol.80 , pp. 1138-1145
    • van Balkom, B.W.1    Pisitkun, T.2    Verhaar, M.C.3    Knepper, M.A.4
  • 86
    • 45149125850 scopus 로고    scopus 로고
    • Increased incidence of acute kidney injury with aprotinin use during cardiac surgery detected with urinary NGAL
    • Wagener G, Gubitosa G, Wang S, Borregaard N, Kim M, Lee HT. Increased incidence of acute kidney injury with aprotinin use during cardiac surgery detected with urinary NGAL. Am J Nephrol 28: 576-582, 2008.
    • (2008) Am J Nephrol , vol.28 , pp. 576-582
    • Wagener, G.1    Gubitosa, G.2    Wang, S.3    Borregaard, N.4    Kim, M.5    Lee, H.T.6
  • 89
    • 80053643935 scopus 로고    scopus 로고
    • Earlier recognition of nephrotoxicity using novel biomarkers of acute kidney injury
    • Waring WS, Moonie A. Earlier recognition of nephrotoxicity using novel biomarkers of acute kidney injury. Clin Toxicol (Phila) 49: 720-728, 2011.
    • (2011) Clin Toxicol (Phila) , vol.49 , pp. 720-728
    • Waring, W.S.1    Moonie, A.2
  • 90
    • 1542509577 scopus 로고    scopus 로고
    • Targeted prevention of renal accumulation and toxicity of gentamicin by aminoglycoside binding receptor antagonists
    • Watanabe A, Nagai J, Adachi Y, Katsube T, Kitahara Y, Murakami T, Takano M. Targeted prevention of renal accumulation and toxicity of gentamicin by aminoglycoside binding receptor antagonists. J Control Release 95: 423-433, 2004.
    • (2004) J Control Release , vol.95 , pp. 423-433
    • Watanabe, A.1    Nagai, J.2    Adachi, Y.3    Katsube, T.4    Kitahara, Y.5    Murakami, T.6    Takano, M.7
  • 93
    • 34547843502 scopus 로고    scopus 로고
    • A cytoplasmic PPPSP motif determines megalin's phosphorylation and regulates receptor's recycling and surface expression
    • Yuseff MI, Farfan P, Bu G, Marzolo MP. A cytoplasmic PPPSP motif determines megalin's phosphorylation and regulates receptor's recycling and surface expression. Traffic 8: 1215-1230, 2007.
    • (2007) Traffic , vol.8 , pp. 1215-1230
    • Yuseff, M.I.1    Farfan, P.2    Bu, G.3    Marzolo, M.P.4
  • 94
    • 0026059991 scopus 로고
    • Myoglobin depletes renal adenine nucleotide pools in the presence and absence of shock
    • Zager RA. Myoglobin depletes renal adenine nucleotide pools in the presence and absence of shock. Kidney lnt 39: 111-119, 1991.
    • (1991) Kidney Lnt , vol.39 , pp. 111-119
    • Zager, R.A.1
  • 95
    • 0030070639 scopus 로고    scopus 로고
    • Rhabdomyolysis and myohemoglobinuric acute renal failure
    • Zager RA. Rhabdomyolysis and myohemoglobinuric acute renal failure. Kidney lnt 49: 314-326, 1996.
    • (1996) Kidney Lnt , vol.49 , pp. 314-326
    • Zager, R.A.1
  • 97
    • 4544339737 scopus 로고    scopus 로고
    • Linking receptor-mediated endocytosis and cell signaling: Evidence for regulated intramembrane proteolysis of megalin in proximal tubule
    • Zou Z, Chung B, Nguyen T, Mentone S, Thomson B, Biemesderfer D. Linking receptor-mediated endocytosis and cell signaling: evidence for regulated intramembrane proteolysis of megalin in proximal tubule. J Biol Chem 279: 34302-34310, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 34302-34310
    • Zou, Z.1    Chung, B.2    Nguyen, T.3    Mentone, S.4    Thomson, B.5    Biemesderfer, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.