Survivin mediates renal proximal tubule recovery from AKI

Journal of the American Society of Nephrology

Volumn 24, Issue 12, 2013, Pages 2023-2033

  Chen, Jianchun ^a,b   Chen, Jian Kang ^c   Conway, Edward M ^d   Harris, Raymond C ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DEPARTMENT OF VETERANS AFFAIRS   (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIMYCIN A1; GAMMA SECRETASE INHIBITOR; NOTCH2 RECEPTOR; STAT3 PROTEIN; SURVIVIN; TRANSCRIPTION FACTOR HES 1; ANTIINFECTIVE AGENT; BIRC5 PROTEIN, MOUSE; INHIBITOR OF APOPTOSIS PROTEIN; NOTCH2 PROTEIN, MOUSE; REPRESSOR PROTEIN; STAT3 PROTEIN, MOUSE;

ACUTE KIDNEY FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CORTEX; KIDNEY FUNCTION; KIDNEY PROXIMAL TUBULE; KIDNEY STRUCTURE; KIDNEY TUBULE EPITHELIUM; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; UPREGULATION; UREA NITROGEN BLOOD LEVEL; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; CONVALESCENCE; CYTOLOGY; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ACUTE KIDNEY INJURY; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMYCIN A; CELL LINE; INHIBITOR OF APOPTOSIS PROTEINS; KIDNEY TUBULES, PROXIMAL; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; RECEPTOR, NOTCH2; RECOVERY OF FUNCTION; REPERFUSION INJURY; REPRESSOR PROTEINS; STAT3 TRANSCRIPTION FACTOR; UP-REGULATION;

EID: 84888985504     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2013010076     Document Type: Article

References (36)

1. Rifkin DE, Coca SG, Kalantar-Zadeh K: Does AKI truly lead to CKD? J Am Soc Nephrol 23: 979-984, 2012
2. Lameire N, Van Biesen W, Vanholder R: The changing epidemiology of acute renal failure. Nat Clin Pract Nephrol 2: 364-377, 2006
3. Chawla LS, Amdur RL, Amodeo S, Kimmel PL, Palant CE: The severity of acute kidney injury predicts progression to chronic kidney disease. Kidney Int 79: 1361-1369, 2011
4. Ishani A, Nelson D, Clothier B, Schult T, Nugent S, Greer N, Slinin Y, Ensrud KE: The magnitude of acute serum creatinine increase after cardiac surgery and the risk of chronic kidney disease, progression of kidney disease, and death. Arch Intern Med 171: 226-233, 2011
5. Bonventre JV: Mechanisms of ischemic acute renal failure. Kidney Int 43: 1160-1178, 1993
6. Nony PA, Schnellmann RG: Mechanisms of renal cell repair and regeneration after acute renal failure. J Pharmacol Exp Ther 304: 905-912, 2003
7. Duffield JS, Humphreys BD: Origin of new cells in the adult kidney: Results from genetic labeling techniques. Kidney Int 79: 494-501, 2011
8. Wilson A, Radtke F: Multiple functions of Notch signaling in self-renewing organs and cancer. FEBS Lett 580: 2860-2868, 2006
9. Chiba S: Notch signaling in stem cell systems. Stem Cells 24: 2437-2447, 2006
10. Gupta S, Li S, Abedin MJ,Wang L, Schneider E, Najafian B, Rosenberg M: Effect of Notch activation on the regenerative response to acute renal failure. Am J Physiol Renal Physiol 298: F209-F215, 2010
11. Kamakura S, Oishi K, Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y: Hes binding to STAT3 mediates crosstalk between Notch and JAKSTAT signalling. Nat Cell Biol 6: 547-554, 2004
12. AmbrosiniG, AdidaC, Altieri DC: A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 3: 917-921, 1997
13. Mita AC, Mita MM, Nawrocki ST, Giles FJ: Survivin: Key regulator of mitosis and apoptosis and novel target for cancer therapeutics. Clin Cancer Res 14: 5000-5005, 2008
14. Asanuma H, Torigoe T, Kamiguchi K, Hirohashi Y, Ohmura T, Hirata K, Sato M, Sato N: Survivin expression is regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via phosphatidylinositol 3-kinase/AKT signaling pathway in breast cancer cells. Cancer Res 65: 11018-11025, 2005
15. Aoki Y, Feldman GM, Tosato G: Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood 101: 1535-1542, 2003
16. Dan HC, Jiang K, Coppola D, Hamilton A, Nicosia SV, Sebti SM, Cheng JQ: Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis. Oncogene 23: 706-715, 2004
17. Altieri DC: Survivin, versatile modulation of cell division and apoptosis in cancer. Oncogene 22: 8581-8589, 2003
18. AltieriDC: Targeted therapy by disabling crossroad signaling networks: The survivin paradigm. Mol Cancer Ther 5: 478-482, 2006
19. Lechler P, Wu X, Bernhardt W, Campean V, Gastiger S, Hackenbeck T, Klanke B, Weidemann A, Warnecke C, Amann K, Engehausen D, WillamC, Eckardt KU, Rödel F,WiesenerMS: The tumor gene survivin is highly expressed in adult renal tubular cells: Implications for a pathophysiological role in the kidney. Am J Pathol 171: 1483-1498, 2007
20. Kindt N,Menzebach A, Van deWouwer M, Betz I, De Vriese A, Conway EM: Protective role of the inhibitor of apoptosis protein, survivin, in toxin-induced acute renal failure. FASEB J 22: 510-521, 2008
21. Uren AG, Wong L, Pakusch M, Fowler KJ, Burrows FJ, Vaux DL, Choo KH: Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. Curr Biol 10: 1319-1328, 2000
22. Xing Z, Conway EM, Kang C, Winoto A: Essential role of survivin, an inhibitor of apoptosis protein, in T cell development, maturation, and homeostasis. J Exp Med 199: 69-80, 2004
23. Iwano M, Plieth D, Danoff TM, Xue C, Okada H, Neilson EG: Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 110: 341-350, 2002
24. Zhang MZ, Yao B, Yang S, Jiang L, Wang S, Fan X, Yin H, Wong K, Miyazawa T, Chen J, Chang I, Singh A, Harris RC: CSF-1 signaling mediates recovery from acute kidney injury. J Clin Invest 122: 4519- 4532, 2012
25. Vaira V, Lee CW, Goel HL, Bosari S, Languino LR, Altieri DC: Regulation of survivin expression by IGF-1/mTOR signaling. Oncogene 26: 2678-2684, 2007
26. Chen JK, Chen J, Thomas G, Kozma SC, Harris RC: S6 Kinase 1 knockout inhibits Uninephrectomy-or diabetes-induced renal hypertrophy. Am J Physiol, Renal Physiol 297, F585-593, 2009
27. Shen Y, Devgan G, Darnell JE Jr, Bromberg JF: Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1. Proc Natl Acad Sci U S A 98: 1543-1548, 2001
28. Conway EM, Zwerts F, Van Eygen V, DeVriese A, Nagai N, Luo W, Collen D: Survivin-dependent angiogenesis in ischemic brain: Molecular mechanisms of hypoxia-induced up-regulation. Am J Pathol 163: 935-946, 2003
29. Gunning PT, KattWP, Glenn M, Siddiquee K, KimJS, Jove R, Sebti SM, Turkson J, Hamilton AD: Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: Structural recognition of STAT SH2 domains. Bioorg Med Chem Lett 17: 1875- 1878, 2007
30. McCright B, Gao X, Shen L, Lozier J, Lan Y, Maguire M, Herzlinger D, Weinmaster G, Jiang R, Gridley T: Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development 128: 491-502, 2001
31. Cheng HT, Kim M, Valerius MT, Surendran K, Schuster-Gossler K, Gossler A,McMahon AP, Kopan R: Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development 134: 801-811, 2007
32. Kobayashi T, Terada Y, Kuwana H, Tanaka H, Okado T, Kuwahara M, Tohda S, Sakano S, Sasaki S: Expression and function of the Delta- 1/Notch-2/Hes-1 pathway during experimental acute kidney injury. Kidney Int 73: 1240-1250, 2008
33. Luistro L,He W,SmithM, Packman K, VilenchikM, CarvajalD, Roberts J, Cai J, Berkofsky-Fessler W, Hilton H, Linn M, Flohr A, Jakob-Røtne R, Jacobsen H, Glenn K, Heimbrook D, Boylan JF: Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties. Cancer Res 69: 7672-7680, 2009
34. Wang Z, Chen JK, Wang SW, Moeckel G, Harris RC: Importance of functional EGF receptors in recovery from acute nephrotoxic injury. J Am Soc Nephrol 14: 3147-3154, 2003
35. Chen J, Chen JK, Nagai K, Plieth D, Tan M, Lee TC, Threadgill DW, Neilson EG, Harris RC: EGFR signaling promotes TGFb-dependent renal fibrosis. J Am Soc Nephrol 23: 215-224, 2012
36. Haverty TP, Kelly CJ, HinesWH, Amenta PS,Watanabe M, Harper RA, Kefalides NA, Neilson EG: Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis. J Cell Biol 107: 1359-1368, 1988