Earlier recognition of nephrotoxicity using novel biomarkers of acute kidney injury

Clinical Toxicology

Volumn 49, Issue 8, 2011, Pages 720-728

  Waring, W Stephen ^a   Moonie, Alasdair ^a  

^a YORK HOSPITAL   (United Kingdom)

Author keywords

Acute tubular necrosis; Creatinine; Cyclophyllin; Cystatin C; Proteinuria

Indexed keywords

ACETYLGLUCOSAMINIDASE; ALBUMIN; ALPHA 1 MICROGLOBULIN; AUROTHIOMALATE; BETA 2 MICROGLOBULIN; BIOLOGICAL MARKER; CAFFEIC ACID; CAFFEIC ACID PHENETHYL ESTER; CREATININE; CYCLOPHILIN; CYCLOPHILIN A; CYCLOPHILIN D; CYSTATIN C; DEXTRO SERINE; FATTY ACID BINDING PROTEIN; FIBRINOGEN; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE TRANSFERASE; INTERLEUKIN 18; KIDNEY INJURY MOLECULE 1; LACTATE DEHYDROGENASE; LITHIUM; LIVER TYPE FATTY ACID BINDING PROTEIN; MERCURY; MICROSOMAL AMINOPEPTIDASE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; PARACETAMOL; PARAQUAT; TETRAMETHYLPYRAZINE; UNCLASSIFIED DRUG; VANCOMYCIN;

ACUTE KIDNEY FAILURE; ACUTE TOXICITY; ANTIOXIDANT ACTIVITY; BIBLIOGRAPHIC DATABASE; CELL MEMBRANE; CREATININE BLOOD LEVEL; DRUG OVERDOSE; EMBASE; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYMURIA; GLOMERULUS FILTRATION; HUMAN; KIDNEY FUNCTION; KIDNEY ISCHEMIA; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE EPITHELIUM; KIDNEY TUBULE EXCRETION; KIDNEY TUBULE NECROSIS; LIPID PEROXIDATION; MEDLINE; NEPHROTOXICITY; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEINURIA; RENAL REPLACEMENT THERAPY; REVIEW;

ACUTE KIDNEY INJURY; ANIMALS; BIOLOGICAL MARKERS; EARLY DIAGNOSIS; HUMANS; KIDNEY; PHARMACEUTICAL PREPARATIONS;

EID: 80053643935     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.3109/15563650.2011.615319     Document Type: Review

References (87)

1. Vaidya VS, Ozer JS, Dieterle F, Collings FB, Ramirez V, Troth S, et al. Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualifi cation studies. Nat Biotechnol 2010; 28:478-485.
2. Rouse RL, Zhang J, Stewart SR, Rosenzweig BA, Espandiari P, Sadrieh NK. Comparative profi le of commercially available urinary biomarkers in preclinical drug-induced kidney injury and recovery in rats. Kidney Int 2011; 79:1186-1197.
3. Harpur E, Ennulat D, Hoffman D, Betton G, Gautier JC, Riefke B, et al. On behalf of the HESI Technical Committee on Biomarkers of Toxicity, Nephrotoxicity. Biological Qualifi cation of Biomarkers of Chemical-induced Renal Toxicity in Two Strains of Male Rat. Toxicol Sci 2011 May 18. [epub ahead of print]
4. Dieterle F, Perentes E, Cordier A, Roth DR, Verdes P, Grenet O, et al. Urinary clusterin, cystatin C, beta-2-microglobulin and total protein as markers to detect drug-induced kidney injury. Nat Biotechnol 2010; 28:463-469.
5. Yu Y, Jin H, Holder D, Ozer JS, Villarreal S, Shughrue P, et al. Urinary biomarkers trefoil factor 3 and albumin enable early detection of kidney tubular injury. Nat Biotechnol 2010; 28:470-477.
6. Spencer K. Analytical reviews in clinical biochemistry: The estimation of creatinine. Ann Clin Biochem 1986; 23:1-25. (Pubitemid 16178799)
7. Blijenberg BG, Brouwer RJ, Baadenhuijsen H, Boerma GJ. Creatinine and surveys: An assessment. Eur J Clin Chem Clin Biochem 1995; 33:855-858.
8. Schoenmakers CH, Kuller T, Lindemans J, Blijenberg BG. Automated enzymatic methods for creatinine measurement with special attention to bilirubin interference. Eur J Clin Chem Clin Biochem 1993; 31:861-868. (Pubitemid 24015312)
9. Weber JA, van Zanten AP. Interferences in current methods for measurements of creatinine. Clin Chem 1991; 37:695-700. (Pubitemid 21892711)
10. Perrone RD, Madias NE, Levey AS. Serum creatinine as an index of renal function: New insights into old concepts. Clin Chem 1992; 38:1933-1953.
11. Carter AJ, Muller RE. Application and validation of an ion-exchange high-performance liquid chromatographic method for measuring adenine nucleotides, creatine and creatine phosphate in mouse brain. J Chromatogr 1990; 527:31-39. (Pubitemid 20148209)
12. Tran TC, Huq TA, Kantes HL, Crane JN, Strein TG. Determination of creatinine and other uremic toxins in human blood sera with micellar electrokinetic capillary electrophoresis. J Chromatogr B Biomed Sci Appl 1997; 690:35-42. (Pubitemid 27136453)
13. Madaras MB, Buck RP. Miniaturized biosensors employing electropolymerized permselective fi lms and their use for creatinine assays in human serum. Anal Chem 1996; 68:3832-3839.
14. Crim MC, Calloway DH, Margen S. Creatine metabolism in men: Creatine pool size and turnover in relation to creatine intake. J Nutr 1976; 106:371-381.
15. Herrera J, Rodriguez-Iturbe B. Stimulation of tubular secretion of creatinine in health and in conditions associated with reduced nephron mass. Evidence for a tubular functional reserve. Nephrol Dial Transplant 1998; 13:623-629. (Pubitemid 28119042)
16. Caregaro L, Menon F, Angeli P, Amodio P, Merkel C, Bortoluzzi A, et al. Limitations of serum creatinine level and creatinine clearance as fi ltration markers in cirrhosis. Arch Intern Med 1994; 154: 201-205. (Pubitemid 24032194)
17. Jones JD, Burnett PC. Creatinine metabolism and toxicity. Kidney Int 1975; 7 (Suppl.):S294-S298.
18. Jones JD, Burnett PC. Creatinine metabolism in humans with decreased renal function: Creatinine defi cit. Clin Chem 1974; 20:1204-1212.
19. Mitch WE, Collier VU, Walser M. Creatinine metabolism in chronic renal failure. Clin Sci 1980; 58:327-335. (Pubitemid 10058162)
20. Dunn SR, Gabuzda GM, Superdock KR, Kolecki RS, Schaedler RW, Simenhoff ML. Induction of creatininase activity in chronic renal failure: Timing of creatinine degradation and effect of antibiotics. Am J Kidney Dis 1997; 29:72-77. (Pubitemid 27020798)
21. Abitbol CL, Ingelfi nger JR. Nephron mass and cardiovascular and renal disease risks. Semin Nephrol 2009; 29:445-454.
22. Brenner BM, Mackenzie HS. Nephron mass as a risk factor for progression of renal disease. Kidney Int Suppl 1997; 63:S124-S127. (Pubitemid 28020450)
23. Vanholder R, De Smet R, Glorieux G, Argilé s A, Baurmeister U, Brunet P et al. European Uremic Toxin Work Group (EUTox). Review on uremic toxins: Classifi cation, concentration, and interindividual variability. Kidney Int 2003; 63:1934-1943.
24. Edwards A. Modeling transport in the kidney: Investigating function and dysfunction. Am J Physiol Renal Physiol 2010; 298:F475-484.
25. Waring WS, Jamie H, Leggett GE. Delayed onset of acute renal failure after signifi cant paracetamol overdose: A case series. Hum Exp Toxicol 2010; 29:63-8.
26. McMartin K.Are calcium oxalate crystals involved in the mechanism of acute renal failure in ethylene glycol poisoninĝClin Toxicol (Phila) 2009; 47:859-869.
27. Olgar S, Oktem F, Dindar A, Kilbas A, Turkoglu UD, Cetin H, et al. Volatile solvent abuse caused glomerulopathy and tubulopathy in street children. Hum Exp Toxicol 2008; 27:477-483.
28. Ali BH, Al-Moundhri M, Eldin MT, Nemmar A, Al-Siyabi S, Annamalai K. Amelioration of cisplatin-induced nephrotoxicity in rats by tetramethylpyrazine, a major constituent of the Chinese herb Ligusticum wallichi. Exp Biol Med 2008; 233:891-896.
29. Li J, Li QX, Xie XF, Ao Y, Tie CR, Song RJ. Differential roles of dihydropyridine calcium antagonist nifedipine, nitrendipine and amlodipine on gentamicin-induced renal tubular toxicity in rats. Eur J Pharmacol 2009; 620:97-104.
30. Xu Z, Yang J, Yu J, Yin Z, Sun W, Li J. Effects of BSO, GSH, Vit-C and DMPS on the nephrotoxicity of mercury. Toxicol Ind Health 2007; 23:403-410. (Pubitemid 351664868)
31. Ali BH, Al Moundhri MS, Tag Eldin M, Nemmar A, Tanira MO. The ameliorative effect of cysteine prodrug L-2-oxothiazolidine-4- carboxylic acid on cisplatin-induced nephrotoxicity in rats. Fundam Clin Pharmacol 2007; 21:547-553. (Pubitemid 47404322)
32. Oktem F, Ozguner F, Sulak O, Olgar S, Akturk O, Yilmaz HR, Altuntas I. Lithium-induced renal toxicity in rats: Protection by a novel antioxidant caffeic acid phenethyl ester. Mol Cell Biochem 2005; 277:109-115. (Pubitemid 41236192)
33. Engel LS, Taioli E, Pfeiffer R, Garcia-Closas M, Marcus PM, Lan Q, et al. Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: A HuGE review. Am J Epidemiol 2002; 156:95109.
34. Branten AJ, Mulder TP, Peters WH, Assmann KJ, Wetzels JF. Urinary excretion of glutathione S transferases alpha and pi in patients with proteinuria: Refl ection of the site of tubular injury. Nephron 2000; 85:120-6. (Pubitemid 30330534)
35. Ku ź niar J, Marchewka Z, Krasnowski R, Boratyn ́ ska M, D l ugosz A, Klinger M. Enzymuria and low molecular weight protein excretion as the differentiating marker of complications in the early post kidney transplantation period. Int Urol Nephrol 2006; 38:753-758. (Pubitemid 46336035)
36. Svendsen KB, Ellingsen T, Bech JN, Pfeiffer-Jensen M, Stengaard- Pedersen K, Pedersen EB. Urinary excretion of alpha-GST and albumin in rheumatoid arthritis patients treated with methotrexate or other DMARDs alone or in combination with NSAIDs. Scand J Rheumatol 2005; 34:34-39. (Pubitemid 40445056)
37. Brü ning T, Sundberg AG, Birner G, Lammert M, Bolt HM, Appelkvist EL, et al. Glutathione transferase alpha as a marker for tubular damage after trichloroethylene exposure. Arch Toxicol 1999; 73:246-254. (Pubitemid 29356688)
38. Brü ning T, Thier R, Mann H, Melzer H, Brö de P, Dallner G, Bolt HM. Pathological excretion patterns of urinary proteins in miners highly exposed to dinitrotoluene. J Occup Environ Med 2001; 43:610-615. (Pubitemid 32641229)
39. Racusen LC, Fivush BA, Li YL, Slatnik I, Solez K. Dissociation of tubular cell detachment and tubular cell death in clinical and experimental "acute tubular necrosis". Lab Invest 1991; 64:546-556.
40. Spasovski D, Masin-Spasovska J, Nada M, Calovski J, Sandevska E, Osmani B, Sotirova T, Balkanov S, Dukovski D, Ljatifi A, Spasovski G. Diagnostic value of brush border enzymes of the proximal renal tubules in rheumatoid arthritis. Clin Lab 2011; 57:305-314.
41. National Toxicology Program. Toxicology and carcinogenesis s tudies of tetralin (CAS No. 119-64-2) in F344/N rats and B6C3F1 mice (inhalation studies). Natl Toxicol Program Tech Rep Ser 2011; 561:1-198.
42. Santos C, Marcelino P, Carvalho T, Coelho J, Bispo M, Mourã o L, et al. The value of tubular enzymes for early detection of acute kidney injury after liver transplantation: An observational study. Transplant Proc 2010; 42:3639-3643.
43. Jenderny S, Lin H, Garrett T, Tew KD, Townsend DM. Protective effects of a glutathione disulfi de mimetic (NOV-002) against cisplatin induced kidney toxicity. Biomed Pharmacother 2010; 64:73-76.
44. Ogura T, Takaoka M, Yamauchi T, Oishi T, Mimura Y, Hashimoto M, et al. Changes in urinary enzyme activity and histochemical fi ndings in experimental tubular injury induced by gold sodium thiomalate J Med. 1996; 27:41-55. (Pubitemid 26269407)
45. Whiting PH, Brown PA. The relationship between enzymuria and kidney enzyme activities in experimental gentamicin nephrotoxicity. Ren Fail 1996; 18:899-909. (Pubitemid 26399128)
46. Naghibi B, Ghafghazi T, Hajhashemi V, Talebi A. Vancomycininduced nephrotoxicity in rats: Is enzyme elevation a consistent fi nding in tubular injury? J Nephrol 2007; 20:482-488. (Pubitemid 350081504)
47. Kocao ĝlu S, Karan A, Berkan T, Bas ̧ demir G. Acute acetaminophen nephrotoxicity and urinary gamma-glutamyl transferase activity in rats. Drug Metabol Drug Interact 1997; 14:47-54. (Pubitemid 28032031)
48. Miti ć -Zlatkovi ć M, Stefanovi ć V. Acute effects of acetaminophen on renal function and urinary excretion of some proteins and enzymes in patients with kidney disease. Ren Fail. 1999; 21:525-32. (Pubitemid 29459951)
49. Alata ş O, Sahin A, Colak O, Inal M, K ö ken T, Ya ş ar B, Karah ü seyinoglu E. Benefi cial effects of allopurinol on glutathione levels and glutathione peroxidase activity in rat ischaemic acute renal failure. J Int Med Res 1996; 24:33-39.
50. Cowland JB, Borregaard N: Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans. Genomics 1997; 45:17-23. (Pubitemid 27449379)
51. Xu SY, Pauksen K, Venge P. Serum measurements of human neutrophil lipocalin (HNL) discriminate between acute bacterial and viral infections. Scand J Clin Lab Invest 1995; 55:125-131.
52. Schmidt-Ott KM, Mori K, Kalandadze A, Li JY, Paragas N, Nicholas T, et al. Neutrophil gelatinase-associated lipocalin-mediated iron traffi c in kidney epithelia. Curr Opin Nephrol Hypertens 2006; 15:442-449. (Pubitemid 44297988)
53. Hewitt SM, Dear J, Star RA: Discovery of protein biomarkers for renal diseases. J Am Soc Nephrol 2004; 15:1677-1689. (Pubitemid 38822046)
54. Srisawat N, Murugan R, Lee M, Kong L, Carter M, Angus DC, Kellum JA. Plasma neutrophil gelatinase-associated lipocalin predicts recovery from acute kidney injury following community-acquired pneumonia. Kidney Int 2011 Jun 15. doi: 10.1038/ki.2011.160. [Epub ahead of print]
55. Damman K, Masson S, Hillege HL, Maggioni AP, Voors AA, Opasich C, et al. Clinical outcome of renal tubular damage in chronic heart failure. Eur Heart J 2011 Jun 11. [Epub ahead of print]
56. Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 2005; 365:1231-1238. (Pubitemid 40469655)
57. Wagener G, Jan M, Kim M, Mori K, Barasch JM, Sladen RN, Lee HT: Association between increases in urinary neutrophil gelatinaseassociated lipocalin and acute renal dysfunction after adult cardiac surgery. Anesthesiology 2006; 105:485-491. (Pubitemid 44310430)
58. Siew ED, Ware LB, Gebretsadik T, Shintani A, Moons KG, Wickersham N, et al. Urine neutrophil gelatinase-associated lipocalin moderately predicts acute kidney injury in critically ill adults. J Am Soc Nephrol 2009; 20:1823-1846.
59. Roberts DM, Wilks MF, Roberts MS, Swaminathan R, Mohamed F, Dawson AH, Buckley NA. Changes in the concentrations of creatinine, cystatin C and NGAL in patients with acute paraquat selfpoisoning. Toxicol Lett 2011; 202:69-74.
60. Delanaye P, Rozet E, Krzesinski JM, Cavalier E. Urinary NGAL measurement: Biological variation and ratio to creatinine. Clin Chim Acta 2011; 412:390.
61. Bagshaw SM, Bennett M, Haase M, Haase-Fielitz A, Egi M, Morimatsu H, et al. Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness. Intensive Care Med 2010; 36:452-461.
62. Nickolas TL, O'Rourke MJ, Yang J, Sise ME, Canetta PA, Barasch N, et al. Sensitivity and specifi city of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann Intern Med 2008; 148:810-819. (Pubitemid 351786928)
63. de Boer IH, Katz R, Cao JJ, Fried LF, Kestenbaum B, Mukamal K, et al. Cystatin C, albuminuria, and mortality among older adults with diabetes. Diabetes Care 2009; 32:1833-1838.
64. Delanaye P, Cavalier E, Radermecker RP, Paquot N, Depas G, Chapelle JP, et al. Cystatin C or creatinine for detection of stage 3 chronic kidney disease in anorexia nervosa. Nephron Clin Pract 2008; 110: C158-c163
65. Beringer PM, Hidayat L, Heed A, Zheng L, Owens H, Benitez D, Rao AP. GFR estimates using cystatin C are superior to serum creatinine in adult patients with cystic fi brosis. J Cyst Fibros 2009; 8:19-25.
66. Halacova M, Kotaska K, Kukacka J, Vavrova V, Kuzelova M, Ticha J, Prusa R. Serum cystatin C level for better assessment of glomerular fi ltration rate in cystic fi brosis patients treated by amikacin. J Clin Pharm Ther 2008; 33:409-417.
67. Herget-Rosenthal S, Poppen D, H ü sing J, Marggraf G, Pietruck F, Jakob HG, et al. Prognostic value of tubular proteinuria and enzymuria in nonoliguric acute tubular necrosis. Clin Chem 2004; 50:552-558. (Pubitemid 38297305)
68. Kim DJ, Kang HS, Choi HS, Cho HJ, Kim ES, Keum B, et al. Serum cystatin C level is a useful marker for the evaluation of renal function in patients with cirrhotic ascites and normal serum creatinine levels. Korean J Hepatol 2011; 17:130-138.
69. Mårtensson J, Martling CR, Oldner A, Bell M. Impact of sepsis on levels of plasma cystatin C in AKI and non-AKI patients. Nephrol Dial Transplant 2011 Jul 17. [Epub ahead of print]
70. Park JS, Pasupulati R, Feldkamp T, Roeser NF, Weinberg JM. Cyclophilin D and the mitochondrial permeability transition in kidney proximal tubules after hypoxic and ischemic injury. Am J Physiol Renal Physiol 2011; 301:F134-F150.
71. Waring WS, Stephen AF, Robinson OD, Dow MA, Pettie JM. Serum urea concentration and the risk of hepatotoxicity after paracetamol overdose. QJM 2008; 101:359-363. (Pubitemid 351619243)
72. Waring WS, Stephen AF, Malkowska AM, Robinson OD. Acute acetaminophen overdose is associated with dose-dependent hypokalaemia: A prospective study of 331 patients. Basic Clin Pharmacol Toxicol 2008; 102:325-328. (Pubitemid 351287566)
73. Nicolai MPJ, Catterson JH, Huizinga T, Dhaliwal K, Constant SL, Bateman DN, et al. Cyclophilin is a mediator of paracetamol-induced liver injury. Basic Clin Pharmacol Toxicol 2009; 105 (Suppl. 1):36.
74. Benhalim S, Leggett GE, Jamie H, Waring WS. Proteinuria is unrelated to the extent of acute acetaminophen overdose: A prospective clinical study. J Med Toxicol 2008; 4:232-237.
75. Pakravan N, Simpson KJ, Waring WS, Bates CM, Bateman DN. Renal injury at fi rst presentation as a predictor for poor outcome in severe paracetamol poisoning referred to a liver transplant unit. Eur J Clin Pharmacol 2009; 65:163-168.
76. Bonventre J. Kidney injury molecule 1: A urinary biomarker and much more. Neph Dial Trans 2009; 24:3265-3268.
77. Huang Y, Don-Wauchope AC. The clinical utility of kidney injury molecule 1 in the prediction, diagnosis and prognosis of acute kidney injury: A systematic review. Infl amm Allergy Drug Targets 2011; 10:260-271.
78. Han WK, Bailly V, Abichandani R, Thadhani R, Bonventre JV. Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury. Kidney Int 2002; 62:237-244. (Pubitemid 34754067)
79. Zhou Y, Vaidya VS, Brown RP, Zhang J, Rosenzweig BA, Thompson KL, et al. Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. Toxicol Sci 2008; 101:159-170. (Pubitemid 350239020)
80. Orozco-Ibarra M, Medina-Campos ON, S á nchez-Gonz á lez DJ, Mart í nez-Mart í nez CM, Floriano-S á nchez E, Santamar í a A, et al. Evaluation of oxidative stress in D-serine induced nephrotoxicity. Toxicology 2007; 229:123-135. (Pubitemid 44911082)
81. Zhang PL, Rothblum LI, Han WK, Blasick TM, Potdar S, Bonventre JV. Kidney injury molecule-1 expression in transplant biopsies is a sensitive measure of cell injury. Kidney Int 2008; 73:608-614. (Pubitemid 351264105)
82. Han WK, Alinani A, Wu CL, Michaelson D, Loda M, McGovern FJ, et al. Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma. J Am Soc Nephrol 2005; 16:1126-1134. (Pubitemid 41710324)
83. Vaidya VS, Ford GM, Waikar SS, Wang Y, Clement MB, Ramirez V, et al. A rapid urine test for early detection of kidney injury. Kidney Int 2009; 76:108-114.
84. Kwon O, Molitoris BA, Pescovitz M, Kelly KJ. Urinary actin, interleukin-6, and interleukin-8 may predict sustained ARF after ischemic injury in renal allografts. Am J Kidney Dis 2003; 41:1074-1087. (Pubitemid 36532143)
85. Metzger J, Kirsch T, Schiffer E, Ulger P, Mentes E, Brand K, et al. Urinary excretion of twenty peptides forms an early and accurate diagnostic pattern of acute kidney injury. Kidney Int 2010; 78:1252-1262.
86. Erdem N, Kanbak M, Saricaoglu F, Ocal T, Tanyel C, Ertas ̧ N, et al. Extrahepatic metabolism and renal effects of sevofl urane in a case of liver transplantation. Transplant Proc 2006; 38:1463-1466.
87. Trof RJ, Di Maggio F, Leemreis J, Groeneveld AB. Biomarkers of acute renal injury and renal failure. Shock 2006; 26:245-53.