Significance of urinary full-length and ectodomain forms of megalin in patients with type 2 diabetes

Diabetes Care

Volumn 35, Issue 5, 2012, Pages 1112-1118

  Ogasawara, Shinya ^a,b   Hosojima, Michihiro ^a   Kaseda, Ryohei ^a   Kabasawa, Hideyuki ^a   Yamamoto Kabasawa, Keiko ^a   Kurosawa, Hiroyuki ^b   Sato, Hiroyoshi ^a   Iino, Noriaki ^a   Takeda, Tetsuro ^a   Suzuki, Yoshiki ^c   Narita, Ichiei ^a   Yamagata, Kunihiro ^d   Tomino, Yasuhiko ^e   Gejyo, Fumitake ^a   Hirayama, Yoshiaki ^b   Sekine, Sakari ^b   Saito, Akihiko ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b DENKA COMPANY LIMITED   (Japan)

^c NIIGATA UNIVERSITY   (Japan)

^d UNIVERSITY OF TSUKUBA   (Japan)

^e JUNTENDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

A MEGALIN; ALBUMIN; ANTIANEMIC AGENT; BIOLOGICAL MARKER; C MEGALIN; HEMOGLOBIN; MEGALIN; MONOCLONAL ANTIBODY; PHOSPHATE; PHOSPHATE BINDING AGENT; PROTEIN HYDROLYSATE; UNCLASSIFIED DRUG; VITAMIN D DERIVATIVE;

ADULT; AGED; ALBUMIN BLOOD LEVEL; ALBUMINURIA; ARTICLE; BLEEDING; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENZYME IMMUNOASSAY; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; PHOSPHATE BLOOD LEVEL; URINARY EXCRETION; URINE LEVEL;

ADULT; AGED; DIABETES MELLITUS, TYPE 2; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-2; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 84862058062     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc11-1684     Document Type: Article

References (40)

1. Schiffrin EL, Lipman ML, Mann JF. Chronic kidney disease: effects on the cardiovascular system. Circulation 2007;116:85-97 (Pubitemid 47016250)
2. Levey AS, Cattran D, Friedman A, et al. Proteinuria as a surrogate outcome in CKD: report of a scientific workshop sponsored by the National Kidney Foundation and the US Food and Drug Administration. Am J Kidney Dis 2009;54:205-226
3. Thomson SC, Vallon V, Blantz RC. Kidney function in early diabetes: the tubular hypothesis of glomerular filtration. Am J Physiol Renal Physiol 2004;286:F8-F15 (Pubitemid 38045037)
4. Singh DK, Winocour P, Farrington K. Mechanisms of disease: the hypoxic tubular hypothesis of diabetic nephropathy. Nat Clin Pract Nephrol 2008;4:216-226 (Pubitemid 351451302)
5. Nangaku M. Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J Am Soc Nephrol 2006;17:17-25
6. Saito A, Kaseda R, Hosojima M, Sato H. Proximal tubule cell hypothesis for cardiorenal syndrome in diabetes. Int J Nephrol 2010;2011:957164
7. Saito A, Pietromonaco S, Loo AK, Farquhar MG. Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the lowdensity lipoprotein receptor gene family. Proc Natl Acad Sci U S A 1994;91:9725-9729
8. Hjälm G, Murray E, Crumley G, et al. Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties. Eur J Biochem 1996;239:132-137 (Pubitemid 26228150)
9. Saito A, Sato H, Iino N, Takeda T. Molecular mechanisms of receptor-mediated endocytosis in the renal proximal tubular epithelium. J Biomed Biotechnol 2010;2010:403272
10. Zou Z, Chung B, Nguyen T, Mentone S, Thomson B, Biemesderfer D. Linking receptor-mediated endocytosis and cell signaling: evidence for regulated intramembrane proteolysis of megalin in proximal tubule. J BiolChem 2004;279:34302-34310 (Pubitemid 39318054)
11. Biemesderfer D. Regulated intramembrane proteolysis of megalin: linking urinary protein and gene regulation in proximal tubule? Kidney Int 2006;69:1717-1721 (Pubitemid 43739196)
12. Tojo A, Onozato ML, Ha H, et al. Reduced albumin reabsorption in the proximal tubule of early-stage diabetic rats. Histochem Cell Biol 2001;116:269-276 (Pubitemid 32930140)
13. Russo LM, del Re E, Brown D, Lin HY. Evidence for a role of transforming growth factor (TGF)-beta1 in the induction of postglomerular albuminuria in diabetic nephropathy:amelioration by soluble TGFbeta type II receptor. Diabetes 2007;56:380-388
14. Pontuch P, Jensen T, Deckert T, Ondrejka P, Mikulecky M. Urinary excretion of retinol-binding protein in type 1 (insulin-dependent) diabetic patients with microalbuminuria and clinical diabetic nephropathy. Acta Diabetol 1992;28:206-210
15. Ishibashi F. Microalbuminuria in NIDDM is caused by increased excretion of unmodified albumin. Diabetes 1996;45:731-735 (Pubitemid 26166767)
16. Hong CY, Hughes K, Chia KS, Ng V, Ling SL. Urinary alpha1-microglobulin as a marker of nephropathy in type 2 diabetic Asian subjects in Singapore. Diabetes Care 2003;26:338-342 (Pubitemid 36929052)
17. Norden AG, Lapsley M, Igarashi T, et al. Urinary megalin deficiency implicates abnormal tubular endocytic function in Fanconi syndrome. J Am Soc Nephrol 2002;13:125-133 (Pubitemid 34042019)
18. Thrailkill KM, Nimmo T, Bunn RC, et al. Microalbuminuria in type 1 diabetes is associated with enhanced excretion of the endocytic multiligand receptors megalin and cubilin. Diabetes Care 2009;32:1266-1268
19. Tsutsumi H, Flanagan TD, Ogra PL. Monoclonal antibodies to the large glycoproteins of respiratory syncytial virus: possible evidence for several functional antigenic sites. J Gen Virol 1987;68:2161-2167
20. Tanuma A, Sato H, Takeda T, et al. Functional characterization of a novel missense CLCN5 mutation causing alterations in proximal tubular endocytic machinery in Dent's disease. Nephron Physiol 2007;107:87-97
21. Ishikawa E, Imagawa M, Hashida S, Yoshitake S, Hamaguchi Y, Ueno T. Enzyme-labeling of antibodies and their fragments for enzyme immunoassay and immunohistochemical staining. J Immunoassay 1983;4:209-327 (Pubitemid 13016332)
22. Matsushita K, van der Velde M, Astor BC, et al.; Chronic Kidney Disease Prognosis Consortium. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet 2010;375:2073-2081
23. Pisitkun T, Shen RF, Knepper MA. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci U S A 2004;101:13368-13373 (Pubitemid 39209672)
24. Simpson RJ, Jensen SS, Lim JW. Proteomic profiling of exosomes: current perspectives. Proteomics 2008;8:4083-4099
25. Matsuo S, Imai E, Horio M, et al.; Collaborators developing the Japanese equation for estimated GFR. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis 2009;53:982-992
26. Wang Y, Roche O, Yan MS, et al. Regulation of endocytosis via the oxygen-sensing pathway. Nat Med 2009;15:319-324
27. Brown MS, Ye J, Rawson RB, Goldstein JL. Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell 2000;100:391-398
28. Louvi A, Artavanis-Tsakonas S. Notch signalling in vertebrate neural development. Nat Rev Neurosci 2006;7:93-102 (Pubitemid 43151596)
29. Li Y, Cong R, Biemesderfer D. The COOH terminus of megalin regulates gene expression in opossum kidney proximal tubule cells. Am J Physiol Cell Physiol 2008;295:C529-C537 (Pubitemid 352755778)
30. Leheste JR, Rolinski B, Vorum H, et al. Megalin knockoutmice as an animalmodel of low molecular weight proteinuria. Am J Pathol 1999;155:1361-1370 (Pubitemid 29488943)
31. Saito A, Kazama JJ, Iino N, et al. Bio-engineered implantation of megalin-expressing cells: a potential intracorporeal therapeutic model for uremic toxin protein clearance in renal failure. J Am Soc Nephrol 2003;14:2025-2032 (Pubitemid 36909910)
32. Kramer HJ, Nguyen QD, Curhan G, Hsu CY. Renal insufficiency in the absence of albuminuria and retinopathy among adults with type 2 diabetesmellitus. JAMA 2003;289:3273-3277 (Pubitemid 37430080)
33. MacIsaac RJ, Tsalamandris C, Panagiotopoulos S, Smith TJ, McNeil KJ, Jerums G. Nonalbuminuric renal insufficiency in type 2 diabetes. Diabetes Care 2004;27:195-200 (Pubitemid 38196732)
34. MacIsaac RJ, Panagiotopoulos S, McNeil KJ, et al. Is nonalbuminuric renal insufficiency in type 2 diabetes related to an increase in intrarenal vascular disease? Diabetes Care 2006;29:1560-1566 (Pubitemid 44127581)
35. Yokoyama H, Sone H, Oishi M, Kawai K, Fukumoto Y, Kobayashi M; Japan Diabetes Clinical Data Management Study Group. Prevalence of albuminuria and renal insufficiency and associated clinical factors in type 2 diabetes: the Japan Diabetes Clinical Data Management study (JDDM15). Nephrol Dial Transplant 2009;24:1212-1219
36. Palazzuoli A, Gallotta M, Iovine F, Nuti R, Silverberg DS. Anaemia in heart failure: a common interaction with renal insufficiency called the cardio-renal anaemia syndrome. Int J Clin Pract 2008;62:281-286
37. Shanks JH, Hill CM, Lappin TR, Maxwell AP. Localization of erythropoietin gene expression in proximal renal tubular cells detected by digoxigenin-labelled oligonucleotide probes. J Pathol 1996;179:283-287 (Pubitemid 26266407)
38. Horiguchi H, Oguma E, Kayama F. Cadmium and cisplatin damage erythropoietin- producing proximal renal tubular cells. Arch Toxicol 2006;80:680-686 (Pubitemid 44394528)
39. Kestenbaum B, Sampson JN, Rudser KD, et al. Serum phosphate levels and mortality risk among people with chronic kidney disease. J Am Soc Nephrol 2005;16:520-528 (Pubitemid 41725150)
40. Bachmann S, Schlichting U, Geist B, et al. Kidney-specific inactivation of the megalin gene impairs trafficking of renal inorganic sodium phosphate cotransporter (NaPi-IIa). J Am Soc Nephrol 2004;15:892-900 (Pubitemid 38375308)