Role of active site residues in promoting cobalt-carbon bond Homolysis in adenosylcobalamin-dependent Mutases revealed through experiment and computation

Biochemistry

Volumn 53, Issue 1, 2014, Pages 169-177

  Román Meléndez, Gabriel D ^a   Von Glehn, Patrick ^b   Harvey, Jeremy N ^b   Mulholland, Adrian J ^b   Marsh, E Neil G ^a,c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE RESIDUES; ADENOSYLCOBALAMIN; COBALT-CARBON BOND; COMPUTATIONAL APPROACH; MOLECULAR DYNAMICS SIMULATIONS; MOLECULAR-LEVEL INSIGHTS; ORDERS OF MAGNITUDE; WILD-TYPE ENZYMES;

AMINO ACIDS; CARBON; COBALT COMPOUNDS; HYDROGEN BONDS; MOLECULAR DYNAMICS; PROTEINS; SUBSTRATES; TRITIUM;

ENZYMES;

CARBON; COBALT; COBAMAMIDE; GLUTAMIC ACID; HYDROGEN; LYSINE; MUTASE; TRITIUM;

ARTICLE; CHEMICAL BOND; COENZYME; COMPUTER MODEL; DISSOCIATION; ENZYME ACTIVE SITE; ENZYME MECHANISM; GENE MUTATION; HYDROGEN BOND; MOLECULAR DYNAMICS; MUTANT; PRIORITY JOURNAL; ROLE PLAYING; SIMULATION; STATIC ELECTRICITY; WILD TYPE;

COBALT; COBAMIDES; GLUTAMIC ACID; HYDROGEN BONDING; INTRAMOLECULAR TRANSFERASES; LYSINE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION;

EID: 84892572697     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi4012644     Document Type: Article

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