Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase

Journal of Biological Chemistry

Volumn 285, Issue 18, 2010, Pages 13942-13950

  Wolthers, Kirsten R ^a   Levy, Colin ^a   Scrutton, Nigel S ^a   Leys, David ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSYLCOBALAMIN; AEROBIC CONDITION; ASYMMETRIC UNIT; CO-C BOND; COFACTORS; DOMAIN DYNAMICS; DOMAIN MOTIONS; DOMAIN MOVEMENT; OPEN CONFORMATION; ROSSMANN; SUBSTRATE BINDING; SUBSTRATE-FREE; TRIOSEPHOSPHATE ISOMERASE BARRELS;

CATALYSIS; CRYSTAL STRUCTURE; CRYSTALS; DATA FLOW ANALYSIS; ENZYMES; OXYGEN;

COBALT;

COBAMAMIDE; HETERODIMER; ORNITHINE 4,5 AMINOMUTASE; UNCLASSIFIED DRUG;

ARTICLE; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM STICKLANDII; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME MECHANISM; LIGAND BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; THERMOANAEROBACTER;

BACTERIAL PROTEINS; CATALYSIS; CLOSTRIDIUM STICKLANDII; COBAMIDES; COENZYMES; CRYSTALLOGRAPHY, X-RAY; FREE RADICALS; INTRAMOLECULAR TRANSFERASES; ORNITHINE; PROTEIN STRUCTURE, TERTIARY; PYRIDOXAL PHOSPHATE; STRUCTURE-ACTIVITY RELATIONSHIP;

CLOSTRIDIUM STICKLANDII;

EID: 77951581676     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.068908     Document Type: Article

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