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Volumn 561, Issue , 2014, Pages 146-150

Reduction of Liver X Receptor β expression in primary rat neurons by antisense oligodeoxynucleotides decreases secreted amyloid β levels

Author keywords

Alzheimer's disease; Amyloid ; ATP binding cassette transporter; Cholesterol; Liver X Receptor

Indexed keywords

ABC TRANSPORTER A1; ADAM10 ENDOPEPTIDASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTISENSE OLIGODEOXYNUCLEOTIDE; BETA SECRETASE 1; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIVER X RECEPTOR BETA; MESSENGER RNA;

EID: 84892490841     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.12.055     Document Type: Article
Times cited : (6)

References (27)
  • 1
    • 75149136696 scopus 로고    scopus 로고
    • Alzheimer's disease and the amyloid-beta peptide
    • (PubMed: 20061647)
    • Murphy M.P., LeVine H. Alzheimer's disease and the amyloid-beta peptide. J. Alzheimers Dis. 2010, 19:311-323. (PubMed: 20061647).
    • (2010) J. Alzheimers Dis. , vol.19 , pp. 311-323
    • Murphy, M.P.1    LeVine, H.2
  • 2
    • 77953280950 scopus 로고    scopus 로고
    • Membrane rafts in Alzheimer's disease beta-amyloid production
    • (PubMed: 20303415)
    • Vetrivel K.S., Thinakaran G. Membrane rafts in Alzheimer's disease beta-amyloid production. Biochim. Biophys. Acta 2010, 1801:860-867. (PubMed: 20303415).
    • (2010) Biochim. Biophys. Acta , vol.1801 , pp. 860-867
    • Vetrivel, K.S.1    Thinakaran, G.2
  • 4
    • 79955051063 scopus 로고    scopus 로고
    • Linking lipids to Alzheimer's disease: cholesterol and beyond
    • (PubMed: 21448224)
    • Di Paolo G., Kim T.W. Linking lipids to Alzheimer's disease: cholesterol and beyond. Nat. Rev. Neurosci. 2012, 12:284-296. (PubMed: 21448224).
    • (2012) Nat. Rev. Neurosci. , vol.12 , pp. 284-296
    • Di Paolo, G.1    Kim, T.W.2
  • 5
    • 84862687669 scopus 로고    scopus 로고
    • Liver X receptor biology and pharmacology: new pathways, challenges and opportunities
    • (PubMed: 22541735)
    • Jakobsson T., Treuter E., Gustafsson J.Å., Steffensen K.R. Liver X receptor biology and pharmacology: new pathways, challenges and opportunities. Trends Pharmacol. Sci. 2012, 33:394-404. (PubMed: 22541735).
    • (2012) Trends Pharmacol. Sci. , vol.33 , pp. 394-404
    • Jakobsson, T.1    Treuter, E.2    Gustafsson, J.Å.3    Steffensen, K.R.4
  • 6
    • 33746287715 scopus 로고    scopus 로고
    • Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1
    • (PubMed: 16798073)
    • Cavelier C., Lorenzi I., Rohrer L., von Eckardstein A. Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1. Biochim. Biophys. Acta 2006, 1761:655-666. (PubMed: 16798073).
    • (2006) Biochim. Biophys. Acta , vol.1761 , pp. 655-666
    • Cavelier, C.1    Lorenzi, I.2    Rohrer, L.3    von Eckardstein, A.4
  • 10
    • 80555155558 scopus 로고    scopus 로고
    • Activation of liver X receptor decreases BACE1 expression and activity by reducing membrane cholesterol levels
    • (PubMed: 21630010)
    • Cui W., Sun Y., Wang Z., Xu C., Xu L., Wang F., Chen Z., Peng Y., Li R. Activation of liver X receptor decreases BACE1 expression and activity by reducing membrane cholesterol levels. Neurochem. Res. 2011, 36:1910-1921. (PubMed: 21630010).
    • (2011) Neurochem. Res. , vol.36 , pp. 1910-1921
    • Cui, W.1    Sun, Y.2    Wang, Z.3    Xu, C.4    Xu, L.5    Wang, F.6    Chen, Z.7    Peng, Y.8    Li, R.9
  • 11
    • 0042346382 scopus 로고    scopus 로고
    • Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion
    • (PubMed: 12754201)
    • Sun Y., Yao J., Kim T.W., Tall A.R. Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion. J. Biol. Chem. 2003, 278:27688-27694. (PubMed: 12754201).
    • (2003) J. Biol. Chem. , vol.278 , pp. 27688-27694
    • Sun, Y.1    Yao, J.2    Kim, T.W.3    Tall, A.R.4
  • 12
    • 76649100139 scopus 로고    scopus 로고
    • Liver X receptor in cholesterol metabolism
    • (PubMed: 19837721)
    • Zhao C., Dahlman-Wright K. Liver X receptor in cholesterol metabolism. J. Endocrinol. 2010, 204:233-240. (PubMed: 19837721).
    • (2010) J. Endocrinol. , vol.204 , pp. 233-240
    • Zhao, C.1    Dahlman-Wright, K.2
  • 13
    • 14844359386 scopus 로고    scopus 로고
    • Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice
    • (PubMed: 15738425)
    • Andersson S., Gustafsson N., Warner M., Gustafsson J.A. Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:3857-3862. (PubMed: 15738425).
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 3857-3862
    • Andersson, S.1    Gustafsson, N.2    Warner, M.3    Gustafsson, J.A.4
  • 15
    • 33744901183 scopus 로고    scopus 로고
    • Strategies for examination of Alzheimer's disease amyloid precursor protein isoforms
    • (PubMed: 16741768)
    • Newton J.R., Parkinson D., Clench M.R. Strategies for examination of Alzheimer's disease amyloid precursor protein isoforms. Anal. Bioanal. Chem. 2006, 385:692-699. (PubMed: 16741768).
    • (2006) Anal. Bioanal. Chem. , vol.385 , pp. 692-699
    • Newton, J.R.1    Parkinson, D.2    Clench, M.R.3
  • 16
    • 79960459422 scopus 로고    scopus 로고
    • Cholesterol metabolism in neurons and astrocytes
    • (PubMed: 21741992)
    • Pfrieger F.W., Ungerer N. Cholesterol metabolism in neurons and astrocytes. Prog. Lipid Res. 2011, 50:357-371. (PubMed: 21741992).
    • (2011) Prog. Lipid Res. , vol.50 , pp. 357-371
    • Pfrieger, F.W.1    Ungerer, N.2
  • 17
    • 34547582862 scopus 로고    scopus 로고
    • Regulation of central nervous system cholesterol homeostasis by the liver X receptor agonist TO-901317
    • (PubMed: 17662526)
    • Eckert G.P., Vardanian L., Rebeck G.W., Burns M.P. Regulation of central nervous system cholesterol homeostasis by the liver X receptor agonist TO-901317. Neurosci. Lett. 2007, 423:47-52. (PubMed: 17662526).
    • (2007) Neurosci. Lett. , vol.423 , pp. 47-52
    • Eckert, G.P.1    Vardanian, L.2    Rebeck, G.W.3    Burns, M.P.4
  • 19
    • 79956311751 scopus 로고    scopus 로고
    • Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis
    • (PubMed: 21562267)
    • Terwel D., Steffensen K.R., Verghese P.B., Kummer M.P., Gustafsson J.Å, Holtzman D.M., Heneka M.T. Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis. J. Neurosci. 2011, 31:7049-7059. (PubMed: 21562267).
    • (2011) J. Neurosci. , vol.31 , pp. 7049-7059
    • Terwel, D.1    Steffensen, K.R.2    Verghese, P.B.3    Kummer, M.P.4    Gustafsson J.Å5    Holtzman, D.M.6    Heneka, M.T.7
  • 20
    • 81855168382 scopus 로고    scopus 로고
    • Processing of endogenous AβPP in blood-brain barrier endothelial cells is modulated by liver-X receptor agonists and altered cellular cholesterol homeostasis
    • (PubMed: 21811018)
    • Schweinzer C., Kober A., Lang I., Etschmaier K., Scholler M., Kresse A., Sattler W., Panzenboeck U. Processing of endogenous AβPP in blood-brain barrier endothelial cells is modulated by liver-X receptor agonists and altered cellular cholesterol homeostasis. J. Alzheimers Dis. 2011, 27:341-360. (PubMed: 21811018).
    • (2011) J. Alzheimers Dis. , vol.27 , pp. 341-360
    • Schweinzer, C.1    Kober, A.2    Lang, I.3    Etschmaier, K.4    Scholler, M.5    Kresse, A.6    Sattler, W.7    Panzenboeck, U.8
  • 21
    • 0011176887 scopus 로고    scopus 로고
    • A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene
    • (PubMed: 8647822)
    • Vallett S.M., Sanchez H.B., Rosenfeld J.M., Osborne T.F. A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene. J. Biol. Chem. 1996, 271:12247-12253. (PubMed: 8647822).
    • (1996) J. Biol. Chem. , vol.271 , pp. 12247-12253
    • Vallett, S.M.1    Sanchez, H.B.2    Rosenfeld, J.M.3    Osborne, T.F.4
  • 22
    • 67650751079 scopus 로고    scopus 로고
    • Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain
    • (PubMed: 19489738)
    • Russell D.W., Halford R.W., Ramirez D.M., Shah R., Kotti T. Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain. Annu. Rev. Biochem. 2009, 78:1017-1040. (PubMed: 19489738).
    • (2009) Annu. Rev. Biochem. , vol.78 , pp. 1017-1040
    • Russell, D.W.1    Halford, R.W.2    Ramirez, D.M.3    Shah, R.4    Kotti, T.5
  • 23
    • 0038265008 scopus 로고    scopus 로고
    • Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover
    • (PubMed: 12686551)
    • Lund E.G., Xie C., Kotti T., Turley S.D., Dietschy J.M., Russell D.W. Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. J. Biol. Chem. 2003, 278:22980-22988. (PubMed: 12686551).
    • (2003) J. Biol. Chem. , vol.278 , pp. 22980-22988
    • Lund, E.G.1    Xie, C.2    Kotti, T.3    Turley, S.D.4    Dietschy, J.M.5    Russell, D.W.6
  • 24
    • 0027376081 scopus 로고
    • Age-related change in the proportion of amyloid precursor protein mRNAs in the gray matter of cerebral cortex
    • (PubMed: 8295726)
    • Tanaka S., Nakamura S., Kimura J., Ueda K. Age-related change in the proportion of amyloid precursor protein mRNAs in the gray matter of cerebral cortex. Neurosci. Lett. 1993, 163:19-21. (PubMed: 8295726).
    • (1993) Neurosci. Lett. , vol.163 , pp. 19-21
    • Tanaka, S.1    Nakamura, S.2    Kimura, J.3    Ueda, K.4
  • 27
    • 63449094785 scopus 로고    scopus 로고
    • Amyloid beta mediates memory formation
    • (PubMed: 19318468)
    • Garcia-Osta A., Alberini C.M. Amyloid beta mediates memory formation. Learn. Mem. 2009, 16:267-272. (PubMed: 19318468).
    • (2009) Learn. Mem. , vol.16 , pp. 267-272
    • Garcia-Osta, A.1    Alberini, C.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.