Activation of liver x receptor decreases BACE1 expression and activity by reducing membrane cholesterol levels

Neurochemical Research

Volumn 36, Issue 10, 2011, Pages 1910-1921

  Cui, Weigang ^a   Sun, Yan ^a   Wang, Zhongping ^b   Xu, Chongchong ^a   Xu, Li ^a   Wang, Fei ^a   Chen, Zulin ^c   Peng, Yuwen ^a   Li, Ruixi ^a  

^a FUDAN UNIVERSITY   (China)

^b JIUJIANG UNIVERSITY   (China)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; BACE1; Beta amyloid; Liver X receptor; Membrane cholesterol

Indexed keywords

ABC TRANSPORTER A1; BETA SECRETASE; BETA SECRETASE 1; CHOLESTEROL; LIVER X RECEPTOR; MESSENGER RNA; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; IN VIVO STUDY; LIPID TRANSPORT; MOUSE; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; APOLIPOPROTEINS E; ASPARTIC ACID ENDOPEPTIDASES; ATP-BINDING CASSETTE TRANSPORTERS; CELL MEMBRANE; CELLS, CULTURED; CHOLESTEROL; GENE EXPRESSION; HIPPOCAMPUS; HUMANS; HYDROCARBONS, FLUORINATED; MICE; MICE, TRANSGENIC; NEURONS; OLIGOPEPTIDES; ORPHAN NUCLEAR RECEPTORS; PEPTIDE FRAGMENTS; PRESENILIN-1; SULFONAMIDES;

EID: 80555155558     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-011-0513-3     Document Type: Article

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