Thyroid hormones, mitochondrial bioenergetics and lipid handling

Current Opinion in Endocrinology, Diabetes and Obesity

Volumn 17, Issue 5, 2010, Pages 402-407

  Cioffi, Federica ^a   Lanni, Antonia ^a   Goglia, Fernando ^b  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF SANNIO   (Italy)

Author keywords

dyslipidaemias; mitochondria; thyroid hormone; uncoupling protein

Indexed keywords

DIIODOTHYRONINE; LIOTHYRONINE; THYROID HORMONE; THYROXINE; UNCOUPLING PROTEIN 3;

ATHEROSCLEROSIS; BIOENERGY; CARDIOVASCULAR DISEASE; DYSLIPIDEMIA; ELECTRON TRANSPORT; ENERGY METABOLISM; FATTY LIVER; HUMAN; LIPID METABOLISM; MITOCHONDRION; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; REVIEW; THERMOGENESIS;

ACETIC ACIDS; ADIPOSITY; ANILIDES; ANIMALS; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASES; CLINICAL TRIALS AS TOPIC; DIIODOTHYRONINES; DYSLIPIDEMIAS; ENERGY METABOLISM; FATTY LIVER; HUMANS; LIPID METABOLISM; MICE; MITOCHONDRIA; OBESITY; PHENOLS; RATS; THYROID HORMONES;

EID: 77956265941     PISSN: 1752296X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MED.0b013e32833cf354     Document Type: Review

References (35)

1. Cheng SY. Multiple mechanisms for regulation of the transcriptional activity of thyroid hormone receptors. Rev Endocr Metab Disord 2000; 1:9-18.
2. Cheng SY, Leonard JL, Davis PJ. Molecular aspects of thyroid hormone actions. Endocrine Rev 2010; 31:139-170.
3. Flamant F, Gauthier K, Samarut J. Thyroid hormones signalling is getting more complex: STORMs are coming. Mol Endocrinol 2007; 21:321-333.
4. Magnus-Levy A. Uber den respiratorischen Gaswechechseiil unter dem Einfluss der Thyroideasowie unter verschiedenen pathologischen Zustanden (1985). Berl Klin Wochenschr 1895; 32: 650-652.
5. Mozo J, Emre Y, Bouillaud F, et al. Thermoregulation: what role for UCPs in mammals and birds? Biosci Rep 2005; 25:227-249.
6. Weitzel JM, Iwen KA, Seitz HJ. Regulation of mitochondrial biogenesis by thyroid hormone. Exp Physiol 2003; 88:121-128.
7. Liu Y, Fiskum G, Schubert D. Generation of reactive oxygen species by the mitochondrial electron transport chain. J Neurochem 2002; 80:780-787.
8. Bayir H, Fadeel B, Palladino MJ, et al. Apoptotic interactions of cytochrome c: redox flirting with anionic phospholipids within and outside of mitochondria. Biochim Biophys Acta Bioenerg 2006; 1757:648-659.
9. Fruehauf JP, Meyskens FL Jr. Reactive oxygen species: a breath of life or death? Clin Cancer Res 2007; 13:789-794.
10. Tata JR, Ernster L, Lindberg O. Control of basal metabolic rate by thyroid hormones and cellular function. Nature 1962; 193:1058-1060.
11. Cioffi F, Senese R, de Lange P. Uncoupling proteins: a complex journey to functions discovery. Biofactors 2009; 35:417-428.
12. Lanni A, Moreno M, Lombardi A, Goglia F. Thyroid hormone and uncoupling proteins. FEBS Lett 2003; 543:5-10.
13. Lanni A, De Felice M, Lombardi A, et al. Induction of UCP2 mRNA by thyroid hormones in rat heart. FEBS Lett 1997; 418:171-174.
14. Lanni A, Beneduce L, Lombardi A, et al. Expression of uncoupling protein-3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle. FEBS Lett 1999; 444:250-254.
15. de Lange P, Lanni A, Beneduce L, et al. Uncoupling protein-3 is a molecular determinant for the regulation of resting metabolic rate by thyroid hormone. Endocrinology 2001; 142:3414-3420.
16. Brand MD, Pakay LJ, Ocloo A, et al. The basal proton conductance of mitochondria depends on adenine nucleotide translocase content. Biochem J 2005; 392:353-362.
17. Yehuda-Shnaidman E, Kalderon B, Azazmeh N, Bar-Tana J. Gating of the mitochondrial permeability transition pore by thyroid hormone. FASEBJ 2010; 24:93-104.
18. Silvestri E, Moreno M, Schiavo L, et al. A proteomics approach to identify protein expression changes in rat liver following administration of 3,5,3'-triiodo-L-thyronine. J Proteome Res 2006; 5:2317-2327.
19. Silvestri E, Burrone L, de Lange P, et al. Thyroid-state influence on protein-expression profile of rat skeletal muscle. J Proteome Res 2007; 6:3187-3196.
20. Flandin P, Lehr L, Asensio C, et al. Uncoupling protein-3 as a molecular determinant of the action of 3,5,3'-triiodothyronine on energy metabolism. Endocrine 2009; 36:246-254.
21. Goglia F, Skulachev VP. A function for novel uncoupling proteins: antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet. FASEB J 2003; 17:1585-1591.
22. Lombardi A, Busiello RA, Napolitano R, et al. Uncoupling protein-3 translocates lipid hydroperoxides and mediates lipid hydroperoxides-dependent mitochondrial uncoupling. J Biol Chem 2010. doi: 10.1074/jbc.M110.102699. dants.
23. Moreno M, de Lange P, Lombardi A, et al. Metabolic effects of thyroid hormone derivatives. Thyroid 2008; 18:239-253.
24. Baxter JD, Webb P. Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes. Nat Rev Drug Discov 2009; 8:308-320.
25. Horst C, Rokos H, Seitz HJ. Rapid stimulation of hepatic oxygen consumption by 3,5-di-iodo-L-thyronine. Biochem J 1989; 261:945-950.
26. Lombardi A, Lanni A, Moreno M, et al. Effect of 3,5-di-iodo-L-thyronine on the mitochondrial energy-transduction apparatus. Biochem J 1998; 330:521-526.
27. Moreno M, Lanni A, Lombardi A, Goglia F. How the thyroid controls metabolism in the rat: different roles for triiodothyronine and diiodothyronines. J Physiol 1997; 505:529-538.
28. Lanni A, Moreno M, Lombardi A. 3,5-diiodo-L-thyronine powerfully reduces adiposity in rats by increasing the burning of fats. FASEB J 2005; 19:1552-1554.
29. Grasselli E, Canesi L, Voci A, et al. Effects of 3,5-diiodo-L-thyronine administration on the liver of high fat diet-fed rats. Exp Biol Med (Maywood) 2008; 233:549-557.
30. Mollica MP, Lionetti L, Moreno M. 3,5-diiodo-l-thyronine, by modulating mitochondrial functions, reverses hepatic fat accumulation in rats fed a high-fat diet. J Hepatol 2009; 51:363-370.
31. Mangiullo R, Gnoni A, Damiano F, et al. 3,5-diiodo-L-thyronine upregulates ratliver mitochondrial F(o)F(1)-ATP synthase by GA-binding protein/nuclearrespiratory factor-2. Biochim Biophys Acta 2010; 1797:233-240.
32. Perra A, Simbula G, Simbula M, et al. Thyroid hormone (T3) and TRbeta agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats. FASEB J 2008; 22:2981-2989.
33. Villicev CM, Freitas FR, Aoki MS, et al. Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. J Endocrinol 2007; 193:21-29.
34. Venditti P, Chiellini G, Di Stefano L, et al. The TRbeta-selective agonist, GC-1, stimulates mitochondrial oxidative processes to a lesser extent than triiodothyronine. J Endocrinol 2010; 205:279-289.
35. Ladenson PW, Kristensen JD, Ridgway EC, et al. Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia. N Engl J Med 2010;362:906-916.