MicroRNA Let-7f: A Novel Regulator of Innate Immune Response in Human Endocervical Cells

American Journal of Reproductive Immunology

Volumn 71, Issue 2, 2014, Pages 137-153

  Sathe, Ameya ^a   Patgaonkar, Mandar S ^b   Bashir, Tahir ^a   Reddy, Kudumula Venkata Rami ^a  

^a NATIONAL INSTITUTE FOR RESEARCH IN REPRODUCTIVE HEALTH   (India)

^b TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

Author keywords

Blimp1; Cytokines; Let 7f; MiRNA; Pathogen recognition receptors; Tolerance

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; HISTONE DEACETYLASE 2; INTERLEUKIN 6; INTERLEUKIN 8; MICRORNA; MICRORNA LET 7F; RETINOIC ACID INDUCIBLE PROTEIN I; RNA 18S; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; CPG ODN 2006; DDX58 PROTEIN, HUMAN; DEAD BOX PROTEIN; HYDROXAMIC ACID; MIRNLET7 MICRORNA, HUMAN; OLIGODEOXYRIBONUCLEOTIDE; POLYINOSINIC POLYCYTIDYLIC ACID; TRANSCRIPTOME; TRICHOSTATIN A;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE RESPONSE; FEMALE; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IMMUNOSTIMULATION; INHIBITION KINETICS; INNATE IMMUNITY; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UTERINE ENDOCERVIX; AGONISTS; CELL CULTURE; CYTOLOGY; EPITHELIUM CELL; GENETICS; IMMUNOLOGY; METABOLISM; TRANSGENE; UTERINE CERVIX;

CELLS, CULTURED; CERVIX UTERI; DEAD-BOX RNA HELICASES; EPITHELIAL CELLS; FEMALE; HUMANS; HYDROXAMIC ACIDS; IMMUNITY, INNATE; MICROARRAY ANALYSIS; MICRORNAS; OLIGODEOXYRIBONUCLEOTIDES; POLY I-C; TOLL-LIKE RECEPTOR 9; TRANSCRIPTOME; TRANSGENES;

EID: 84892421349     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/aji.12165     Document Type: Article

References (47)

1. Kawai T, Akira S: The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 2010; 11:373-384.
2. Hu G, Zhou R, Liu J, Gong AY, Chen XM: MicroRNA-98 and let-7 regulate expression of suppressor of cytokine signaling-4 in biliary epithelial cells in response to Cryptosporidium parvum infection. J Infect Dis 2010; 202:125-135.
3. Akira S, Takeda K: Toll-like receptor signaling. Nat Rev Immunol 2004; 4:499-511.
4. Hart KM, Murphy AJ, Barrett KT, Wira CR, Guyre PM, Pioli PA: Functional expression of pattern recognition receptors in tissues of the human female reproductive tract. J Reprod Immunol 2009; 80:33-40.
5. Li Y, Shi X: MicroRNAs in the regulation of TLR and RIG-I pathways. Cell Mol Immunol 2013; 10:65-71.
6. Cavassani KA, Ishii M, Wen H, Schaller MA, Lincoln PM, Lukacs NW, Hogaboam CM, Kunkel SL. TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events. J Exp Med 2008; 205: 2609-2621.
7. Lee J, Mo JH, Katakura K, Alkalay I, Rucker AN, Liu YT, Lee HK, Shen C, Cojocaru G, Shenouda S, Kagnoff M, Eckmann L, Ben-Neriah Y, Raz E: Maintenance of colonic homeostasis by distinctive apical TLR9 signaling in intestinal epithelial cells. Nat Cell Biol 2006; 8:1327-1336.
8. Li XD, Chiu YH, Ismail AS, Behrendt CL, Wight-Carter M, Hooper LV, Chen ZJ: Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis. Proc Natl Acad Sci USA 2011; 108:17390-17395.
9. Kobayashi KS, Flavell RA: Shielding the double-edged sword: negative regulation of the innate immune system. J Leukoc Biol 2004; 75:428-433.
10. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116:281-297.
11. Tili E, Michaille JJ, Cimino A, Costinean S, Dumitru CD, Adair B, Fabbri M, Alder H, Liu CG, Calin GACroce CM: Modulation of miR-155 and miR-125b levels following lipopolysaccharide/ TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol 2007; 17:5082-5089.
12. Zhou R, O'Hara SP, Chen XM: MicroRNA regulation of innate immune responses in epithelial cells. Cell Mol Immunol 2011; 8:371-379.
13. O'Neill LA, Sheedy FJ, McCoy CE: MicroRNAs: the fine tuners of Toll-like receptor signaling. Nat Rev Immunol 2011; 11:163-175.
14. Xu L, Wen Z, Zhou Y, Liu Z, Li Q, Fei G, Luo J, Ren T: MicroRNA-7 regulated TLR9 signaling enhanced growth and metastatic potential of human lung cancer cells by altering the phosphoinositide-3-kinase, regulatory subunit 3/Akt pathway. Mol Biol Cell 2013; 24:42-55.
15. Ambros V: The functions of animal microRNAs. Nature 2004; 431:350-355.
16. O'Connell RM, Rao DS, Baltimore D: microRNA regulation of inflammatory responses. Annu Rev Immunol 2012; 30:295-312.
17. He Y, Yang C, Kirkmire CM, Wang ZJ: Regulation of opioid tolerance by let-7 family microRNA targeting the opioid receptor. J Neurosci 2010; 30:10251-10258.
18. Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D, Slack FJ: RAS is regulated by the let-7 microRNA family. Cell 2005; 120:635-647.
19. Ricarte-Filho JC, Fuziwara CS, Yamashita AS, Rezende E, da-Silva MJ, Kimura ET: Effects of let-7 microRNA on cell growth and differentiation of papillary thyroid cancer. Transl Oncol 2009; 2:236-241.
20. Schulte LN, Eulalio A, Mollenkopf HJ, Reinhardt R, Vogel J: Analysis of the host microRNA response to Salmonella uncovers the control of major cytokines by the let-7 family. EMBO J 2011; 30:1977-1988.
21. Chen XM, Splinter PL, O'Hara SP, LaRusso NF: A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection. J Biol Chem 2007; 282:28929-28938.
22. Olarerin-George AO, Anton L, Hwang YC, Michal A, Elovitz MA, John B, Hogenesch JB: A functional genomics screen for microRNA regulators of NF-kappa B signaling. BMC Biol 2013; 11:19-34.
23. Ashburner BP, Westerheide SD, Baldwin AS Jr: The p65 (RelA) subunit of NF-kappa B interacts with the histone deacetylase (HDAC) co-repressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol Cell Biol 2001; 21:7065-7077.
24. Harper J, Mould A, Andrews RM, Bikoff EK, Robertson EJ: The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes. Proc Natl Acad Sci USA 2011; 108:10585-10590.
25. Miranda KC, Huynh T, Tay Y, Ang YS, Tam WL, Thomson AM, Lim B, Rigoutsos I: A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell 2006; 12:1203-1217.
26. Wira C, Patel M, Ghosh M, Mukura L, Fahey J: Innate immunity in the human female reproductive tract: endocrine regulation of endogenous antimicrobial protection against HIV and other sexually transmitted infections. Am J Reprod Immunol 2011; 65:196-211.
27. Kaisho T, Akira S: Critical roles of Toll-like receptors in host defense. Crit Rev Immunol 2000; 20:393-405.
28. Mogensen TH: Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev 2009; 22:240-273.
29. Fichorova RN, Rheinwald JG, Anderson DJ: Generation of papillomavirus-immortalized cell lines from normal human ectocervical, endocervical, and vaginal epithelium that maintain expression of tissue-specific differentiation proteins. Biol Reprod 1997; 57:847-855.
30. Harada K, Sato Y, Isse K, Ikeda H, Nakanuma Y: Induction of innate immune response and absence of subsequent tolerance to dsRNA in biliary epithelial cells relate to the pathogenesis of biliary atresia. Liver Int 2008; 28:614-621.
31. Groskreutz DJ, Monick MM, Powers LS, Yarovinsky TO, Look DC, Hunninghake GW: Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells. J Immunol 2006; 176:1733-1739.
32. Bakre A, Mitchell P, Coleman JK, Jones LP, Saavedra G, Teng M, Tompkins SM, Tripp RA: Respiratory syncytial virus modifies microRNAs regulating host genes that affect virus replication. J Gen Virol 2012; 93:2346.
33. Martins G, Calame K: Regulation and functions of Blimp-1 in T and B lymphocytes. Annu Rev Immunol 2008; 26:133-169.
34. Nie K, Zhang T, Allawi H, Gomez M, Liu Y, Chadburn A, Wang YL, Knowles DM, Tam W: Epigenetic down-regulation of the tumor suppressor gene PRDM1/Blimp-1 in diffuse large B cell lymphomas: a potential role of the microRNA let-7. Am J Pathol 2010; 177:1470-1479.
35. Chan YH, Chiang MF, Tsai YC, Su ST, Chen MH, Hou MS, Lin K: Absence of the transcriptional repressor Blimp-1 in hematopoietic lineages reveals its role in dendritic cell homeostatic development and function. J Immunol 2009; 183:7039-7046.
36. Kuo TC, Calame K: B Lymphocyte-induced maturation protein (Blimp)-1, IFN regulatory factor (IRF)-1, and IRF-2 can bind to the same regulatory sites. J Immunol 2004; 173:5556-5563.
37. Yu J, Angelin-Duclos C, GreenwoodJ Liao J, Greenwood J, Liao J: Transcriptional repression by Blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase. Mol Cell Biol 2000; 20:2592-2603.
38. Foster SL, Hargreaves DC, Medzhitov R: Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature 2007; 447:972-978.
39. Kim SJ, Zou YR, Goldstein J, Reizis B, Diamond B: Tolerogenic function of Blimp-1in dendritic cells. J Exp Med 2011; 208:2193-2199.
40. Lui WO, Pourmand N, Patterson BK, Fire A: Patterns of known and novel small RNAs in human cervical cancer. Cancer Res 2007; 67:6031-6043.
41. Zhao Y, Deng C, Lu W, Xiao J, Ma D, Guo M, Recker RR, Gatalica Z, Wang Z, Xiao GG: Let-7 microRNAs induce tamoxifen sensitivity by down-regulation of estrogen receptor α signaling in breast cancer. Mol Med 2011; 17:1233-1241.
42. Kunkel SL, Lukacs NW, Chensue SW, Strieter RM: Chemokines and the inflammatory response. In Cytokines in Health and Disease, DG Remick, JS Friedland (eds). 2nd edn, New York, Marcel Dekker, Inc, 1997, pp 121-131.
43. Sands BE, Podolsky DK: The trefoil peptide family. Annu Rev Physiol 1996; 58:253-273.
44. Eckert RL, Broome AM, Ruse M, Robinson N, Ryan D, Lee K: S100 proteins in the epidermis. J Invest Dermatol 2004; 123: 23-33.
45. Sutherland CL, Chalupny NJ, Schooley K, Vandenbos T, Kubin M, Cosman D: UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells. J Immunol 2002; 168:671-679.
46. Poss KD, Tonegawa S: Reduced stress defense in hemeoxygenase 1-deficient cells. Proc Natl Acad Sci USA 1997; 94:10925-10930.
47. Roush S, Slack FJ: The let-7 family of microRNAs. Trends Cell Biol 2008; 18:505-516.