The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 26, 2011, Pages 10585-10590

  Harper, James ^a   Mould, Arne ^a   Andrews, Robert M ^b   Bikoff, Elizabeth K ^a   Robertson, Elizabeth J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

Cell fate; Enterocyte maturation; Gut development; Nutrition

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CELL STRUCTURE; CONTROLLED STUDY; CRYPT CELL; EMBRYO; FEMALE; GENE EXPRESSION PROFILING; GENE INACTIVATION; INTESTINE EPITHELIUM; MALE; NEWBORN; NEWBORN MORTALITY; NONHUMAN; NUCLEAR REPROGRAMMING; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALS; ENTEROCYTES; FEMALE; GENE EXPRESSION PROFILING; INTESTINES; MALE; MICE; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

MAMMALIA;

EID: 79960586513     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1105852108     Document Type: Article

References (47)

1. Trier JS, Moxey PC (1979) Morphogenesis of the small intestine during fetal development. Ciba Found Symp 70:3-29.
2. van der Flier LG, Clevers H (2009) Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol 71:241-260.
3. Bikoff EK, Morgan MA, Robertson EJ (2009) An expanding job description for Blimp-1/ PRDM1. Curr Opin Genet Dev 19:379-385.
4. Keller AD, Maniatis T (1991) Identification and characterization of a novel repressor of beta-interferon gene expression. Genes Dev 5:868-879. (Pubitemid 21906003)
5. Turner CA, Jr., Mack DH, Davis MM (1994) Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulinsecreting cells. Cell 77:297-306. (Pubitemid 24138626)
6. Ohinata Y, et al. (2005) Blimp1 is a critical determinant of the germ cell lineage in mice. Nature 436:207-213. (Pubitemid 41021265)
7. Vincent SD, et al. (2005) The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse. Development 132:1315-1325. (Pubitemid 40528791)
8. Robertson EJ, et al. (2007) Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice. Development 134:4335-4345.
9. Martins G, Calame K (2008) Regulation and functions of Blimp-1 in T and B lymphocytes. Annu Rev Immunol 26:133-169. (Pubitemid 351600373)
10. Horsley V, et al. (2006) Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell 126:597-609. (Pubitemid 44163616)
11. Magnúsdóttir E, et al. (2007) Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1. Proc Natl Acad Sci USA 104:14988-14993. (Pubitemid 47619580)
12. Ohinata Y, Sano M, Shigeta M, Yamanaka K, Saitou M (2008) A comprehensive, non-invasive visualization of primordial germ cell development in mice by the Prdm1-mVenus and Dppa3-ECFP double transgenic reporter. Reproduction 136:503-514.
13. Soriano P (1999) Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21:70-71.
14. el Marjou F, et al. (2004) Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis 39:186-193.
15. Shapiro-Shelef M, et al. (2003) Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 19:607-620. (Pubitemid 37311441)
16. Yang Q, Bermingham NA, Finegold MJ, Zoghbi HY (2001) Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science 294:2155-2158. (Pubitemid 33150670)
17. Katz JP, et al. (2002) The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development 129:2619-2628. (Pubitemid 34874246)
18. Suzuki K, et al. (2005) Hes1-deficient mice show precocious differentiation of Paneth cells in the small intestine. Biochem Biophys Res Commun 328:348-352. (Pubitemid 40164675)
19. Mori-Akiyama Y, et al. (2007) SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology 133:539-546. (Pubitemid 47187347)
20. Lin Y, Wong K, Calame K (1997) Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation. Science 276:596-599. (Pubitemid 27193684)
21. Sansom OJ, et al. (2007) Myc deletion rescues Apc deficiency in the small intestine. Nature 446:676-679. (Pubitemid 46606884)
22. Korinek V, et al. (1998) Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet 19:379-383. (Pubitemid 28357912)
23. Huang W, Sherman BT, Lempicki RA (2009) Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37:1-13.
24. Kuo TC, Calame KL (2004) B lymphocyte-induced maturation protein (Blimp)-1, IFN regulatory factor (IRF)-1, and IRF-2 can bind to the same regulatory sites. J Immunol 173:5556-5563. (Pubitemid 39392142)
25. Hurwitz R, Kretchmer N (1986) Development of arginine-synthesizing enzymes in mouse intestine. Am J Physiol 251:G103-G110.
26. Patel HR, Hewer A, Hayes JD, Phillips DH, Campbell FC (1998) Age-dependent change of metabolic capacity and genotoxic injury in rat intestine. Chem Biol Interact 113:27-37. (Pubitemid 28279789)
27. Kawai J, et al. (2001) RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium (2001) Functional annotation of a full-length mouse cDNA collection. Nature 409:685-690.
28. Doell RG, Kretchmer N (1962) Studies of small intestine during development. I. Distribution and activity of beta-galactosidase. Biochim Biophys Acta 62:353-362.
29. Dickson JJ, Messer M (1978) Intestinal neuraminidase activity of suckling rats and other mammals. Relationship to the sialic acid content of milk. Biochem J 170:407-413.
30. Wu G, Bazer FW, Tuo W, Flynn SP (1996) Unusual abundance of arginine and ornithine in porcine allantoic fluid. Biol Reprod 54:1261-1265. (Pubitemid 26149246)
31. Koldovský O, Herbst J (1971) N-acetyl-beta-glucosaminidase in the small intestine and its changes during postnatal development of the rat. Biol Neonate 17:1-9.
32. Tyska MJ, Mooseker MS (2004) A role for myosin-1A in the localization of a brush border disaccharidase. J Cell Biol 165:395-405. (Pubitemid 38649914)
33. Andrews GK, Dziadek M, Tamaoki T (1982) Expressionandmethylation of themouse alpha-fetoprotein gene in embryonic, adult, and neoplastic tissues. J Biol Chem 257:5148-5153. (Pubitemid 12054835)
34. Makover A, Soprano DR, Wyatt ML, Goodman DS (1989) An in situ-hybridization study of the localization of retinol-binding protein and transthyretin messenger RNAs during fetal development in the rat. Differentiation 40:17-25. (Pubitemid 19149289)
35. Moog F, Denes AE, Powell PM (1973) Disaccharidases in the small intestine of the mouse: normal development and influence of cortisone, actinomycin D, and cycloheximide. Dev Biol 35:143-159.
36. Lebenthal E, Sunshine P, Kretchmer N (1973) Effect of prolonged nursing on the activity of intestinal lactase in rats. Gastroenterology 64:1136-1141.
37. Gao N, White P, Kaestner KH (2009) Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2. Dev Cell 16:588-599.
38. Boyd M, Bressendorff S, Møller J, Olsen J, Troelsen JT (2009) Mapping of HNF4alpha target genes in intestinal epithelial cells. BMC Gastroenterol 9:68.
39. Boudreau F, et al. (2002) Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene. J Biol Chem 277:31909-31917. (Pubitemid 34968999)
40. Beck F (2004) The role of Cdx genes in the mammalian gut. Gut 53:1394-1396.
41. D'Angelo A, et al. (2010) Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epithelium. Development 137: 1573-1582.
42. Stegmann A, et al. (2006) Metabolome, transcriptome, and bioinformatic cis-element analyses point to HNF-4 as a central regulator of gene expression during enterocyte differentiation. Physiol Genomics 27:141-155. (Pubitemid 46705407)
43. Rutishauser RL, et al. (2009) Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties. Immunity 31:296-308.
44. Doody GM, et al. (2010) An extended set of PRDM1/BLIMP1 target genes links binding motif type to dynamic repression. Nucleic Acids Res 38:5336-5350.
45. Verzi MP, et al. (2010) Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2. Dev Cell 19:713-726.
46. Tou L, Liu Q, Shivdasani RA (2004) Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases. Mol Cell Biol 24:3132-3139. (Pubitemid 38452059)
47. Nagy A, Gertsenstein M, Vintersten K, Behringer R (2003) Manipulating The Mouse Embryo: A Laboratory Manual (Cold Spring Harbor Lab Press, Cold Spring Harbor, NY).