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Volumn 8, Issue 1, 2011, Pages

A systems-based mathematical modelling framework for investigating the effect of drugs on solid tumours

Author keywords

bottom up approach; drug effect; intracellular signalling; modelling framework; Solid tumour; systems approach; transport

Indexed keywords

ANTINEOPLASTIC AGENT;

EID: 82755190457     PISSN: None     EISSN: 17424682     Source Type: Journal    
DOI: 10.1186/1742-4682-8-45     Document Type: Article
Times cited : (11)

References (19)
  • 1
    • 0141790758 scopus 로고    scopus 로고
    • Drug delivery and transport to solid tumors
    • DOI 10.1023/A:1025785505977
    • Drug delivery and transport to solid tumors. Jang SH, Wientjes MG, Lu D, Au JL, Pharm Res 2003 20 1337 1350 10.1023/A:1025785505977 14567626 (Pubitemid 37164040)
    • (2003) Pharmaceutical Research , vol.20 , Issue.9 , pp. 1337-1350
    • Jang, S.H.1    Wientjes, M.G.2    Lu, D.3    Au, J.L.-S.4
  • 2
    • 35148881028 scopus 로고    scopus 로고
    • Drug resistance and the solid tumor microenvironment
    • 10.1093/jnci/djm135 17895480
    • Drug resistance and the solid tumor microenvironment. Trédan O, Galmarini CM, Patel K, Tannock IF, J Natl Cancer Inst 2007 99 1441 1454 10.1093/jnci/djm135 17895480.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 1441-1454
    • Trédan, O.1    Galmarini, C.M.2    Patel, K.3    Tannock, I.F.4
  • 3
    • 80052931582 scopus 로고    scopus 로고
    • Use of mathematical models to understand anticancer drug delivery and its effect on solid tumors
    • 10.2217/pgs.11.71 21919608
    • Use of mathematical models to understand anticancer drug delivery and its effect on solid tumors. Liu C, Krishnan J, Stebbing J, Xu XY, Pharmacogenomics 2011 12 1337 1348 10.2217/pgs.11.71 21919608
    • (2011) Pharmacogenomics , vol.12 , pp. 1337-1348
    • Liu, C.1    Krishnan, J.2    Stebbing, J.3    Xu, X.Y.4
  • 4
    • 0033822142 scopus 로고    scopus 로고
    • A mathematical model for comparison of bolus injection, continuous infusion, and liposomal delivery of doxorubicin to tumor cells
    • 10.1038/sj.neo.7900096 11005567
    • A mathematical model for comparison of bolus injection, continuous infusion, and liposomal delivery of doxorubicin to tumor cells. El-Kareh AW, Secomb TW, Neoplasia 2000 2 325 338 10.1038/sj.neo.7900096 11005567
    • (2000) Neoplasia , vol.2 , pp. 325-338
    • El-Kareh, A.W.1    Secomb, T.W.2
  • 5
    • 23244457368 scopus 로고    scopus 로고
    • Two-mechanism peak concentration model for cellular pharmacodynamics of doxorubicin
    • DOI 10.1593/neo.05118
    • Two-mechanism peak concentration model for cellular pharmacodynamics of Doxorubicin. El-Kareh AW, Secomb TW, Neoplasia 2005 7 705 713 10.1593/neo.05118 16026650 (Pubitemid 41099424)
    • (2005) Neoplasia , vol.7 , Issue.7 , pp. 705-713
    • El-Kareh, A.W.1    Secomb, T.W.2
  • 6
    • 20344394143 scopus 로고    scopus 로고
    • Transient interstitial fluid flow in brain tumors: Effect on drug delivery
    • DOI 10.1016/j.ces.2005.04.008, PII S0009250905002873
    • Transient interstitial fluid flow in brain tumors: Effect on drug delivery. Teo CS, Hor Keong Tan W, Lee T, Wang C-H, Chemical Engineering Science 2005 60 4803 4821 10.1016/j.ces.2005.04.008 (Pubitemid 40792952)
    • (2005) Chemical Engineering Science , vol.60 , Issue.17 , pp. 4803-4821
    • Teo, C.S.1    Tan, W.H.K.2    Lee, T.3    Wang, C.-H.4
  • 7
    • 34247391996 scopus 로고    scopus 로고
    • Effect of heterogeneous vasculature on interstitial transport within a solid tumor
    • DOI 10.1016/j.mvr.2006.12.003, PII S0026286206001464
    • Effect of heterogeneous vasculature on interstitial transport within a solid tumor. Zhao J, Salmon H, Sarntinoranont M, Microvasc Res 2007 73 224 236 10.1016/j.mvr.2006.12.003 17307203 (Pubitemid 46628694)
    • (2007) Microvascular Research , vol.73 , Issue.3 , pp. 224-236
    • Zhao, J.1    Salmon, H.2    Sarntinoranont, M.3
  • 8
    • 69849096664 scopus 로고    scopus 로고
    • A tumor cord model for doxorubicin delivery and dose optimization in solid tumors
    • 10.1186/1742-4682-6-16 19664243
    • A tumor cord model for doxorubicin delivery and dose optimization in solid tumors. Eikenberry S, Theor Biol Med Model 2009 6 16 10.1186/1742-4682-6- 16 19664243
    • (2009) Theor Biol Med Model , vol.6 , pp. 16
    • Eikenberry, S.1
  • 9
    • 77953809368 scopus 로고    scopus 로고
    • Dissecting Variability in Responses to Cancer Chemotherapy Through Systems Pharmacology
    • 10.1038/clpt.2010.96 20520606
    • Dissecting Variability in Responses to Cancer Chemotherapy Through Systems Pharmacology. Yang R, Niepel M, Mitchison TK, Sorger PK, Clin Pharmacol Ther 2010 88 34 38 10.1038/clpt.2010.96 20520606
    • (2010) Clin Pharmacol Ther , vol.88 , pp. 34-38
    • Yang, R.1    Niepel, M.2    Mitchison, T.K.3    Sorger, P.K.4
  • 10
    • 85028100315 scopus 로고    scopus 로고
    • A mathematical framework for agent based models of complex biological networks
    • 10.1007/s11538-010-9582-8 20878493
    • A mathematical framework for agent based models of complex biological networks. Hinkelmann F, Murrugarra D, Jarrah AS, Laubenbacher R, Bull Math Biol 2011 73 1583 1602 10.1007/s11538-010-9582-8 20878493
    • (2011) Bull Math Biol , vol.73 , pp. 1583-1602
    • Hinkelmann, F.1    Murrugarra, D.2    Jarrah, A.S.3    Laubenbacher, R.4
  • 13
    • 33749370199 scopus 로고    scopus 로고
    • Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability
    • DOI 10.1371/journal.pcbi.0020120
    • Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability. Legewie S, Bluthgen N, Herzel H, Plos Comput Biol 2006 2 1061 1073. (Pubitemid 44495720)
    • (2006) PLoS Computational Biology , vol.2 , Issue.9 , pp. 1061-1073
    • Legewie, S.1    Bluthgen, N.2    Herzel, H.3
  • 14
    • 68949136900 scopus 로고    scopus 로고
    • Computational analysis of dynamical responses to the intrinsic pathway of programmed cell death
    • 10.1016/j.bpj.2009.04.053 19619456
    • Computational analysis of dynamical responses to the intrinsic pathway of programmed cell death. Zhang T, Brazhnik P, Tyson J, Biophys J 2009 97 415 434 10.1016/j.bpj.2009.04.053 19619456
    • (2009) Biophys J , vol.97 , pp. 415-434
    • Zhang, T.1    Brazhnik, P.2    Tyson, J.3
  • 15
    • 84883829346 scopus 로고    scopus 로고
    • Modeling a snap-action, variable-delay switch controlling extrinsic cell death
    • 19053173
    • Modeling a snap-action, variable-delay switch controlling extrinsic cell death. Albeck J, Burke J, Spencer S, Lauffenburger D, Sorger P, PLoS Biol 2008 6 2831 2852 19053173
    • (2008) PLoS Biol , vol.6 , pp. 2831-2852
    • Albeck, J.1    Burke, J.2    Spencer, S.3    Lauffenburger, D.4    Sorger, P.5
  • 16
    • 0037605637 scopus 로고    scopus 로고
    • Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible
    • 10.1063/1.1349894 12779456
    • Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible. Ferrell JE, Xiong W, Chaos 2001 11 227 236 10.1063/1.1349894 12779456
    • (2001) Chaos , vol.11 , pp. 227-236
    • Ferrell, J.E.1    Xiong, W.2
  • 18
    • 79952593286 scopus 로고    scopus 로고
    • A modular systems approach to elucidating the interaction of adaptive and monostable and bistable threshold modules
    • 10.1049/iet-syb.2009.0061 21405196
    • A modular systems approach to elucidating the interaction of adaptive and monostable and bistable threshold modules. Seaton D, Krishnan J, IET Systems Biology 2011 5 81 94 10.1049/iet-syb.2009.0061 21405196.
    • (2011) IET Systems Biology , vol.5 , pp. 81-94
    • Seaton, D.1    Krishnan, J.2
  • 19
    • 0022891086 scopus 로고
    • A pharmacokinetic study of adriamycin and 4'epi-adriamycin after simultaneous intra-arterial liver administration
    • A pharmacokinetic study of adriamycin and 4'epi-adriamycin after simultaneous intra-arterial liver administration. Eksborg S, Andersson M, Domellöf L, Lönroth U, Med Oncol Tumor Pharmacother 1986 3 105 110 3462442 (Pubitemid 16007600)
    • (1986) Medical Oncology and Tumor Pharmacotherapy , vol.3 , Issue.2 , pp. 105-110
    • Eksborg, S.1    Andersson, M.2    Domellof, L.3    Lonroth, U.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.