Dipeptidyl peptidase IV inhibition activates CREB and improves islet vascularization through VEGF-A/VEGFR-2 signaling pathway

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Samikannu, Balaji ^a   Chen, Chunguang ^b   Lingwal, Neelam ^a   Padmasekar, Manju ^a   Engel, Felix B ^c   Linn, Thomas ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

^c UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DIPEPTIDYL PEPTIDASE IV; GLUCAGON LIKE PEPTIDE 1; INSULIN; SITAGLIPTIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY DENSITY; CELL PROLIFERATION; CELL VOLUME; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME INHIBITION; EX VIVO STUDY; GRAFT SURVIVAL; IN VIVO STUDY; INSULIN SYNTHESIS; KIDNEY CAPSULE; MOUSE; NONHUMAN; PANCREAS BLOOD FLOW; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; TISSUE SECTION; TRANSCRIPTION INITIATION; VASCULARIZATION;

ANIMALS; BLOOD GLUCOSE; CELL PROLIFERATION; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; ENDOTHELIAL CELLS; GLUCAGON-LIKE PEPTIDE 1; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; PYRAZINES; REGIONAL BLOOD FLOW; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; SWINE; TOR SERINE-THREONINE KINASES; TRIAZOLES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84892409235     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0082639     Document Type: Article

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