Shear-induced endothelial mechanotransduction: The interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications

Journal of Biomedical Science

Volumn 21, Issue 1, 2014, Pages

  Hsieh, Hsyue Jen ^a   Liu, Ching Ann ^b   Huang, Bin ^c   Tseng, Anne Hh ^b   Wang, Danny Ling ^b,d  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d TZU CHI UNIVERSITY   (Taiwan)

Author keywords

Endothelial cell; Flow pattern; Mechanotransduction; Nitric oxide (NO); Reactive oxygen species (ROS); Shear stress

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALMODULIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEME OXYGENASE 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; KRUPPEL LIKE FACTOR 2; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; OXIDIZED LOW DENSITY LIPOPROTEIN; PEROXYNITRITE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REGULATOR PROTEIN; SUPEROXIDE; THIOREDOXIN 1; THIOREDOXIN REDUCTASE 1; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NRF2; TYROSINE; UNCLASSIFIED DRUG; UNCOUPLED ENDOTHELIAL NITRIC OXIDE SYNTHASE; VASCULAR CELL ADHESION MOLECULE 1; XANTHINE OXIDASE;

ANTIOXIDANT RESPONSIVE ELEMENT; ATHEROGENESIS; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR DISEASE; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FLOW KINETICS; GENE EXPRESSION REGULATION; HEMODYNAMICS; HOMEOSTASIS; LAMINAR FLOW; MECHANOTRANSDUCTION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NITRATION; NITROSYLATION; OSCILLATION; OXIDATION REDUCTION REACTION; OXIDATIVE PHOSPHORYLATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTON TRANSPORT; PULSATILE FLOW; REVIEW; S GLUTATHIONYLATION; S NITROSYLATION; SHEAR STRESS; TYROSINE NITRATION; VASCULAR ENDOTHELIUM; GENETICS; HUMAN; MECHANICAL STRESS; METABOLISM; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

HEMODYNAMICS; HUMANS; MECHANOTRANSDUCTION, CELLULAR; NITRIC OXIDE; OXIDATIVE STRESS; PROTEIN PROCESSING, POST-TRANSLATIONAL; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STRESS, MECHANICAL;

EID: 84892402112     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-21-3     Document Type: Review

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