(-)-[18F]Flubatine: Evaluation in rhesus monkeys and a report of the first fully automated radiosynthesis validated for clinical use

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 56, Issue 12, 2013, Pages 595-599

  Hockley, Brian G ^a   Stewart, Megan N ^b   Sherman, Phillip ^a   Quesada, Carole ^a   Kilbourn, Michael R ^a   Albin, Roger L ^a,c   Scott, Peter J H ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c VAAAHS   (United States)

Author keywords

nicotinic acetylcholine receptors; norchloro fluoro homoepibatidine; positron emission tomography (PET) imaging

Indexed keywords

AUTOMATION; CHLORINE COMPOUNDS; FLUORINE COMPOUNDS; MAMMALS; MEDICAL IMAGING; POSITRON EMISSION TOMOGRAPHY; QUALITY CONTROL;

ACETYLCHOLINE RECEPTOR; AUTOMATED SYNTHESIS; CLINICAL USE; FULLY AUTOMATED; ISOTONIC SOLUTION; NICOTINIC ACETYLCHOLINE; NICOTINIC ACETYLCHOLINE RECEPTOR; NORCHLORO-FLUORO-HOMOEPIBATIDINE; POSITRON EMISSION TOMOGRAPHY IMAGING; TOMOGRAPHY IMAGING;

BRAIN;

EPIBATIDINE; FLUBATINE FLUORINE F 18; FLUORINE 18; NICOTINIC AGENT; NICOTINIC RECEPTOR ALPHA4BETA2; NIFENE; UNCLASSIFIED DRUG;

ALGORITHM; ANIMAL EXPERIMENT; ARTICLE; AUTOMATION; BRAIN; DRUG CLEARANCE; DRUG DOSE COMPARISON; DRUG SYNTHESIS; FEMALE; FLUORINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMAGE RECONSTRUCTION; MOLECULAR IMAGING; NONHUMAN; PET SCANNER; POSITRON EMISSION TOMOGRAPHY; QUALITY CONTROL; RADIOCHEMISTRY; RHESUS MONKEY; THALAMUS; THREE DIMENSIONAL IMAGING; VALIDATION STUDY;

MACACA MULATTA; PRIMATES;

(-)-[18F]NCFHEB; NICOTINIC ACETYLCHOLINE RECEPTORS; NORCHLORO-FLUORO-HOMOEPIBATIDINE; POSITRON EMISSION TOMOGRAPHY (PET) IMAGING;

ANIMALS; AUTOMATION, LABORATORY; BENZAMIDES; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; DRUG EVALUATION, PRECLINICAL; FEMALE; FLUORINE RADIOISOTOPES; ISOTOPE LABELING; MACACA MULATTA; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS;

EID: 84887818483     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.3069     Document Type: Article

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