Anti-inflammatory effects of β-hydroxyisovalerylshikonin in BV2 microglia are mediated through suppression of the PI3K/Akt/NF-kB pathway and activation of the Nrf2/HO-1 pathway

Food and Chemical Toxicology

Volumn 65, Issue , 2014, Pages 82-89

  Jayasooriya, Rajapaksha Gedara Prasad Tharanga ^a   Lee, Kyoung Tae ^b   Lee, Hak Ju ^b   Choi, Yung Hyun ^c   Jeong, Jin Woo ^d   Kim, Gi Young ^a  

^a Jeju National University   (South Korea)

^b Korea Forest Research Institute   (South Korea)

^c Dong Eui University   (South Korea)

^d Daegu Gyeongbuk Institute of Science and Technology   (South Korea)

Author keywords

Hydroxyisovalerylshikonin; Heme oxygenase 1; Nitric oxide; Nuclear factor B; Nuclear factor erythroid 2 related factor 2; Prostaglandin E2

Indexed keywords

(3 HYDROXYISOVALERYL)SHIKONIN; CYCLOOXYGENASE 2; DNA; HEME OXYGENASE 1; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN E2; PROTEIN KINASE B; SHIKONIN DERIVATIVE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; BETA HYDROXYISOVALERYLSHIKONIN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; COX 2 GENE; DOWN REGULATION; DRUG STRUCTURE; ENZYME INDUCTION; GENE EXPRESSION REGULATION; INOS GENE; MICROGLIA; NERVE CELL CULTURE; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; UPREGULATION; DNA BINDING; DRUG MECHANISM; DRUG RESEARCH; PROTEIN EXPRESSION; PROTEIN SECRETION;

HEME OXYGENASE-1; NITRIC OXIDE; NUCLEAR FACTOR-ERYTHROID 2-RELATED FACTOR 2; NUCLEAR FACTOR-ΚB; PROSTAGLANDIN E2; Β-HYDROXYISOVALERYLSHIKONIN;

ANIMALS; CELL LINE; DINOPROSTONE; HEME OXYGENASE-1; LIPOPOLYSACCHARIDES; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICROGLIA; MOLECULAR STRUCTURE; NAPHTHOQUINONES; NF-E2-RELATED FACTOR 2; NF-KAPPA B; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLIDINES; THIOCARBAMATES;

EID: 84892170770     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.12.011     Document Type: Article

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