Effects of electroacupuncture on apoptotic pathways in a rat model of focal cerebral ischemia

International Journal of Molecular Medicine

Volumn 32, Issue 6, 2013, Pages 1303-1310

  Kim, Yu Ri ^a   Kim, Ha Neui ^a   Jang, Ji Yeon ^a   Park, Cheol ^b   Lee, Jun Hyuk ^c   Shin, Hwa Kyoung ^a   Choi, Yung Hyun ^b   Choi, Byung Tae ^a  

^a Pusan National University   (South Korea)

^b Dong Eui University   (South Korea)

^c Korea Intellectual Property Office   (South Korea)

Author keywords

Apoptosis; Bcl 2; Caspase; Cerebral ischemia; Death receptor; Electroacupuncture

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; DEATH RECEPTOR 5; HOE 33342; INHIBITOR OF APOPTOSIS PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN REGION; CASPASE ASSAY; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; ELECTROACUPUNCTURE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BENZIMIDAZOLES; BLOTTING, WESTERN; BRAIN ISCHEMIA; CASPASES; CEREBRAL INFARCTION; DENSITOMETRY; ELECTROACUPUNCTURE; IN SITU NICK-END LABELING; MALE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84892169165     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1511     Document Type: Article

References (44)

1. Shichita T, Hasegawa E, Kimura A, et al: Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain. Nat Med 18: 911-917, 2012.
2. Lansberg MG, Bluhmki E and Thijs VN: Efficacy and safety of tissue plasminogen activator 3 to 4.5 hours after acute ischemic stroke: a metaanalysis. Stroke 40: 2438-2441, 2009.
3. Li X, Luo P, Wang Q and Xiong L: Electroacupuncture pretreatment as a novel avenue to protect brain against ischemia and reperfusion injury. Evid Based Complement Alternat Med 2012: 195397, 2012.
4. Nakka VP, Gusain A, Mehta SL and Raghubir R: Molecular mechanisms of apoptosis in cerebral ischemia: multiple neuroprotective opportunities. Mol Neurobiol 37: 7-38, 2008.
5. Ginsberg MD: The new language of cerebral ischemia. AJNR Am J Neuroradiol 18: 1435-1445, 1997.
6. Love S: Apoptosis and brain ischaemia. Prog Neuropsychopharmacol Biol Psychiatry 27: 267-282, 2003.
7. Kato H and Kogure K: Biochemical and molecular characteristics of the brain with developing cerebral infarction. Cell Mol Neurobiol 19: 93-108, 1999.
8. Kerr JF, Wyllie AH and Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257, 1972.
9. Choi DW: Glutamate neurotoxicity and diseases of the nervous system. Neuron 1: 623-634, 1988.
10. Lee JM, Zipfel GJ and Choi DW: The changing landscape of ischaemic brain injury mechanisms. Nature 399: A7-A14, 1999.
11. Krajewski S, Krajewska M, Ellerby LM, et al: Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. Proc Natl Acad Sci USA 96: 5752-5757, 1999.
12. Lam TT, Abler AS and Tso MO: Apoptosis and caspases after ischemia-reperfusion injury in rat retina. Invest Ophthalmol Vis Sci 40: 967-975. 1999.
13. Xiong ZQ and McNamara JO: Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack. Neuron 36: 363-374, 2002.
14. Neumar RW, Hagle SM, DeGracia DJ, Krause GS and White BC: Brain mu-calpain autolysis during global cerebral ischemia. J Neurochem 66: 421-424, 1996.
15. Namura S, Zhu J, Fink K, et al: Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. J Neurosci 18: 3659-3668, 1998.
16. Broughton BR, Reutens DC and Sobey CG: Apoptotic mechanisms after cerebral ischemia. Stroke 40: e331-e339, 2009.
17. Campbell MT, Dagher P, Hile KL, et al: Tumor necrosis factor-alpha induces intrinsic apoptotic signaling during renal obstruction through truncated bid activation. J Urol 180: 2694-2700, 2008.
18. Wang SJ, Omori N, Li F, et al: Potentiation of Akt and suppression of caspase-9 activations by electroacupuncture after transient middle cerebral artery occlusion in rats. Neurosci Lett 331: 115-118, 2002.
19. Du Y, Shi L, Li J, Xiong J, Li B and Fan X: Angiogenesis and improved cerebral blood flow in the ischemic boundary area were detected after electroacupuncture treatment to rats with ischemic stroke. Neurol Res 33: 101-107, 2011.
20. Wang Q, Li X, Chen Y, et al: Activation of epsilon protein kinase C-mediated anti-apoptosis is involved in rapid tolerance induced by electroacupuncture pretreatment through cannabinoid receptor type 1. Stroke 42: 389-396, 2011.
21. Sze FK, Wong E, Yi X and Woo J: Does acupuncture have additional value to standard poststroke motor rehabilitation? Stroke 33: 186-194, 2002.
22. Fang Z, Ning J, Xiong C and Shulin Y: Effects of electroacupuncture at head points on the function of cerebral motor areas in stroke patients: a PET study. Evid Based Complement Alternat Med 2012: 902413, 2012.
23. Foley LM, Hitchens TK, Barbe B, et al: Quantitative temporal profiles of penumbra and infarction during permanent middle cerebral artery occlusion in rats. Transl Stroke Res 1: 220-229, 2010.
24. Li P, Nijhawan D, Budihardjo I, et al: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489, 1997.
25. Cui M, Wang L, Liang X, et al: Blocking TRAIL-DR5 signaling with soluble DR5 reduces delayed neuronal damage after transient global cerebral ischemia. Neurobiol Dis 39: 138-147, 2010.
26. Velier JJ, Ellison JA, Kikly KK, Spera PA, Barone FC and Feuerstein GZ: Caspase-8 and caspase-3 are expressed by different populations of cortical neurons undergoing delayed cell death after focal stroke in the rat. J Neurosci 19: 5932-5941, 1999.
27. Krupinski J, Lopez E, Marti E and Ferrer I: Expression of caspases and their substrates in the rat model of focal cerebral ischemia. Neurobiol Dis 7: 332-342, 2000.
28. Li H, Zhu H, Xu CJ and Yuan J: Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94: 491-501, 1998.
29. Luo X, Budihardjo I, Zou H, Slaughter C and Wang X: Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94: 481-490, 1998.
30. Wilkinson JC, Wilkinson AS, Scott FL, Csomos RA, Salvesen GS and Duckett CS: Neutralization of Smac/Diablo by inhibitors of apoptosis (IAPs). A caspase-independent mechanism for apoptotic inhibition. J Biol Chem 279: 51082-51090, 2004.
31. Eckelman BP, Salvesen GS and Scott FL: Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Rep 7: 988-994, 2006.
32. Rothe M, Pan MG, Henzel WJ, Ayres TM and Goeddel DV: The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 83: 1243-1252, 1995.
33. Guicciardi ME, Mott JL, Bronk SF, Kurita S, Fingas CD and Gores GJ: Cellular inhibitor of apoptosis 1 (cIAP-1) degradation by caspase 8 during TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. Exp Cell Res 317: 107-116. 2011.
34. Sugawara T, Fujimura M, Morita-Fujimura Y, Kawase M and Chan PH: Mitochondrial release of cytochrome c corresponds to the selective vulnerability of hippocampal CA1 neurons in rats after transient global cerebral ischemia. J Neurosci 19: RC39, 1999.
35. Earnshaw WC, Martins LM and Kaufmann SH: Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 68: 383-424, 1999.
36. Yuan J and Yankner BA: Apoptosis in the nervous system. Nature 407: 802-809, 2000.
37. Oltvai ZN, Milliman CL and Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74: 609-619, 1993.
38. Sedlak TW, Oltvai ZN, Yang E, et al: Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad Sci USA 92: 7834-7838, 1995.
39. Kuida K, Haydar TF, Kuan CY, et al: Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94: 325-337, 1998.
40. Noshita N, Sugawara T, Fujimura M, Morita-Fujimura Y and Chan PH: Manganese superoxide dismutase affects cytochrome c release and caspase-9 activation after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab 21: 557-567, 2001.
41. Shehadah A, Chen J, Zacharek A, et al: Niaspan treatment induces neuroprotection after stroke. Neurobiol Dis 40: 277-283, 2010.
42. Hsu AL, Ching TT, Wang DS, Song X, Rangnekar VM and Chen CS: The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. J Biol Chem 275: 11397-11403, 2000.
43. Rau TF, Kothiwal A, Zhang L, et al: Low dose methamphetamine mediates neuroprotection through a PI3K-AKT pathway. Neuropharmacology 61: 677-686, 2011.
44. Kim YR, Kim HN, Jang JY, et al: Electroacupuncture confers beneficial effects through ionotropic glutamate receptors involving phosphatidylinositol-3 kinase/Akt signaling pathway in focal cerebral ischemia in rats. Eur J Integr Med 4: e413-420, 2012.