Brain μ-calpain autolysis during global cerebral ischemia

Journal of Neurochemistry

Volumn 66, Issue 1, 1996, Pages 421-424

  Neumar, Robert W ^a   Hagle, Scott M ^a   DeGracia, Donald J ^a   Krause, Gary S ^a   White, Blaine C ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Calcium; Calpain; Cerebral ischemia; Proteolysis

Indexed keywords

CALPAIN;

ANIMAL TISSUE; ARTICLE; AUTOLYSIS; BRAIN ISCHEMIA; BRAIN PERFUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; RABBIT; REPERFUSION INJURY;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0029671032     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66010421.x     Document Type: Article

References (44)

1. Croall D. E. and Demartino G. N. (1984) Comparison of two calcium-dependent proteinases from bovine heart. Biochim. Biophys. Acta 788, 348-355.
2. Croall D. E. and Demartino G. N. (1991) Calcium-activated neutral protease (calpain) system: structure, function, and regulation. Physiol. Rev. 3, 813-847.
3. Croall D. E., Slaughter C. A., Wortham H. S., Skelly C. M., DeOgny L., and Moomaw C. R. (1992) Polyclonal antisera specific for the proenzyme form of each calpain. Biochim. Biophys. Acta 1121, 47-53.
4. 2+-dependent proteinases (μ-calpain and m-calpain). J. Biol. Chem. 264, 10096-10103.
5. Dayton W. R. (1982) Comparison of low- and high-calcium-requiring forms of the calcium-activated protease with their autocatalytic breakdown products. Biochim. Biophys. Acta 709, 166-172.
6. Dux E., Mies G., Hossman K.-A., and Siklós L. (1987) Calcium in the mitochondria following brief ischemia of gerbil brain. Neurosci. Lett. 78, 295-300.
7. Edmunds T., Nagainis P. A., Sathe S. K., Thompson V. F., and Goll D. E. (1991) Comparison of the autolyzed and unautolyzed forms of μ- and m-calpain from bovine skeletal muscle. Biochim. Biophys. Acta 1077, 197-208.
8. Elce J. S., Sigmund L., and Fox M. J. (1989) Calpain I activation is not correlated with aggregation in human platelets. Biochem. J. 261, 1039-1042.
9. Erecińska M. and Silver I. A. (1991) Relationships between ions and energy metabolism: cerebral calcium movements during ischaemia and subsequent recovery. Can. J. Physiol. 70 (Suppl.), S190-S193.
10. Fukuda T., Adachi E., Kawashamia S., Yoshiya I., and Hashimoto P. H. (1990) Immunohistochemical distribution of calcium-activated neutral proteinases and endogenous CANP inhibitor in the rabbit hippocampus. J. Comp Neurol. 302, 100-109.
11. Hayashi M., Inomata M., Saito Y., Ito H., and Kawashima S. (1991) Activation of intracellular calcium-activated neutral proteinase in erythrocytes and its inhibition by exogenously added inhibitors. Biochim. Biophys. Acta 1094, 249-256.
12. Hong S. C., Goto Y., Lanzino G., Soleau S., Kassell N. F., and Lee K. S. (1994) Neuroprotection with a calpain inhibitor in a model of focal cerebral ischemia. Stroke 25, 663-669.
13. Inomata M., Nomoto M., Hayashi M., Nakamura M., Imahori K., and Kawashima S. (1984) Comparison of low and high calcium requiring forms of the calcium-activated neutral protease (CANP) from rabbit skeletal muscle. J. Biochem. (Tokyo) 95, 1661-1670.
14. Inomata M., Hayashi M., Nakamura M., Imahori K., and Kawashima S. (1985) Hydrolytic and autolytic behavior of two forms of calcium-activated neutral protease (CANP). J. Biochem. (Tokyo) 98, 407-416.
15. Inuzuka T., Tamura A., Sato S., Kirino T., Toyoshima I., and Miyatake T. (1990a) Suppressive effect of E-64c on ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rat. Brain Res. 526, 177-179.
16. Inuzuka T., Tamura A., Sato S., Kirino T., Yanagisawa K., Toyoshima I., and Miyatake T. (1990b) Changes in the concentrations of cerebral proteins following occlusion of the middle cerebral artery in rats. Stroke 21, 917-922.
17. Kaku Y., Yonekawa Y., Tsukahara T., Ogata N., Kimura T., and Taniguchi T. (1993) Alterations of a 200 kDa neurofilament in the rat hippocampus after forebrain ischemia. J. Cereb. Blood Flow Metab. 13, 402-408.
18. Kishimoto A., Mikawa K., Hashimoto K., Yasuda I., Tanaka S., Tominaga M., Kuroda T., and Nishizuka Y. (1989) Limited proteolysis of protein kinase C subspecies by calcium dependent neutral protease (calpain). J. Biol. Chem. 264, 4088-4092.
19. Kitagawa K., Matsumoto M., Niinobe M., Mikoshiba K., Hata R., Ueda H., Handa N., Fukunaga R., Isaka Y., Kiuura K., and Kamada T. (1989) Microtubule-associated protein 2 as a sensitive marker for cerebral ischemic damage - immunohistochemical investigation of dendritic damage. Neuroscience 31, 401-411.
20. Kumar K., Goosmann M., Krause G., Nayini N., Estrada R., Hoehner T., White B., and Koestner A. (1987) Ultrastructural and ionic studies in global ischemic dog brain. Acta Neuropathol. (Berl.) 73, 393-399.
21. Kuwaki T., Satoh H., Ono T., Shibayama F., Yamashita T., and Nishimura T. (1989) Nilvadipine attenuates ischemic degradation of gerbil brain cytoskeletal proteins. Stroke 20, 78-83.
22. Lee K. S., Frank S., Vanderklish P., Aral A., and Lynch G. (1991) Inhibition of proteolysis protects hippocampal neurons from ischemia. Proc. Natl. Acad. Sci. USA 88, 7233-7237.
23. 2+-activated neutral protease is active in the erythrocyte membrane in its nonautolyzed 80-kDa form. J. Biol. Chem. 269, 27992-27995.
24. 2+-dependent proteinase from bovine skeletal muscle. Fed. Proc. 42, 1780.
25. Neumar R. W., DeGracia D. J., White B. C., McDermott P. J., Evans D. R., and Krause G. S. (1995) Eukaryotic initiation factor 4E degradation during brain ischemia. J. Neurochem. 65, 1391-1394.
26. 2+/calmodulin-dependent protein kinase II immunoreactivity in the rat hippocampus after forebrain ischemia. Neurosci. Lett. 113, 134-138.
27. Rami A. and Krieglstein J. (1993) Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo. Brain Res. 609, 67-70.
28. Roberts-Lewis J. M. and Siman R. (1993) Spectrin proteolysis in the hippocampus: a biochemical marker for neuronal injury and neuroprotection. Ann. NY Acad. Sci. 679, 78-86.
29. Roberts-Lewis J. M., Savage M. J , Marcy V. R., Pinsker L. R., and Siman R. (1994) Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain. J. Neurosci. 14, 3934-3944.
30. Saido T. C., Yokota M., Nagao S., Yamaura I., Tani E., Tsuchiya T., Suzuki K., and Kawashima S. (1993) Spatial resolution of fodrin proteolysis in postischemic brain. J. Biol. Chem. 268, 25239-25243.
31. Saido T. C., Sorimachi H., and Suzuki K. (1994) Calpain: new perspectives in molecular diversity and physiological-pathological involvement. FASEB J. 8, 814-822.
32. Samis J. A., Zboril G., and Elce J. S. (1987) Calpain I remains intact and intracellular during platelet activation. Biochem. J. 246, 481-488.
33. Schlaepfer W. W. and Zimmerman U.-J. P. (1985) Mechanisms underlying the neuronal response to ischemic injury. Calcium-activated proteolysis of neurofilaments. Prog. Brain Res. 63, 185-196.
34. Seubert P., Lee K., and Lynch G. (1989) Ischemia triggers NMDA receptor-linked cytoskeletal proteolysis in hippocampus. Brain Res. 492, 366-370.
35. Siesjö B. K. (1993) A new perspective on ischemic brain damage? Prog. Brain Res. 96, 1-9.
36. Siman R. and Noszek J. C. (1988) Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo. Neuron 1, 279-287.
37. Sorimachi H., Saido T. C., and Suzuki K. (1994) New era of calpain research; discovery of tissue-specific calpains. FEBS Lett. 343, 1-5.
38. Suzuki K., Saido T. C., and Hirai S. (1992) Modulation of cellular signals by calpain. Ann. NY Acad. Sci. 674, 218-227.
39. Tomimoto H. and Yanagihara T. (1992) Immunoelectron microscopic study of tubulin and microtubule-associated proteins after transient cerebral ischemia in gerbils. Acta Neuropathol. (Berl.) 84, 394-399.
40. Wang K. K. W. (1990) Developing selective inhibitors of calpain. Trends Pharmacol. Sci. 11, 139-142.
41. White B. C., Grossman L. I., and Krause G. S. (1993) Membrane damage and repair in brain injury by ischemia and reperfusion. Neurology 43, 1656-1665.
42. Wieloch T., Cardell M., Bingren H., Zivin J., and Saitoh T. (1991) Changes in the activity of protein kinase C and the differential subcellular redistribution of its isozymes in the rat striatum during and following transient forebrain ischemia. J. Neurochem. 56, 1227-1235.
43. Yamamoto H., Fukunaga K., Lee K., and Soderling T. R. (1992) Ischemia-induced loss of brain calcium/calmodulin-dependent protein kinase II. J. Neurochem. 58, 1110-1117.
44. Yanagihara T., Brengman J. M., and Mushynski W. E. (1990) Differential vulnerability of microtubule components in cerebral ischemia. Acta Neuropathol. (Berl.) 80, 499-505.