Electroacupuncture confers beneficial effects through ionotropic glutamate receptors involving phosphatidylinositol-3 kinase/Akt signaling pathway in focal cerebral ischemia in rats

European Journal of Integrative Medicine

Volumn 4, Issue 4, 2012, Pages

  Kim, Yu Ri ^a   Kim, Ha Neui ^a   Jang, Ji Yeon ^a   Park, Cheol ^b   Choi, Yung Hyun ^b   Shin, Hwa Kyoung ^a   Choi, Byung Tae ^a  

^a Pusan National University   (South Korea)

^b Dong Eui University   (South Korea)

Author keywords

Cerebral ischemia; Electroacupuncture; N methyl d aspartate; Phosphatidylinositol 3 kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; IONOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ACUPRESSURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL SURVIVAL; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; ELECTROACUPUNCTURE; ENZYME ACTIVATION; EXCITOTOXICITY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL; NEUROLOGIC EXAMINATION; NEUROPROTECTION; NONHUMAN; PARIETAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

EID: 84872410433     PISSN: 18763820     EISSN: 18763839     Source Type: Journal    
DOI: 10.1016/j.eujim.2012.06.004     Document Type: Article

References (26)

1. Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1988, 1:623-634.
2. Lee J.M., Zipfel G.J., Choi D.W. The changing landscape of ischaemic brain injury mechanisms. Nature 1999, 1399:A7-A14.
3. Lipton S.A., Rosenberg P.A. Excitatory amino acids as a final common pathway for neurologic disorders. New England Journal of Medicine 1994, 330:613-622.
4. Swanson R.A., Farrell K., Simon R.P. Acidosis causes failure of astrocyte glutamate uptake during hypoxia. Journal of Cerebral Blood Flow and Metabolism 1995, 15:417-424.
5. Nakanishi N., Tu S., Shin Y., Cui J., Kurokawa T., Zhang D., et al. Neuroprotection by the NR3A subunit of the NMDA receptor. Journal of Neuroscience 2009, 29:5260-5265.
6. Ankarcrona M., Dypbukt J.M., Bonfoco E., Zhivotovsky B., Orrenius S., Lipton S.A., et al. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 1995, 15:961-973.
7. Xiong Z.Q., McNamara J.O. Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack. Neuron 2002, 36:363-374.
8. Endres M., Dirnagl U. Ischemia and stroke. Molecular and cellular biology of neuroprotection in the CNS, advances in experimental medicine and biology 2003, 455-473. Kluwer Academic/Plenum Publishers, New York. C. Alzheimer (Ed.).
9. Stanika R.I., Pivovarova N.B., Brantner C.A., Watts C.A., Winters C.A., Andrews S.B. Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:9854-9859.
10. Namura S., Zhu J., Fink K., Endres M., Srinivasan A., Tomaselli K.J., et al. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. Journal of Neuroscience 1998, 18:3659-3668.
11. Neumar R.W., Hagle S.M., DeGracia D.J., Krause G.S., White B.C. Brain mu-calpain autolysis during global cerebral ischemia. Journal of Neurochemistry 1996, 66:421-424.
12. Du Y., Shi L., Li J., Xiong J., Li B., Fan X. Angiogenesis and improved cerebral blood flow in the ischemic boundary area were detected after electroacupuncture treatment to rats with ischemic stroke. Neurological Research 2011, 33:101-107.
13. Wang Q., Li X., Chen Y., Wang F., Yang Q., Chen S., et al. Activation of epsilon protein kinase C-mediated anti-apoptosis is involved in rapid tolerance induced by electroacupuncture pretreatment through cannabinoid receptor type 1. Stroke 2011, 42:389-396.
14. Lee G.J., Yin C.S., Choi S.K., Choi S., Yang J.S., Lee H., et al. Acupuncture attenuates extracellular glutamate level in global ischemia model of rat. Neurological Research 2010, 32:S79-S83.
15. Mori H., Mishina M. Structure and function of the NMDA receptor channel. Neuropharmacology 1995, 34:1219-1237.
16. Cull-Candy S., Brickley S., Farrant M. NMDA receptor subunits: diversity, development and disease. Current Opinion in Neurobiology 2001, 11:327-335.
17. Pellegrini-Giampietro D.E., Gorter J.A., Bennett M.V., Zukin R.S. The GluR2 (GluR-B) hypothesis: Ca(2+)-permeable AMPA receptors in neurological disorders. Trends in Neurosciences 1997, 20:464-470.
18. Hardingham G.E., Fukunaga Y., Bading H. Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nature Neuroscience 2002, 5:405-414.
19. Gascón S., Sobrado M., Roda J.M., Rodríguez-Peña A., Díaz-Guerra M. Excitotoxicity and focal cerebral ischemia induce truncation of the NR2A and NR2B subunits of the NMDA receptor and cleavage of the scaffolding protein PSD-95. Molecular Psychiatry 2008, 13:99-114.
20. Zhang Y.Q., Ji G.C., Wu G.C., Zhao Z.Q. Excitatory amino acid receptor antagonists and electroacupuncture synergetically inhibit carrageenan-induced behavioral hyperalgesia and spinal fos expression in rats. Pain 2002, 99:525-535.
21. Leitges M., Kovac J., Plomann M., Linden D.J. A unique PDZ ligand in PKCalpha confers induction of cerebellar long-term synaptic depression. Neuron 2004, 44:585-594.
22. Noshita N., Sugawara T., Fujimura M., Morita-Fujimura Y., Chan P.H. Manganese superoxide dismutase affects cytochrome c release and caspase-9 activation after transient focal cerebral ischemia in mice. Journal of Cerebral Blood Flow and Metabolism 2001, 21:557-567.
23. Shehadah A., Chen J., Zacharek A., Cui Y., Ion M., Roberts C., et al. Niaspan treatment induces neuroprotection after stroke. Neurobiology of Disease 2010, 40:277-283.
24. Roberts-Lewis J.M., Savage M.J., Marcy V.R., Pinsker L.R., Siman R. Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain. Journal of Neuroscience 1994, 14:3934-3944.
25. Fujiki M., Abe E., Nagai Y., Shiqi K., Kubo T., Ishii K., et al. Electroconvulsive seizure-induced VEGF is correlated with neuroprotective effects against cerebral infarction: involvement of the phosphatidylinositol-3 kinase/Akt pathway. Experimental Neurology 2010, 225:377-383.
26. Schulz J.B., Weller M., Matthews R.T., Heneka M.T., Groscurth P., Martinou J.C., et al. Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia. Cell Death and Differentiation 1998, 5:847-857.