Functional significance of CD57 expression on human NK cells and relevance to disease

Frontiers in Immunology

Volumn 4, Issue DEC, 2013, Pages

  Nielsen, Carolyn M ^a   White, Matthew J ^a   Goodier, Martin R ^a   Riley, Eleanor M ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Ageing; Autoimmune diseases; Cancer; CD57; Chronic infection; HCMV infection; NK cells; T cells

Indexed keywords

CD28 ANTIGEN; CD57 ANTIGEN; CD8 ANTIGEN; FAS ANTIGEN; GLYCOPROTEIN GP 130; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 18; INTERLEUKIN 2; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3;

AGING; ALOPECIA AREATA; ATOPIC DERMATITIS; AUTOIMMUNITY; CELL DIFFERENTIATION; CHIKUNGUNYA; CYTOMEGALOVIRUS INFECTION; DISEASE COURSE; HANTAVIRUS INFECTION; HEPATITIS B; HEPATITIS C; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOGLOBULIN A NEPHROPATHY; INFECTION; LYME DISEASE; NATURAL KILLER CELL; NEOPLASM; NONHUMAN; PROTEIN EXPRESSION; PSORIASIS; SHORT SURVEY; SJOEGREN SYNDROME;

EID: 84892158821     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00422     Document Type: Short Survey

References (129)

1. Abo T, Balch CM. A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). J Immunol (1981) 127(3):1024-9.
2. Knapp W, Rieber P, Dörken B, Schmidt RE, Stein H, vd Borne AE. Towards a better definition of human leucocyte surface molecules. Immunol Today (1989) 10(8):253-8. doi:10.1016/0167-5699(89)90135-7.
3. Abo T, Cooper MD, Balch CM. Characterization of HNK-1+ (Leu-7) human lymphocytes. I. Two distinct phenotypes of human NK cells with different cytotoxic capability. J Immunol (1982) 129(4):1752-7.
4. Lanier LL, Le AM, Phillips JH, Warner NL, Babcock GF. Subpopulations of human natural killer cells defined by expression of the Leu-7 (HNK-1) and Leu-11 (NK-15) antigens. J Immunol (1983) 131(4):1789-96.
5. Manara GC, Ferrari C, De Panfilis G. HNK-1 antigen is not specific for natural killer cells. J Invest Dermatol (1988) 91(4):374-5. doi:10.1111/1523-1747.ep12476309.
6. Clement LT, Grossi CE, Gartland GL. Morphologic and phenotypic features of the subpopulation of Leu-2+ cells that suppresses B cell differentiation. J Immunol (1984) 133(5):2461-8.
7. Markey AC, MacDonald DM. HNK-1 antigen is not specific for natural killer cells. J Invest Dermatol (1989) 92(5):774-5. doi:10.1111/1523-1747.ep12722580.
8. Lipinski M, Braham K, Caillaud JM, Carlu C, Tursz T. HNK-1 antibody detects an antigen expressed on neuroectodermal cells. J Exp Med (1983) 158(5):1775-80. doi:10.1084/jem.158.5.1775.
9. Schuller-Petrovic S, Gebhart W, Lassmann H, Rumpold H, Kraft D. A shared antigenic determinant between natural killer cells and nervous tissue. Nature (1983) 306(5939):179-81. doi:10.1038/306179a0.
10. Shioda Y, Nagura H, Tsutsumi Y, Shimamura K, Tamaoki N. Distribution of Leu 7 (HNK-1) antigen in human digestive organs: an immunohistochemical study with monoclonal antibody. Histochem J (1984) 16(8):843-54. doi:10.1007/BF01002790.
11. Ando I, Tamaki K. HNK-I antibody reacts with peripheral nerves and sweat glands in the skin. Br J Dermatol (1985) 113(2):175-8. doi:10.1111/j.1365-2133.1985.tb02061.x.
12. Bunn PA Jr, Linnoila I, Minna JD, Carney D, Gazdar AF. Small cell lung cancer, endocrine cells of the fetal bronchus, and other neuroendocrine cells express the Leu-7 antigenic determinant present on natural killer cells. Blood (1985) 65(3):764-8.
13. Lauweryns JM, Van Ranst L. Leu-7 immunoreactivity in human, monkey, and pig bronchopulmonary neuroepithelial bodies and neuroendocrine cells. J Histochem Cytochem (1987) 35(6):687-91. doi:10.1177/35.6.3106468.
14. Chou DK, Ilyas AA, Evans JE, Costello C, Quarles RH, Jungalwala FB. Structure of sulfated glucuronyl glycolipids in the nervous system reacting with HNK-1 antibody and some IgM paraproteins in neuropathy. J Biol Chem (1986) 261(25):11717-25.
15. Voshol H, van Zuylen CW, Orberger G, Vliegenthart JF, Schachner M. Structure of the HNK-1 carbohydrate epitope on bovine peripheral myelin glycoprotein P0. J Biol Chem (1996) 271(38):22957-60. doi:10.1074/jbc.271.38.22957.
16. Ariga T, Kohriyama T, Freddo L, Latov N, Saito M, Kon K, et al. Characterization of sulfated glucuronic acid containing glycolipids reacting with IgM M-proteins in patients with neuropathy. J Biol Chem (1987) 262(2):848-53.
17. Künemund V, Jungalwala FB, Fischer G, Chou DK, Keilhauer G, Schachner M. The L2/HNK-1 carbohydrate of neural cell adhesion molecules is involved in cell interactions. J Cell Biol (1988) 106(1):213-23. doi:10.1083/jcb.106.1.213.
18. Cebo C, Durier V, Lagant P, Maes E, Florea D, Lefebvre T, et al. Function and molecular modeling of the interaction between human interleukin 6 and its HNK-1 oligosaccharide ligands. J Biol Chem (2002) 277(14):12246-52. doi:10.1074/jbc.M106816200.
19. Sze DM, Giesajtis G, Brown RD, Raitakari M, Gibson J, Ho J, et al. Clonal cytotoxic T cells are expanded in myeloma and reside in the CD8(+)CD57(+)CD28(-) compartment. Blood (2001) 98(9):2817-27. doi:10.1182/blood.V98.9.2817.
20. Vallejo AN. CD28 extinction in human T cells: altered functions and the program of T-cell senescence. Immunol Rev (2005) 205:158-69. doi:10.1111/j.0105-2896.2005.00256.x.
21. Focosi D, Bestagno M, Burrone O, Petrini M. CD57+ T lymphocytes and functional immune deficiency. J Leukoc Biol (2010) 87(1):107-16. doi:10.1189/jlb.0809566.
22. Chong LK, Aicheler RJ, Llewellyn-Lacey S, Tomasec P, Brennan P, Wang EC. Proliferation and interleukin 5 production by CD8hi CD57+ T cells. Eur J Immunol (2008) 38(4):995-1000. doi:10.1002/eji.200737687.
23. Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ, Crotty LE, et al. Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood (2003) 101(7):2711-20. doi:10.1182/blood-2002-07-2103.
24. Wood KL, Twigg HL III, Doseff AI. Dysregulation of CD8+ lymphocyte apoptosis, chronic disease, and immune regulation. Front Biosci (Landmark Ed) (2009) 14:3771-81. doi:10.2741/3487.
25. Pedroza-Seres M, Linares M, Voorduin S, Enrique RR, Lascurain R, Garfias Y, et al. Pars planitis is associated with an increased frequency of effector-memory CD57+ T cells. Br J Ophthalmol (2007) 91(10):1393-8. doi:10.1136/bjo.2007.116277.
26. Chattopadhyay PK, Betts MR, Price DA, Gostick E, Horton H, Roederer M, et al. The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression. J Leukoc Biol (2009) 85(1):88-97. doi:10.1189/jlb.0208107.
27. Vivier E, Anfossi N. Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future. Nat Rev Immunol (2004) 4(3):190-8. doi:10.1038/nri1306.
28. Papagno L, Spina CA, Marchant A, Salio M, Rufer N, Little S, et al. Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol (2004) 2(2):E20. doi:10.1371/journal.pbio.0020020.
29. Lopez-Vergès S, Milush JM, Pandey S, York VA, Arakawa-Hoyt J, Pircher H, et al. CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset. Blood (2010) 116(19):3865-74. doi:10.1182/blood-2010-04-282301.
30. Björkström NK, Riese P, Heuts F, Andersson S, Fauriat C, Ivarsson MA, et al. Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education. Blood (2010) 116(19):3853-64. doi:10.1182/blood-2010-04-281675.
31. Abo T, Miller CA, Balch CM. Characterization of human granular lymphocyte subpopulations expressing HNK-1 (Leu-7) and Leu-11 antigens in the blood and lymphoid tissues from fetuses, neonates and adults. Eur J Immunol (1984) 14(7):616-23. doi:10.1002/eji.1830140707.
32. Phillips JH, Lanier LL. A model for the differentiation of human natural killer cells. Studies on the in vitro activation of Leu-11+ granular lymphocytes with a natural killer-sensitive tumor cell, K562. J Exp Med (1985) 161(6):1464-82. doi:10.1084/jem.161.6.1464.
33. Solana R, Tarazona R, Gayoso I, Lesur O, Dupuis G, Fulop T. Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans. Semin Immunol (2012) 24(5):331-41. doi:10.1016/j.smim.2012.04.008.
34. Cichocki F, Miller JS, Anderson SK, Bryceson YT. Epigenetic regulation of NK cell differentiation and effector functions. Front Immunol (2013) 4:55. doi:10.3389/fimmu.2013.00055.
35. Krishnaraj R, Svanborg A. Preferential accumulation of mature NK cells during human immunosenescence. J Cell Biochem (1992) 50(4):386-91. doi:10.1002/jcb.240500407.
36. Vesely MD, Kershaw MH, Schreiber RD, Smyth MJ. Natural innate and adaptive immunity to cancer. Annu Rev Immunol (2011) 29:235-71. doi:10.1146/annurev-immunol-031210-101324.
37. Strioga M, Pasukoniene V, Characiejus D. CD8+ CD28-and CD8+ CD57+ T cells and their role in health and disease. Immunology (2011) 134(1):17-32. doi:10.1111/j.1365-2567.2011.03470.x.
38. Characiejus D, Pasukoniene V, Kazlauskaite N, Valuckas KP, Petraitis T, Mauricas M, et al. Predictive value of CD8highCD57+ lymphocyte subset in interferon therapy of patients with renal cell carcinoma. Anticancer Res (2002) 22(6B):3679-83.
39. Characiejus D, Pasukoniene V, Jonusauskaite R, Azlauskaite N, Aleknavicius E, Mauricas M, et al. Peripheral blood CD8highCD57+ lymphocyte levels may predict outcome in melanoma patients treated with adjuvant interferon-alpha. Anticancer Res (2008) 28(2B):1139-42.
40. Akagi J, Baba H. Prognostic value of CD57(+) T lymphocytes in the peripheral blood of patients with advanced gastric cancer. Int J Clin Oncol (2008) 13(6):528-35. doi:10.1007/s10147-008-0789-8.
41. Sze DM, Brown RD, Yuen E, Gibson J, Ho J, Raitakari M, et al. Clonal cytotoxic T cells in myeloma. Leuk Lymphoma (2003) 44(10):1667-74. doi:10.1080/1042819031000097438.
42. Van den Hove LE, Vandenberghe P, Van Gool SW, Ceuppens JL, Demuynck H, Verhoef GE, et al. Peripheral blood lymphocyte subset shifts in patients with untreated hematological tumors: evidence for systemic activation of the T cell compartment. Leuk Res (1998) 22(2):175-84. doi:10.1016/S0145-2126(97)00152-5.
43. Atayar C, Poppema S, Visser L, van den Berg A. Cytokine gene expression profile distinguishes CD4+/CD57+ T cells of the nodular lymphocyte predominance type of Hodgkin's lymphoma from their tonsillar counterparts. J Pathol (2006) 208(3):423-30. doi:10.1002/path.1894.
44. Serrano D, Monteiro J, Allen SL, Kolitz J, Schulman P, Lichtman SM, et al. Clonal expansion within the CD4+CD57+ and CD8+CD57+ T cell subsets in chronic lymphocytic leukemia. J Immunol (1997) 158(3):1482-9.
45. Di Girolamo W, Coronato S, Portiansky E, Laguens G. Profile of immune cells in lymph nodes draining human malignant tumors. Medicina (B Aires) (2008) 68(6):423-7.
46. Kiessling R, Klein E, Wigzell H. "Natural" killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype. Eur J Immunol (1975) 5(2):112-7. doi:10.1002/eji.1830050208.
47. Herberman RB, Nunn ME, Lavrin DH. Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic acid allogeneic tumors. I. Distribution of reactivity and specificity. Int J Cancer (1975) 16(2):216-29. doi:10.1002/ijc.2910160205.
48. Herberman RB, Nunn ME, Holden HT, Lavrin DH. Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells. Int J Cancer (1975) 16(2):230-9. doi:10.1002/ijc.2910160205.
49. Lakshmi Narendra B, Eshvendar Reddy K, Shantikumar S, Ramakrishna S. Immune system: a double-edged sword in cancer. Inflamm Res (2013) 62(9):823-34. doi:10.1007/s00011-013-0645-9.
50. Bubenik J. MHC class I down-regulation: tumour escape from immune surveillance? (review). Int J Oncol (2004) 25(2):487-91.
51. Vivier E, Ugolini S, Blaise D, Chabannon C, Brossay L. Targeting natural killer cells and natural killer T cells in cancer. Nat Rev Immunol (2012) 12(4):239-52. doi:10.1038/nri3174.
52. Ménard C, Blay JY, Borg C, Michiels S, Ghiringhelli F, Robert C, et al. Natural killer cell IFN-gamma levels predict long-term survival with imatinib mesylate therapy in gastrointestinal stromal tumor-bearing patients. Cancer Res (2009) 69(8):3563-9. doi:10.1158/0008-5472.CAN-08-3807.
53. Abo T, Cooper MD, Balch CM. Postnatal expansion of the natural killer and keller cell population in humans identified by the monoclonal HNK-1 antibody. J Exp Med (1982) 155(1):321-6. doi:10.1084/jem.155.1.321.
54. Krishnaraj R, Blandford G. Age-associated alterations in human natural killer cells. 2. Increased frequency of selective NK subsets. Cell Immunol (1988) 114(1):137-48. doi:10.1016/0008-8749(88)90261-4.
55. McNerlan SE, Rea IM, Alexander HD, Morris TC. Changes in natural killer cells, the CD57CD8 subset, and related cytokines in healthy aging. J Clin Immunol (1998) 18(1):31-8. doi:10.1023/A:1023283719877.
56. Gayoso I, Sanchez-Correa B, Campos C, Alonso C, Pera A, Casado JG, et al. Immunosenescence of human natural killer cells. J Innate Immun (2011) 3(4):337-43. doi:10.1159/000328005.
57. Sorskaar D, Forre O, Lie SO. Increased natural-killer cell-activity and numbers of Leu-7 and Leu-11b (Cd 16)-positive cells in bone-marrow of children in remission from acute lymphoblastic-leukemia. Scand J Immunol (1989) 29(1):65-72. doi:10.1111/j.1365-3083.1989.tb01100.x.
58. Ortaç R, Aktas S, Diniz G, Erbay A, Vergin C. Prognostic role of natural killer cells in pediatric mixed cellularity and nodular sclerosing Hodgkin's disease. Anal Quant Cytol Histol (2002) 24(5):249-53.
59. Vaquero J, Zurita M, Aguayo C, Coca S. Apoptosis is not correlated with the presence of CD57+ NK-cells in brain metastases. Acta Neurochir (Wien) (2003) 145(9):773-6. doi:10.1007/s00701-003-0087-1.
60. Adachi W, Usuda N, Sugenoya A, Iida F. Immune-competent cells of regional lymph-nodes in colorectal-cancer patients: 2. Immunohistochemical analysis of Leu-7+ cells. J Surg Oncol (1990) 45(4):234-41. doi:10.1002/jso.2930450406.
61. Hermann GG, Petersen KR, Steven K, Zeuthen J. Reduced LAK cytotoxicity of peripheral blood mononuclear cells in patients with bladder cancer: decreased LAK cytotoxicity caused by a low incidence of CD56+ and CD57+ mononuclear blood cells. J Clin Immunol (1990) 10(6):311-20. doi:10.1007/BF00917476.
62. Park MH, Lee JS, Yoon JH. High expression of CX3CL1 by tumor cells correlates with a good prognosis and increased tumor-infiltrating CD8+ T cells, natural killer cells, and dendritic cells in breast carcinoma. J Surg Oncol (2012) 106(4):386-92. doi:10.1002/jso.23095.
63. Ishigami S, Natsugoe S, Tokuda K, Nakajo A, Che X, Iwashige H, et al. Prognostic value of intratumoral natural killer cells in gastric carcinoma. Cancer (2000) 88(3):577-83. doi:10.1002/(SICI)1097-0142(20000201)88:3<577::AID-CNCR13>3.0.CO;2-V.
64. Turkseven MR, Oygur T. Evaluation of natural killer cell defense in oral squamous cell carcinoma. Oral Oncol (2010) 46(5):E34-7. doi:10.1016/j.oraloncology.2010.02.019.
65. Giscombe R, Wang XB, Kakoulidou M, Lefvert AK. Characterization of the expanded T-cell populations in patients with Wegener's granulomatosis. J Intern Med (2006) 260(3):224-30. doi:10.1111/j.1365-2796.2006.01688.x.
66. Ratts RB, Karandikar NJ, Hussain RZ, Choy J, Northrop SC, Lovett-Racke AE, et al. Phenotypic characterization of autoreactive T cells in multiple sclerosis. J Neuroimmunol (2006) 178(1-2):100-10. doi:10.1016/j.jneuroim.2006.06.010.
67. Mikulkova Z, Praksova P, Stourac P, Bednarik J, Strajtova L, Pacasova R, et al. Numerical defects in CD8+CD28-T-suppressor lymphocyte population in patients with type 1 diabetes mellitus and multiple sclerosis. Cell Immunol (2010) 262(2):75-9. doi:10.1016/j.cellimm.2010.02.002.
68. Sun Z, Zhong W, Lu X, Shi B, Zhu Y, Chen L, et al. Association of Graves' disease and prevalence of circulating IFN-gamma-producing CD28(-) T cells. J Clin Immunol (2008) 28(5):464-72. doi:10.1007/s10875-008-9213-4.
69. Wang EC, Lawson TM, Vedhara K, Moss PA, Lehner PJ, Borysiewicz LK. CD8high+ (CD57+) T cells in patients with rheumatoid arthritis. Arthritis Rheum (1997) 40(2):237-48. doi:10.1002/art.1780400208.
70. Takahashi K, Miyake S, Kondo T, Terao K, Hatakenaka M, Hashimoto S, et al. Natural killer type 2 bias in remission of multiple sclerosis. J Clin Invest (2001) 107(5):R23-9. doi:10.1172/JCI11819.
71. Kastrukoff LF, Morgan NG, Zecchini D, White R, Petkau AJ, Satoh J, et al. A role for natural killer cells in the immunopathogenesis of multiple sclerosis. J Neuroimmunol (1998) 86(2):123-33. doi:10.1016/S0165-5728(98)00014-9.
72. Aramaki T, Ida H, Izumi Y, Fujikawa K, Huang M, Arima K, et al. A significantly impaired natural killer cell activity due to a low activity on a per-cell basis in rheumatoid arthritis. Mod Rheumatol (2009) 19(3):245-52. doi:10.1007/s10165-009-0160-6.
73. Izumi Y, Ida H, Huang M, Iwanaga N, Tanaka F, Aratake K, et al. Characterization of peripheral natural killer cells in primary Sjogren's syndrome: impaired NK cell activity and low NK cell number. J Lab Clin Med (2006) 147(5):242-9. doi:10.1016/j.lab.2006.01.001.
74. Park YW, Kee SJ, Cho YN, Lee EH, Lee HY, Kim EM, et al. Impaired differentiation and cytotoxicity of natural killer cells in systemic lupus erythematosus. Arthritis Rheum (2009) 60(6):1753-63. doi:10.1002/art.24556.
75. Ciampolillo A, Guastamacchia E, Amati L, Magrone T, Munno I, Jirillo E, et al. Modifications of the immune responsiveness in patients with autoimmune thyroiditis: evidence for a systemic immune alteration. Curr Pharm Des (2003) 9(24):1946-50. doi:10.2174/1381612033454270.
76. Cameron AL, Kirby B, Griffiths CE. Circulating natural killer cells in psoriasis. Br J Dermatol (2003) 149(1):160-4. doi:10.1046/j.1365-2133.2003.05319.x.
77. O'Gorman M, Smith R, Garrison A, Shamiyeh E, Pachman L. Lymphocyte subsets in peripheral blood from newly diagnosed, untreated patients with juvenile dermatomyositis (JDM) are associated with disease activity scores (DAS). Arthritis Rheum (2002) 46(9):S490-490.
78. Wouters CHP, Ceuppens JL, Stevens EAM. Different circulating lymphocyte profiles in patients with different subtypes of juvenile idiopathic arthritis. Clin Exp Rheumatol (2002) 20(2):239-48.
79. Takahashi K, Aranami T, Endoh M, Miyake S, Yamamura T. The regulatory role of natural killer cells in multiple sclerosis. Brain (2004) 127:1917-27. doi:10.1093/brain/awh219.
80. Rabbani GR, Phyliky RL, Tefferi A. A long-term study of patients with chronic natural killer cell lymphocytosis. Br J Haematol (1999) 106(4):960-6. doi:10.1046/j.1365-2141.1999.01624.x.
81. Tefferi A, Li CY, Witzig TE, Dhodapkar MV, Okuno SH, Phyliky RL. Chronic natural killer cell lymphocytosis: a descriptive clinical study. Blood (1994) 84(8):2721-5.
82. Dotta F, Censini S, van Halteren AG, Marselli L, Masini M, Dionisi S, et al. Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc Natl Acad Sci U S A (2007) 104(12):5115-20. doi:10.1073/pnas.0700442104.
83. Ottaviani C, Nasorri F, Bedini C, de Pità O, Girolomoni G, Cavani A. CD56(bright)CD16(-) NK cells accumulate in psoriatic skin in response to CXCL10 and CCL5 and exacerbate skin inflammation. Eur J Immunol (2006) 36(1):118-28. doi:10.1002/eji.200535243.
84. Dalbeth N, Callan MFC. A subset of natural killer cells is greatly expanded within inflamed joints. Arthritis Rheum (2002) 46(7):1763-72. doi:10.1002/art.10410.
85. Batista MD, Ho EL, Kuebler PJ, Milush JM, Lanier LL, Kallas EG, et al. Skewed distribution of natural killer cells in psoriasis skin lesions. Exp Dermatol (2013) 22(1):64-6. doi:10.1111/exd.12060.
86. de Matos CT, Berg L, Michaëlsson J, Felländer-Tsai L, Kärre K, Söderström K. Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretion. Immunology (2007) 122(2):291-301. doi:10.1111/j.1365-2567.2007.02638.x.
87. Lv L, Pan K, Li XD, She KL, Zhao JJ, Wang W, et al. The accumulation and prognosis value of tumor infiltrating IL-17 producing cells in esophageal squamous cell carcinoma. PLoS One (2011) 6(3):e18219. doi:10.1371/journal.pone.0018219.
88. Villegas FR, Coca S, Villarrubia VG, Jiménez R, Chillón MJ, Jareño J, et al. Prognostic significance of tumor infiltrating natural killer cells subset CD57 in patients with squamous cell lung cancer. Lung Cancer (2002) 35(1):23-8. doi:10.1016/S0169-5002(01)00292-6.
89. Takanami I, Takeuchi K, Giga M. The prognostic value of natural killer cell infiltration in resected pulmonary adenocarcinoma. J Thorac Cardiovasc Surg (2001) 121(6):1058-63. doi:10.1067/mtc.2001.113026.
90. Balch CM, Tilden AB, Dougherty PA, Cloud GA. Depressed levels of granular lymphocytes with natural killer (NK) cell function in 247 cancer patients. Ann Surg (1983) 198(2):192-9. doi:10.1097/00000658-198308000-00014.
91. Imai R, Miura J, Numata K, Aikawa Y, Takamori K, Ogawa H. Analysis of T cell, activated T cell and NK cell subsets in peripheral blood lymphocytes from patients with alopecia areata. In: Van Neste D, Lachapelle JM, Antoine JL, editors. Trends in Human Hair Growth and Alopecia Research. Springer Netherlands (1989). p. 299-304. doi:10.1007/978-94-011-7873-0_31.
92. Fateminasab FD, Shahgasempour S, Mirsaeidi SM, Tabarsi P, Mansoori SD, Entezami Z. Increased activation and expansion of a CD57+ subset within peripheral CD8+ T lymphocytes in Mycobacterium tuberculosis-infected patients. Arch Iran Med (2006) 9(1):53-7.
93. García-Muñoz R, Rodríguez-Otero P, Galar A, Merino J, Beunza JJ, Páramo JA, et al. Expansion of CD8+CD57+ T cells in an immunocompetent patient with acute toxoplasmosis. Adv Hematol (2009) 2009:173439. doi:10.1155/2009/173439.
94. Dolstra H, Preijers F, Van de Wiel-van Kemenade E, Schattenberg A, Galama J, de Witte T. Expansion of CD8+CD57+ T cells after allogeneic BMT is related with a low incidence of relapse and with cytomegalovirus infection. Br J Haematol (1995) 90(2):300-7. doi:10.1111/j.1365-2141.1995.tb05150.x.
95. Mendes AV, Kallas EG, Benard G, Pannuti CS, Menezes R, Dulley FL, et al. Impact of cytomegalovirus and grafts versus host disease on the dynamics of CD57+CD28-CD8+ T cells after bone marrow transplant. Clinics (Sao Paulo) (2008) 63(5):667-76. doi:10.1590/S1807-59322008000500016.
96. Borysiewicz LK, Rodgers B, Morris S, Graham S, Sissons JG. Lysis of human cytomegalovirus infected fibroblasts by natural killer cells: demonstration of an interferon-independent component requiring expression of early viral proteins and characterization of effector cells. J Immunol (1985) 134(4):2695-701.
97. Béziat V, Dalgard O, Asselah T, Halfon P, Bedossa P, Boudifa A, et al. CMV drives clonal expansion of NKG2C+ NK cells expressing self-specific KIRs in chronic hepatitis patients. Eur J Immunol (2012) 42(2):447-57. doi:10.1002/eji.201141826.
98. Gumá M, Angulo A, Vilches C, Gómez-Lozano N, Malats N, López-Botet M. Imprint of human cytomegalovirus infection on the NK cell receptor repertoire. Blood (2004) 104(12):3664-71. doi:10.1182/blood-2004-05-2058.
99. Lopez-Vergès S, Milush JM, Schwartz BS, Pando MJ, Jarjoura J, York VA, et al. Expansion of a unique CD57(+)NKG2Chi natural killer cell subset during acute human cytomegalovirus infection. Proc Natl Acad Sci U S A (2011) 108(36):14725-32. doi:10.1073/pnas.1110900108.
100. Hong HS, Eberhard JM, Keudel P, Bollmann BA, Ballmaier M, Bhatnagar N, et al. HIV infection is associated with a preferential decline in less-differentiated CD56dim CD16+ NK cells. J Virol (2010) 84(2):1183-8. doi:10.1128/JVI.01675-09.
101. Gumá M, Cabrera C, Erkizia I, Bofill M, Clotet B, Ruiz L, et al. Human cytomegalovirus infection is associated with increased proportions of NK cells that express the CD94/NKG2C receptor in aviremic HIV-1-positive patients. J Infect Dis (2006) 194(1):38-41. doi:10.1086/504719.
102. Mela CM, Goodier MR. The contribution of cytomegalovirus to changes in NK cell receptor expression in HIV-1-infected individuals. J Infect Dis (2007) 195(1):158-9. author reply 159-60, doi:10.1086/509811.
103. Peppa D, Gill US, Reynolds G, Easom NJ, Pallett LJ, Schurich A, et al. Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion. J Exp Med (2013) 210(1):99-114. doi:10.1084/jem.20121172.
104. Wallace DL, Masters JE, De Lara CM, Henson SM, Worth A, Zhang Y, et al. Human cytomegalovirus-specific CD8(+) T-cell expansions contain long-lived cells that retain functional capacity in both young and elderly subjects. Immunology (2011) 132(1):27-38. doi:10.1111/j.1365-2567.2010.03334.x.
105. Le Priol Y, Puthier D, Lécureuil C, Combadière C, Debré P, Nguyen C, et al. High cytotoxic and specific migratory potencies of senescent CD8+ CD57+ cells in HIV-infected and uninfected individuals. J Immunol (2006) 177(8):5145-54.
106. Manfras BJ, Weidenbach H, Beckh KH, Kern P, Möller P, Adler G, et al. Oligoclonal CD8+ T-cell expansion in patients with chronic hepatitis C is associated with liver pathology and poor response to interferon-alpha therapy. J Clin Immunol (2004) 24(3):258-71. doi:10.1023/B:JOCI.0000025447.23473.ab.
107. Lynne JE, Schmid I, Matud JL, Hirji K, Buessow S, Shlian DM, et al. Major expansions of select CD8+ subsets in acute Epstein-Barr virus infection: comparison with chronic human immunodeficiency virus disease. J Infect Dis (1998) 177(4):1083-7. doi:10.1086/517400.
108. Isa A, Kasprowicz V, Norbeck O, Loughry A, Jeffery K, Broliden K, et al. Prolonged activation of virus-specific CD8+T cells after acute B19 infection. PLoS Med (2005) 2(12):e343. doi:10.1371/journal.pmed.0020343.
109. Aronsson B, Troye-Blomberg M, Smedman L. Increase of circulating CD8+CD57+ lymphocytes after measles infection but not after measles vaccination. J Clin Lab Immunol (2004) 53:1-12.
110. Gratama JW, Kluin-Nelemans HC, Langelaar RA, den Ottolander GJ, Stijnen T, D'Amaro J, et al. Flow cytometric and morphologic studies of HNK1+ (Leu 7+) lymphocytes in relation to cytomegalovirus carrier status. Clin Exp Immunol (1988) 74(2):190-5.
111. Foley B, Cooley S, Verneris MR, Pitt M, Curtsinger J, Luo X, et al. Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function. Blood (2012) 119(11):2665-74. doi:10.1182/blood-2011-10-386995.
112. Foley B, Cooley S, Verneris MR, Curtsinger J, Luo X, Waller EK, et al. Human cytomegalovirus (CMV)-induced memory-like NKG2C(+) NK cells are transplantable and expand in vivo in response to recipient CMV antigen. J Immunol (2012) 189(10):5082-8. doi:10.4049/jimmunol.1201964.
113. Wu Z, Sinzger C, Frascaroli G, Reichel J, Bayer C, Wang L, et al. Human cytomegalovirus-induced NKG2Chi CD57hi natural killer cells are effectors dependent on humoral antiviral immunity. J Virol (2013) 87(13):7717-25. doi:10.1128/JVI.01096-13.
114. Björkström NK, Lindgren T, Stoltz M, Fauriat C, Braun M, Evander M, et al. Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus. J Exp Med (2011) 208(1):13-21. doi:10.1084/jem.20100762.
115. Petitdemange C, Becquart P, Wauquier N, Béziat V, Debré P, Leroy EM, et al. Unconventional repertoire profile is imprinted during acute chikungunya infection for natural killer cells polarization toward cytotoxicity. PLoS Pathog (2011) 7(9):e1002268. doi:10.1371/journal.ppat.1002268.
116. Björkström NK, Svensson A, Malmberg KJ, Eriksson K, Ljunggren HG. Characterization of natural killer cell phenotype and function during recurrent human HSV-2 infection. PLoS One (2011) 6(11):e27664. doi:10.1371/journal.pone.0027664.
117. Stricker RB, Burrascano J, Winger E. Longterm decrease in the CD57 lymphocyte subset in a patient with chronic Lyme disease. Ann Agric Environ Med (2002) 9(1):111-3.
118. Stricker RB, Winger EE. Decreased CD57 lymphocyte subset in patients with chronic Lyme disease. Immunol Lett (2001) 76(1):43-8. doi:10.1016/S0165-2478(00)00316-3.
119. Marques A, Brown MR, Fleisher TA. Natural killer cell counts are not different between patients with post-Lyme disease syndrome and controls. Clin Vaccine Immunol (2009) 16(8):1249-50. doi:10.1128/CVI.00167-09.
120. Weekes MP, Wills MR, Mynard K, Hicks R, Sissons JG, Carmichael AJ. Large clonal expansions of human virus-specific memory cytotoxic T lymphocytes within the CD57+ CD28-CD8+ T-cell population. Immunology (1999) 98(3):443-9. doi:10.1046/j.1365-2567.1999.00901.x.
121. Fagnoni FF, Vescovini R, Mazzola M, Bologna G, Nigro E, Lavagetto G, et al. Expansion of cytotoxic CD8+ CD28-T cells in healthy ageing people, including centenarians. Immunology (1996) 88(4):501-7. doi:10.1046/j.1365-2567.1996.d01-689.x.
122. Borrego F, Alonso MC, Galiani MD, Carracedo J, Ramirez R, Ostos B, et al. NK phenotypic markers and IL2 response in NK cells from elderly people. Exp Gerontol (1999) 34(2):253-65. doi:10.1016/S0531-5565(98)00076-X.
123. Chidrawar SM, Khan N, Chan YL, Nayak L, Moss PA. Ageing is associated with a decline in peripheral blood CD56bright NK cells. Immun Ageing (2006) 3:10. doi:10.1186/1742-4933-3-10.
124. Le Garff-Tavernier M, Béziat V, Decocq J, Siguret V, Gandjbakhch F, Pautas E, et al. Human NK cells display major phenotypic and functional changes over the life span. Aging Cell (2010) 9(4):527-35. doi:10.1111/j.1474-9726.2010.00584.x.
125. Tilden AB, Grossi CE, Itoh K, Cloud GA, Dougherty PA, Balch CM. Subpopulation analysis of human granular lymphocytes: associations with age, gender and cytotoxic activity. Nat Immun Cell Growth Regul (1986) 5(2):90-9.
126. Wehrmann W, Reinhold U, Kukel S, Franke N, Uerlich M, Kreysel HW. Selective alterations in natural killer cell subsets in patients with atopic dermatitis. Int Arch Allergy Appl Immunol (1990) 92(3):318-22. doi:10.1159/000235196.
127. Matsumura G. [Leu7 (HNK-1)-positive cells in peripheral blood and natural killer cell activity in patients with atopic dermatitis]. Nihon Hifuka Gakkai Zasshi (1990) 100(1):57-62.
128. Struyf NJ, Snoeck HW, Bridts CH, De Clerck LS, Stevens WJ. Natural killer cell activity in Sjogren's syndrome and systemic lupus erythematosus: stimulation with interferons and interleukin-2 and correlation with immune complexes. Ann Rheum Dis (1990) 49(9):690-3. doi:10.1136/ard.49.9.690.
129. Antonaci S, Polignano A, Ottolenghi A, Tortorella C, Schena FP. Redistribution of natural killer (NK) cell frequency and NK cytotoxic activity in primary IgA nephropathy. Cytobios (1992) 69(276):27-34.