Oligoclonal CD8+ T-cell expansion in patients with chronic hepatitis C is associated with liver pathology and poor response to interferon-α therapy

Journal of Clinical Immunology

Volumn 24, Issue 3, 2004, Pages 258-271

  Manfras, Burkhard J ^a   Weidenbach, Hans ^a   Beckh, Karl Heinz ^a   Kern, Peter ^a   Möller, Peter ^a   Adler, Guido ^a   Mertens, Thomas ^a   Boehm, Bernhard O ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

CD8+ T cells; Hepatitis C virus (HCV); IFN therapy; Liver fibrosis; rMHC peptide tetramers

Indexed keywords

ALPHA INTERFERON; CD8 ANTIGEN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FOLLOW UP; HEPATITIS C; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER CIRRHOSIS; LIVER DISEASE; LIVER FIBROSIS; PATHOLOGY; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TREATMENT OUTCOME;

ADULT; AGED; ANTIGENS, CD28; ANTIGENS, CD57; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CLONE CELLS; FEMALE; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; HEPATITIS C, CHRONIC; HLA-DR ANTIGENS; HUMANS; IMMUNOLOGIC MEMORY; INTERFERON-ALPHA; LIVER CIRRHOSIS; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; T-LYMPHOCYTE SUBSETS;

EID: 3543069990     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:JOCI.0000025447.23473.ab     Document Type: Article

References (55)

1. Seeff LB: Natural history of hepatitis C. Hepatology 26:21-28, 1997
2. Lauer GM, Walker BD: Hepatitis C virus infection. N Engl J Med 345:41-52, 2001
3. Muller R: The natural history of hepatitis C: Clinical experiences. J Hepatol 24:52-54, 1996
4. Kenny-Walsh E: The Irish Hepatology Research Group: Clinical outcomes after hepatitis C infection from contaminated anti-D immune globulin. N Engl J Med 340:1228-1233, 1999
5. Guerret S, Desmouliere A, Chossegros P, Costa AM, Badid C, Trepo C, Grimaud JA, Chevallier M: Long-term administration of interferon-alpha in non-responder patients with chronic hepatitis C: Follow-up of liver fibrosis over 5 years. J Viral Hepat 6:125-133, 1999
6. + T cells in chronic hepatitis C virus infection. J Immunol 169:3447-3458, 2002
7. Jaeckel E, Cornberg M, Wedemeyer H, Santantonio T, Mayer J, Zankel M, Pastore G, Dietrich M, Trautwein C, Manns MP: The German Acute Hepatitis C Therapy Group: Treatment of acute hepatitis C with interferon alfa-2b. N Engl J Med: 1452-1457, 2001
8. Tilg H: New insights into the mechanisms of interferon alpha: An immunoregulatory and anti-inflammatory cytokine. Gastroenterology 112:1017-1021, 1997
9. Isaacs A: Inferon. Adv Virus Res 10:1-38, 1963
10. Cella M, Salio M, Sakakibara Y, Langen H, Julkunen I, Lanzavecchia A: Maturation, activation, and protection of dendritic cells induced by double-stranded RNA. J Exp Med 189:821-829, 1999
11. Kaser A, Nagata S, Tilg H: Interferon alpha augments activation-induced T cell death by upregulation of Fas (CD95/APO-1) and Fas ligand expression. Cytokine 11:736-743, 1999
12. Nishiguchi S, Kuroki T, Nakatani S, Morimoto H, Takeda T, Nakajima S, Shiomi S, Seki S, Kobayashi K, Otani S: Randomised trial of effects of interferon-alpha on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis. Lancet 346:1051-1055, 1995
13. + T cells in peripheral blood. Viral Immunol 14:59-69, 2001
14. Jin Y, Fuller L, Carreno M, Zucker K, Roth D, Esquenazi V, Karatzas T, Swanson SJ, III, Tzakis AG, Miller J: The immune reactivity role of HCV-induced liver infiltrating lymphocytes in hepatocellular damage. J Clin Immunol 17:140-153, 1997
15. Bantel H, Lugering A, Poremba C, Lugering N, Held I, Domschke W, Schulze-Osthoff K: Caspase activation correlates with the degree of inflammatory liver injury in chronic hepatitis C virus infection. Hepatology 34:758-767, 2001
16. + T cells in acute infectious mononucleosis. Nat Med 2:906-911, 1996
17. Wucherpfennig KW, Hafler DA: A review of T-cell receptors in multiple sclerosis: Clonal expansion and persistence of human T-cells specific for an immunodominant myelin basic protein peptide. Ann N Y Acad Sci 756:241-258, 1995
18. + T cells with a predominant V beta usage during the primary immune response to HIV. Nature 370:463-467, 1994
19. Kluin Nelemans JC, Kester MG, Melenhorst JJ, Landegent JE, van de Corput L, Willemze R, Falkenburg JH: Persistent clonal excess and skewed T-cell repertoire in T cells from patients with hairy cell leukemia. Blood 87:3795-3802, 1996
20. + T cells in patients with multiple myeloma and paraproteinemia. Blood 87:3297-3306, 1996
21. Pannetier C, Even J, Kourilsky P: T-cell repertoire diversity and clonal expansions in normal and clinical samples. Immunol Today 16:176-181, 1995
22. + repertoire during antiviral therapy. Nat Med 4:215-221, 1998
23. + subset. J Immunol 154:6182-6190, 1995
24. + lymphocytes in chronic inflammatory bowel disease. J Immunol 157:3183-3191, 1996
25. Silins SL, Cross SM, Krauer KG, Moss DJ, Schmidt CW, Misko IS: A functional link for major TCR expansions in healthy adults caused by persistent Epstein-Barr virus infection. J Clin Invest 102:1551-1558, 1998
26. + T-cell population. Immunology 98:443-449, 1999
27. Lieberman J, Manjunath N, Shankar P: Avoiding the kiss of death: How HIV and other chronic viruses survive. Curr Opin Immunol 14:478-486, 2002
28. Olive C: T cell receptor usage in autoimmune disease. Immunol Cell Biol 73:297-307, 1995
29. Prevost Blondel A, Lengagne R, Letourneur F, Pannetier C, Gomard E, Guillet JG: In vivo longitudinal analysis of a dominant TCR repertoire selected in human response to influenza virus. Virology 233:93-104, 1997
30. Sensi M, Parmiani G: Analysis of TCR usage in human tumors: A new tool for assessing tumor-specific immune responses. Immunol Today 16:588-595, 1995
31. Valteau D, Scott V, Carcelain G, Hartmann O, Escudier B, Hercend T, Triebel F: T-cell receptor repertoire in neuroblastoma patients. Cancer Res 56:362-369, 1996
32. + T lymphocytes in normal, healthy individuals are oligoclonal and respond to human cytomegalovirus. J Immunol 155:5046-5056, 1995
33. Matsumoto Y, Yoon WK, Jee Y, Fujihara K, Misu T, Sato S, Nakashima I, Itoyama Y: Complementarity-determining region 3 spectratyping analysis of the TCR repertoire in multiple sclerosis. J Immunol 170:4846-4853, 2003
34. Gorski J, Yassai M, Zhu X, Kissella B, Keever C, Flomenberg N: Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status. J Immunol 152:5109-5119, 1994
35. Manfras BJ, Rudert WA, Trucco M, Boehm BO: Analysis of the alpha/beta T-cell receptor repertoire by competitive and quantitative family-specific PCR with exogenous standards and high resolution fluorescence based CDR3 size imaging. J Immunol Methods 210:235-249, 1997
36. + T cells in the chronic helminth infection Alveolar Echinococcosis. Infect Immun 70:1186-1174, 2002
37. Menghini G: One-second needle biopsy. Gastroenterology 35:190-199, 1958
38. Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ: Classification of chronic hepatitis: Diagnosis, grading and staging. Hepatology 19:1513-1520, 1994
39. Caruso A, Licenziati S, Corulli M, Canaris AD, De Francesco MA, Fiorentini S, Peroni L, Fallacara F, Dima F, Balsari A, Turano A: Flow cytometric analysis of activation markers on stimulated T cells and their correlation with cell proliferation. Cytometry 27:71-76, 1997
40. +-T-Cell responses against hepatitis C virus reveals multiple unpredicted specificities. J Virol 76:6104-6113, 2002
41. Moss PA, Bell JI: Comparative sequence analysis of the human T cell receptor TCRA and TCRB CDR3 regions. Hum Immunol 48:32-38, 1996
42. Moss PA, Bell JI: Sequence analysis of the human alpha beta T-cell receptor CDR3 region. Immunogenetics 42:10-18, 1995
43. + subset in normal human subjects. J Immunol 151:5762-5769, 1993
44. Posnett DN, Sinha R, Kabak S, Russo C: Clonal populations of T cells in normal elderly humans: The T cell equivalent to "benign monoclonal gammapathy." J Exp Med 179:609-618, 1994
45. Spertini O, Luscinskas FW, Kansas GS, Munro JM, Griffin JD, Gimbrone MA, Jr, Tedder TF: Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. J Immunol 147:2565-2573, 1991
46. + T lymphocytes are derived from CD57-precursors by differentiation occurring in late immune responses. Eur J Immunol 24:1503-1511, 1994
47. Khan N, Shariff N, Cobbold M, Bruton R, Ainsworth JA, Sinclair AJ, Nayak L, Moss PAH: Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol 169:1984-1992, 2002
48. Azuma M, Phillips JH, Lanier LL: CD28-T lymphocytes. Antigenic and functional properties. J Immunol 150:1147-1159, 1993
49. + T cells vary in differentiation phenotype in different persistent virus infections. Nat Med 8:379-385, 2002
50. Zhang D, Shankar P, Xu Z, Harnisch B, Chen G, Lange C, Lee SJ, Valdez H, Lederman MM, Lieberman J: Most antiviral CD8 T cells during chronic viral infection do not express high levels of perform and are not directly cytotoxic. Blood 101:226-235, 2003
51. Cerny A, Chisari FV: Pathogenesis of chronic hepatitis C: Immunological features of hepatic injury and viral persistence. Hepatology 30:595-601, 1999
52. Bertoletti A, Maini MK: Protection or damage: A dual role for the virus-specific cytotoxic T lymphocyte response in hepatitis B and C infection? Curr Opin Microbiol 3:387-392, 2000
53. Koziel MJ, Dudley D, Wong JT, Dienstag J, Houghton M, Ralston R, Walker BD: Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis. J Immunol 149:3339-3344, 1992
54. Valiante NM, D'Andrea A, Crotta S, Lechner F, Klenerman P, Nuti S, Wack A, Abrignani S: Life, activation and death of intrahepatic lymphocytes in chronic hepatitis C. Immunol Rev 174:77-89, 2000
55. Saracco G, Rizzetto M: The long-term efficacy of interferon alfa in chronic hepatitis C patients: A critical review. J Gastroenterol Hepatol 10:668-73, 1995