Human cytomegalovirus-specific CD8+ T-cell expansions contain long-lived cells that retain functional capacity in both young and elderly subjects

Immunology

Volumn 132, Issue 1, 2011, Pages 27-38

  Wallace, Diana L ^a   Masters, Joanne E ^a   De Lara, Catherine M ^b   Henson, Sian M ^a   Worth, Andrew ^b   Zhang, Yan ^c   Kumar, Shikha R ^c   Beverley, Peter C ^b   Akbar, Arne N ^a   Macallan, Derek C ^c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

CD8 cytotoxic T cells; Cytomegalovirus; Senescence; T cells; Viruses viral immunity

Indexed keywords

CD45RA ANTIGEN; CD45RO ANTIGEN; GLUCOSE; HLA A2 ANTIGEN; HLA B7 ANTIGEN; KI 67 ANTIGEN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1;

ADULT; AGED; ARTICLE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL PROLIFERATION; EX VIVO STUDY; HUMAN; HUMAN CYTOMEGALOVIRUS; IMMUNE RESPONSE; IN VIVO STUDY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS IMMUNITY;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD95; APOPTOSIS; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; KI-67 ANTIGEN; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; YOUNG ADULT;

EID: 78649992006     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2010.03334.x     Document Type: Article

References (39)

1. Sinclair J, Sissons P. Latency and reactivation of human cytomegalovirus. J Gen Virol 2006; 87:1763-79.
2. Waller EC, Day E, Sissons JG, Wills MR. Dynamics of T cell memory in human cytomegalovirus infection. Med Microbiol Immunol 2008; 197:83-96.
3. Klenerman P, Hill A. T cells and viral persistence: lessons from diverse infections. Nat Immunol 2005; 6:873-9.
4. Pawelec G, Larbi A, Derhovanessian E. Senescence of the human immune system. J Comp Pathol 2010; 142S:S39-44.
5. Pawelec G, Akbar A, Caruso C, Solana R, Grubeck-Loebenstein B, Wikby A. Human immunosenescence: is it infectious? Immunol Rev 2005; 205:257-68.
6. Akbar AN, Beverley PC, Salmon M. Will telomere erosion lead to a loss of T-cell memory? Nat Rev Immunol 2004; 4:737-43.
7. Goronzy JJ, Fulbright JW, Crowson CS, Poland GA, O'Fallon WM, Weyand CM. Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J Virol 2001; 75:12182-7.
8. Kishimoto S, Tomino S, Mitsuya H, Fujiwara H, Tsuda H. Age-related decline in the in vitro and in vivo syntheses of anti-tetanus toxoid antibody in humans. J Immunol 1980; 125:2347-52.
9. Olsson J, Wikby A, Johansson B, Lofgren S, Nilsson BO, Ferguson FG. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech Ageing Dev 2000; 121:187-201.
10. Wikby A, Johansson B, Olsson J, Lofgren S, Nilsson BO, Ferguson F. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp Gerontol 2002; 37:445-53.
11. Hadrup SR, Strindhall J, Kollgaard T, Seremet T, Johansson B, Pawelec G, Thor SP, Wikby A. Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly. J Immunol 2006; 176:2645-53.
12. Messaoudi I, Lemaoult J, Guevara-Patino JA, Metzner BM, Nikolich-Zugich J. Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense. J Exp Med 2004; 200:1347-58.
13. + memory T cells in aged individuals. Immunol Rev 2005; 205:170-89.
14. Khan N, Hislop A, Gudgeon N, Cobbold M, Khanna R, Nayak L, Rickinson AB, Moss PA. Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection. J Immunol 2004; 173:7481-9.
15. Akbar AN, Fletcher JM. Memory T cell homeostasis and senescence during aging. Curr Opin Immunol 2005; 17:480-5.
16. Khan N, Shariff N, Cobbold M, Bruton R, Ainsworth JA, Sinclair AJ, Nayak L, Moss PA. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol 2002; 169:1984-92.
17. Clambey ET, Kappler JW, Marrack P. CD8 T cell clonal expansions & aging: a heterogeneous phenomenon with a common outcome. Exp Gerontol 2007; 42:407-11.
18. Stowe RP, Kozlova EV, Yetman DL, Walling DM, Goodwin JS, Glaser R. Chronic herpesvirus reactivation occurs in aging. Exp Gerontol 2007; 42:563-70.
19. + T cells in healthy carriers are continuously driven to replicative exhaustion. J Immunol 2005; 175:8218-25.
20. Macallan DC, Asquith B, Zhang Y, De Lara CM, Ghattas H, Defoiche J, Beverley PC. Measurement of proliferation and disappearance of rapid turnover cell populations in human studies using deuterium-labelled glucose. Nat Protoc 2009; 4:1313-27.
21. + T cell accumulation during a human cutaneous antigen-specific memory response in vivo. J Clin Invest 2008; 118:3639-50.
22. Ghattas H, Darboe BM, Wallace DL, Griffin GE, Prentice AM, Macallan DC. Measuring lymphocyte kinetics in tropical field settings. Trans R Soc Trop Med Hyg 2005; 99:675-85.
23. Busch R, Neese RA, Awada M, Hayes GM, Hellerstein MK. Measurement of cell proliferation by heavy water labeling. Nat Protoc 2007; 2:3045-57.
24. Asquith B, Debacq C, Macallan DC, Willems L, Bangham C. Lymphocyte kinetics: the interpretation of labelling data. Trends Immunol 2002; 23:596-601.
25. Macallan DC, Asquith B, Irvine A et al. Measurement and modeling of human T cell kinetics. Eur J Immunol 2003; 33:2316-26.
26. Akbar AN, Terry L, Timms A, Beverley PC, Janossy G. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. J Immunol 1988; 140:2171-8.
27. + T cells vary in differentiation phenotype in different persistent virus infections. Nat Med 2002; 8:379-85.
28. Appay V, Van Lier RA, Sallusto F, Roederer M. Phenotype and function of human T lymphocyte subsets: consensus and issues. Cytometry A 2008; 73:975-83.
29. + T lymphocytes depend on infection with CMV. J Immunol 2003; 170:4342-8.
30. Van De Berg PJ, Griffiths SJ, Yong SL et al. Cytomegalovirus infection reduces telomere length of the circulating T cell pool. J Immunol 2010; 184:3417-23.
31. + T lymphocytes in healthy seropositive donors. J Virol 2000; 74:8140-50.
32. + T cells comprise both naive and memory cells. J Immunol 1999; 162:7080-7.
33. Wallace DL, Zhang Y, Ghattas H et al. Direct measurement of T cell subset kinetics in vivo in elderly men and women. J Immunol 2004; 173:1787-94.
34. - cells are induced by antigen and evolve through extensive rounds of division. Int Immunol 1999; 11:1027-33.
35. + T-cell population. Immunol 1999; 98:443-9.
36. + T cells in aged humans. Exp Gerontol 2008; 43:266-74.
37. Redmond WL, Marincek BC, Sherman LA. Distinct requirements for deletion versus anergy during CD8 T cell peripheral tolerance in vivo. J Immunol 2005; 174:2046-53.
38. Rocha B, Grandien A, Freitas AA. Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance. J Exp Med 1995; 181:993-1003.
39. + T cells. Blood 2007; 110:4360-6.