The ion channels to cytoskeleton connection as potential mechanism of mechanosensitivity

Biochimica et Biophysica Acta - Biomembranes

Volumn 1838, Issue 2, 2014, Pages 682-691

  Martinac, Boris ^a,b  

^a VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Bilayer mechanism; C. elegans; Dual tether single tether mechanism; Hair cell; Mechanosensory transduction channel

Indexed keywords

CALCIUM CHANNEL; EPITHELIAL SODIUM CHANNEL; MEMBRANE PROTEIN; PIEZO 1; PIEZO 2; POLYCYSTIN 1; POLYCYSTIN 2; POTASSIUM CHANNEL; PROTEIN TRAAK; PROTEIN TREK1; PROTEIN TREK2; SODIUM CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M3; TRANSIENT RECEPTOR POTENTIAL CHANNEL M4; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 2; VANILLOID RECEPTOR 4;

BIOMECHANICS; CYTOSKELETON; HAIR CELL; HEART ATRIUM FIBRILLATION; HEART VENTRICLE HYPERTROPHY; HUMAN; KIDNEY POLYCYSTIC DISEASE; MECHANOTRANSDUCTION; MEMBRANE CHANNEL; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; MUSCULAR DYSTROPHY; NONHUMAN; PATHOPHYSIOLOGY; PHYLOGENY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW;

ANIMALIA; BACTERIA (MICROORGANISMS); CAENORHABDITIS ELEGANS;

BILAYER MECHANISM; C. ELEGANS; DUAL-TETHER/SINGLE-TETHER MECHANISM; HAIR CELL; MECHANOSENSORY TRANSDUCTION CHANNEL;

ANIMALS; CYTOSKELETON; HUMANS; ION CHANNELS; MECHANOTRANSDUCTION, CELLULAR;

EID: 84892151878     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2013.07.015     Document Type: Review

References (158)

1. C.R. Woese There must be a prokaryote somewhere: microbiology's search for itself Microbiol. Rev. 58 1994 1 9
2. B. Martinac Bacterial mechanosensitive channels as a paradigm for mechanosensory transduction Cell Physiol. Biochem. 28 2011 1051 1060
3. C. Kung, Y. Saimi, and B. Martinac Mechanosensitive ion channels in microbes and the early evolutionary origin of solvent sensing T. Claudio, Current Topics in Membranes and Transport 1990 Academic Press New York 9451 9455
4. P.G. Gillespie, and R.G. Walker Molecular basis of mechanosensory transduction Nature 413 2001 194 202 (Pubitemid 32867884)
5. O.P. Hamill, and B. Martinac Molecular basis of mechanotransduction in living cells Physiol. Rev. 81 2001 685 740 (Pubitemid 32267076)
6. M. Chalfie Neurosensory mechanotransduction Nat. Rev. Mol. Cell Biol. 10 2009 44 52
7. C. Kung, B. Martinac, and S. Sukharev Mechanosensitive channels in microbes Annu. Rev. Microbiol. 64 2010 313 329
8. N. Levina, S. Totemeyer, N.R. Stokes, P. Louis, M.A. Jones, and I.R. Booth Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity EMBO J. 18 1999 1730 1737 (Pubitemid 29158517)
9. O.P. Hamill, and D.W. McBride Jr. Induced membrane hypo/hyper- mechanosensitivity: a limitation of patch-clamp recording Annu. Rev. Physiol. 59 1997 621 631 (Pubitemid 27142458)
10. C. Spagnoli, A. Beyder, S. Besch, and F. Sachs Atomic force microscopy analysis of cell volume regulation Phys. Rev. E Stat. Nonlinear Soft Matter Phys. 78 2008 031916
11. C.E. Morris Mechanoprotection of the plasma membrane in neurons and other non-erythroid cells by the spectrin-based membrane skeleton Cell. Mol. Biol. Lett. 6 2001 703 720 (Pubitemid 33678440)
12. C.E. Morris The membrane skeleton: mechanoprotector and mediator of mechanosensitive surface area Cell. Mol. Biol. Lett. 6 2001 222 223
13. C.E. Morris, and U. Homann Cell surface area regulation and membrane tension J. Membr. Biol. 179 2001 79 102 (Pubitemid 32121602)
14. X. Wan, P. Juranka, and C.E. Morris Activation of mechanosensitive currents in traumatized membrane Am. J. Physiol. 276 1999 C318 C327
15. T.L. Herring, I.M. Slotin, J.M. Baltz, and C.E. Morris Neuronal swelling and surface area regulation: elevated intracellular calcium is not a requirement Am. J. Physiol. 274 1998 C272 C281
16. L.R. Mills, and C.E. Morris Neuronal plasma membrane dynamics evoked by osmomechanical perturbations J. Membr. Biol. 166 1998 223 235 (Pubitemid 28557791)
17. J.W. Dai, M.P. Sheetz, T. Herring, and C.E. Morris Membrane tension in swelling and shrinking molluscan neurons Mol. Biol. Cell 7 1996 2614
18. C.S. Cohan, E.A. Welnhofer, T.L. Herring, and C.E. Morris Actin and filopodial dynamics in osmotically perturbed molluscan neurons Mol. Biol. Cell 8 1997 1482
19. X. Wan, and C.E. Morris Capacitance changes of neurons during large osmomechanical perturbations FASEB J. 8 1994 A113
20. A. Kloda, L. Lua, R. Hall, D.J. Adams, and B. Martinac Liposome reconstitution and modulation of recombinant N-methyl-d-aspartate receptor channels by membrane stretch Proc. Natl. Acad. Sci. U. S. A. 104 2007 1540 1545 (Pubitemid 46214626)
21. E. Honore The neuronal background K2P channels: focus on TREK1 Nat. Rev. Neurosci. 8 2007 251 261 (Pubitemid 46452327)
22. R. Maroto, A. Raso, T.G. Wood, A. Kurosky, B. Martinac, and O.P. Hamill TRPC1 forms the stretch-activated cation channel in vertebrate cells Nat. Cell Biol. 7 2005 179 185 (Pubitemid 40268133)
23. Y. Zhang, F. Gao, V.L. Popov, J.W. Wen, and O.P. Hamill Mechanically gated channel activity in cytoskeleton-deficient plasma membrane blebs and vesicles from Xenopus oocytes J. Physiol. 523 Pt 1 2000 117 130 (Pubitemid 30135825)
24. A.J. Hudspeth How the ear's works work Nature 341 1989 397 404 (Pubitemid 19241904)
25. S. Bechstedt, and J. Howard Models of hair cell mechanotransduction O.P. Hamill, Mechanosensitive Ion Channels, Part B vol. 59 2007 Academic Press San Diego 399 424
26. V.S. Markin, and A.J. Hudspeth Gating-spring models of mechanoelectrical transduction by hair cells of the internal ear Annu. Rev. Biophys. Biomol. Struct. 24 1995 59 83
27. K.J. Spinelli, and P.G. Gillespie Bottoms up: transduction channels at tip link bases Nat. Neurosci. 12 2009 529 530
28. M. Beurg, R. Fettiplace, J.H. Nam, and A.J. Ricci Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging Nat. Neurosci. 12 2009 553 558
29. D.P. Corey, J. Garcia-Anoveros, J.R. Holt, K.Y. Kwan, S.Y. Lin, M.A. Vollrath, A. Amalfitano, E.L. Cheung, B.H. Derfler, A. Duggan, G.S. Geleoc, P.A. Gray, M.P. Hoffman, H.L. Rehm, D. Tamasauskas, and D.S. Zhang TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells Nature 432 2004 723 730 (Pubitemid 39656287)
30. K.Y. Kwan, A.J. Allchorne, M.A. Vollrath, A.P. Christensen, D.S. Zhang, C.J. Woolf, and D.P. Corey TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction Neuron 50 2006 277 289
31. M. Bandell, G.M. Story, S.W. Hwang, V. Viswanath, S.R. Eid, M.J. Petrus, T.J. Earley, and A. Patapoutian Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin Neuron 41 2004 849 857 (Pubitemid 38429729)
32. A.J. Ricci, and B. Kachar Hair cell mechanotransduction: the dynamic interplay between structure and function O.P. Hamill, Mechanosensitive Ion Channels Part B vol. 59 2007 Academic Press San Diego 339 374
33. K. Kurima, L.M. Peters, Y. Yang, S. Riazuddin, Z.M. Ahmed, S. Naz, D. Arnaud, S. Drury, J. Mo, T. Makishima, M. Ghosh, P.S. Menon, D. Deshmukh, C. Oddoux, H. Ostrer, S. Khan, P.L. Deininger, L.L. Hampton, S.L. Sullivan, J.F. Battey Jr., B.J. Keats, E.R. Wilcox, T.B. Friedman, and A.J. Griffith Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function Nat. Genet. 30 2002 277 284
34. Y. Kawashima, G.S. Geleoc, K. Kurima, V. Labay, A. Lelli, Y. Asai, T. Makishima, D.K. Wu, C.C. Della Santina, J.R. Holt, and A.J. Griffith Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes J. Clin. Invest. 121 2011 4796 4809
35. S.M. van Netten, and C.J. Kros Gating energies and forces of the mammalian hair cell transducer channel and related hair bundle mechanics Proc. Biol. Sci. 267 2000 1915 1923
36. G. Lee, K. Abdi, Y. Jiang, P. Michaely, V. Bennett, and P.E. Marszalek Nanospring behaviour of ankyrin repeats Nature 440 2006 246 249 (Pubitemid 43372106)
37. W. Xiong, N. Grillet, H.M. Elledge, T.F. Wagner, B. Zhao, K.R. Johnson, P. Kazmierczak, and U. Muller TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells Cell 151 2012 1283 1295
38. C.M. Longo-Guess, L.H. Gagnon, S.A. Cook, J. Wu, Q.Y. Zheng, and K.R. Johnson A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice Proc. Natl. Acad. Sci. U. S. A. 102 2005 7894 7899 (Pubitemid 40781034)
39. P.G. Gillespie, and U. Muller Mechanotransduction by hair cells: models, molecules, and mechanisms Cell 139 2009 33 44
40. R. Maroto, A. Kurosky, and O.P. Hamill Mechanosensitive Ca(2 +) permeant cation channels in human prostate tumor cells Channels (Austin) 6 2012 290 307
41. R. O'Hagan, M. Chalfie, and M.B. Goodman The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals Nat. Neurosci. 8 2008 43 50 (Pubitemid 41236730)
42. B. Martinac Mechanosensitive ion channels: molecules of mechanotransduction J. Cell Sci. 117 2004 2449 2460 (Pubitemid 38877841)
43. A. Anishkin, and C. Kung Stiffened lipid platforms at molecular force foci Proc. Natl. Acad. Sci. U. S. A. 110 2013 4886 4892
44. J.R. Martens, K. O'Connell, and M. Tamkun Targeting of ion channels to membrane microdomains: localization of KV channels to lipid rafts Trends Pharmacol. Sci. 25 2004 16 21 (Pubitemid 38076952)
45. A. Maguy, T.E. Hebert, and S. Nattel Involvement of lipid rafts and caveolae in cardiac ion channel function Cardiovasc. Res. 69 2006 798 807 (Pubitemid 43227978)
46. S.L. Grage, A.M. Keleshian, T. Turdzeladze, A.R. Battle, W.C. Tay, R.P. May, S.A. Holt, S.A. Contera, M. Haertlein, M. Moulin, P. Pal, P.R. Rohde, V.T. Forsyth, A. Watts, K.C. Huang, A.S. Ulrich, and B. Martinac Bilayer-mediated clustering and functional interaction of MscL channels Biophys. J. 100 2011 1252 1260
47. T. Nomura, C.G. Cranfield, E. Deplazes, D.M. Owen, A. Macmillan, A.R. Battle, M. Constantine, M. Sokabe, and B. Martinac Differential effects of lipids and lyso-lipids on the mechanosensitivity of the mechanosensitive channels MscL and MscS Proc. Natl. Acad. Sci. U. S. A. 109 2012 8770 8775
48. T. Ursell, K.C. Huang, E. Peterson, and R. Phillips Cooperative gating and spatial organization of membrane proteins through elastic interactions PLoS Comput. Biol. 3 2007 e81
49. C. Bae, R. Gnanasambandam, C. Nicolai, F. Sachs, and P.A. Gottlieb Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1 Proc. Natl. Acad. Sci. U. S. A. 110 2013 E1162 E1168
50. B. Martinac, J. Adler, and C. Kung Mechanosensitive ion channels of E. coli activated by amphipaths Nature 348 1990 261 263
51. F. Sachs Mechanical transduction in biological systems Crit. Rev. Biomed. Eng. 16 1988 141 169
52. F. Sachs, and C.E. Morris Mechanosensitive ion channels in nonspecialized cells Reviews of Physiology Biochemistry and Pharmacology vol. 132 1998 Springer-Verlag Berlin Berlin 1 77 (33)
53. W.E. Brownell, A.A. Spector, R.M. Raphael, and A.S. Popel Micro- and nanomechanics of the cochlear outer hair cell Annu. Rev. Biomed. Eng. 3 2001 169 194 (Pubitemid 32928037)
54. N.C. Pan, J.J. Ma, and H.B. Peng Mechanosensitivity of nicotinic receptors Pflugers Arch. 464 2012 193 203
55. E. Perozo, A. Kloda, D.M. Cortes, and B. Martinac Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating Nat. Struct. Biol. 9 2002 696 703 (Pubitemid 34977304)
56. L. Rajendran, and K. Simons Lipid rafts and membrane dynamics J. Cell Sci. 118 2005 1099 1102 (Pubitemid 40528680)
57. B. Martinac, and O.P. Hamill Gramicidin A channels switch between stretch activation and stretch inactivation depending on bilayer thickness Proc. Natl. Acad. Sci. U. S. A. 99 2002 4308 4312 (Pubitemid 34285981)
58. V.I. Chubinskiy-Nadezhdin, Y.A. Negulyaev, and E.A. Morachevskaya Cholesterol depletion-induced inhibition of stretch-activated channels is mediated via actin rearrangement Biochem. Biophys. Res. Commun. 412 2011 80 85
59. H. Sackin Mechanosensitive channels Annu. Rev. Physiol. 57 1995 333 353
60. J.B. Lansman, and A. Franco-Obregon Mechanosensitive ion channels in skeletal muscle: a link in the membrane pathology of muscular dystrophy Clin. Exp. Pharmacol. Physiol. 33 2006 649 656 (Pubitemid 43894029)
61. N. Wang, J.P. Butler, and D.E. Ingber Mechanotransduction across the cell surface and through the cytoskeleton Science 260 1993 1124 1127 (Pubitemid 23186787)
62. D.E. Ingber Cellular mechanotransduction: putting all the pieces together again FASEB J. 20 2006 811 827 (Pubitemid 44943939)
63. D.E. Ingber Tensegrity: the architectural basis of cellular mechanotransduction Annu. Rev. Physiol. 59 1997 575 599 (Pubitemid 27142456)
64. B.D. Matthews, C.K. Thodeti, and D. Ingber Activation of mechanosensitive ion channels by forces transmitted through integrins and the cytoskeleton O.P. Hamill, Mechanosensitive Ion Channels Part A vol. 58 2007 Elsevier San Diego 59 85
65. H. Tatsumi, K. Hayakawa, H. Hirata, and M. Sokabe The role of actin filaments as a force-transmitter and force-sensor M.S. Yong de Shi, Boris Martinac, Keiji Naruse, Wojciech Dzwolak, Recent Advances in Mechanobiology vol. 1 2012 Shanghai Scientific and Technological Literature Publishing House Shanghai 153 160
66. K. Hayakawa, H. Tatsumi, and M. Sokabe Actin stress fibers transmit and focus force to activate mechanosensitive channels J. Cell Sci. 121 2008 496 503 (Pubitemid 351405058)
67. S. Sukharev, and F. Sachs Molecular force transduction by ion channels: diversity and unifying principles J. Cell Sci. 125 2012 3075 3083
68. V. Vogel, and M. Sheetz Local force and geometry sensing regulate cell functions Nat. Rev. Mol. Cell Biol. 7 2006 265 275
69. F. Meng, and F. Sachs Visualizing dynamic cytoplasmic forces with a compliance-matched FRET sensor J. Cell Sci. 124 2011 261 269
70. F. Meng, T.M. Suchyna, E. Lazakovitch, R.M. Gronostajski, and F. Sachs Real time FRET based detection of mechanical stress in cytoskeletal and extracellular matrix proteins Cell. Mol. Bioeng. 4 2011 148 159
71. F. Meng, T.M. Suchyna, and F. Sachs A fluorescence energy transfer-based mechanical stress sensor for specific proteins in situ FEBS J. 275 2008 3072 3087 (Pubitemid 351743583)
72. J. Rahimzadeh, F. Meng, F. Sachs, J. Wang, D. Verma, and S.Z. Hua Real-time observation of flow-induced cytoskeletal stress in living cells Am. J. Physiol. Cell Physiol. 301 2011 C646 C652
73. Y. Wang, F. Meng, and F. Sachs Genetically encoded force sensors for measuring mechanical forces in proteins Commun. Integr. Biol. 4 2011 385 390
74. F. Meng, and F. Sachs Measuring strain of structural proteins in vivo in real time P. Kohl, F. Sachs, M.R. Franz, Cardiac Mechano-electric Coupling and Arrhythmia: From Pipette to Patient 2011 Oxford University Press Oxford 431 434
75. M. Chalfie, and M. Au Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons Science 243 1989 1027 1033 (Pubitemid 19072579)
76. K. Hong, and M. Driscoll A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans Nature 367 1994 470 473 (Pubitemid 24046050)
77. M.B. Goodman, and E.M. Schwarz Transducing touch in Caenorhabditis elegans Annu. Rev. Physiol. 65 2003 429 452 (Pubitemid 38249162)
78. B. Martinac, and A. Kloda Mechanosensory transduction M. Montal, Comprehensive Biophysics vol. 6(18) 2011 Elsevier Amsterdam 1 55
79. S. Kellenberger, and L. Schild Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure Physiol. Rev. 82 2002 735 767 (Pubitemid 34743337)
80. + channel by membrane tension J. Gen. Physiol. 112 1998 97 111 (Pubitemid 28369154)
81. L.G. Palmer, and G. Frindt Gating of Na channels in the rat cortical collecting tubule: effects of voltage and membrane stretch J. Gen. Physiol. 107 1996 35 45 (Pubitemid 26028779)
82. H.P. Ma, O. Al-Khalili, S. Ramosevac, S. Saxena, Y.Y. Liang, D.G. Warnock, and D.C. Eaton Steroids and exogenous gamma-ENaC subunit modulate cation channels formed by alpha-ENaC in human B lymphocytes J. Biol. Chem. 279 2004 33206 33212 (Pubitemid 39062966)
83. M.D. Carattino, S. Sheng, and T.R. Kleyman Mutations in the pore region modify epithelial sodium channel gating by shear stress J. Biol. Chem. 280 2005 4393 4401 (Pubitemid 40288603)
84. M.S. Awayda, W. Shao, F. Guo, M. Zeidel, and W.G. Hill ENaC-membrane interactions: regulation of channel activity by membrane order J. Gen. Physiol. 123 2004 709 727 (Pubitemid 38781376)
85. + channel proteins: components of a vascular mechanosensor Hypertension 44 2004 643 648 (Pubitemid 39435233)
86. G. Gu, G.A. Caldwell, and M. Chalfie Genetic interactions affecting touch sensitivity in Caenorhabditis elegans Proc. Natl. Acad. Sci. U. S. A. 93 1996 6577 6582 (Pubitemid 26230350)
87. C. Kung A possible unifying principle for mechanosensation Nature 436 2005 647 654 (Pubitemid 41117260)
88. F. Sachs Biophysics of mechanoreception Membr. Biochem. 6 1986 173 195
89. B. Martinac Force from lipids: physical principles of gating mechanosensitive channels by mechanical force revealed by chemical manipulation of cellular membranes Chem. Educ. 10 2 2005 107 114
90. K.N. Alagramam, R.J. Goodyear, R. Geng, D.N. Furness, A.F. van Aken, W. Marcotti, C.J. Kros, and G.P. Richardson Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells PLoS One 6 2011 e19183
91. M. Sotomayor, D.P. Corey, and K. Schulten In search of the hair-cell gating spring elastic properties of ankyrin and cadherin repeats Structure 13 2005 669 682
92. J.G. Cueva, A. Mulholland, and M.B. Goodman Nanoscale organization of the MEC-4 DEG/ENaC sensory mechanotransduction channel in Caenorhabditis elegans touch receptor neurons J. Neurosci. 27 2007 14089 14098 (Pubitemid 351377855)
93. D.J. Beech TRPC1: store-operated channel and more Pflugers Arch. 451 2005 53 60 (Pubitemid 41424907)
94. T. Hofmann, A.G. Obukhov, M. Schaefer, C. Harteneck, T. Gudermann, and G. Schultz Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol Nature 397 1999 259 263
95. C. Cui, D.O. Smith, and J. Adler Characterization of mechanosensitive channels in Escherichia coli cytoplasmic membrane by whole-cell patch clamp recording J. Membr. Biol. 144 1995 31 42
96. D.G. Welsh, A.D. Morielli, M.T. Nelson, and J.E. Brayden Transient receptor potential channels regulate myogenic tone of resistance arteries Circ. Res. 90 2002 248 250 (Pubitemid 34633924)
97. P.A. Gottlieb, T.M. Suchyna, L.W. Ostrow, and F. Sachs Mechanosensitive ion channels as drug targets Curr. Drug Targets CNS Neurol. Disord. 3 2004 287 295 (Pubitemid 39242915)
98. M.A. Spassova, T. Hewavitharana, W. Xu, J. Soboloff, and D.L. Gill A common mechanism underlies stretch activation and receptor activation of TRPC6 channels Proc. Natl. Acad. Sci. U. S. A. 103 2006 16586 16591 (Pubitemid 44715239)
99. P. Gottlieb, J. Folgering, R. Maroto, A. Raso, T.G. Wood, A. Kurosky, C. Bowman, D. Bichet, A. Patel, F. Sachs, B. Martinac, O.P. Hamill, and E. Honore Revisiting TRPC1 and TRPC6 mechanosensitivity Pflugers Arch. 455 2008 1097 1103 (Pubitemid 351169977)
100. A. Jara-Oseguera, A. Nieto-Posadas, A. Szallasi, L.D. Islas, and T. Rosenbaum Molecular mechanisms of TRPV1 channel activation Open Pain J. 3 2010 68 81
101. O.S. Ahmed, M.H. Bakr, X. Li, and T. Nomura Adjoint variable method for two-dimensional plasmonic structures Opt. Lett. 37 2012 3453 3455
102. K. Muraki, Y. Iwata, Y. Katanosaka, T. Ito, S. Ohya, M. Shigekawa, and Y. Imaizumi TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes Circ. Res. 93 2003 829 838 (Pubitemid 37363057)
103. S.F. Pedersen, and B. Nilius Transient receptor potential channels in mechanosensing and cell volume regulation Methods Enzymol. 428 2007 183 207
104. D.M. Cohen TRPV4 and the mammalian kidney Pflugers Arch. 451 2005 168 175 (Pubitemid 41424920)
105. W. Liedtke, Y. Choe, M.A. Marti-Renom, A.M. Bell, C.S. Denis, A. Sali, A.J. Hudspeth, J.M. Friedman, and S. Heller Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor Cell 103 2000 525 535
106. H. Morita, A. Honda, R. Inoue, Y. Ito, K. Abe, M.T. Nelson, and J.E. Brayden Membrane stretch-induced activation of a TRPM4-like nonselective cation channel in cerebral artery myocytes J. Pharmacol. Sci. 103 2007 417 426 (Pubitemid 46640694)
107. C. Grimm, R. Kraft, G. Schultz, and C. Harteneck Activation of the melastatin-related cation channel TRPM3 by d-erythro-sphingosine [corrected] Mol. Pharmacol. 67 2005 798 805 (Pubitemid 40365327)
108. T. Numata, T. Shimizu, and Y. Okada Direct mechano-stress sensitivity of TRPM7 channel Cell. Physiol. Biochem. 19 2007 1 8
109. C. Grimm, R. Kraft, S. Sauerbruch, G. Schultz, and C. Harteneck Molecular and functional characterization of the melastatin-related cation channel TRPM3 J. Biol. Chem. 278 2003 21493 21501 (Pubitemid 36792546)
110. S.M. Nauli, F.J. Alenghat, Y. Luo, E. Williams, P. Vassilev, X. Li, A.E. Elia, W. Lu, E.M. Brown, S.J. Quinn, D.E. Ingber, and J. Zhou Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells Nat. Genet. 33 2003 129 137 (Pubitemid 36177063)
111. H.A. Praetorius, and K.R. Spring The renal cell primary cilium functions as a flow sensor Curr. Opin. Nephrol. Hypertens. 12 2003 517 520 (Pubitemid 37083112)
112. R.C. Hardie, and K. Franze Photomechanical responses in Drosophila photoreceptors Science 338 2012 260 263
113. + ion channel Science 335 2012 436 441
114. + channel EMBO J. 17 1998 4283 4290 (Pubitemid 28362619)
115. + channels Trends Neurosci. 24 2001 339 346 (Pubitemid 32455435)
116. E. Honore, A.J. Patel, J. Chemin, T. Suchyna, and F. Sachs Desensitization of mechano-gated K2P channels Proc. Natl. Acad. Sci. U. S. A. 103 2006 6859 6864
117. I. Lauritzen, J. Chemin, E. Honore, M. Jodar, N. Guy, M. Lazdunski, and A. Jane Patel Cross-talk between the mechano-gated K2P channel TREK-1 and the actin cytoskeleton EMBO Rep. 6 2005 642 648 (Pubitemid 41122432)
118. J. Chemin, A.J. Patel, P. Delmas, F. Sachs, M. Lazdunski, and E. Honore Regulation of the mechano-gated K2P channel TREK-1 by membrane phospholipids O.P. Hamill, Mechanosensitive Ion Channels Part B vol. 59 2007 Academic Press San Diego 155 189
119. + channels J. Biol. Chem. 280 2005 4415 4421 (Pubitemid 40288605)
120. B. Coste, B. Xiao, J.S. Santos, R. Syeda, J. Grandl, K.S. Spencer, S.E. Kim, M. Schmidt, J. Mathur, A.E. Dubin, M. Montal, and A. Patapoutian Piezo proteins are pore-forming subunits of mechanically activated channels Nature 483 2012 176 181
121. B. Coste, J. Mathur, M. Schmidt, T.J. Earley, S. Ranade, M.J. Petrus, A.E. Dubin, and A. Patapoutian Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels Science 330 2010 55 60
122. C. Bae, F. Sachs, and P.A. Gottlieb The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4 Biochemistry 50 2011 6295 6300
123. C.L. Bowman, P.A. Gottlieb, T.M. Suchyna, Y.K. Murphy, and F. Sachs Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology Toxicon 49 2007 249 270 (Pubitemid 46148998)
124. P.A. Gottlieb, and F. Sachs Piezo1: properties of a cation selective mechanical channel Channels (Austin) 6 2012 214 219
125. P.A. Gottlieb, C. Bae, and F. Sachs Gating the mechanical channel Piezo1: a comparison between whole-cell and patch recording Channels (Austin) 6 2012 282 289
126. Y. Roudaut, A. Lonigro, B. Coste, J. Hao, P. Delmas, and M. Crest Touch sense: functional organization and molecular determinants of mechanosensitive receptors Channels (Austin) 6 2012 234 245
127. B. Martinac, P.R. Rohde, A.R. Battle, E. Petrov, P. Pal, A.F. Foo, V. Vasquez, T. Huynh, and A. Kloda Studying mechanosensitive ion channels using liposomes Methods Mol. Biol. 606 2010 31 53
128. P. Moe, and P. Blount Assessment of potential stimuli for mechano-dependent gating of MscL: effects of pressure, tension, and lipid headgroups Biochemistry 44 2005 12239 12244 (Pubitemid 41285722)
129. T.P. Lele, J.E. Sero, B.D. Matthews, S. Kumar, S. Xia, M. Montoya-Zavala, T. Polte, D. Overby, N. Wang, and D.E. Ingber Tools to study cell mechanics and mechanotransduction Methods Cell Biol. 83 2007 443 472
130. C. Mazzochi, D.J. Benos, and P.R. Smith Interaction of epithelial ion channels with the actin-based cytoskeleton Am. J. Physiol. Renal Physiol. 291 2006 F1113 F1122
131. C. Mazzochi, J.K. Bubien, P.R. Smith, and D.J. Benos The carboxyl terminus of the alpha-subunit of the amiloride-sensitive epithelial sodium channel binds to F-actin J. Biol. Chem. 281 2006 6528 6538 (Pubitemid 43847586)
132. T. Hunt, H.C. Atherton-Watson, J. Axford, S.P. Collingwood, K.J. Coote, B. Cox, S. Czarnecki, H. Danahay, N. Devereux, C. Howsham, P. Hunt, V. Paddock, D. Paisley, and A. Young Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: quaternary amines Bioorg. Med. Chem. Lett. 22 2012 929 932
133. T. Hunt, H.C. Atherton-Watson, S.P. Collingwood, K.J. Coote, S. Czarnecki, H. Danahay, C. Howsham, P. Hunt, D. Paisley, and A. Young Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 2: alpha-branched quaternary amines Bioorg. Med. Chem. Lett. 22 2012 2877 2879
134. R. Sharif-Naeini, A. Dedman, J.H. Folgering, F. Duprat, A. Patel, B. Nilius, and E. Honore TRP channels and mechanosensory transduction: insights into the arterial myogenic response Pflugers Arch. 456 2008 529 540
135. B. Nilius, G. Owsianik, T. Voets, and J.A. Peters Transient receptor potential cation channels in disease Physiol. Rev. 87 2007 165 217 (Pubitemid 46207713)
136. 2 + channels in HL-7702 cells with non-invasive micro-test technique World J. Gastroenterol. 15 2009 4150 4155
137. 2 + signaling Cell Calcium 40 2006 261 275
138. M. Raisinghani, and L.S. Premkumar Block of native and cloned vanilloid receptor 1 (TRPV1) by aminoglycoside antibiotics Pain 113 2005 123 133 (Pubitemid 40038453)
139. M. Kanzaki, Y.Q. Zhang, H. Mashima, L. Li, H. Shibata, and I. Kojima Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I Nat. Cell Biol. 1 1999 165 170 (Pubitemid 129656021)
140. M.P. Cuajungco, C. Grimm, K. Oshima, D. D'Hoedt, B. Nilius, A.R. Mensenkamp, R.J. Bindels, M. Plomann, and S. Heller PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4 J. Biol. Chem. 281 2006 18753 18762 (Pubitemid 44035536)
141. D. D'Hoedt, G. Owsianik, J. Prenen, M.P. Cuajungco, C. Grimm, S. Heller, T. Voets, and B. Nilius Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3 J. Biol. Chem. 283 2008 6272 6280
142. 2 +-activated TRP channels: TRPM4 and TRPM5 W.B. Liedtke, S. Heller, TRP Ion Channel Function in Sensory Transduction and Cellular Signaling 2007 CRC Press Boca Raton
143. R. Vennekens, and B. Nilius Insights into TRPM4 function, regulation and physiological role Handb. Exp. Pharmacol. 2007 269 285
144. 2 +-activated cation channel TRPM4 J. Biol. Chem. 278 2003 30813 30820 (Pubitemid 36994589)
145. X. Qin, Z. Yue, B. Sun, W. Yang, J. Xie, E. Ni, Y. Feng, R. Mahmood, Y. Zhang, and L. Yue Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels Br. J. Pharmacol. 168 2013 1294 1312
146. T. Numata, T. Shimizu, and Y. Okada TRPM7 is a stretch- and swelling-activated cation channel involved in volume regulation in human epithelial cells Am. J. Physiol. Cell Physiol. 292 2007 C460 C467
147. B. Nilius Polycystins under pressure Cell 139 2009 466 467
148. R. Sharif-Naeini, J.H. Folgering, D. Bichet, F. Duprat, I. Lauritzen, M. Arhatte, M. Jodar, A. Dedman, F.C. Chatelain, U. Schulte, K. Retailleau, L. Loufrani, A. Patel, F. Sachs, P. Delmas, D.J. Peters, and E. Honore Polycystin-1 and -2 dosage regulates pressure sensing Cell 139 2009 587 596
149. J. Zhu, Y. Yu, M.H. Ulbrich, M.H. Li, E.Y. Isacoff, B. Honig, and J. Yang Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach Proc. Natl. Acad. Sci. U. S. A. 108 2011 10133 10138
150. 2 + channel antagonists J. Pharmacol. Exp. Ther. 323 2007 39 48 (Pubitemid 47443249)
151. F. Maingret, A.J. Patel, F. Lesage, M. Lazdunski, and E. Honore Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK J. Biol. Chem. 275 2000 10128 10133 (Pubitemid 30202065)
152. + channel family J. Biol. Chem. 275 2000 17412 17419 (Pubitemid 30430778)
153. F. Lesage, and M. Lazdunski Molecular and functional properties of two-pore-domain potassium channels Am. J. Physiol. Renal Physiol. 279 2000 F793 F801
154. + channel J. Biol. Chem. 274 1999 1381 1387
155. F. Maingret, A.J. Patel, F. Lesage, M. Lazdunski, and E. Honore Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel J. Biol. Chem. 274 1999 26691 26696
156. M. Parnas, B. Katz, S. Lev, V. Tzarfaty, D. Dadon, A. Gordon-Shaag, H. Metzner, R. Yaka, and B. Minke Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels J. Neurosci. 29 2009 2371 2383
157. A. Kloda, B. Martinac, and D.J. Adams Polymodal regulation of NMDA receptor channels Channels (Austin) 1 2007 334 343
158. R. Xiao, and X.Z. Xu Mechanosensitive channels: in touch with Piezo Curr. Biol. 20 2010 R936 R938