Regulation of the epithelial Na+ channel by membrane tension

Journal of General Physiology

Volumn 112, Issue 2, 1998, Pages 97-111

  Awayda, Mouhamed S ^a   Subramanyam, Muthangi ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Epithelial Na channel; Mechanosensitivity; Osmolarity; Patch clamp; Xenopus oocytes

Indexed keywords

ACTIN; AMILORIDE; CYTOCHALASIN B; POTASSIUM CHLORIDE; SODIUM CHANNEL; SODIUM ION;

ANIMAL CELL; ARTICLE; CELL SWELLING; CELL VOLUME; CONTROLLED STUDY; CYTOSKELETON; EPITHELIUM; NONHUMAN; OOCYTE; OSMOLARITY; PATCH CLAMP; RAT; SODIUM CURRENT; TENSION; VOLTAGE CLAMP; XENOPUS;

ACTINS; AMILORIDE; ANIMALS; CELL MEMBRANE; CELL SIZE; CYTOCHALASIN B; CYTOSKELETON; DIURETICS; EPITHELIAL CELLS; EPITHELIAL SODIUM CHANNEL; ION CHANNEL GATING; OOCYTES; OSMOLAR CONCENTRATION; PATCH-CLAMP TECHNIQUES; POTASSIUM CHLORIDE; RATS; SODIUM; SODIUM CHANNELS; STRESS, MECHANICAL; XENOPUS;

EID: 0031872457     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.112.2.97     Document Type: Article

References (23)

1. + channel protein displays stretch activation in planar lipid bilayers. Am. J. Physiol. 268:C1450-C1459.
2. +-channel. J. Gen. Physiol. 108:49-65.
3. +-channel by its beta and gamma subunits. Am. J. Physiol. 273:1889-1899.
4. 6.3-helices. Biophys. J. 53: 689-695.
5. Canessa, C.M., J.-D. Horisberger, and B.C. Rossier. 1993. Epithelial sodium channel related to proteins involved in neurodegeneration. Nature. 361:467-470.
6. + channel is made of three homologous subunits. Nature. 367:463-467.
7. Garty, H., and L.G. Palmer. 1997. Epithelial sodium channels: functions, structure, and regulation. Physiol. Rev. 77:359-396.
8. Hamill, O.P., A. Marty, E. Neher, B. Sakmann, and F.J. Sigworth. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 391:85-100.
9. + channel. J Biol. Chem. 271:807-816.
10. Kizer, N.L., X.-L. Guo, and K. Hruska. 1997. Reconstitution of stretch activated cation channels by expression of the a subunit of the epithelial sodium channel cloned from osteoblasts. Proc. Natl. Acad. Sci. USA. 94:1013-1018.
11. + channel. A new channel type with homologies to Caenorhabditis elegans degenerins. FEBS Lett. 318:95-99.
12. McDonald, F.J., M.P. Price, P.M. Snyder, and M.J. Welsh. 1995. Cloning and expression of the β- and γ-subunits of the human epithelial sodium channel. Am. J. Physiol. 268:C1157-C1163.
13. Morris, C.E. 1992. Are stretch-sensitive channels in molluscan cells and elsewhere physiological mechanotransducers? Experientia (Basel). 48:852-858.
14. Palmer, L.G. 1992. Epithelial Na channels: function and diversity. Annu. Rev. Physiol. 54:51-66.
15. Palmer, L.G., and G. Frindt. 1996. Gating of Na channels in the rat cortical collecting tubule: effects of voltage and membrane stretch. J. Gen. Physiol. 107:35-45.
16. Puoti, A., A. May, C.M. Canessa, J.-D. Horisberger, L. Schild, and B.C. Rossier. 1995. The highly selective low-conductance epithelial Na channel of Xenopus laevis A6 kidney cells. Am. J. Physiol. 269:C188-C197.
17. Sachs, F. 1986. Mechanotransducing ion channels. In Ionic Channels in Cells and Model Systems. R. Latorre, editor. Plenum Publishing Corp., New York. 181-193.
18. Sackin, H. 1994. Stretch activated ion channels. In Cellular and Molecular Physiology of Cell Volume Regulation. K.L. Strange, editor. CRC Press, Boca Raton, FL. 215-240.
19. Schild, L., E. Schneeberger, I. Gautschi, and D. Firsov. 1997. Identification of amino acid residues in the alpha, beta, and gamma subunits of the epithelial sodium channel (ENaC) involved in amiloride block and ion permeation. J. Gen. Physiol. 109:15-26.
20. + channels. Annu. Rev. Physiol. 53:509-530.
21. Sokabe, M., F. Sachs, and Z. Jing. 1991. Quantitative video microscopy of patch clamped membranes: stress, strain, capacitance, and stretch activation. Biophys. J. 59:722-728.
22. + channel; biophysical properties, pharmacology, ontogenesis, and molecular cloning. Proc. Natl. Acad. Sci. USA. 91: 247-251.
23. + channel activity in cultured renal (A6) epithelium: regulation by solution osmolarity. J. Membr. Biol. 121:79-90.