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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 8, 2012, Pages 2877-2879

Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 2: α-Branched quaternary amines

(10) Hunt, Thomas a Atherton Watson, Hazel C a Collingwood, Stephen P a Coote, Kevin J a Czarnecki, Sarah a Danahay, Henry a Howsham, Catherine a Hunt, Peter a Paisley, Derek a Young, Alice a

a Novartis Institutes of Biomedical Research (United Kingdom)

Author keywords

Amiloride; Cystic fibrosis; ENaC blocker; Epithelial sodium channel; Quaternary amine

Indexed keywords

AMILORIDE; EPITHELIAL SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT;

ANIMAL EXPERIMENT; ARTICLE; BRONCHUS MUCOSA; CHIRALITY; CONTROLLED STUDY; DRUG BINDING SITE; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; NONHUMAN; TRACHEA;

AMINES; ANIMALS; BINDING SITES; BRONCHI; EPITHELIAL CELLS; EPITHELIAL SODIUM CHANNEL; GUINEA PIGS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZINES; SODIUM CHANNEL BLOCKERS;

CAVIA;

EID: 84859443832 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.02.067 Document Type: Article

Times cited : (17)

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