The stratum corneum and aging

Textbook of Aging Skin

Volumn , Issue , 2010, Pages 55-75

  Rawlings, Anthony V ^a  

^a AVR Consulting Ltd   (United Kingdom)

Author keywords

Barrier; desquamation; dry skin; moisturizer; stratum corneum

Indexed keywords

EID: 84892138988     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-540-89656-2_7     Document Type: Chapter

References (126)

1. Kligman AM. Perspectives and problems in cutaneous gerontology. J Invest Dermatol. 1979;73:39-46.
2. Plewig G, Marples RR. Regional differences of cell sizes in the human stratum corneum. I. J Invest Dermatol. 1970;54(1):13-18.
3. Grove GL. Exfoliative cytological procedures as a nonintrusive method for dermatogerontological studies. J Invest Dermatol. 1979;73 (1):67-69.
4. Marks R, Dawber RP. Skin surface biopsy: An improved technique for the examination of the horny layer. Br J Dermatol. 1971;84 (2):117-123.
5. Imokawa G, Abe A, Jin Y, et al. Decreased level of ceramides in stratum corneum of atopic dermatitis: An etiologic factor in atopic dry skin? J Invest Dermatol. 1991;96(4):523-526.
6. Denda M, Hori J, Koyama J. Stratum corneum sphingolipids and free amino acids in experimentally induced scaly skin. Arch Dermatol Res. 1992;284(6):363-367.
7. Hara M, Kikuchi K, Watanabe M, et al. Senile xerosis: Functional, morphological and biochemical studies. J Geriatr Dermatol. 1993;1:111-120.
8. Fulmer AW, Kramer GJ. Stratum corneum lipid abnormalities in surfactant induced dry scaly skin. J Invest Dermatol. 1986;86 (5):598-602.
9. Rogers J, Harding CR, Mayo A, et al. Stratum corneums lipids: The effect of ageing and the seasons. Arch Dermatol Res. 1996;288: 765-770.
10. Ghadially R, Brown BE, Sequeira-Martin SM, et al. The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. J Clin Invest. 1995;95(5):2281-2290.
11. Rawlings AV, Watkinson A, Rogers J, et al. Abnormalities in stratum corneum structure lipid composition and desmosome degradation in soap-induced winter xerosis. J Soc Cosmet Chem. 1994;45: 203-220.
12. Bouwstra JA, Gooris GS, Van Der Spek JA, et al. Structural investigations of human stratum corneum by small-angle X-ray scattering. J Invest Dermatol. 1991;97(6):1005-1012.
13. Horii I, Nakayama Y, Obata M, et al. Stratum corneum hydration and amino acid content in xerotic skin. Br J Dermatol. 1989;121 (5):587-592.
14. Jacobson TM, Yüksel JC, Geesin JC, et al. Effects of aging and xerosis on the amino acid composition of human skin. J Invest Dermatol. 1990;95(3):296-300.
15. Koyama J, Nakanishi J, Masuda Y, et al. The mechanism of desquamation in the stratum corneum and its relevance to skin care. Proceedings of the 19th IFSCC Congress, Sydney, 1996.
16. Harding CR, Watkinson A, Rawlings AV. Dry skin, moisturization and corneodesmolysis. Int J Cosmet Sci. 2000;22:21-52.
17. Long S, Banks J, Watkinson A, et al. Desmocollins: A key marker for desmosome processing in stratum corneum. J Invest Dermatol. 1996;106:872.
18. Simon M, Bernard D, Minondo AM, et al. Persistence of both peripheral and non-peripheral corneodesmosomes in the upper stratum corneum of winter xerosis skin versus only peripheral in normal skin. J Invest Dermatol. 2001;116:23-30.
19. Michel S, Schmidt R, Shroot B, et al. Morphological and biochemical characterization of the cornified envelopes from human epidermal keratinocytes of different origin. J Invest Dermatol. 1988;91(1):11-15.
20. Hirao T, Denda M, Takahashi M. Identification of immature cornfield envelopes in the barrier-impaired epidermis by characterization of their hydrophobicity and antigenicities of the components. Exp Dermatol. 2001;10:35-44.
21. Marks R, Black D, Hamami I, et al. A simplified method for measurement of desquamation using dansyl chloride fluorescence. Br J Dermatol. 1984;111(3):265-270.
22. Kligman AM. The biology of the stratum corneum. In:MontagnaW, Lobitz WC (eds) The Epidermis. New York: Academic, 1964, pp. 387-433.
23. Blank IH. Factors which influence the water content of the stratum corneum. J Invest Dermatol. 1952;18:433-440.
24. Warner RR, Lilly NA. Correlation of water content with ultrastructure in the stratum corneum. In: Elsner P, Berardesca E, Maibach HI (eds) Bioengineering of the Skin: Water and the Stratum Corneum. Boca Raton: CRC Press, 1994, pp. 3-12.
25. Rawlings AV, Watkinson A, Hope J, et al. The effect of glycerol and humidity on desmosome degradation in stratum corneum. Arch Dermatol Res. 1995;287:457-464.
26. Bowser PA, White RJ. Isolation, barrier properties and lipid analysis of stratum compactum, a discrete region of the stratum corneum. Br J Dermatol. 1985;112(1):1-14.
27. Pfeiffer S, Vielhaber G, Vietzke JP, et al. High-pressure freezing provides new information on human epidermis: Simultaneous protein antigen and lamellar lipid structure preservation. Study on human epidermis by cryoimmobilization. J Invest Dermatol. 2000;114(5):1030-1038.
28. Norlen L. Skin barrier structure and function: The single gel phase model. J Invest Dermatol. 2001;117:830-836.
29. Bouwstra JA, De Graaff A, Gooris GS, et al. Water distribution and related morphology in human stratum corneum at different hydration levels. J Invest Dermatol. 2003;120(5):750-758.
30. Richter T, Peuckert C, Sattler M, et al. Dead but highly dynamic-the stratum corneum is divided into three hydration zones. Skin Pharmacol Physiol. 2004;17(5):246-257.
31. Downing DT, Stewart ME. Epidermal composition. In: Loden M, Maibach HI (eds) Dry Skin and Moisturizers Chemistry and Function. Boca Raton: CRC Press, 2000, pp. 13-26.
32. Motta SM, Monti M, Sesana S, et al. Ceramide composition of psoriatic scale. Biochim Biophys Acta. 1993;1182:147-151.
33. Oku H, Mimura K, Tokitsu Y, et al. Biased distribution of the branched-chain fatty acids in ceramides of vernix caseosa. Lipids. 2000;35(4):373-381.
34. Chopart M, Castiel-Higounenc I, Arbey E, et al. A new type of covalently bound ceramide in human epithelium. Stratum Corneum III, Basel, 2001.
35. Hill J, Paslin D, Wertz PW. A new covalently bound ceramide from human stratum corneum-o-hydroxyacylphytosphingosine. Int J Cosmet Sci. 2006;28(3):225-230.
36. Hamanaka S, Hara M, Nishio H, et al. Human epidermal glucosylceramides are major precursors of stratum corneum ceramides. J Invest Dermatol. 2002;119:416-423.
37. Wertz PW, Miethke MC, Long SA, et al. The composition of the ceramides from human stratum corneum and from comedones. J Invest Dermatol. 1985;84(5):410-412.
38. Farwanah H, Pierstorff B, Schmelzer CEH, et al. Separation and mass spectrometric characterization of covalently bound ceramides using LC/APCI-MS and Nano-ESI-MS/MS. J Chromatogr. 2007;852:562-570.
39. Rawlings AV, Hinder H, Puch P, et al. Composition of human stratum corneum ceramide EOS omega-hydroxy fatty acids. IFSCC Congress, 2008.
40. Pilgram GSK, Engelsma-van Pelt AM, Bouwstra JA, et al. Electron diffraction provides new information on human stratum corneum lipid organisation studied in relation to depth and temperature. J Invest Dermatol. 1999;113:403-409.
41. Brancaleon L, Bamberg MP, Sakamaki T, et al. Attenuated total reflection-Fourier transform infrared spectroscopy as a possible method to investigate biophysical parameters of stratum corneum in vivo. J Invest Dermatol. 2001;116:380-386.
42. Bouwstra J, Pilgram G, Gooris G, et al. New aspects of the skin barrier organization. Skin Pharm Appl Skin Physiol. 2001;14:52-62.
43. Bouwstra J, Gooris GS, Dubbelaar FER, et al. Phase behaviour of stratum corneum lipid mixtures based on human ceramides: The role of natural and synthetic ceramide 1. J Invest Dermatol. 2002;118:606-617.
44. Conti A, Rogers J, Verdejo P, et al. Seasonal changes in stratum corneum ceramide one fatty acid levels and the influence of topical fatty acids. Int J Cosmet Sci. 1996;18:1-12.
45. Rawlings AV, Critchley P, Ackerman C, et al. The functional role of ceramide one in the stratum corneum. 17th IFSCC, Yokohama, Japan, 1992.
46. Oldroyd J, Critchley P, Tiddy GJT, et al. A specialized role for ceramide one in the stratum corneum water barrier. J Invest Dermatol. 1994;102:525.
47. de Jager M, Groenink W, Van Der Spek J, et al. Preparation and characterization of a stratum corneum substitute for in vitro percutaneous penetration studies. Biochim Biophys Acta. 2006;1758 (5):636-644.
48. Meldrum H et al. The characteristic decrease in scalp stratum corneum lipids in dandruff is reversed by use of a ZnPTO containing shampoo. IFSCC Mag. 2003;6(1):3-6.
49. Denda M, Sato J, Masuda Y, et al. Exposure to a dry environment enhances epidermal permeability barrier function. J Invest Dermatol. 1998;111:858-863.
50. Sato J, Denda M, Chang S, et al. Abrupt decreases in environmental humidity induce abnormalities in permeability barrier homeostasis. J Invest Dermatol. 2002;119:900-904.
51. Chou TC, Lin KH, Wang SM, et al. Transepidermal water loss and skin capacitance alterations among workers in an ultra-low humidity environment. Arch Dermatol Res. 2005;296:489-495.
52. Warner RR, Boissy YL. Effect of moisturizing products on the structure of lipids in the outer stratum corneum of humans. In: Loden M, Maibach HI (eds) Dry Skin and Moisturisers. Boca Raton: CRC Press, 2000, pp. 349-372.
53. Berry N, Charmeil C, Gouion C, et al. A clinical, biometrological and ultrastructural study of xerotic skin. Int J Cosmet Sci. 1999;21: 241-249.
54. Sheu HM, Chao SC, Wong TW, et al. Human skin surface lipid film: An ultrastructural study and interaction with corneocytes and intercellular lipid lamellae of the stratum corneum. Br J Dermatol. 1999;140(3):385-391.
55. Wertz PW, Downing DT. Hydroxyacid derivatives in human epidermis. Lipids. 1988;23(5):415-418.
56. Long SA, Wertz PW, Strauss JS, et al. Human stratum corneum polar lipids and desquamation. Arch Dermatol Res. 1985;277(4):284-287.
57. Chen YL, Wiedmann TS. Human stratum corneum lipids have a distorted orthorhombic packing at the surface of cohesive failure. J Invest Dermatol. 1996;107(1):15-19.
58. King CS, Barton SP, et al. The change in properties of the stratum corneum as a function of depth. Br J Dermatol. 1979;100(2):165-172.
59. Marks R, Lawson A, Nicholls S. Age-related changes in stratum corneum structure and function. In: MarksR (ed) The Stratum Corneum. Cardiff: Stratum Corneum Group, 1986, pp. 10-15.
60. Choi EH, Man MQ, Xu P, et al. Stratum corneum acidification is impaired in moderately aged human and murine skin. J Invest Dermatol. 2007;127:2847-2856.
61. Serre G, Mils V, Haftek M, et al. Identification of late differentiation antigens of human cornified epithelia, expressed in re-organized desmosomes and bound to cross-linked envelope. J Invest Dermatol. 1991;97:1061-1072.
62. Simon M, Jonca N, Guerrin M, et al. Refined characterization of corneodesmosin proteolysis during terminal differentiation of human epidermis and its relationship to desquamation. J Biol Chem. 2001;276:20292-20299.
63. Caubet C, et al. Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family. J Invest Dermatol. 2004;122:1235-1244.
64. Duhieu S, Laperdrix C, Hashimoto T, et al. Desmosome-binding antibody KM48 recognises an extracellular antigen different from desmosomal cadherins Dsg 1-3 and Dsc 1-3. Eur J Dermatol. 2006;15(2):80-84.
65. Lundstörm A, Egelud T. Cell shedding from human plantar skin in vitro: Evidence that two different types of protein structures are degraded by a chymotrypsin-like enzyme. Arch Dermatol Res. 1990;282:234-237.
66. Suzuki Y, Nomura J, Koyama J, et al. The role of proteases in stratum corneum: Involvement in stratum corneum desquamation. Arch Dermatol Res. 1994;286:249-253.
67. Horikoshi T, Igarashi S, Uchiwa H, et al. Role of endogenous cathepsin D-like and chymotrypsin-like proteolysis in human epidermal desquamation. Br J Dermatol. 1999;141:453-459.
68. Horikoshi T, Arany I, Rajaraman S, et al. Isoforms of cathepsin D human epidermal differentiation. Biochimie. 1998;80:605-612.
69. Watkinson A. Stratum corneum thiol protease (SCTP): A novel cysteine protease of late epidermal differentiation. Arch Dermatol Res. 1999;291:260-268.
70. Bernard D, et al. Analysis of proteins with caseinolytic activity in a human SC extract revealed a yet unidentified cysteine protease and identified the so called "SC thiol protease" as Cathepsin L2. J Invest Dermatol. 2003;120:592-600.
71. Komatsu N, Saijoh K, Sidiropoulos M, et al. Quantification of human tissue kallikreins in the stratum corneum: Dependence on age and gender. J Invest Dermatol. 2005;125:1182-1189.
72. Borgoño CA, Michael IP, Komatsu N, et al. A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation. J Biol Chem. 2007;282(6):640-652.
73. Kishibe M, Bando Y, Terayama R, et al. Kallikrein 8 is involved in skin desquamation in cooperation with other kallikreins. J Biol Chem. 2007;282(8):5834-5841.
74. Suzuki Y, Nomura J, Hori J, et al. Detection and characterization of endogenous protease associated with desquamation of stratum corneum. Arch Dermatol Res. 1994;285:372-377.
75. Voegeli R, Rawlings AV, Doppler S, et al. Profiling of serine protease activities in human stratum corneum and detection of a stratum corneum tryptase-like enzyme. Int J Cosmet Sci. 2007;29:191-200.
76. Bernard D, Mehul B, Delattre C, et al. Purification and characterization of the endoglycosidase heparanase 1 from human plantar stratum corneum: A key enzyme in epidermal physiology. J Invest Dermatol. 2001;117:1266-1273.
77. Sondell B, Thornell LE, Stigbrand T, et al. Immunolocalization of SCCE in human skin. Histo Cyto. 1994;42:459-465.
78. Watkinson A, Smith C, Coan P, et al. The role of Pro-SCCE and SCCE in desquamation. 21st IFSCC Congress, Berlin, 2000, pp. 16-25.
79. Igarashi S, Takizawa T, Yasuda Y, et al. Cathepsin D, and not cathepsin E, degrades desmosomes during epidermal desquamation. Br J Dermatol. 2004;151:355-361.
80. Ishida-Yamamoto I, et al. Epidermal lamellar granules transport different cargoes as distinct aggregates. J Invest Dermatol. 2004; 122:1145-1153.
81. Watkinson A, Harding C, Moore A, et al. Water modulation of stratum corneum chymotryptic enzyme activity and desquamation. Arch Dermatol Res. 2001;293:470-476.
82. Komatsu N, Takata M, Otsuki N, et al. Elevated stratum corneum hydrolytic activity in Netherton syndrome suggests an inhibitory regulation of desquamation by SPINK5-derived peptides. J Invest Dermatol. 2002;118:436-443.
83. Deraison C, Bonnart C, Lopez F, et al. LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction. Mol Biol Cell. 2007;18(9):3607-3619.
84. Yamasaki K, Di Nardo A, Bardan A, et al. Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat Med. 2007;13(8):975-980.
85. Declercq L, Muizzuddin N, Hellemans L, et al. Adaptation response in human skin barrier to a hot and dry environment. J Invest Dermatol. 2002;119:716.
86. Bernard D, Méhul B, Thomas-Collignon A, et al. Identification and characterization of a novel retroviral-like aspartic protease specifically expressed in human epidermis. J Invest Dermatol. 2005;125(2): 278-287.
87. Fischer H, Stichenwirth M, Dockal M, et al. Stratum corneumderived caspase-14 is catalytically active. FEBS Lett. 2004;577 (3):446-450.
88. Watkinson A, Smith C, Rawlings AV. The identification and localization of tryptic and chymotryptic-like enzymes in human stratum corneum. J Invest Dermatol. 1994;102:637.
89. King CS, Nicholls S, Barton S, et al. Is the stratum corneum of uninvolved psoriatic skin abnormal? Acta Dermatol Venereol Suppl (Stockh). 1979;59(85):95-100.
90. Watkinson A, Harding CR, Rawlings AV. The cornified envelope: Its role on stratum corneum structure and maturation. In: Leyden JJ, Rawlings AV (eds) Skin Moisturization. New York: Marcel Dekker, 2002, pp. 95-117.
91. Candi E, et al. Transglutaminase cross linking properties of the small proline rich 1 family of cornified envelope proteins. J Biol Chem. 1999;274:7226-7237.
92. Kim IG, Gorman JJ, et al. The deduced sequence of the novel protransglutaminase-E (TGase 3) of human and Mouse. J Biol Chem. 1993;268:12682-12690.
93. Nemes Z, Marekov LN, Steinert PM. Involucrin cross linking by transglutaminase 1. J Biol Chem. 1999;274:11013-11021.
94. Cabral A, Voskamp P, Cleton-Jansen M, et al. Structural organisation and regulation of the small proline rich family of cornified envelope precursors suggest a role in adaptive barrier function. J Biol Chem. 2001;26:19231-19237.
95. Mils A, Vincent C, Croute F, et al. The expression of desmosomal and corneodesmosomal antigens shows specific variations during the terminal differentiation of epidermis and hair follicle epithelia. J Histochem Cytochem. 1992;40:1329-1337.
96. Kashibuchi N, Hirai Y, O'Goshi K, et al. Three-dimensional analyses of individual corneocytes with atomic force microscope: Morphological changes related to age, location and to the pathologic skin conditions. Skin Res Technol. 2002;8:203-211.
97. Harding CR, Long S, Richardson J, et al. The cornified cell envelope: An important marker of stratum corneum maturation in healthy and dry skin. Int J Cosmet Sci. 2003;25:1-11.
98. Marks R, Nicolls S, King CS. Studies on isolated corneocytes. Int J Cosmet Sci. 1981;3:251-258.
99. Kunii T, Hirao H, Kikuchi K, et al. Stratum corneum lipid profile and maturation pattern of corneocytes in the outermost layer of fresh scars: The presence of immature corneocytes plays a much more important role in the barrier dysfunction than do changes in intercellular lipids. Br J Dermatol. 2003;149(4):749-756.
100. Mechin MC, Enji M, Nachat R, et al. The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations. CMLS DO1 2005;1-12.
101. Harding CR, Rawlings AV.Natural moisturising factor. In: Loden M, Maibach H (eds) Dry Skin and Moisturizers. Boca Raton: CRC Press, 2006, Chapter 18, pp. 187-209.
102. Katagiri C, Sato J, Nomura J, et al. Changes in environmental humidity affect the water-holding property of the stratum corneum and its free amino acid content, and the expression of filaggrin in the epidermis of hairless mice. J Dermatol Sci. 2003;31 (1):29-35.
103. Jokura Y, et al. Molecular analysis of elastic properties of the stratum corneum by solid-state C-13-nuclear magnetic resonance spectroscopy. J Invest Dermatol. 1995;104:806.
104. Rawlings AV, Scott IR, Harding CR, et al. Stratum corneum moisturization at the molecular level. J Invest Dermatol. 1994;103: 731-740.
105. Takahashi M, Tezuka T. The content of free amino acids in the stratum corneum is increased in senile xerosis. Arch Dermatol Res. 2004;295(10):448-452.
106. Sakai S, et al. Hyaluronan exists in the normal stratum corneum. J Invest Dermatol. 2000;114:1184.
107. Fluhr JW, et al. Glycerol regulates stratum corneum hydration in sebaceous gland deficient (Asebia) mice. J Invest Dermatol. 2003;120:728.
108. Choi EH, Man MQ, Wang F, et al. Is endogenous glycerol a determinant of stratum corneum hydration in humans. J Invest Dermatol. 2005;125:288-293.
109. Fluhr JW, et al. Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity. J Invest Dermatol. 2001;117:44
110. Krein PM, Kermici M. Evidence for the existence of a self-regulated enzymatic process within the human stratum corneum-an unexpected role for urocanic acid. J Invest Dermatol. 2000;115:414.
111. Nakagawa N, et al. Relationship between NMF (potassium and lactate) content and the physical properties of the stratum corneum in healthy subjects. J Invest Dermatol. 2004;122:755.
112. Katsura Y, Yoshida Y, Kawai E, et al. Urokinase-type plasminogen activator is activated in stratum corneum after barrier disruption. J Dermatol Sci. 2003;32:55-57.
113. Rawlings AV, Hope J, Rogers J, et al. Mechanisms of desquamation: New insights into dry flaky skin conditions. Proceedings of the 17th IFSCC, 1992, vol. 2, pp. 865-880.
114. Van Overloop L, Declercq L, Maes D. Visual scaling of human skin correlates to decreased ceramide levels and decreased stratum corneum protease activity. J Invest Dermatol. 2001;117:811.
115. Saint-Leger D, Francois AM, Leveque JL, et al. Stratum corneum lipids in skin xerosis. Dermatologica. 1989;178:151-155.
116. Chopart M, Castiel-Higounenc C, Arbey E, et al. Quantitative analysis of ceramides in stratum corneum of normal and dry skin. Stratum Corneum III. 2001.
117. Schreiner V, Gooris GS, Pfeiffer S, et al. Barrier characteristics of different human skin types investigated with x-ray diffraction, lipid analysis and electron microscopy imaging. J Invest Dermatol. 2000;114:654-660.
118. Harding CR, Richardson J, Ginger R, et al. Role of transglutaminase in the continued cross linking of cornified envelope protein during stratum corneum maturation. 22nd IFSCC Congress P139, 2002.
119. Ginger RS, Blachford S, Rowland J, et al. Filaggrin repeat number polymorphism is associated with a dry skin phenotype. Arch Dermatol Res. 2005;297(6):235-241.
120. Engelke M, Jensen JM, Ekanayake-Mudiyanselage S, et al. Effects of xerosis and ageing on epidermal proliferation and differentiation. Br J Dermatol. 1997;137(2):219-225.
121. Leveque JL, Grove G, De Rigal J, et al. Biophysical characterization of dry facial skin. J Soc Cosmet Chem. 1987;82:171-177.
122. Bhawan J, Oh CH, Lew R, et al. Histopathologic differences in the photoaging process in facial versus arm skin. Am J Dermatopathol. 1992;14(3):224-230.
123. Egawa M, Tagami H. Comparison of the depth profiles of water and water-binding substances in the stratum corneum determined in vivo by Raman spectroscopy between the cheek and volar forearm skin: Effects of age, seasonal changes and artificial forced hydration. Br J Dermatol. 2008;158(2):251-260.
124. Voegeli R, Rawlings AV, Doppler S, et al. Increased basal transepidermal water loss leads to elevation of some but not all stratum corneum serine proteases. Int J Cosmet Sci. 2008;30(6):435-442.
125. Cork MJ, Robinson DA, Vasilopoulos Y, et al. New perspectives on epidermal barrier dysfunction in atopic dermatitis:gene-environment interactions. J Allergy Clin Immunol. 2006;118(1):3-21, quiz 22-23.
126. Matts PJ, Gray J, Rawlings AV. The "Dry Skin Cycle"-a new model of dry skin and mechanisms for intervention. International Congress and Symposium Series. London: The Royal Society of Medicine Press Ltd, 2005, pp. 1-38.