Human skin surface lipid film: An ultrastructural study and interaction with corneocytes and intercellular lipid lamellae of the stratum corneum

British Journal of Dermatology

Volumn 140, Issue 3, 1999, Pages 385-391

  Sheu, Hamm Ming ^a   Chao, Sheau Chiou ^a   Wong, Tak Wah ^a   Lee, J Yu Yun ^a   Tsai, Jui Chen ^b  

^a NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Corneocytes; Intercellular lipid lamella; Sebum; Skin surface lipid film; Stratum corneum

Indexed keywords

RUTHENIUM DERIVATIVE;

ADULT; ARTICLE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INTERCELLULAR SPACE; LIPID BILAYER; LIPID MEMBRANE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SEBUM; SKIN BIOPSY; SKIN CELL; SKIN SURFACE; STRATUM CORNEUM; TRANSMISSION ELECTRON MICROSCOPY;

ADULT; BIOPSY; FEMALE; HUMANS; LIPIDS; MALE; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; SEBUM; SKIN;

EID: 0032940794     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.1999.02697.x     Document Type: Article

References (21)

1. 1 Downing DT. Stewart ME, Wertz PW et al. Lipids of the epidermis and the sebaceous glands. In: Dermatology in General Medicine (Fitzpatrick TB, Eisen AZ, Wolff K et al. eds.), 4th edn, Vol. I . New York: McGraw-Hill, Inc., 1993: 210-21.
2. 2 Plewig G, Kligman AM. Acne and Rosacea, 2nd edn. Berlin: Springer-Verlag. 1993: 52-3.
3. 3 Wilhelm KP, Cua AB, Maibach HI. Skin aging. Arch Dermatol 1991; 127: 1806-9.
4. 4 Greene RS, Downing DT, Pochi PE et al. Anatomical variation in the amount and composition of human skin surface lipid. J Invest Dermatol 1970; 54: 240-7.
5. 5 Kligman AM, Shelley WB. An investigation of the biology of the human sebaceous gland. J Invest Dermatol 1958; 30: 99-125.
6. 6 Kligman AM. The uses of sebum. Br J Dermatol 1963; 75: 307-19.
7. 7 Madison KC, Swartzendruber DC, Wertz PW et al. Presence of intact intercellular lipid lamellae in the upper layer of the stratum corneum. J Invest Dermatol 1987; 88: 714-18.
8. 8 Blair C. Morphology and thickness of the human stratum corneum. Br J Dermatol 1968; 80: 490-6.
9. 9 Sheu H-M, Lee JY-Y, Chai CY et al. Depletion of stratum corneum intercellular lipid lamellae and barrier function abnormalities after long-term topical corticosteroids. Br J Dermatol 1997; 136:884-90.
10. 10 Grubauer G, Feingold KR, Harris RM et al. Lipid content and lipid type as determinants of the epidermal permeability barrier. J Lipid Res 1989; 30: 89-96.
11. 11 Clarys P, Barel A. Quantitative evaluation of skin surface lipids. Clin Dermatol 1995; 13: 307-21.
12. 12 Fowler SD, Greenspan P. Application of Nile red, a fluorescent Hydrophobie probe, for the detection of neutral lipid deposits in tissue sections: comparison with oil red O. J Histochem Cytochem 1985; 33: 833-6.
13. 13 Swartzendruber DC, Wertz PW, Madison KC et al. Evidence that the corncocyte has a chemically bound lipid envelope. J Invest Dermatol 1987; 88: 709-13.
14. 14 Mavon A, Redoules D, Gall PA et al. Does sebum make droplets before spreading on the skin surface? J Invent Dermatol 1997; 108: 374 (Abstr.).
15. 15 Bommannan D, Potts RO. Guy RH. Examination of stratum corneum barrier function in vivo by infrared spectroscopy. J Invest Dermatol 1990; 95: 403-8.
16. 16 Leyden JJ. New understandings of the pathogenesis of acne. J Am Acad Dermatol 1995; 32: S15-25.
17. 17 Elias PM, Feingold KR. Lipid-related barriers and gradients in the epidermis. Ann NY Acad Sci 1988; 548: 4-13.
18. 18 Elias PM. Epidermal barrier function: intercellular lamellar lipid structures, origin, composition and metabolism. J Controlled Release 1991; 15: 199-208.
19. 19 Wert PW, Swartzendruber DC, Madison KC et. al. Composition and morphology of epidermal cyst lipids. J Invest Dermatol 1987; 89: 419-25.
20. 20 Rawlings AV, Watkinson A, Roger J et al. Abnormalities in stratum corneum structure, lipid composition, and desmosome degradation in soap-induced winter xerosis. J Soc Cosmet Chem 1994; 45: 203-20.
21. 21 Hashimoto K. Fine structure of horny cells of the vermilion border of the lip compared with skin. Arch Oral Biol 1971; 16: 397-410.