Quantification of human tissue kallikreins in the stratum corneum: Dependence on age and gender

Journal of Investigative Dermatology

Volumn 125, Issue 6, 2005, Pages 1182-1189

  Komatsu, Nahoko ^a,b   Saijoh, Kiyofumi ^b   Sidiropoulos, Michael ^a   Tsai, Brian ^a   Levesque, Michael A ^a   Elliott, Marc B ^a,c   Takehara, Kazuhiko ^b   Diamandis, Eleftherios P ^a,c  

^a MOUNT SINAI HOSPITAL   (Canada)

^b KANAZAWA UNIVERSITY   (Japan)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Aging; Desquamation; Human kallikreins; Serine proteases; Stratum corneum

Indexed keywords

CHYMOTRYPSIN; KALLIKREIN; PROTEIN HK10; PROTEIN HK11; PROTEIN HK13; PROTEIN HK14; PROTEIN HK5; PROTEIN HK6; PROTEIN HK7; PROTEIN HK8; SERINE PROTEINASE; TRYPSIN; UNCLASSIFIED DRUG; TISSUE KALLIKREIN;

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORNEODESMOSOME; DESMOSOME; DESQUAMATION; DRY WEIGHT; ENZYME ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LOCALIZATION; ENZYME REGULATION; EPIDERMIS GRANULAR LAYER; FEMALE; GENDER; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SCHOOL CHILD; SKIN APPENDAGE; STATISTICAL SIGNIFICANCE; STRATUM CORNEUM; AGE DISTRIBUTION; CHILD; CUTANEOUS PARAMETERS; CYTOLOGY; ENZYMOLOGY; KINETICS; METABOLISM; MIDDLE AGED; SEXUAL DEVELOPMENT; SKIN;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; CHILD; FEMALE; HUMANS; KINETICS; MALE; MIDDLE AGED; SEX CHARACTERISTICS; SKIN; SKIN AGING; TISSUE KALLIKREINS; TRYPSIN;

EID: 33644822940     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2005.23933.x     Document Type: Article

References (41)

1. Borgono CA, Grass L, Soosaipillai A, et al: Human kallikrein 14: A new potential biomarker for ovarian and breast cancer. Cancer Res 63:9032-9041, 2003
2. Brattsand M, Egelrud T: Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation. J Biol Chem 274:30033-30040, 1999
3. Brattsand M, Stefansson K, Lundh C, Haasum Y, Egelrud T: A proteolytic cascade of kallikreins in the stratum corneum. J Invest Dermatol 124:198-203, 2005
4. Caubet C, Jonca N, Brattsand M, et al: Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7. J Invest Dermatol 122:1235-1244, 2004
5. Chapman SJ, Walsh A: Desmosomes, corneosomes and desquamation. An ultrastructural study of adult pig epidermis. Arch Dermatol Res 282: 304-310, 1990
6. Diamandis EP, Okui A, Mitsui S, et al: Human kallikrein 11: A new biomarker of prostate and ovarian carcinoma. Cancer Res 62:295-300, 2002
7. Diamandis EP, Yousef GM, Soosaipillai AR, Grass L, Porter A, Little S, Sotiropoulou G: Immunofluorometric assay of human kallikrein 6 (zyme/protease M/neurosin) and preliminary clinical applications. Clin Biochem 33:369-375, 2000
8. Dickson EF, Pollak A, Diamandis EP: Ultrasensitive bioanalytical assays using time-resolved fluorescence detection. Pharmacol Ther 66:207-235, 1995
9. Ekholm E, Egelrud T: Stratum corneum chymotryptic enzyme in psoriasis. Arch Dermatol Res 291:195-200, 1999
10. Ekholm IE, Brattsand M, Egelrud T: Stratum corneum tryptic enzyme in normal epidermis: A missing link in the desquamation process? J Invest Dermatol 114:56-63, 2000
11. Ferguson RA, Yu H, Kalyvas M, Zammit S, Diamandis EP: Ultrasensitive detection of prostate-specific antigen by a time-resolved immunofluorometric assay and the Immulite immunochemiluminescent third-generation assay: Potential applications in prostate and breast cancers. Clin Chem 42:675-684, 1996
12. Franzke CW, Baici A, Bartels J, Christophers E, Wiedow O: Antileukoprotease inhibits stratum corneum chymotryptic enzyme. Evidence for a regulative function in desquamation. J Biol Chem 271:21886-21890, 1996
13. Gan L, Lee I, Smith R, et al: Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. Gene 257:119-130, 2000
14. Halprin KM: Epidermal "turnover time" - A re-examination. Br J Dermatol 86: 14-19, 1972
15. Hansson L, Stromqvist M, Backman A, Wallbrandt P, Carlstein A, Egelrud T: Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase. J Biol Chem 269:19420-19426, 1994
16. Harding CR: The stratum corneum: Structure and function in health and disease. Dermatol Ther 17 (Suppl. 1):6-15, 2004
17. Harding CR, Watkinson A, Rawlings AV, Scott IR: Dry skin, moisturization and corneodesmolysis. Int J Cosmet Sci 22:21-52, 2000
18. Harvey TJ, Hooper JD, Myers SA, Stephenson SA, Ashworth LK, Clements JA: Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4. J Biol Chem 275:37397-37406, 2000
19. Ishida-Yamamoto A, Deraison C, Bonnart C, et al: LEKTI is llocalized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum. J Invest Dermatol 124:360-366, 2005
20. Ishida-Yamamoto A, Simon M, Kishibe M, et al: Epidermal lamellar granules transport different cargoes as distinct aggregates. J Invest Dermatol 122:1137-1144, 2004
21. Kapadia C, Chang A, Sotiropoulou G, et al: Human kallikrein 13: Production and purification of recombinant protein and monoclonal and polyclonal antibodies, and development of a sensitive and specific immunofluorometric assay. Clin Chem 49:77-86, 2003
22. Kirihara T, Matsumoto-Miyai K, Nakamura Y, Sadayama T, Yoshida S, Shiosaka S: Prolonged recovery of ultraviolet B-irradiated skin in neuropsin (KLK8)-deficient mice. Br J Dermatol 149:700-706, 2003
23. Kishi T, Grass L, Soosaipillai A, et al: Human kallikrein 8, a novel biomarker for ovarian carcinoma. Cancer Res 63:2771-2774, 2003
24. Kishi T, Soosaipillai A, Grass L, Little SP, Johnstone EM, Diamandis EP: Development of an immunofluorometric assay and quantification of human kallikrein 7 in tissue extracts and biological fluids. Clin Chem 50:709-716, 2004
25. Kligman AM: In: Montagna W, Lobits WC Jr. Jr. (eds). The Epidermis. New York: Academic Press, 1964; p 287
26. Komatsu N, Saijoh K, Otsuki N, et al: Multiple tissue kallikrein mRNA and protein expression in normal skin and skin diseases. Br J Dermatol 153:274-281, 2005
27. Komatsu N, Takata M, Otsuki N, Ohka R, Amano O, Takehara K, Saijoh K: Elevated stratum corneum hydrolytic activity in Netherton syndrome suggests an inhibitory regulation of desquamation by SPINK5-derived peptides. J Invest Dermatol 118:436-443, 2002
28. Komatsu N, Takata M, Otsuki N, Toyama T, Ohka R, Takehara K, Saijoh K: Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages. J Invest Dermatol 121:542-549, 2003
29. Luo LY, Grass L, Howarth DJ, Thibault P, Ong H, Diamandis EP: Immunofluorometric assay of human kallikrein 10 and its identification in biological fluids and tissues. Clin Chem 47:237-246, 2001
30. Marks R: The stratum corneum barrier: The final frontier. J Nutr 134:2017S-2021S, 2004
31. Obiezu CV, Soosaipillai A, Jung K, Stephan C, Scorilas A, Howarth DH, Diamandis EP: Detection of human kallikrein 4 in healthy and cancerous prostatic tissues by immunofluorometry and immunohistochemistry. Clin Chem 48:1232-1240, 2002
32. Pierard GE, Goffin V, Hermanns-Le T, Pierard-Franchimont C: Corneocyte desquamation. Int J Mol Med 6:217-221, 2000
33. Simon M, Jonca N, Guerrin M, et al: Refined characterization of corneodesmosin proteolysis during terminal differentiation of human epidermis and its relationship to desquamation. J Biol Chem 276:20292-20299, 2001
34. Suzuki Y, Koyama J, Moro O, Horii I, Kikuchi K, Tanida M, Tagami H: The role of two endogenous proteases of the stratum corneum in degradation of desmoglein-1 and their reduced activity in the skin of ichthyotic patients. Br J Dermatol 134:460-464, 1996
35. Ya-Xian Z, Suetake T, Tagami H: Number of cell layers of the stratum corneum in normal skin - relationship to the anatomical location on the body, age, sex and physical parameters. Arch Dermatol Res 291:555-559, 1999
36. Yousef GM, Diamandis EP: The new kallikrein-like gene KLK-L2: Molecular characterization, mapping, tissue expression and hormonal regulation. J Biol Chem 274:37511-37516, 1999
37. Yousef GM, Diamandis EP: The new human tissue kallikrein gene family: Structure, function, and association to disease. Endocr Rev 22:184-204, 2001
38. Yousef GM, Diamandis EP: Human tissue kallikreins: A new enzymatic cascade pathway? Biol Chem 383:1045-1057, 2002
39. Yousef GM, Fracchioli S, Scorilas A, et al: Steroid hormone regulation and prognostic value of the human kallikrein gene 14 in ovarian cancer. Am J Clin Pathol 119:346-355, 2003a
40. Yousef GM, Luo LY, Scherer SW, Sotiropoulou G, Diamandis EP: Molecular characterization of zyme/protease M/neurosin (PRSS9), a hormonally regulated kallikrein-like serine protease. Genomics 62:251-259, 1999
41. Yousef GM, Polymeris ME, Grass L, et al: Human kallikrein 5: A potential novel serum biomarker for breast and ovarian cancer. Cancer Res 63:3958-3965, 2003b