Intradermal immunization with combined baculovirus and tumor cell lysate induces effective antitumor immunity in mice

International Journal of Oncology

Volumn 43, Issue 6, 2013, Pages 2023-2030

  Kawahara, Mamoru ^a,b   Takaku, Hiroshi ^b  

^a Kiyose   (Japan)

^b CHIBA INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Adjuvant; Baculovirus; CT26; Immunotherapy; Vaccine

Indexed keywords

BACULOVIRUS VECTOR; CANCER VACCINE; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 12P70; INTERLEUKIN 6; TUMOR LYSATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BACULOVIRUS; CANCER ADJUVANT THERAPY; CANCER IMMUNIZATION; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELL LYSATE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPATHOGENIC EFFECT; DENDRITIC CELL; DRUG EFFICACY; DRUG POTENTIATION; FEMALE; IMMUNE RESPONSE; IMMUNOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR IMMUNITY; WILD TYPE;

ADJUVANTS, PHARMACEUTIC; ANIMALS; BACULOVIRIDAE; CANCER VACCINES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; DENDRITIC CELLS; FEMALE; INTERLEUKIN-12; INTERLEUKIN-6; MICE; MICE, INBRED BALB C; NEOPLASMS; VACCINATION;

EID: 84891958750     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.2125     Document Type: Article

References (43)

1. Paoletti X, Burzykowski T, Michiels S, Ohashi Y, Pignon JP, Rougier P, Sakamoto J, Sargent D, Sasako M, Van Cutsem E and Buyse M: Benefit of adjuvant chemotherapy for resectable gastric cancer: a meta-analysis. JAMA 303: 1729-1737, 2010.
2. Ochsenbein AF: Principles of tumor immunosurveillance and implications for immunotherapy. Cancer Gene Ther 9: 1043-1055, 2002.
3. Kirkwood JM, Butterfield LH, Tarhini AA, Zarour H, Kalinski P and Ferrone S: Immunotherapy of cancer in 2012. CA Cancer J Clin 62: 309-335, 2012.
4. Rosenberg SA, Yang JC and Restifo NP: Cancer immunotherapy: moving beyond current vaccines. Nat Med 10: 909-915, 2004.
5. Toes RE, Blom RJ, Offringa R, Kast WM and Melief CJ: Enhanced tumor outgrowth after peptide vaccination. Functional deletion of tumor-specific CTL induced by peptide vaccination can lead to the inability to reject tumors. J Immunol 156: 3911-3918, 1996.
6. Toes RE, Offringa R, Blom RJ, Melief CJ and Kast WM: Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction. Proc Natl Acad Sci USA 93: 7855-7860, 1996.
7. + T cells. J Immunol 185: 3768-3776, 2010.
8. Bour H, Horvath C, Lurquin C, Cerottini JC and MacDonald HR: Differential requirement for CD4 help in the development of an antigen-specific CD8+ T cell response depending on the route of immunization. J Immunol 160: 5522-5529, 1998.
9. + T cell responses in antitumor immunity. Curr Opin Immunol 10: 588-594, 1998.
10. Toes RE, Ossendorp F, Offringa R and Melief CJ: CD4 T cells and their role in antitumor immune responses. J Exp Med 189: 753-756, 1999.
11. + T lymphocytes. Nature 421: 852-856, 2003.
12. Shedlock DJ and Shen H: Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300: 337-339, 2003.
13. Lizée G, Rasvanyi LG, Overwijik WW and Hwu P: Immunosuppression in melanoma immunotherapy: potential opportunities for intervention. Clin Cancer Res 12: S2359-S2365, 2006.
14. Jackson AM, Mulcathy LA, Zhu XW, O'Donnell D and Patel PM: Tumor-mediated disruption of dendritic cell function: inhibiting the MEK1/2-p44/42 axis restores IL-12 production and Th1-generation. Int J Cancer 123: 623-632, 2008.
15. Yang DH, Park JS, Jin CJ, Kang HK, Nam JH, Rhee JH, Kim YK, Chung SY, Choi SJN, Kim HJ, Chung IJ and Lee JJ: The dysfunction and abnormal signaling pathway of dendritic cells loaded by tumor antigen can be overcome by neutralizing VEGF in multiple myeloma. Leuk Res 33: 665-670, 2009.
16. Schnurr M, Toy T, Stoitzner P, Cameron P, Shin A, Beecroft T, Davis ID, Cebon J and Maraskovsky E: ATP gradients inhibit the migratory capacity of specific human dendritic cell types: implications for P2Y11 receptor signaling. Blood 102: 613-620, 2003.
17. Pinzon-Charry A, Maxwell T and Lopez JA: Dendritic cell dysfunction in cancer: a mechanism for immunosuppression. Immunol Cell Biol 83: 451-461, 2005.
18. Bennaceur K, Popa I, Portoukalian J, Bethier-Vergnes O and Peguet-Navarro J: Melanoma-derived gangliosides impair migratory and antigen-presenting function of human epidermal Langerhans cells and induce their apoptosis. Int Immunol 18: 879-886, 2006.
19. Stewart LM, Hirst M, López-Ferber M, Merryweather AT, Cayley PJ and Possee RD: Construction of an improved baculovirus insecticide containing an insect-specific toxin gene. Nature 352: 85-88, 1991.
20. Jennifer SC, Mark LH, Trevor W, Rosemary SH, David G, Bernadette MG, Timothy MC, Robert DP, Cayley PJ and Bishop DHL: Field trial of a genetically improved baculovirus insecticide. Nature 370: 138-140, 1994.
21. Matsuura Y, Possee RD, Overton HA and Bishop DHL: Baculovirus expression vectors: the requirements for high level expression of proteins, including glycoproteins. J Gen Virol 68: 1233-1250, 1987.
22. Luckow VA and Summers MD: Trends in the development of baculovirus expression vectors. Biotechnology 6: 47-55, 1988.
23. Hofmann C, Sandig V, Gennings G, Rudolph M, Schlag P and Strauss M: Efficient gene transfer into human hepatocytes by baculovirus vectors. Proc Natl Acad Sci USA 92: 10099-10103, 1995.
24. Boyce FM and Bucher NLR: Baculovirus-mediated gene transfer into mammalian cells. Proc Natl Acad Sci USA 93: 2348-2352, 1996.
25. Sandig V and Strauss M: Liver-directed gene transfer and application to therapy. J Mol Med 74: 205-212, 1996.
26. Pieroni L and La Monica N: Towards the use of baculovirus as a gene therapy vector. Curr Opin Mol Ther 3: 464-467, 2001.
27. Kost TA and Condreay JP: Recombinant baculoviruses as mammalian gene-delivery vectors. Trends Biotechnol 20: 173-180, 2002.
28. Gronowski AM, Hilbert DM, Sheehan KCF, Garotta G and Schreiber RD: Baculovirus stimulates antiviral effects in mammalian cells. J Virol 73: 9944-9951, 1999.
29. Beck NB, Sidhu JS and Omiecinski CJ: Baculovirus vectors repress phenobarbital-mediated gene induction and stimulate cytokine expression in primary cultures of rat hepatocytes. Gene Ther 7: 1274-1283, 2000.
30. Kitajima M, Abe T, Miyano-Kurosaki N, Taniguchi M, Nakayama T and Takaku H: Induction of natural killer cell-dependent antitumor immunity by the Autographa californica multiple nuclear polyhedrosis virus. Mol Ther 16: 261-268, 2008.
31. Suzuki T, Chang MO, Kitajima M and Takaku H: Baculovirus activates murine dendritic cells and induces non-specific NK cell and T cell immune responses. Cell Immunol 262: 35-43, 2010.
32. Suzuki T, Chang MO, Kitajima M and Takaku H: Induction of antitumor immunity against mouse carcinoma by baculovirus-infected dendritic cells. Cell Mol Immunol 7: 440-446, 2010.
33. Schöttker B and Schmidt-Wolf IGH: Pulsing with blast cell lysate or blast-derived total RNA reverses the dendritic cell-mediated cytotoxic activity of cytokine-induced killer cells against allogeneic acute myelogenous leukemia cells. Ger Med Sci doi: 10.3205/000141, URN: urn:nbn:de:0183-0001410, 2011.
34. Reis e Sousa C: Dendritic cells in a mature age. Nat Rev Immunol 6: 476-483, 2006.
35. + T cell-mediated suppression by dendritic cells. Science 299: 1033-1036, 2003.
36. Shevach EM: Regulatory T cells in autoimmmunity*. Annu Rev Immunol 18: 423-449, 2000.
37. Maloy KJ and Powrie F: Regulatory T cells in the control of immune pathology. Nat Immunol 2: 816-822, 2001.
38. + immunoregulatory cells. J Immunol 167: 1137-1140, 2001.
39. + regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 6: 345-352, 2005.
40. Turk MJ, Guevara-Patiño JA, Rizzuto GA, Engelhorn ME, Sakaguchi S and Houghton AN: Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells. J Exp Med 200: 771-782, 2004.
41. + cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors. J Exp Med 201: 779-791, 2005.
42. Tani H, Nishijima M, Ushijima H, Miyamura T and Matsuura Y: Characterization of cell-surface determinants important for baculovirus infection. Virology 279: 343-353, 2001.
43. Akira S, Takeda K and Kaisho T: Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2: 675-680, 2001.