Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 1, 2014, Pages

  Bedel, Romain ^a   Berry, Richard ^b   Mallevaey, Thierry ^a,g   Matsuda, Jennifer L ^a   Zhang, Jingjing ^a   Godfrey, Dale I ^c   Rossjohn, Jamie ^b,d   Kappler, John W ^a,e,f   Marrack, Philippa ^a,e,f   Gapin, Laurent ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d CARDIFF UNIVERSITY   (United Kingdom)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^f UNIVERSITY OF COLORADO   (United States)

^g UNIVERSITY OF TORONTO   (Canada)

Author keywords

Deletion; Thymus

Indexed keywords

CD1D ANTIGEN; EARLY GROWTH RESPONSE FACTOR 2; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CELL DIFFERENTIATION; CELL FUNCTION; CELL LINEAGE; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; CELL SELECTION; CELLULAR PARAMETERS; CONTROLLED STUDY; EFFECTOR CELL; IN VIVO STUDY; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PRE T LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RECEPTOR BINDING; SEQUENCE ANALYSIS;

DELETION; THYMUS;

ANIMALS; ANTIGENS, CD1D; CELL DIFFERENTIATION; EARLY GROWTH RESPONSE PROTEIN 2; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; IMMUNE SYSTEM; LYMPH NODES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NATURAL KILLER T-CELLS; PROMOTER REGIONS, GENETIC; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RETROVIRIDAE; SURFACE PLASMON RESONANCE; THYMOCYTES; TIME FACTORS;

EID: 84891941527     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1320777110     Document Type: Article

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