Natural Killer T cell obsession with self-antigens

Current Opinion in Immunology

Volumn 25, Issue 2, 2013, Pages 168-173

  Gapin, Laurent ^a   Godfrey, Dale I ^b   Rossjohn, Jamie ^c  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD1D ANTIGEN; LIPID ANTIGEN; SELF ANTIGEN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; UNCLASSIFIED DRUG;

ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; CELL MATURATION; HUMAN; IMMUNE RESPONSE; IMMUNOREGULATION; NATURAL KILLER T CELL; NONHUMAN; PROTEIN EXPRESSION;

AUTOANTIGENS; HUMANS; NATURAL KILLER T-CELLS;

EID: 84877073135     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2013.01.002     Document Type: Article

References (58)

1. Godfrey D.I., MacDonald H.R., Kronenberg M., Smyth M.J., Van Kaer L. NKT cells: what's in a name?. Nat Rev Immunol 2004, 4:231-237.
2. Kadri N., Blomqvist M., Cardell S.L. Type II Natural Killer T cells: a new target for immunomodulation?. Expert Rev Clin Immunol 2008, 4:615-627.
3. Rhost S., Sedimbi S., Kadri N., Cardell S.L. Immunomodulatory type II Natural Killer T lymphocytes in health and disease. Scand J Immunol 2012, 76:246-255.
4. Blomqvist M., Rhost S., Teneberg S., Löfbom L., Østerbye T., Brigl M., Månsson J.-E., Cardell S.L. Multiple tissue-specific isoforms of sulfatide activate CD1d-restricted type II NKT cells. Eur J Immunol 2009, 39:1726-1735.
5. Jahng A., Maricic I., Aguilera C., Cardell S.L., Halder R., Kumar V. Prevention of autoimmunity by targeting a distinct, noninvariant CD1d-reactive T cell population reactive to sulfatide. J Exp Med 2004, 199:947-957.
6. Rhost S., Lofbom L., Rynmark B.M., Pei B., Mansson J.E., Teneberg S., Blomqvist M., Cardell S.L. Identification of novel glycolipid ligands activating a sulfatide-reactive, CD1d-restricted, type II Natural Killer T lymphocyte. Eur J Immunol 2012, 42:2851-2860.
7. Watarai H., Sekine-Kondo E., Shigeura T., Motomura Y., Yasuda T., Satoh R., Yoshida H., Kubo M., Kawamoto H., Koseki H., et al. Development and function of invariant Natural Killer T cells producing T(h)2- and T(h)17-cytokines. PLoS Biol 2012, 10:e1001255.
8. Doisne J.M., Soulard V., Becourt C., Amniai L., Henrot P., Havenar-Daughton C., Blanchet C., Zitvogel L., Ryffel B., Cavaillon J.M., et al. Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1-invariant NKT cells to bacteria. J Immunol 2011, 186:662-666.
9. Kinjo Y., Kronenberg M. Detection of microbes by Natural Killer T cells. Adv Exp Med Biol 2009, 633:17-26.
10. Lynch L., Nowak M., Varghese B., Clark J., Hogan A.E., Toxavidis V., Balk S.P., O'Shea D., O'Farrelly C., Exley M.A. Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity 2012, 37:574-587.
11. Ji Y., Sun S., Xia S., Yang L., Li X., Qi L. Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via Natural Killer T cells and interleukin-4. J Biol Chem 2012, 287:24378-24386.
12. Wu L., Parekh V.V., Gabriel C.L., Bracy D.P., Marks-Shulman P.A., Tamboli R.A., Kim S., Mendez-Fernandez Y.V., Besra G.S., Lomenick J.P., et al. Activation of invariant Natural Killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice. Proc Natl Acad Sci U S A 2012, 109:E1143-E1152.
13. Schipper H.S., Rakhshandehroo M., van de Graaf S.F., Venken K., Koppen A., Stienstra R., Prop S., Meerding J., Hamers N., Besra G., et al. Natural Killer T cells in adipose tissue prevent insulin resistance. J Clin Invest 2012, 122:3343-3354.
14. Moran A.E., Holzapfel K.L., Xing Y., Cunningham N.R., Maltzman J.S., Punt J., Hogquist K.A. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J Exp Med 2011, 208:1279-1289.
15. Wang X., Bishop K.A., Hegde S., Rodenkirch L.A., Pike J.W., Gumperz J.E. Human invariant Natural Killer T cells acquire transient innate responsiveness via histone H4 acetylation induced by weak TCR stimulation. J Exp Med 2012, 209:987-1000.
16. Zeng J., Howard J.C. Spontaneous focal activation of invariant Natural Killer T (iNKT) cells in mouse liver and kidney. BMC Biol 2010, 8:142.
17. Brigl M., Bry L., Kent S.C., Gumperz J.E., Brenner M.B. Mechanism of CD1d-restricted Natural Killer T cell activation during microbial infection. Nat Immunol 2003, 4:1230-1237.
18. Paget C., Mallevaey T., Speak A.O., Torres D., Fontaine J., Sheehan K.C., Capron M., Ryffel B., Faveeuw C., Leite de Moraes M., et al. Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids. Immunity 2007, 27:597-609.
19. Brigl M., Tatituri R.V., Watts G.F., Bhowruth V., Leadbetter E.A., Barton N., Cohen N.R., Hsu F.F., Besra G.S., Brenner M.B. Innate and cytokine-driven signals, rather than microbial antigens, dominate in Natural Killer T cell activation during microbial infection. J Exp Med 2011, 208:1163-1177.
20. Rossjohn J., Pellicci D.G., Patel O., Gapin L., Godfrey D.I. Natural Killer T cell antigen receptor recognition of CD1d-restricted antigens. Nature Review Immunology 2012, 112:845-857.
21. Pellicci D.G., Clarke A.J., Patel O., Mallevaey T., Beddoe T., Le Nours J., Uldrich A.P., McCluskey J., Besra G.S., Porcelli S.A., et al. Recognition of beta-linked self glycolipids mediated by Natural Killer T cell antigen receptors. Nat Immunol 2011, 12:827-833.
22. Yu E.D., Girardi E., Wang J., Zajonc D.M. Cutting edge: structural basis for the recognition of beta-linked glycolipid antigens by invariant NKT cells. J Immunol 2011, 187:2079-2083.
23. Novak J., Beaudoin L., Park S., Griseri T., Teyton L., Bendelac A., Lehuen A. Prevention of type 1 diabetes by invariant NKT cells is independent of peripheral CD1d expression. J Immunol 2007, 178:1332-1340.
24. Wesley J.D., Tessmer M.S., Chaukos D., Brossay L. NK cell-like behavior of Vα14i NK T cells during MCMV infection. PLoS Pathog 2008, 4:e1000106.
25. Nagarajan N.A., Kronenberg M. Invariant NKT cells amplify the innate immune response to lipopolysaccharide. J Immunol 2007, 178:2706-2713.
26. Wong C.H., Jenne C.N., Lee W.Y., Leger C., Kubes P. Functional innervation of hepatic iNKT cells is immunosuppressive following stroke. Science 2011, 334:101-105.
27. Gapin L. iNKT cell autoreactivity; what is 'self' and how is it recognized?. Nat Rev Immunol 2010, 10:272-277.
28. Mallevaey T., Clarke A.J., Scott-Browne J.P., Young M.H., Roisman L.C., Pellicci D.G., Patel O., Vivian J.P., Matsuda J.L., McCluskey J., et al. A molecular basis for NKT cell recognition of CD1d-self-antigen. Immunity 2011, 34:315-326.
29. Matulis G., Sanderson J.P., Lissin N.M., Asparuhova M.B., Bommineni G.R., Schumperli D., Schmidt R.R., Villiger P.M., Jakobsen B.K., Gadola S.D. Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3β loop. PLoS Biol 2010, 8:e1000402.
30. Borg N.A., Wun K.S., Kjer-Nielsen L., Wilce M.C., Pellicci D.G., Koh R., Besra G.S., Bharadwaj M., Godfrey D.I., McCluskey J., et al. CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor. Nature 2007, 448:44-49.
31. Scott Browne J., Matsuda J.L., Mallevaey T., Borg N.A., White J., McCluskey J., Rossjohn J., Kappler J., Marrack P., Gapin L. Germline-encoded recognition of diverse glycolipids by NKT cells. Nat Immunol 2007, 8:1105-1113.
32. Wun K.S., Borg N.A., Kjer-Nielsen L., Beddoe T., Koh R., Richardson S.K., Thakur M., Howell A.R., Scott-Browne J.P., Gapin L., et al. A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR. J Exp Med 2008, 205:939-949.
33. Cox D., Fox L., Tian R., Bardet W., Skaley M., Mojsilovic D., Gumperz J., Hildebrand W. Determination of cellular lipids bound to human CD1d molecules. PLoS ONE 2009, 4:e5325.
34. Muindi K., Cernadas M., Watts G.F.M., Royle L., Neville D.C.A., Dwek R.A., Besra G.S., Rudd P.M., Butters T.D., Brenner M.B. Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by CD1d. Proc Natl Acad Sci U S A 2010, 107:3052-3057.
35. Yuan W., Kang S.J., Evans J.E., Cresswell P. Natural lipid ligands associated with human CD1d targeted to different subcellular compartments. J Immunol 2009, 182:4784-4791.
36. Haig N.A., Guan Z., Li D., McMichael A., Raetz C.R., Xu X.N. Identification of self-lipids presented by CD1c and CD1d proteins. J Biol Chem 2011, 286:37692-37701.
37. Zhou D., Mattner J., Cantu C., Schrantz N., Yin N., Gao Y., Sagiv Y., Hudspeth K., Wu Y.P., Yamashita T., et al. Lysosomal glycosphingolipid recognition by NKT cells. Science 2004, 306:1786-1789.
38. Porubsky S., Speak A.O., Salio M., Jennemann R., Bonrouhi M., Zafarulla R., Singh Y., Dyson J., Luckow B., Lehuen A., et al. Globosides but not isoglobosides can impact the development of invariant NKT cells and their interaction with dendritic cells. J Immunol 2012, 189:3007-3017.
39. Porubsky S., Speak A.O., Luckow B., Cerundolo V., Platt F.M., Grone H.-F. Normal development and function of invariant Natural Killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency. Proc Natl Acad Sci U S A 2007, 104:5977-5982.
40. Christiansen D., Milland J., Mouhtouris E., Vaughan H., Pellicci D.G., McConville M.J., Godfrey D.I., Sandrin M.S. Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation. PLoS Biol 2008, 6:e172.
41. Brennan P.J., Tatituri R.V., Brigl M., Kim E.Y., Tuli A., Sanderson J.P., Gadola S.D., Hsu F.F., Besra G.S., Brenner M.B. Invariant Natural Killer T cells recognize lipid self antigen induced by microbial danger signals. Nat Immunol 2011, 12:1202-1211.
42. Pandey M.K., Rani R., Zhang W., Setchell K., Grabowski G.A. Immunological cell type characterization and Th1-Th17 cytokine production in a mouse model of Gaucher disease. Mol Genet Metab 2012, 106:310-322.
43. Gault C.R., Obeid L.M., Hannun Y.A. An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol 2010, 688:1-23.
44. Facciotti F., Ramanjaneyulu G.S., Lepore M., Sansano S., Cavallari M., Kistowska M., Forss-Petter S., Ni G., Colone A., Singhal A., et al. Peroxisome-derived lipids are self antigens that stimulate invariant Natural Killer T cells in the thymus. Nat Immunol 2012, 13:474-480.
45. Pei B., Speak A.O., Shepherd D., Butters T., Cerundolo V., Platt F.M., Kronenberg M. Diverse endogenous antigens for mouse NKT cells: self-antigens that are not glycosphingolipids. J Immunol 2011, 186:1348-1360.
46. Braverman N.E., Moser A.B. Functions of plasmalogen lipids in health and disease. Biochim Biophys Acta 2012, 1822:1442-1452.
47. Zeissig S., Murata K., Sweet L., Publicover J., Hu Z., Kaser A., Bosse E., Iqbal J., Hussain M.M., Balschun K., et al. Hepatitis B virus-induced lipid alterations contribute to Natural Killer T cell-dependent protective immunity. Nat Med 2012, 18:1060-1068.
48. Fox L.M., Cox D.G., Lockridge J.L., Wang X., Chen X., Scharf L., Trott D.L., Ndonye R.M., Veerapen N., Besra G.S., et al. Recognition of lyso-phospholipids by human Natural Killer T lymphocytes. PLoS Biol 2009, 7:e1000228.
49. Lopez-Sagaseta J., Sibener L.V., Kung J.E., Gumperz J., Adams E.J. Lysophospholipid presentation by CD1d and recognition by a human Natural Killer T-cell receptor. EMBO J 2012, 31:2047-2059.
50. Chen X., Wang X., Keaton J.M., Reddington F., Illarionov P.A., Besra G.S., Gumperz J.E. Distinct endosomal trafficking requirements for presentation of autoantigens and exogenous lipids by human CD1d molecules. J Immunol 2007, 178:6181-6190.
51. Wun K.S., Ross F., Patel O., Besra G.S., Porcelli S.A., Richardson S.K., Keshipeddy S., Howell A.R., Godfrey D.I., Rossjohn J. Human and mouse type I Natural Killer T-cell antigen receptors exhibit different fine specificities for CD1d-antigen. J Biol Chem 2012, 287:39139-39148.
52. Cui J., Shin T., Kawano T., Sato H., Kondo E., Toura I., Kaneko Y., Koseki H., Kanno M., Taniguchi M. Requirement for Vα14 NKT cells in IL-12-mediated rejection of tumors. Science 1997, 278:1623-1626.
53. Bedel R., Matsuda J.L., Brigl M., White J., Kappler J., Marrack P., Gapin L. Lower TCR repertoire diversity in Traj18-deficient mice. Nat Immunol 2012, 13:705-706.
54. Riegert P., Gilfillan S. A conserved sequence block in the murine and human TCR Jα region: assessment of regulatory function in vivo. J Immunol 1999, 162:3471-3480.
55. Uldrich A.P., Patel O., Cameron G., Pellicci D.G., Day E.B., Sullivan L.C., Kyparissoudis K., Kjer-Nielsen L., Vivian J.P., Cao B., et al. A semi-invariant Vα10+ T cell antigen receptor defines a population of Natural Killer T cells with distinct glycolipid antigen-recognition properties. Nat Immunol 2011, 12:616-623.
56. Girardi E., Zajonc D.M. Molecular basis of lipid antigen presentation by CD1d and recognition by Natural Killer T cells. Immunol Rev 2012, 250:167-179.
57. Girardi E., Maricic I., Wang J., Mac T.T., Iyer P., Kumar V., Zajonc D.M. Type II Natural Killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens. Nat Immunol 2012, 13:851-856.
58. Patel O., Pellicci D.G., Gras S., Sandoval-Romero M.L., Uldrich A.P., Mallevaey T., Clarke A.J., Le Nours J., Theodossis A., Cardell S.L., et al. Recognition of CD1d-sulfatide mediated by a type II Natural Killer T cell antigen receptor. Nat Immunol 2012, 13:857-863.