Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 18, 2013, Pages 7407-7412

  Ziȩtara, Natalia ^a   Łyszkiewicz, Marcin ^a   Witzlau, Katrin ^a   Naumann, Ronald ^b   Hurwitz, Robert ^c   Langemeier, Jörg ^a   Bohne, Jens ^a   Sandrock, Inga ^a   Ballmaier, Matthias ^a   Weiss, Siegfried ^d   Prinz, Immo ^a   Krueger, Andreas ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

^c MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 181A; MICRORNA 181B1; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM TRANSPORT; CD4+ CD8+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FATE; CELL LINEAGE; CELL MATURATION; CELL PROLIFERATION; CELL SELECTION; CONTROLLED STUDY; GENE DELETION; LIGAND BINDING; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THYMOCYTE;

ANIMALS; CELL PROLIFERATION; CLONAL SELECTION, ANTIGEN-MEDIATED; LIGANDS; MICE; MICE, INBRED C57BL; MICRORNAS; NATURAL KILLER T-CELLS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA;

MUS;

EID: 84876919870     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1221984110     Document Type: Article

References (36)

1. Bendelac A, Savage PB, Teyton L (2007) The biology of NKT cells. Annu Rev Immunol 25:297-336. (Pubitemid 46697911)
2. Bendelac A, et al. (1995) CD1 recognition by mouse NK1+ T lymphocytes. Science 268(5212):863-865.
3. Wei DG, Curran SA, Savage PB, Teyton L, Bendelac A (2006) Mechanisms imposing the Vbeta bias of Valpha14 natural killer T cells and consequences for microbial glycolipid recognition. J Exp Med 203(5):1197-1207. (Pubitemid 43736590)
4. Gapin L, Matsuda JL, Surh CD, Kronenberg M (2001) NKT cells derive from double-positive thymocytes that are positively selected by CD1d. Nat Immunol 2(10):971-978. (Pubitemid 32976171)
5. Benlagha K, Kyin T, Beavis A, Teyton L, Bendelac A (2002) A thymic precursor to the NK T cell lineage. Science 296(5567):553-555. (Pubitemid 34408679)
6. Benlagha K, Wei DG, Veiga J, Teyton L, Bendelac A (2005) Characterization of the early stages of thymic NKT cell development. J Exp Med 202(4):485-492. (Pubitemid 41186947)
7. Pellicci DG, et al. (2002) A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stage. J Exp Med 195(7):835-844. (Pubitemid 34286755)
8. Moran AE, et al. (2011) T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J Exp Med 208(6):1279-1289.
9. Chun T, et al. (2003) CD1d-expressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cells. J Exp Med 197(7):907-918. (Pubitemid 36437867)
10. Pellicci DG, et al. (2003) Intrathymic NKT cell development is blocked by the presence of alpha-galactosylceramide. Eur J Immunol 33(7):1816-1823. (Pubitemid 37120852)
11. Griewank K, et al. (2007) Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. Immunity 27(5):751-762. (Pubitemid 350102258)
12. Gadue P, Morton N, Stein PL (1999) The Src family tyrosine kinase Fyn regulates natural killer T cell development. J Exp Med 190(8):1189-1196.
13. Eberl G, Lowin-Kropf B, MacDonald HR (1999) Cutting edge: NKT cell development is selectively impaired in Fyn-deficient mice. J Immunol 163(8):4091-4094. (Pubitemid 29474468)
14. Pasquier B, et al. (2005) Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product. J Exp Med 201(5):695-701. (Pubitemid 40395115)
15. Nichols KE, et al. (2005) Regulation of NKT cell development by SAP, the protein defective in XLP. Nat Med 11(3):340-345. (Pubitemid 40460564)
16. Neilson JR, Zheng GXY, Burge CB, Sharp PA (2007) Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev 21(5):578-589. (Pubitemid 46409472)
17. Kirigin FF, et al. (2012) Dynamic microRNA gene transcription and processing during T cell development. J Immunol 188(7):3257-3267.
18. Li Q-J, et al. (2007) miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell 129(1):147-161. (Pubitemid 46507589)
19. Ebert PJR, Jiang S, Xie J, Li Q-J, Davis MM (2009) An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. Nat Immunol 10(11):1162-1169.
20. Fragoso R, et al. (2012) Modulating the strength and threshold of NOTCH oncogenic signals by mir-181a-1/b-1. PLoS Genet 8(8):e1002855.
21. Zheng Q, Zhou L, Mi Q-S (2012) MicroRNA miR-150 is involved in Vα14 invariant NKT cell development and function. J Immunol 188(5):2118-2126.
22. Bezman NA, Chakraborty T, Bender T, Lanier LL (2011) miR-150 regulates the development of NK and iNKT cells. J Exp Med 208(13):2717-2731.
23. Fedeli M, et al. (2009) Dicer-dependent microRNA pathway controls invariant NKT cell development. J Immunol 183(4):2506-2512.
24. Zhou L, et al. (2009) Tie2cre-induced inactivation of the miRNA-processing enzyme Dicer disrupts invariant NKT cell development. Proc Natl Acad Sci USA 106(25):10266-10271.
25. Seo KH, et al. (2010) Loss of microRNAs in thymus perturbs invariant NKT cell development and function. Cell Mol Immunol 7(6):447-453.
26. Yamagata T, Mathis D, Benoist C (2004) Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells. Nat Immunol 5(6):597-605. (Pubitemid 38811884)
27. Lambolez F, et al. (2006) The thymus exports long-lived fully committed T cell precursors that can colonize primary lymphoid organs. Nat Immunol 7(1):76-82. (Pubitemid 41823871)
28. Hu T, Simmons A, Yuan J, Bender TP, Alberola-Ila J (2010) The transcription factor c- Myb primes CD4+CD8+ immature thymocytes for selection into the iNKT lineage. Nat Immunol 11(5):435-441.
29. Dose M, et al. (2009) Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc. Proc Natl Acad Sci USA 106(21):8641-8646.
30. Finlay DK, et al. (2010) Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells. J Immunol 185(10):5973-5982.
31. Seiler MP, et al. (2012) Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling. Nat Immunol 13(3):264-271.
32. Schümann J, Mycko MP, Dellabona P, Casorati G, MacDonald HR (2006) Cutting edge: Influence of the TCR Vbeta domain on the selection of semi-invariant NKT cells by endogenous ligands. J Immunol 176(4):2064-2068. (Pubitemid 43201651)
33. Schümann J, Voyle RB, Wei B-Y, MacDonald HR (2003) Cutting edge: Infl uence of the TCR V beta domain on the avidity of CD1d:alpha- galactosylceramide binding by invariant V alpha 14 NKT cells. J Immunol 170(12):5815-5819. (Pubitemid 36682558)
34. Herranz H, Cohen SM (2010) MicroRNAs and gene regulatory networks: Managing the impact of noise in biological systems. Genes Dev 24(13):1339-1344.
35. Tsang JS, Ebert MS, van Oudenaarden A (2010) Genome-wide dissection of microRNA functions and cotargeting networks using gene set signatures. Mol Cell 38(1):140-153.
36. Becker AM, et al. (2010) Invariant NKT cell development requires a full complement of functional CD3 zeta immunoreceptor tyrosine-based activation motifs. J Immunol 184(12):6822-6832.