Effect of a bispidinone analog on mitochondria-mediated apoptosis in HeLa cells

International Journal of Oncology

Volumn 44, Issue 1, 2014, Pages 327-335

  Yi, Myeongjin ^a   Parthiban, Paramasivam ^a   Hwang, Jiyoung ^a   Zhang, Xin ^a,b   Jeong, Hyunjin ^a   Park, Dong Ho ^a   Kim, Dong Kyoo ^a  

^a Inje University   (South Korea)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bispidinone; Mitochondrial membrane potential; The mitochondria dependent mediated pathway

Indexed keywords

2,4,6,8 TETRAARYL 3,7 DIAZABICYCLO[3.3.1]NONAN 9 ONE DERIVATIVE; ANTINEOPLASTIC AGENT; BISPIDINONE DERIVATIVE; CASPASE 3; CASPASE 8; CASPASE 9; FAS LIGAND; LIPOCORTIN 5; PROCASPASE 8; PROPIDIUM IODIDE; PROTEIN BCL 2; PROTEIN P53; RHODAMINE 123; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL DISRUPTION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA CONTENT; DNA REPLICATION; DNA SYNTHESIS; DRUG SYNTHESIS; FEMALE; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HELA CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MICROSCOPY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; WESTERN BLOTTING; WST-8 ASSAY;

ANNEXIN A5; APOPTOSIS; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL PROLIFERATION; FEMALE; HELA CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; SIGNAL TRANSDUCTION; UTERINE CERVICAL NEOPLASMS;

EID: 84891929623     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.2162     Document Type: Article

References (38)

1. Balaiah V, Jeyaraman R and Chandrasekaran L: Synthesis of 2,6-disubstituted piperidines, oxanes, and thianes. Chem Rev 83: 379, 1983.
2. Vijayakumar V and Sundaravadivelu M: Synthesis and study on 2,4,6,8-tetraaryl-3,7-diazabicyclo[3.3.1]. Magn Reson Chem 43: 479-482, 2005.
3. Juran S, Walther M, Stephan H, Bergmann R, Steinbach J, Kraus W, Emmerling F and Comba P: Hexadentate bispidine derivatives as versatile bifunctional chelate agents for copper(II) radioisotopes. Bioconjug Chem 20: 347-359, 2009.
4. Joensuu H: Systemic chemotherapy for cancer: from weapon to treatment. Lancet Oncol 9: 304, 2008.
5. Degterev A, Boyce M and Yuan J: A decade of caspases. Oncogene 22: 8543-8567, 2003.
6. Ziegler DS and Kung AL: Therapeutic targeting of apoptosis pathways in cancer. Curr Opin Oncol 20: 97-103, 2008.
7. Kurokawa M and Kornbluth S: Caspases and kinases in a death grip. Cell 138: 838-854, 2009.
8. Desagher S and Martinou JC: Mitochondria as the central control point of apoptosis. Trends Cell Biol 10: 369-377, 2000.
9. Cory S and Adams JM: The Bcl-2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2: 647-656, 2002.
10. Farrow NS and Brown R: New members of the Bcl-2 family and their protein partners. Curr Opin Genet Develop 6: 45-49, 1996.
11. Yang E, Zha J, Jockel J, Bosie LH, Thompson CB and Korsmeyer SJ: Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death. Cell 80: 285-291, 1995.
12. Danial NN and Korsmeyer SJ: Cell death: critical control points. Cell 116: 205-219, 2004.
13. Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ and Vaux DL: Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102: 43-53, 2000.
14. Green DR and Reed JC: Mitochondria and apoptosis. Science 281: 1309-1312, 1998.
15. Kumar S and Vaux DL: Apoptosis. A Cinderella caspase takes center stage. Science 297: 1290-1291, 2002.
16. Jin Z and El-Deiry WS: Overview of cell death signaling pathways. Cancer Biol Ther 4: 139-163, 2005.
17. Liu J, Shen M, Yue Z, Yang Z, Wang M, Li C, Xin C, Wang Y, Mei Q and Wang Z: Triptolide inhibits colon-rectal cancer cells proliferation by induction of G1 phase arrest through upregulation of p21. Phytomedicine 19: 756-762, 2012.
18. Lodish H, Berk A, Zipursky SL, Matsudaria P, Baltimore D and Darnell J: Molecular Cell Biology. 4th edition. W.H. Freeman, New York, NY, 2000.
19. Zhao J, Kang SRM, Zhang X, You S, Park JS, Jung JH and Kim DK: Apoptotic activity of a new jasmonate analogue is associated with its induction of DNA damage. Oncol Rep 24: 771-777, 2010.
20. Fisher DE: Apoptosis in cancer therapy: crossing the threshold. Cell 78: 539-542, 1994.
21. Ghobrial IM, Witzig TE and Adjei AA: Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin 55: 178-194, 2005.
22. Tominaga H, Ishiyama M, Ohseto F, Sasamoto K, Hamamoto T, Suzuki K and Watanabe M: A water-soluble tetrazolium salt useful for colorimetric cell viability assay. Anal Commun 36: 47-50, 1999.
23. Zhang X, Zhao Z, Kang SRM, Yi MJ, You S, Shin DS and Kim DK: A novel cromakalim analogue induces cell cycle arrest and apoptosis in human cervical carcinoma HeLa cells through the caspase- and mitochondria-dependent pathway. Int J Oncol 39: 1609-1617, 2011.
24. Lin SY, Liu JD, Chang HC, Yeh SD, Lin CH and Lee WS: Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis. J Cell Biochem 84: 532-544, 2002.
25. Qi F, Li A, Zhao L, Xu H, Inagaki Y, Wang D, Cui X, Gao B, Kokudo N, Nakata M and Tang W: Cinobufacini, an aqueous extract from Bufo bufo gargarizans Cantor, induces apoptosis through a mitochondria-mediated pathway in human hepatocellular carcinoma cells. J Ethnopharmacol 128: 654-661, 2010.
26. Zhang Y, Ahn EY, Jiang Y, Kim DK, Kang SG, Wu C, Kang SW, Park JS, Son BW and Jung JH: 3-Chloro-2,5-dihydroxybenzyl alcohol activates human cervical carcinoma HeLa cell apoptosis by inducing DNA damage. Int J Oncol 31: 1317-1323, 2007.
27. Sánchez I and Dynlacht BD: New insights into cyclins, CDKs, and cell cycle control. Semin Cell Dev Biol 16: 311-321, 2005.
28. Lee S, Christakos S and Small MB: Apoptosis and signal transduction: clues to a molecular mechanism. Curr Opin Cell Biol 5: 286-291, 1993.
29. Dou QP: Putative roles of retinoblastoma protein in apoptosis. Apoptosis 2: 5-18, 1997.
30. Smith DM, Gao G, Zhang X, Wang G and Dou QP: Regulation of tumor cell apoptotic sensitivity during the cell cycle (Review). Int J Mol Med 6: 503-507, 2000.
31. Vermes I, Haanen C, Steffens-Nakken H and Reutelingsperger C: A novel assay for apoptosis flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods 184: 39-51, 1995.
32. Del Bino G, Darzynkiewicz Z, Degraef C, Mosselmans R, Fokan D and Galand P: Comparison of methods based on annexin-V binding, DNA content or TUNEL for evaluating cell death in HL-60 and adherent MCF-7 cells. Cell Prolif 32: 25-37, 1999.
33. Gross A, McDonnell JM and Korsmeyer SJ: BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13: 1899-1911, 1999.
34. Kiechle FL and Zhang X: Apoptosis: biochemical aspects and clinical implications. Clin Chim Acta 326: 27-45, 2002.
35. Otsuki Y, Li Z and Shibata MA: Apoptotic detection methods from morphology to gene. Prog Histochem Cytochem 38: 275-339, 2003.
36. Evan GI and Vousden KH: Proliferation, cell cycle and apoptosis in cancer. Nature 411: 342-348, 2001.
37. Orren DK, Petersen LN and Bohr VA: Persistent DNA damage inhibits S-phase and G2 progression and results in apoptosis. Mol Biol Cell 8: 1129-1142, 1997.
38. Qi F, Inagaki Y, Gao B, Cui X, Xu H, Kokudo N, Li A and Tang W: Bufalin and cinobufagin induce apoptosis of human hepatocellular carcinoma cells via Fas- and mitochondria-mediated pathways. Cancer Sci 102: 951-958, 2011.